Relationship between APOE Genotype Status and Imaging Features in Patients with Alzheimer Disease Being Considered for Antiamyloid β Therapy
Maryam Vejdani-Jahromi, Esteban Calle, Odette Ganem, Saurabh Rohatgi, Hana Farzaneh, Harry Griffin, Shenghua Zhu, Jarrel C. Y. Seah et al.. American Journal of Neuroradiology, 2026-03-01
Topic: Amyloid, tau and blood-test diagnosis
A total of 85 patients were included in the study with rare genotypes excluded from analysis (3 patients). Among the common genotypes, e3/e4 was the most prevalent (55%). Statistical analysis revealed significant association between APOE genotype and microhemorrhage count based on the SWI and GRE sequences (P = .007 and P = .003, respectively). The mean identified microbleed count was 1 (based on SWI) and 0.5 (based on GRE) in the same cohort of patients, with the following genotype-specific means based on SWI sequence: e3/e3 = 0.7; e3/e4 = 0.6; and e4/e4 = 2.7. No significant associations were found between APOE genotype and Montreal Cognitive Assessment, WMH or PVS scores. Post hoc power analysis showed adequate power for SWI-based microbleed detection but low power for WMH and PVS. In this cohort of patients with AD being evaluated for lecanemab therapy, a significant association was identified between APOE genotype and the number of microhemorrhages with higher mean counts of microbleeds detected on SWI sequence compared with microbleeds detected on the GRE sequence of the same patients. No significant associations were found between APOE genotype and WMH, PVS, or cognitive impairment.
Key findings
- A total of 85 patients were included in the study with rare genotypes excluded from analysis (3 patients).
- Among the common genotypes, e3/e4 was the most prevalent (55%).
- Statistical analysis revealed significant association between APOE genotype and microhemorrhage count based on the SWI and GRE sequences (P = .007 and P = .003, respectively).
- The mean identified microbleed count was 1 (based on SWI) and 0.5 (based on GRE) in the same cohort of patients, with the following genotype-specific means based on SWI sequence: e3/e3 = 0.7; e3/e4 = 0.6; and e4/e4 = 2.7.
- No significant associations were found between APOE genotype and Montreal Cognitive Assessment, WMH or PVS scores.
Why it matters
In patients with Alzheimer disease being evaluated for anti-amyloid therapy, APOE genotype was significantly associated with the number of microhemorrhages on brain imaging. No significant associations were found between APOE genotype and white matter hyperintensities, perivascular spaces, or cognitive impairment.
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Study details
- Participants85
- Evidence strengthModerate
How this study scored 41/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (American Journal of Neuroradiology) |
| Journal's citation record | 2 / 4 | American Journal of Neuroradiology: journal h-index 182 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 5 / 5 | 2026 — within 1 year(s) of the newest study here |
| Sample size | 1 / 4 | 85 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 0 / 7 | Cited 0 times (OpenAlex, 2026-10-10) |
| Citations per year | 0 / 5 | 0.0 citations a year over 2 year(s) since 2026 |
| Impact for its field and year | 0 / 6 | Cited 0.0× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 0 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Javier M. Romero: h-index 40 (OpenAlex, whole career) |
| Institution's track record | 3 / 3 | Harvard University: institution h-index 3,235 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 41781178) |
| Free to read | 2 / 2 | Free to read |
| Total | 41 / 100 | — |
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Read the original
- DOI: 10.3174/ajnr.a9056
- PubMed: 41781178
- Original source →
- Free full text: American Journal of Neuroradiology →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Vejdani-Jahromi, M., Calle, E., Ganem, O., Rohatgi, S., Farzaneh, H., Griffin, H., et al. (2026). Relationship between APOE Genotype Status and Imaging Features in Patients with Alzheimer Disease Being Considered for Antiamyloid β Therapy. American Journal of Neuroradiology. https://doi.org/10.3174/ajnr.a9056
Vancouver
Vejdani-Jahromi M, Calle E, Ganem O, Rohatgi S, Farzaneh H, Griffin H, et al. Relationship between APOE Genotype Status and Imaging Features in Patients with Alzheimer Disease Being Considered for Antiamyloid β Therapy. American Journal of Neuroradiology. 2026. doi:10.3174/ajnr.a9056. PMID: 41781178.
BibTeX
@article{vejdanijahromi2026-41781178,
author = {Vejdani-Jahromi, Maryam and Calle, Esteban and Ganem, Odette and Rohatgi, Saurabh and Farzaneh, Hana and Griffin, Harry and Zhu, Shenghua and Seah, Jarrel C. Y. and others},
title = {{Relationship between APOE Genotype Status and Imaging Features in Patients with Alzheimer Disease Being Considered for Antiamyloid β Therapy}},
journal = {American Journal of Neuroradiology},
year = {2026},
doi = {10.3174/ajnr.a9056},
pmid = {41781178},
url = {https://doi.org/10.3174/ajnr.a9056}
}
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