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Newest in this topic

  1. Synaptic loss in alcohol use disorder: clinical and mechanistic insights from a PET imaging study 2026-03-31
  2. Neighborhood environmental deprivation predicts the generalized neurocognitive deficit in schizophrenia 2025-12-19
  3. Bridging the Gap: Can Hippocampal Sclerosis Serve as a Surrogate Biomarker for LATE‐NC? 2025-12-01

Studies

492 studies carry this tag.

Date range

1986 to 2026

Top journals

  • Neurology 38
  • Biological psychiatry 36
  • NeuroImage 32
  • The American journal of psychiatry 22
  • Proceedings of the National Academy of Sciences of the United States of America 20

148 journals in all.

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. Synaptic loss in alcohol use disorder: clinical and mechanistic insights from a PET imaging study

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Journal of Clinical Investigation 2026-03-31 Disease mechanisms

    Alcohol use disorder (AUD) is linked with changes in brain structure and function, with robust evidence for neurodegenerative changes, including synaptic loss in preclinical models.

  2. Neighborhood environmental deprivation predicts the generalized neurocognitive deficit in schizophrenia

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Schizophrenia Research 2025-12-19 Risk factors

    = 0.14. The effect of ADI score was also significant, β = -0.36, t = -2.30, p < .05; while the effect of RUCC, β = 0.06, t = 0.34, p = .73, and the interaction between ADI and RUCC, β = -0.001, t = 0.27, p = .99, were nonsignificant.

  3. Bridging the Gap: Can Hippocampal Sclerosis Serve as a Surrogate Biomarker for LATE‐NC?

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Alzheimer s & Dementia 2025-12-01 Brain tissue and pathology

    Among 1,307 individuals, 36.9% were non-White and 49.7% were women.

  4. The MIND diet association with lower microglial inflammation in the hippocampus: A Community‐Based Neuropathologic Study

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Alzheimer s & Dementia 2025-12-01 Prevention trials

    Higher MIND diet scores during the follow-up were associated with fewer reactive microglia (i.e., less neuroinflammation) in the hippocampus when controlled for age at death, sex, education, calories, and AD pathology (β=-0.035, SE=0.02, p = 0.045), but not with total microglia (β=-4.88, SE=3.08, p = 0.114).

  5. Long-term retrieval performance is associated with CA1 hippocampal volume in older adults and individuals at risk for dementia

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Alzheimer s Research & Therapy 2025-08-22 Cognitive tests and assessment

    Only FCSRT-IR LTR rates sufficiently differentiated SCD from HC (AUC of 0.701; 95% CI 0.537-0.865).

  6. Association of Increase in White Matter Hyperintensity Volume With Rate of Hippocampal Atrophy in a Population-Based Study of Aging

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Neurology 2025-08-19 Vascular contributions

    < 0.1). -ε4 status, and Aβ load, and not mediated by markers of neuroaxonal degradation.

  7. Insomnia, early and late rising are associated with small hippocampal volume and large white matter hyperintensity burden

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Alzheimer s Research & Therapy 2025-04-05 Vascular contributions

    Participants' median age was 70.7 years (Q1-Q3 = 67.8-74.0), with 52.4% being women.

  8. Hippocampal Volume Loss as A Marker of Cognitive Decline in Dementia and Mild Cognitive Impairment: A Comprehensive Prospective Study

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. National Journal of Medical Research 2025-04-01 Cognitive tests and assessment

    The mean hippocampal volumes were significantly smaller in the DEM group compared to the MCI and healthy groups (P <0.0001).

  9. Volume of the posterior and not anterior hippocampus predicts spatial memory performance in Alzheimer´s Disease

    ✓ Peer-reviewed alzhub usefulness score 30 out of 100. Alzheimer's &amp; Dementia 2023 Risk factors

    These results support a functional hippocampal anterior‐posterior differentiation in memory processes and further stress the importance of integrating the dissociation of the hippocampus along its long‐axis concerning functional connectivity in memory processes and dementia.

  10. Gut microbiome, cognitive function and brain structure: a multi-omics integration analysis

    ✓ Peer-reviewed alzhub usefulness score 64 out of 100. Translational neurodegeneration 2022-11-14 Hippocampus size on brain scans

    Our findings reveal that specific gut microbial features are closely associated with cognitive impairment and decreased hippocampal volume, which may play an important role in dementia development.

  11. Early life stress impairs synaptic pruning in the developing hippocampus

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Brain, behavior, and immunity 2022-09-26 TREM2 and immune genetics

    Early life adversity impairs normal hippocampal function and connectivity in various mammalian species, including humans and rodents.

