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Neuropathological consensus criteria for the evaluation of Lewy pathology in post-mortem brains: a multi-centre study
Attems J, Toledo JB, Walker L, Gelpi E, Gentleman S, Halliday G, Hortobagyi T, Jellinger K et al.. Acta neuropathologica, 2021-01-05
Topic: Brain proteins, microglia and lab models
The category of neocortical LP according to the LPC system was associated with a 5.9 OR (p < 0.0001) of dementia in the 134 NBTR cases and a 3.14 OR (p = 0.0001) in the 202 UPBB cases. We expect that it will be reliable and useful in routine diagnostic practice and, therefore, suggest that it should be the standard future approach for the basic post-mortem evaluation of LP.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Attems, J., Toledo, J. B., Walker, L., Gelpi, E., Gentleman, S., Halliday, G., et al. (2021). Neuropathological consensus criteria for the evaluation of Lewy pathology in post-mortem brains: a multi-centre study. Acta neuropathologica. https://doi.org/10.1007/s00401-020-02255-2
Vancouver
Attems J, Toledo JB, Walker L, Gelpi E, Gentleman S, Halliday G, et al. Neuropathological consensus criteria for the evaluation of Lewy pathology in post-mortem brains: a multi-centre study. Acta neuropathologica. 2021. doi:10.1007/s00401-020-02255-2. PMID: 33399945.
BibTeX
@article{attems2021-33399945,
author = {Attems, J. and Toledo, J. B. and Walker, L. and Gelpi, E. and Gentleman, S. and Halliday, G. and Hortobagyi, T. and Jellinger, K. and others},
title = {{Neuropathological consensus criteria for the evaluation of Lewy pathology in post-mortem brains: a multi-centre study}},
journal = {Acta neuropathologica},
year = {2021},
doi = {10.1007/s00401-020-02255-2},
pmid = {33399945},
url = {https://doi.org/10.1007/s00401-020-02255-2}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
Key findings
- The category of neocortical LP according to the LPC system was associated with a 5.9 OR (p < 0.0001) of dementia in the 134 NBTR cases and a 3.14 OR (p = 0.0001) in the 202 UPBB cases.
- We expect that it will be reliable and useful in routine diagnostic practice and, therefore, suggest that it should be the standard future approach for the basic post-mortem evaluation of LP.
Why it matters
This multi-centre study found that the neocortical Lewy pathology category was associated with higher odds of dementia in two case sets. The authors suggest this system should be the standard future approach for basic post-mortem evaluation of Lewy pathology, so it concerns diagnosis after death rather than treatment, cure or prevention.
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Study details
- Participants202
- Effect sizeor 97.1; 11.8%; 26.5%
- Evidence strengthLow
How this study scored 65/100
Published in a leading specialty journal. Scored zero for study design and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Acta neuropathologica) |
| Journal's citation record | 3 / 4 | Acta Neuropathologica: journal h-index 287 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2021 — within 6 year(s) of the newest study here |
| Sample size | 2 / 4 | 202 participants |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 283 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 40.4 citations a year over 7 year(s) since 2021 |
| Impact for its field and year | 4 / 6 | Cited 17.3× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 3 / 6 | Cited by 24 other studies in this library |
| Still being cited | 3 / 4 | Cited 192 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Ian Grant McKeith: h-index 119 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University of Oxford: institution h-index 2,205 (OpenAlex) |
| Multi-centre collaboration | 3 / 3 | OpenAlex lists 27 institution(s) in 12 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 33399945) |
| Free to read | 2 / 2 | Free to read |
| Total | 65 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1007/s00401-020-02255-2
- PubMed: 33399945
- Original source →
- Free full text: Acta Neuropathologica →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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