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Neuropsychological Criteria for Mild Cognitive Impairment and Dementia Risk in the Framingham Heart Study
Jak AJ, Preis SR, Beiser AS, Seshadri S, Wolf PA, Bondi MW, Au R.. Journal of the International Neuropsychological Society : JINS, 2016-03-31
Topic: Risk, prevention and care in population studies
Objectives To refine mild cognitive impairment (MCI) diagnostic criteria, we examined progression to dementia using two approaches to identifying MCI. Methods A total of 1203 Framingham Heart Study participants were classified at baseline as cognitively normal or MCI (overall and four MCI subtypes) via conventional Petersen/Winblad criteria (single cognitive test impaired per domain, >1.5 SD below expectations) or Jak/Bondi criteria (two tests impaired per domain, >1 SD below norms). Cox proportional hazards models were constructed to examine the association between each MCI definition and incident dementia. Results The Petersen/Winblad criteria classified 34% of participants as having MCI while the Jak/Bondi criteria classified 24% as MCI. Over a mean follow-up of 9.7 years, 58 participants (5%) developed incident dementia. Both MCI criteria were associated with incident dementia [Petersen/Winblad: hazards ratio (HR) = 2.64; p-value=.0002; Jak/Bondi: HR=3.30; p-value Conclusions The Jak/Bondi MCI criteria had a similar association with dementia as the conventional Petersen/Winblad MCI criteria, despite classifying ~30% fewer participants as having MCI. Further exploration of alternative methods to conventional MCI diagnostic criteria is warranted. (JINS, 2016, 22, 937-943).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Jak, A. J., Preis, SR., Beiser, A. S., Seshadri, S., Wolf, P. A., Bondi, M. W., et al. (2016). Neuropsychological Criteria for Mild Cognitive Impairment and Dementia Risk in the Framingham Heart Study. Journal of the International Neuropsychological Society : JINS. https://doi.org/10.1017/s1355617716000199
Vancouver
Jak AJ, Preis SR, Beiser AS, Seshadri S, Wolf PA, Bondi MW, et al. Neuropsychological Criteria for Mild Cognitive Impairment and Dementia Risk in the Framingham Heart Study. Journal of the International Neuropsychological Society : JINS. 2016. doi:10.1017/s1355617716000199. PMID: 27029348.
BibTeX
@article{jak2016-27029348,
author = {Jak, A. J. and Preis, SR. and Beiser, A. S. and Seshadri, S. and Wolf, P. A. and Bondi, M. W. and Au, R.},
title = {{Neuropsychological Criteria for Mild Cognitive Impairment and Dementia Risk in the Framingham Heart Study}},
journal = {Journal of the International Neuropsychological Society : JINS},
year = {2016},
doi = {10.1017/s1355617716000199},
pmid = {27029348},
url = {https://doi.org/10.1017/s1355617716000199}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
Key findings
- Methods A total of 1203 Framingham Heart Study participants were classified at baseline as cognitively normal or MCI (overall and four MCI subtypes) via conventional Petersen/Winblad criteria (single cognitive test impaired per domain, >1.5 SD below expectations) or Jak/Bondi criteria (two tests impaired per domain, >1 SD below norms).
- Results The Petersen/Winblad criteria classified 34% of participants as having MCI while the Jak/Bondi criteria classified 24% as MCI.
- Both MCI criteria were associated with incident dementia [Petersen/Winblad: hazards ratio (HR) = 2.64; p-value=.0002; Jak/Bondi: HR=3.30; p-value <.0001].
Why it matters
In 1,203 Framingham Heart Study participants, a stricter way of diagnosing mild cognitive impairment (Jak/Bondi: two low test scores in a thinking domain instead of one) labelled 24% of people with MCI, compared with 34% under the usual Petersen/Winblad rules. Even so, the authors found a "similar" link to later dementia (hazard ratio 3.30 vs 2.64). Over about 9.7 years only 5% of all participants developed dementia, and the authors call for more work on alternatives to conventional MCI criteria rather than declaring a new standard.
Study details
- Participants58
- Effect sizeHR=3.30
- Evidence strengthLow
How this study scored 53/100
Published in a peer-reviewed journal. Scored zero for study design and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of the International Neuropsychological Society : JINS) |
| Journal's citation record | 2 / 4 | Journal of the International Neuropsychological Society: journal h-index 176 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2016 — within 20 year(s) of the newest study here |
| Sample size | 1 / 4 | 58 participants |
| Effect reported | 3 / 3 | Effect reported with a statistic (interval, p-value, ratio or similar) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 148 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 12.3 citations a year over 12 year(s) since 2016 |
| Impact for its field and year | 4 / 6 | Cited 8.0× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 7 other studies in this library |
| Still being cited | 2 / 4 | Cited 44 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Rhoda Au: h-index 90 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University of California San Diego: institution h-index 1,852 (OpenAlex) |
| Multicenter collaboration | 2 / 3 | OpenAlex lists 4 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 27029348) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 53 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1017/s1355617716000199
- PubMed: 27029348
- Original source →
- Free full text: eScholarship (California Digital Library) →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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