  12. Astrocytic Piezo1-mediated mechanotransduction determines adult neurogenesis and cognitive functions

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Neuron 2022-08-12 Hippocampus size on brain scans

    Adult brain activities are generally believed to be dominated by chemical and electrical transduction mechanisms.

  13. Sex differences in brain functional connectivity of hippocampus in mild cognitive impairment

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Frontiers in aging neuroscience 2022-08-10 Long-term cohort studies

    Mild cognitive impairment (MCI) is the prodromal stage of Alzheimer's Disease (AD).

  14. The hearing hippocampus

    ✓ Peer-reviewed alzhub usefulness score 49 out of 100. Progress in neurobiology 2022-07-21 Digital health tools

    The hippocampus has a well-established role in spatial and episodic memory but a broader function has been proposed including aspects of perception and relational processing.

  15. Differential protein expression in the hippocampi of resilient individuals identified by digital spatial profiling

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Acta neuropathologica communications 2022-02-14 Biomarkers

    Clinical symptoms correlate with underlying neurodegenerative changes in the vast majority of people.

  16. Impact of neurodegenerative diseases on human adult hippocampal neurogenesis

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. Science (New York, N.Y.) 2021-10-21 Inflammation and the immune system

    Disrupted hippocampal performance underlies psychiatric comorbidities and cognitive impairments in patients with neurodegenerative disorders.

  17. Identifying the Distinct Cognitive Phenotypes in Multiple Sclerosis

    ✓ Peer-reviewed alzhub usefulness score 66 out of 100. JAMA neurology 2021-04-01 Hippocampus size on brain scans

    Patients with preserved cognition and mild-verbal memory/semantic fluency were younger (mean [SD] age, 36.5 [9.8] years and 38.2 [11.1] years) and had shorter disease duration (mean [SD] 8.0 [7.3] years and 8.3 [7.6] years) compared with patients with mild-multidomain (mean [SD] age, 42.6 [11.2] years; mean [SD] disease duration, 12.8 [9.6] years; P < .001), severe-executive/attention (mean [SD] age, 42.9 [11.7] years; mean [SD] disease duration, 12.2 [9.5] years; P < .001), and severe-multidomain (mean [SD] age, 44.0 [11.0] years; mean [SD] disease duration, 13.3 [10.2] years; P < .001) phenotypes.

  18. Exercise interventions preserve hippocampal volume: A meta-analysis

    ✓ Peer-reviewed alzhub usefulness score 74 out of 100. Hippocampus 2020-12-14 Prevention trials

    Hippocampal volume is a marker of brain health and is reduced with aging and neurological disease.

  19. Profile of MIF in Developing Hippocampus: Association With Cell Proliferation and Neurite Outgrowth

    ✓ Peer-reviewed alzhub usefulness score 34 out of 100. Frontiers in molecular neuroscience 2020-08-12 Biomarkers

    Proinflammatory cytokine macrophage migration inhibitory factor (MIF) is a multifunctional cytokine and has been found involved in many neurological diseases such as Alzheimer disease (AD), epilepsy, and multiple sclerosis.

  20. Spermidine intake is associated with cortical thickness and hippocampal volume in older adults

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. NeuroImage 2020-07-03 Prevention trials

    Previous research has demonstrated beneficial impact of spermidine intake on memory functions in both animal models and humans, suggesting that spermidine may be a preventive approach to delay age-related cognitive decline and possibly even Alzheimer's disease (AD).

  21. Adult Hippocampal Neurogenesis in Major Depressive Disorder and Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Trends in molecular medicine 2020-05-14 Prevention and risk

    Depression and dementia are major public health problems.

  22. Association of Neighborhood-Level Disadvantage With Cerebral and Hippocampal Volume

    ✓ Peer-reviewed alzhub usefulness score 68 out of 100. JAMA neurology 2020-04-01 Prevention and risk

    For cognitively unimpaired individuals, living in the most disadvantaged neighborhoods was associated with significantly lower cerebral volumes, after controlling for maximal premorbid (total intracranial) volume.

  23. Hippocampal vascular reserve associated with cognitive performance and hippocampal volume

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Brain : a journal of neurology 2020-02-01 Hippocampus size on brain scans

    Medial temporal lobe dependent cognitive functions are highly vulnerable to hypoxia in the hippocampal region, yet little is known about the relationship between the richness of hippocampal vascular supply and cognition.

  24. Hippocampal plasticity underpins long-term cognitive gains from resistance exercise in MCI

    ✓ Peer-reviewed alzhub usefulness score 74 out of 100. NeuroImage. Clinical 2020-01-14 Prevention trials

    Furthermore, hippocampal subfields susceptible to atrophy in AD were protected by PRT revealing an elimination of long-term atrophy in the left subiculum, and attenuation of atrophy in left CA1 and dentate gyrus when compared to SHAM+SHAM (p = 0.023, p = 0.020 and p = 0.027).

