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Motor dysfunction in mild cognitive impairment and the risk of incident Alzheimer disease
Aggarwal NT, Wilson RS, Beck TL, Bienias JL, Bennett DA.. Archives of neurology, 2006-12-01
Topic: Risk, prevention and care in population studies
Background Little is known about motor function in mild cognitive impairment (MCI) and its relation to the risk of Alzheimer disease (AD). Objective To examine motor function in persons with MCI and its relation to risk of AD. Design Longitudinal cohort study. Setting More than 40 Catholic religious orders across the United States. Participants We studied 816 older Catholic clergy members from the Religious Orders Study. At the baseline evaluation, they were classified as having no cognitive impairment (n = 558), MCI (n = 198), or dementia (n = 60). Main outcome measures Motor function was assessed at baseline using performance-based measures of upper and lower extremity function and a modified version of the motor section of the Unified Parkinson's Disease Rating Scale, from which previously established measures of parkinsonian signs were derived. Clinical evaluations for dementia and AD were repeated annually for up to 10 years. All analyses controlled for age, sex, educational level, and possession of at least 1 apolipoprotein E epsilon4 allele. Results At baseline, individuals with MCI had impaired motor function relative to those without cognitive impairment and superior motor function vs those with dementia. Among those with MCI, baseline levels of lower extremity motor performance, parkinsonian gait, and bradykinesia were inversely related to risk of AD, even after controlling for clinical stroke. Thus, a person with impaired lower limb performance or parkinsonian gait (10th percentile) was 2 to 3 times more likely to develop AD than a person with good lower limb function (90th percentile). Conclusions Persons with MCI also have impaired motor function, and the degree of impairment in lower extremity function is related to the risk of AD.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Aggarwal, N. T., Wilson, R. S., Beck, T. L., Bienias, J. L., & Bennett, D. A. (2006). Motor dysfunction in mild cognitive impairment and the risk of incident Alzheimer disease. Archives of neurology. https://doi.org/10.1001/archneur.63.12.1763
Vancouver
Aggarwal NT, Wilson RS, Beck TL, Bienias JL, Bennett DA. Motor dysfunction in mild cognitive impairment and the risk of incident Alzheimer disease. Archives of neurology. 2006. doi:10.1001/archneur.63.12.1763. PMID: 17172617.
BibTeX
@article{aggarwal2006-17172617,
author = {Aggarwal, N. T. and Wilson, R. S. and Beck, T. L. and Bienias, J. L. and Bennett, D. A.},
title = {{Motor dysfunction in mild cognitive impairment and the risk of incident Alzheimer disease}},
journal = {Archives of neurology},
year = {2006},
doi = {10.1001/archneur.63.12.1763},
pmid = {17172617},
url = {https://doi.org/10.1001/archneur.63.12.1763}
}
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Key findings
- Results At baseline, individuals with MCI had impaired motor function relative to those without cognitive impairment and superior motor function vs those with dementia.
Study details
- Study designcohort study
- Participants558
- Evidence strengthModerate
How this study scored 60/100
Published in a peer-reviewed journal, and it is a cohort study following people over time. Scored zero for effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 35 of the 58 points we could judge it on, which is 60 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Archives of neurology) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 7 / 12 | A cohort study following people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2006 — older than 20 years, still counted |
| Sample size | 2 / 4 | 558 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 17172617) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 35 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 35 of the 58 points we could judge it on is 60 out of 100. |
| Total | 60 / 100 | — |
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