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69/100

✓ Peer-reviewed alzhub usefulness score 69 out of 100. Disparities

Topic: Risk, prevention and care in population studies

Importance Residence in a disadvantaged neighborhood may be associated with an increased risk for cognitive impairment and dementia but is understudied in nationally representative populations. Results Among the 1 637 484 Veterans Health Administration patients, the mean (SD) age was 68.6 (7.7) years, and 1 604 677 (98.0%) were men. Compared with veterans in the least disadvantaged neighborhood quintile, those in greater disadvantage groups had an increased risk of dementia in models adjusted for sex, race and ethnicity, and psychiatric and medical comorbid conditions (first quintile = reference; second quintile adjusted hazard ratio [HR], 1.09 [95% CI, 1.07-1.10]; third quintile adjusted HR, 1.14 [95% CI, 1.12-1.15]; fourth quintile adjusted HR, 1.16 [95% CI, 1.14-1.18]; and fifth quintile adjusted HR, 1.22 [95% CI, 1.21-1.24]). Repeating the main analysis using competing risk for mortality led to similar results. Conclusions and relevance Results of this study suggest that residence within more disadvantaged neighborhoods was associated with higher risk of dementia among older veterans integrated in a national health care system.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Dintica, C. S., Bahorik, A., Xia, F., Kind, A., & Yaffe, K. (2023). Dementia Risk and Disadvantaged Neighborhoods. JAMA neurology. https://doi.org/10.1001/jamaneurol.2023.2120

Vancouver

Dintica CS, Bahorik A, Xia F, Kind A, Yaffe K. Dementia Risk and Disadvantaged Neighborhoods. JAMA neurology. 2023. doi:10.1001/jamaneurol.2023.2120. PMID: 37464954.

BibTeX

@article{dintica2023-37464954,
  author  = {Dintica, C. S. and Bahorik, A. and Xia, F. and Kind, A. and Yaffe, K.},
  title   = {{Dementia Risk and Disadvantaged Neighborhoods}},
  journal = {JAMA neurology},
  year    = {2023},
  doi     = {10.1001/jamaneurol.2023.2120},
  pmid    = {37464954},
  url     = {https://doi.org/10.1001/jamaneurol.2023.2120}
}

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Key findings

Importance Residence in a disadvantaged neighborhood may be associated with an increased risk for cognitive impairment and dementia but is understudied in nationally representative populations.
Results Among the 1 637 484 Veterans Health Administration patients, the mean (SD) age was 68.6 (7.7) years, and 1 604 677 (98.0%) were men.
Compared with veterans in the least disadvantaged neighborhood quintile, those in greater disadvantage groups had an increased risk of dementia in models adjusted for sex, race and ethnicity, and psychiatric and medical comorbid conditions (first quintile = reference; second quintile adjusted hazard ratio [HR], 1.09 [95% CI, 1.07-1.10]; third quintile adjusted HR, 1.14 [95% CI, 1.12-1.15]; fourth quintile adjusted HR, 1.16 [95% CI, 1.14-1.18]; and fifth quintile adjusted HR, 1.22 [95% CI, 1.21-1.24]).
Repeating the main analysis using competing risk for mortality led to similar results.
Conclusions and relevance Results of this study suggest that residence within more disadvantaged neighborhoods was associated with higher risk of dementia among older veterans integrated in a national health care system.

Why it matters

Among 1,637,484 Veterans Health Administration patients, residence in more disadvantaged neighborhoods was associated with higher risk of dementia in adjusted models. This is an observational association between neighborhood disadvantage and dementia risk, not a treatment, cure, or prevention finding.

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Study details

Study designcohort study
Participants7,318
Effect size98.0%; 0.4%; 9.3%
Evidence strengthModerate

How this study scored 69/100

Published in a leading specialty journal, and it is a cohort study following people over time. Scored zero for randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	9 / 10	Tier 2 — leading specialty journal (JAMA neurology)
Journal's citation record	2 / 4	JAMA Neurology: journal h-index 235 (OpenAlex, 2026-10-29)
Study design	7 / 12	A cohort study following people over time
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	3 / 5	2023 — within 6 year(s) of the newest study here
Sample size	3 / 4	7,318 participants
Effect reported	2 / 3	Effect reported as a number, without an interval or test
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	4 / 7	Cited 90 times (OpenAlex, 2026-10-10)
Citations per year	3 / 5	18.0 citations a year over 5 year(s) since 2023
Impact for its field and year	4 / 6	Cited 16.2× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	3 / 6	Cited by 19 other studies in this library
Still being cited	3 / 4	Cited 87 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	4 / 4	Last-listed author Kristine S. Yaffe: h-index 155 (OpenAlex, whole career)
Institution's track record	2 / 3	University of California, San Francisco: institution h-index 1,915 (OpenAlex)
Multi-centre collaboration	2 / 3	OpenAlex lists 5 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 37464954)
Free to read	0 / 2	Behind a paywall — scores zero
Total	69 / 100	—

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