  25. Association of Prenatal Maternal Psychological Distress With Fetal Brain Growth, Metabolism, and Cortical Maturation

    ✓ Peer-reviewed alzhub usefulness score 69 out of 100. JAMA network open 2020-01-03 Hippocampus size on brain scans

    This study found that the prevalence of maternal psychological distress in healthy, well-educated, and employed pregnant women was high, underappreciated, and associated with impaired fetal brain biochemistry and hippocampal growth as well as accelerated cortical folding.

  26. Hippocampal Volume Loss, Brain Amyloid Accumulation, and APOE Status in Cognitively Intact Elderly Subjects

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Neuro-degenerative diseases 2019-12-17 Biomarkers

    The progressive decrement of neuropsychological performance is associated with HVL long before the emergence of clinically overt symptoms.

  27. Contribution of TDP and hippocampal sclerosis to hippocampal volume loss in older-old persons

    ✓ Peer-reviewed alzhub usefulness score 62 out of 100. Neurology 2019-11-22 Brain scans and imaging

    Both AD and TDP/HS contribute to hippocampal volume loss in older-old persons, with TDP/HS more strongly associated with hippocampal volume than AD in Alzheimer dementia.

  28. Brain age in bipolar disorders: Effects of lithium treatment

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. The Australian and New Zealand journal of psychiatry 2019-06-27 Digital health tools

    Bipolar disorders were associated with greater, whereas Li treatment with lower discrepancy between brain and chronological age.

  29. Hippocampal volume across age: Nomograms derived from over 19,700 people in UK Biobank

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. NeuroImage. Clinical 2019-06-19 Hippocampus size on brain scans

    Measurement of hippocampal volume has proven useful to diagnose and track progression in several brain disorders, most notably in Alzheimer's disease (AD).

  30. Cigarette smoking and gray matter brain volumes in middle age adults: the CARDIA Brain MRI sub-study

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. Translational psychiatry 2019-02-11 Disparities

    Cigarette smoking has been associated with dementia and dementia-related brain changes, notably gray matter (GM) volume atrophy.

  31. The Hippocampus in Depression: More Than the Sum of Its Parts? Advanced Hippocampal Substructure Segmentation in Depression

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Biological psychiatry 2018-09-06 Hippocampus size on brain scans

    Hippocampal involvement in MDD is confined to principal substructures only.

  32. MRI Asymmetry Index of Hippocampal Subfields Increases Through the Continuum From the Mild Cognitive Impairment to the Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. Frontiers in neuroscience 2018-08-21 Mild cognitive impairment

    We found a general trend of increased degree of asymmetry with increasing severity of diagnosis.

  33. Basal Forebrain Volume, but Not Hippocampal Volume, Is a Predictor of Global Cognitive Decline in Patients With Alzheimer's Disease Treated With Cholinesterase Inhibitors

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. Frontiers in neurology 2018-08-14 Long-term cohort studies

    Predicting the progression of cognitive decline in Alzheimer's disease (AD) is important for treatment selection and patient counseling.

  34. Meta-Analysis of 89 Structural MRI Studies in Posttraumatic Stress Disorder and Comparison With Major Depressive Disorder

    ✓ Peer-reviewed alzhub usefulness score 74 out of 100. The American journal of psychiatry 2018-07-19 Hippocampus size on brain scans

    The meta-analyses revealed structural brain abnormalities associated with PTSD and trauma and suggest that global brain volume reductions distinguish PTSD from major depression.

  35. A lexical semantic hub for heteromodal naming in middle fusiform gyrus

    ✓ Peer-reviewed alzhub usefulness score 54 out of 100. Brain : a journal of neurology 2018-07-01 Digital health tools

    We observed three stages of activity during both visual picture naming and auditory naming to definition that were serially organized: sensory processing, lexical semantic processing, and articulation.

  36. Volume of the Human Hippocampus and Clinical Response Following Electroconvulsive Therapy

    ✓ Peer-reviewed alzhub usefulness score 66 out of 100. Biological psychiatry 2018-05-29 Hippocampus size on brain scans

    The number of ECT sessions and electrode placement impacts the extent and laterality of hippocampal enlargement, but volume change is not positively associated with clinical outcome.

  37. Subregional volumes of the hippocampus in relation to cognitive function and risk of dementia

    ✓ Peer-reviewed alzhub usefulness score 58 out of 100. NeuroImage 2018-05-18 Long-term cohort studies

    Total hippocampal volume has been consistently linked to cognitive function and dementia.

