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36/100

✓ Peer-reviewed alzhub usefulness score 36 out of 100. Getting a diagnosis

Topic: Amyloid, tau and blood-test diagnosis

To investigate alterations in resting-state electroencephalogram (EEG) microstates across the cognitive spectrum of Parkinson's disease (PD) and to evaluate their utility as electrophysiological biomarkers of cognitive impairment. Resting-state EEG was recorded using a 19-channel system during a 3-min eyes-closed session in 36 healthy controls (HC), 38 PD patients with normal cognition (PDNC), and 39 PD patients with dementia (PDD). Temporal parameters (duration, occurrence, coverage) of six canonical microstates (A-F) were computed and compared across groups. Correlation analyses were conducted between microstate metrics and Montreal Cognitive Assessment (MoCA) scores. Significant group differences were found in microstate dynamics. The PDD group exhibited a longer mean duration of microstates A, C, and E, and a lower occurrence per second of microstates B and C compared to both the PDNC and HC groups (all P < 0.05). Critically, the duration of microstates A and C showed significant negative correlations with MoCA scores (P < 0.05), while the occurrence of microstates B and C demonstrated positive correlations with MoCA scores (P < 0.05). Specific EEG microstate abnormalities are associated with cognitive status in PD. The prolongation of microstates A and C and the reduced occurrence of microstates B and C are stage-sensitive biomarkers that reflect the severity of cognitive decline, providing novel insights into the neural mechanisms of PD-related cognitive dysfunction.

Key findings

Significant group differences were found in microstate dynamics.
The PDD group exhibited a longer mean duration of microstates A, C, and E, and a lower occurrence per second of microstates B and C compared to both the PDNC and HC groups (all P < 0.05).
Critically, the duration of microstates A and C showed significant negative correlations with MoCA scores (P < 0.05), while the occurrence of microstates B and C demonstrated positive correlations with MoCA scores (P < 0.05).
Specific EEG microstate abnormalities are associated with cognitive status in PD.

Why it matters

This study found that specific EEG microstate patterns differ between Parkinson's disease patients with and without dementia, and these patterns correlate with cognitive test scores. These findings could help identify cognitive decline in Parkinson's disease, but the study does not test any treatment or prevention.

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Study details

Evidence strengthLow

How this study scored 36/100

Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Scientific Reports)
Journal's citation record	3 / 4	Scientific Reports: journal h-index 463 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	5 / 5	2026 — within 1 year(s) of the newest study here
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	0 / 3	Not stated whether this was studied in people — scores zero (not stated in the record — scored 0)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	1 / 7	Cited 1 times (OpenAlex, 2026-10-10)
Citations per year	0 / 5	0.5 citations a year over 2 year(s) since 2026
Impact for its field and year	3 / 6	Cited 4.3× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	0 / 4	Cited 1 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	2 / 4	Last-listed author Xiehua Xue: h-index 20 (OpenAlex, whole career)
Institution's track record	0 / 3	Fujian University of Traditional Chinese Medicine: institution h-index 139 (OpenAlex)
Multi-centre collaboration	0 / 3	OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete)
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 41760696)
Free to read	2 / 2	Free to read
Total	36 / 100	—

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Read the original

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Cite this study APA, Vancouver, BibTeX · download .bib or .ris

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 8 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.

APA 7th

Zhao, Y., Xu, J., Xu, X., Song, J., Cai, J., Shi, H., et al. (2026). EEG microstate alterations in Parkinson’s disease dementia. Scientific Reports. https://doi.org/10.1038/s41598-026-40029-0

Vancouver

Zhao Y, Xu J, Xu X, Song J, Cai J, Shi H, et al. EEG microstate alterations in Parkinson’s disease dementia. Scientific Reports. 2026. doi:10.1038/s41598-026-40029-0. PMID: 41760696.

BibTeX

@article{zhao2026-41760696,
  author  = {Zhao, Yuqing and Xu, Jinfeng and Xu, Xianling and Song, Jian and Cai, Jiayu and Shi, Haoran and Wei, Wei and Xue, Xiehua},
  title   = {{EEG microstate alterations in Parkinson’s disease dementia}},
  journal = {Scientific Reports},
  year    = {2026},
  doi     = {10.1038/s41598-026-40029-0},
  pmid    = {41760696},
  url     = {https://doi.org/10.1038/s41598-026-40029-0}
}

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