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Neurodegenerative disorders: Stereotyped relationships between pathological metabolic topographies and the healthy default mode network
Perovnik M, Eidelberg D.. Research Square, 2026-10-13
Topic: Genetics and APOE
The disorders fell into one of three categories based on the topographic relationship of the disease-specific and healthy networks. Category 1 (bvFTD, PSP, CBD, and XDP) was characterized by substantial spatial overlap of the two metabolic networks, tight correlations between their respective expression levels, and significant DMN reductions. Category 2 (PD, AD, DLB, and their associated prodromal syndromes) was characterized by less pronounced overlap, correspondingly weak correlations, and smaller DMN reductions, particularly at prodromal stages. In this group, correlations with MMSE were greater for the difference between disease network and DMN scores than for the disease network alone. Category 3 (MSA) had no discernible network overlap and no loss of DMN expression. Category 1 disorders were associated with close relationships between the pathological and healthy topographies, indicating primary DMN involvement. Category 2 disorders were characterized by weaker network relationships, consistent with secondary DMN involvement. Category 3 disorders showed no evidence of DMN involvement. The degree to which disease-specific networks overlap with DMN provides unique insight into the underlying neurodegenerative process.
Key findings
- The disorders fell into one of three categories based on the topographic relationship of the disease-specific and healthy networks.
- Category 1 (bvFTD, PSP, CBD, and XDP) was characterized by substantial spatial overlap of the two metabolic networks, tight correlations between their respective expression levels, and significant DMN reductions.
- Category 2 (PD, AD, DLB, and their associated prodromal syndromes) was characterized by less pronounced overlap, correspondingly weak correlations, and smaller DMN reductions, particularly at prodromal stages.
- In this group, correlations with MMSE were greater for the difference between disease network and DMN scores than for the disease network alone.
- Category 3 (MSA) had no discernible network overlap and no loss of DMN expression.
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Study details
- Participants1,117
- Evidence strengthLow
How this study scored 16/100
Preprint — not yet peer-reviewed. It scored 31 on the same rubric, but non-peer-reviewed sources are capped at 16, so it shows as 16. Scored zero for study design, effect reported and randomised / blinded because the record does not state it. We have no data on times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 19 of the 62 points we could judge it on, which is 31 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 2 / 10 | Tier 4 — not a peer-reviewed journal (Research Square) |
| Journal's citation record | 0 / 4 | Not a journal article, so the journal's record does not count |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 4 / 10 | Preprint — not yet peer-reviewed. Hosted on a preprint server. |
| How recent | 5 / 5 | 2026 — within 1 year(s) of the newest study here |
| Sample size | 3 / 4 | 1,117 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 1 / 2 | Not in PubMed, but has a DOI |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 19 / 62 | Scored on 12 of 20 parts. We have no data for the rest, so they are left out: 19 of the 62 points we could judge it on is 31 out of 100. |
| Total | 31 / 100 | Capped to 16 because this is not a peer-reviewed article. |
What each of these 20 components measures, and what this score is not →
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
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APA 7th
Perovnik, M., & Eidelberg, D. (2026). Neurodegenerative disorders: Stereotyped relationships between pathological metabolic topographies and the healthy default mode network. Research Square. https://doi.org/10.21203/rs.3.rs-11320531/v1
Vancouver
Perovnik M, Eidelberg D. Neurodegenerative disorders: Stereotyped relationships between pathological metabolic topographies and the healthy default mode network. Research Square. 2026. doi:10.21203/rs.3.rs-11320531/v1.
BibTeX
@article{perovnik2026-b01fe529,
author = {Perovnik, M. and Eidelberg, D.},
title = {{Neurodegenerative disorders: Stereotyped relationships between pathological metabolic topographies and the healthy default mode network}},
journal = {Research Square},
year = {2026},
doi = {10.21203/rs.3.rs-11320531/v1},
url = {https://doi.org/10.21203/rs.3.rs-11320531/v1}
}