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Mild Cognitive Impairment
Petersen RC.. Continuum (Minneapolis, Minn.), 2016-04-01
Topic: Risk, prevention and care in population studies
Purpose of review As individuals age, the quality of cognitive function becomes an increasingly important topic. The concept of mild cognitive impairment (MCI) has evolved over the past 2 decades to represent a state of cognitive function between that seen in normal aging and dementia. As such, it is important for health care providers to be aware of the condition and place it in the appropriate clinical context. Recent findings Numerous international population-based studies have been conducted to document the frequency of MCI, estimating its prevalence to be between 15% and 20% in persons 60 years and older, making it a common condition encountered by clinicians. The annual rate in which MCI progresses to dementia varies between 8% and 15% per year, implying that it is an important condition to identify and treat. In those MCI cases destined to develop Alzheimer disease, biomarkers are emerging to help identify etiology and predict progression. However, not all MCI is due to Alzheimer disease, and identifying subtypes is important for possible treatment and counseling. If treatable causes are identified, the person with MCI might improve. Summary MCI is an important clinical entity to identify, and while uncertainties persist, clinicians need to be aware of its diagnostic features to enable them to counsel patients. MCI remains an active area of research as numerous randomized controlled trials are being conducted to develop effective treatments.
Key findings
- In those MCI cases destined to develop Alzheimer disease, biomarkers are emerging to help identify etiology and predict progression.
- However, not all MCI is due to Alzheimer disease, and identifying subtypes is important for possible treatment and counseling.
- If treatable causes are identified, the person with MCI might improve.
- Summary MCI is an important clinical entity to identify, and while uncertainties persist, clinicians need to be aware of its diagnostic features to enable them to counsel patients.
- MCI remains an active area of research as numerous randomized controlled trials are being conducted to develop effective treatments.
Why it matters
This review describes mild cognitive impairment as a state between normal aging and dementia, with prevalence of 15% to 20% in people 60 and older and annual progression to dementia of 8% to 15%. It notes that not all mild cognitive impairment is due to Alzheimer's disease and that treatable causes may improve, but it does not present a treatment or cure.
New to this subject? Start with our plain-English guide: Alzheimer's in numbers →
Study details
- Evidence strengthHigh
How this study scored 46/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here and still being cited, so those were left out: it earned 31 of the 68 points we could judge it on, which is 46 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Continuum (Minneapolis, Minn.)) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 5 / 5 | Rated “high” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2016 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | Citation count not trusted: 13 of 42 library studies citing it were published more than a year before it - a sign OpenAlex merged several works under this DOI — left out of this score |
| Citations per year | — / 5 | Citation count not trusted (see above) — left out of this score |
| Impact for its field and year | — / 6 | Citation count not trusted (see above) — left out of this score |
| Cited by studies here | — / 6 | Library citations not trusted (see above) — left out of this score |
| Still being cited | — / 4 | Citation count not trusted (see above) — left out of this score |
| Senior author's track record | 4 / 4 | Last-listed author Ronald Carl Petersen: h-index 209 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | Mayo Clinic: institution h-index 1,606 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 27042901) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 31 / 68 | Scored on 14 of 20 parts. We have no data for the rest, so they are left out: 31 of the 68 points we could judge it on is 46 out of 100. |
| Total | 46 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1212/con.0000000000000313
- PubMed: 27042901
- Original source →
- Free full text: PubMed Central →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Petersen, R. C. (2016). Mild Cognitive Impairment. Continuum (Minneapolis, Minn.). https://doi.org/10.1212/con.0000000000000313
Vancouver
Petersen RC. Mild Cognitive Impairment. Continuum (Minneapolis, Minn.). 2016. doi:10.1212/con.0000000000000313. PMID: 27042901.
BibTeX
@article{petersen2016-27042901,
author = {Petersen, R. C.},
title = {{Mild Cognitive Impairment}},
journal = {Continuum (Minneapolis, Minn.)},
year = {2016},
doi = {10.1212/con.0000000000000313},
pmid = {27042901},
url = {https://doi.org/10.1212/con.0000000000000313}
}
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