Alzheimer Disease Biomarkers and Subjective Cognitive Decline Among Hispanic and/or Latino Adults
Linda C. Gallo, Ariana M. Stickel, Haibo Zhou, Hector M. González, Michael A. Yassa, Deisha F. Valencia, Kevin Gonzalez, Zachary T. Goodman et al.. UNC Libraries, 2026-07-11
Topic: Amyloid, tau and blood-test diagnosis
Among 5712 adults (mean [SD] age, 63.47 (8.15) years; unweighted 3663 [53.92%] female), higher ln(ptau-181) was associated with ECog-12 memory (unstandardized β = 0.088; 95% CI, 0.005-0.170). Higher ln(NfL) levels were associated with greater ECog-12 global (unstandardized β = 0.169; 95% CI, 0.074-0.265), executive (unstandardized β = 0.182; 95% CI, 0.087-0.277), and memory (unstandardized β = 0.156; 95% CI, 0.065-0.248) domains. Higher ln(GFAP) levels were associated with greater ECog-12 global (unstandardized β = 0.109; 95% CI, 0.019-0.198) and executive (unstandardized β = 0.121; 95% CI, 0.031-0.211) domains. Ln(Aβ42/40) was not associated with SCD domains. Cognitive concerns significantly modified the associations between ln(NfL) and ECog-12 domains, with more pronounced associations among those reporting cognitive concerns. No biomarkers were associated with the single-item cognitive concerns score. Conclusions and Relevance: In this study of middle-aged and older Hispanic and/or Latino adults, plasma biomarkers of p-tau181, NfL, and GFAP, but not Aβ42/40, were associated with greater SCD. These findings underscore their potential utility in early ADRD detection strategies.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Gallo, L. C., Stickel, A. M., Zhou, H., González, H. M., Yassa, M. A., Valencia, D. F., et al. (2026). Alzheimer Disease Biomarkers and Subjective Cognitive Decline Among Hispanic and/or Latino Adults. UNC Libraries. https://doi.org/10.17615/x9sz-g140
Vancouver
Gallo LC, Stickel AM, Zhou H, González HM, Yassa MA, Valencia DF, et al. Alzheimer Disease Biomarkers and Subjective Cognitive Decline Among Hispanic and/or Latino Adults. UNC Libraries. 2026. doi:10.17615/x9sz-g140.
BibTeX
@article{gallo2026-034324bf,
author = {Gallo, Linda C. and Stickel, Ariana M. and Zhou, Haibo and González, Hector M. and Yassa, Michael A. and Valencia, Deisha F. and Gonzalez, Kevin and Goodman, Zachary T. and others},
title = {{Alzheimer Disease Biomarkers and Subjective Cognitive Decline Among Hispanic and/or Latino Adults}},
journal = {UNC Libraries},
year = {2026},
doi = {10.17615/x9sz-g140},
url = {https://doi.org/10.17615/x9sz-g140}
}
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Key findings
- Among 5712 adults (mean [SD] age, 63.47 (8.15) years; unweighted 3663 [53.92%] female), higher ln(ptau-181) was associated with ECog-12 memory (unstandardized β = 0.088; 95% CI, 0.005-0.170).
- Higher ln(NfL) levels were associated with greater ECog-12 global (unstandardized β = 0.169; 95% CI, 0.074-0.265), executive (unstandardized β = 0.182; 95% CI, 0.087-0.277), and memory (unstandardized β = 0.156; 95% CI, 0.065-0.248) domains.
- Higher ln(GFAP) levels were associated with greater ECog-12 global (unstandardized β = 0.109; 95% CI, 0.019-0.198) and executive (unstandardized β = 0.121; 95% CI, 0.031-0.211) domains.
- Ln(Aβ42/40) was not associated with SCD domains.
- Cognitive concerns significantly modified the associations between ln(NfL) and ECog-12 domains, with more pronounced associations among those reporting cognitive concerns.
Why it matters
Plasma biomarkers p-tau181, NfL, and GFAP, but not Aβ42/40, were associated with greater subjective cognitive decline in Hispanic and/or Latino adults. These findings underscore their potential utility in early detection strategies.
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Study details
- Study designcross-sectional
- Participants5,712
- Effect size53.92%
- Evidence strengthModerate
How this study scored 45/100
Published in a peer-reviewed journal, and it is a snapshot of people at one point in time. Scored zero for randomized / blinded because the record does not state it. We have no data on journal's citation record, so that was left out: it earned 43 of the 96 points we could judge it on, which is 45 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (UNC Libraries) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 4 / 12 | A snapshot of people at one point in time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 5 / 5 | 2026 — within 1 year(s) of the newest study here |
| Sample size | 3 / 4 | 5,712 participants |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 0 / 7 | Cited 0 times (OpenAlex, 2026-10-10) |
| Citations per year | 0 / 5 | 0.0 citations a year over 2 year(s) since 2026 |
| Impact for its field and year | 0 / 6 | Cited 0.0× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 0 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 1 / 4 | Last-listed author Natasha Z. Anita: h-index 8 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University of North Carolina at Chapel Hill: institution h-index 1,674 (OpenAlex) |
| Multicenter collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 1 / 2 | Not in PubMed, but has a DOI |
| Free to read | 2 / 2 | Free to read |
| Points | 43 / 96 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 43 of the 96 points we could judge it on is 45 out of 100. |
| Total | 45 / 100 | — |
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