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56/100

✓ Peer-reviewed alzhub usefulness score 56 out of 100. Long-term cohort studies

Topic: Amyloid, tau and blood-test diagnosis

The classic pathologic hallmarks of Alzheimer's disease (AD) are amyloid plaques and neurofibrillary tangles (AD neuropathologic changes, or ADNC). However, brains from individuals clinically diagnosed with "AD-type" (amnestic) dementia usually harbor heterogeneous neuropathologies in addition to, or other than, ADNC. We hypothesized that some AD-type dementia associated genetic single nucleotide variants (SNVs) identified from large genomewide association studies (GWAS) were associated with non-ADNC neuropathologies.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Katsumata, Y., Shade, L. M., Hohman, T. J., Schneider, J. A., Bennett, D. A., Farfel, J. M., et al. (2022). Multiple gene variants linked to Alzheimer's-type clinical dementia via GWAS are also associated with non-Alzheimer's neuropathologic entities. Neurobiology of disease. https://doi.org/10.1016/j.nbd.2022.105880

Vancouver

Katsumata Y, Shade LM, Hohman TJ, Schneider JA, Bennett DA, Farfel JM, et al. Multiple gene variants linked to Alzheimer's-type clinical dementia via GWAS are also associated with non-Alzheimer's neuropathologic entities. Neurobiology of disease. 2022. doi:10.1016/j.nbd.2022.105880. PMID: 36191742.

BibTeX

@article{katsumata2022-36191742,
  author  = {Katsumata, Y. and Shade, L. M. and Hohman, T. J. and Schneider, J. A. and Bennett, D. A. and Farfel, J. M. and {Alzheimer’s Disease Genetics Consortium} and Kukull, W. A. and others},
  title   = {{Multiple gene variants linked to Alzheimer's-type clinical dementia via GWAS are also associated with non-Alzheimer's neuropathologic entities}},
  journal = {Neurobiology of disease},
  year    = {2022},
  doi     = {10.1016/j.nbd.2022.105880},
  pmid    = {36191742},
  url     = {https://doi.org/10.1016/j.nbd.2022.105880}
}

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Key findings

However, brains from individuals clinically diagnosed with "AD-type" (amnestic) dementia usually harbor heterogeneous neuropathologies in addition to, or other than, ADNC.
We hypothesized that some AD-type dementia associated genetic single nucleotide variants (SNVs) identified from large genomewide association studies (GWAS) were associated with non-ADNC neuropathologies.
To test this hypothesis, we analyzed data from multiple studies with available genotype and neuropathologic phenotype information.
Clinical AD/dementia risk alleles of interest were derived from the very large GWAS by Bellenguez et al.

Why it matters

This study found that some gene variants linked to Alzheimer's-type dementia are also associated with other brain pathologies besides the classic amyloid plaques and tangles. It does not show that targeting these genes prevents or treats dementia.

Study details

Participants273
Evidence strengthModerate

How this study scored 56/100

Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Neurobiology of disease)
Journal's citation record	2 / 4	Neurobiology of Disease: journal h-index 225 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	3 / 5	2022 — within 6 year(s) of the newest study here
Sample size	2 / 4	273 participants
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	4 / 7	Cited 50 times (OpenAlex, 2026-10-10)
Citations per year	3 / 5	8.3 citations a year over 6 year(s) since 2022
Impact for its field and year	3 / 6	Cited 4.9× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	2 / 6	Cited by 3 other studies in this library
Still being cited	2 / 4	Cited 43 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	3 / 4	Last-listed author Peter T. Nelson: h-index 92 (OpenAlex, whole career)
Institution's track record	3 / 3	University of Washington: institution h-index 3,540 (OpenAlex)
Multi-centre collaboration	2 / 3	OpenAlex lists 4 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 36191742)
Free to read	2 / 2	Free to read
Total	56 / 100	—

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