  38. Environmental enrichment increases transcriptional and epigenetic differentiation between mouse dorsal and ventral dentate gyrus

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Nature communications 2018-01-19 Hippocampus size on brain scans

    Early life experience influences stress reactivity and mental health through effects on cognitive-emotional functions that are, in part, linked to gene expression in the dorsal and ventral hippocampus.

  39. Brain-Derived Neurotrophic Factor and Major Depressive Disorder: Evidence from Meta-Analyses

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Frontiers in psychiatry 2018-01-17 Hippocampus size on brain scans

    Accumulating evidence suggests that brain-derived neurotrophic factor (BDNF) is associated with the pathophysiology of major depressive disorder (MDD).

  40. Differential effects of childhood neglect and abuse during sensitive exposure periods on male and female hippocampus

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. NeuroImage 2017-12-27 Hippocampus size on brain scans

    The hippocampus is a highly stress susceptible structure and hippocampal abnormalities have been reported in a host of psychiatric disorders including major depression and post-traumatic stress disorder (PTSD).

  41. Altered neuro-inflammatory gene expression in hippocampus in major depressive disorder

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Progress in neuro-psychopharmacology & biological psychiatry 2017-11-22 Hippocampus size on brain scans

    Major Depressive Disorder (MDD) is a common psychiatric disorder for which available medications are often not effective.

  42. Effect of aerobic exercise on hippocampal volume in humans: A systematic review and meta-analysis

    ✓ Peer-reviewed alzhub usefulness score 74 out of 100. NeuroImage 2017-11-04 Hippocampus size on brain scans

    Hippocampal volume increase in response to aerobic exercise has been consistently observed in animal models.

  43. Neural basis of major depressive disorder: Beyond monoamine hypothesis

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Psychiatry and clinical neurosciences 2017-10-19 Hippocampus size on brain scans

    The monoamine hypothesis has been accepted as the most common hypothesis of major depressive disorder (MDD) for a long period because of its simplicity and understandability.

  44. Smaller Hippocampal Volume in Posttraumatic Stress Disorder: A Multisite ENIGMA-PGC Study: Subcortical Volumetry Results From Posttraumatic Stress Disorder Consortia

    ✓ Peer-reviewed alzhub usefulness score 76 out of 100. Biological psychiatry 2017-09-20 Hippocampus size on brain scans

    Our study is not subject to the biases of meta-analyses of published data, and it represents an important milestone in an ongoing collaborative effort to examine the neurobiological underpinnings of PTSD and the brain's response to trauma.

  45. Rates of hippocampal atrophy and presence of post-mortem TDP-43 in patients with Alzheimer's disease: a longitudinal retrospective study

    ✓ Peer-reviewed alzhub usefulness score 69 out of 100. The Lancet. Neurology 2017-09-11 Hippocampus size on brain scans

    We aimed to investigate whether hippocampal TDP-43 is associated with increased rates of hippocampal atrophy.

  46. Trauma, PTSD, and the Developing Brain

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Current psychiatry reports 2017-08-19 Hippocampus size on brain scans

    PTSD in youth is common and debilitating.

  47. Slowing gait and risk for cognitive impairment: The hippocampus as a shared neural substrate

    ✓ Peer-reviewed alzhub usefulness score 59 out of 100. Neurology 2017-06-28 Hippocampus size on brain scans

    The association between gait slowing and cognitive impairment is supported by a shared neural substrate that includes a smaller right hippocampus.

  48. Stress and Loss of Adult Neurogenesis Differentially Reduce Hippocampal Volume

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Biological psychiatry 2017-05-22 Hippocampus size on brain scans

    The findings suggest that adult neurogenesis is required to maintain hippocampal volume but is not responsible for stress-induced volume loss.

  49. Hippocampal and Amygdala Gray Matter Loss in Elderly Controls with Subtle Cognitive Decline

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. Frontiers in aging neuroscience 2017-03-07 Brain scans and imaging

    In contrast to the idea that hippocampal and amygdala volume loss occur in late phases of neurodegeneration, recent contributions point to the relevance of preexisting structural deficits that are associated with aging and are independent of amyloid deposition in preclinical Alzheimer disease cases.

  50. Exercise training for neural recovery in a restricted sample of pediatric brain tumor survivors: a controlled clinical trial with crossover of training versus no training

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Neuro-oncology 2017-03-01 Hippocampus size on brain scans

    Exercise training is an effective means for promoting white matter and hippocampal recovery and improving reaction time in children treated with cranial radiation for brain tumors.

From across this tag

8 of the 492 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 8. The same 8 appear here every time.

All topic tags with their study counts