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16/100

⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. Down syndrome and Alzheimer's

Topic: Brain proteins, microglia and lab models

Individuals with Down syndrome (DS) display developmental delay, intellectual disability, premature brain ageing, and an increased risk of Alzheimer-like neurodegeneration. Although the neuropathology of the postnatal and adult DS brain has been widely described, it remains unclear how trisomy 21 alters early human neural and glial development. Here, we used human oligodendrocyte enriched brain organoids derived from trisomic and euploid iPSCs to define the cellular, functional, and molecular consequences of trisomy 21 during early brain development.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Marti, M. B., Morrison, S. D., Pars, S., Al-mhanawi, B., Noakes, P. G., Wolvetang, E. J., et al. (2026). Oligodendrocyte Enriched Brain Organoids Reveal Impaired Oligodendroglial Maturation and Altered Neural Network Activity in Down Syndrome. bioRxiv. https://doi.org/10.64898/2026.08.27.747500

Vancouver

Marti MB, Morrison SD, Pars S, Al-mhanawi B, Noakes PG, Wolvetang EJ, et al. Oligodendrocyte Enriched Brain Organoids Reveal Impaired Oligodendroglial Maturation and Altered Neural Network Activity in Down Syndrome. bioRxiv. 2026. doi:10.64898/2026.08.27.747500.

BibTeX

@article{marti2026-32527300,
  author  = {Marti, M. B. and Morrison, S. D. and Pars, S. and Al-mhanawi, B. and Noakes, P. G. and Wolvetang, E. J. and Shaker, M. R.},
  title   = {{Oligodendrocyte Enriched Brain Organoids Reveal Impaired Oligodendroglial Maturation and Altered Neural Network Activity in Down Syndrome}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.08.27.747500},
  url     = {https://doi.org/10.64898/2026.08.27.747500}
}

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.

Key findings

Although the neuropathology of the postnatal and adult DS brain has been widely described, it remains unclear how trisomy 21 alters early human neural and glial development.
Here, we used human oligodendrocyte enriched brain organoids derived from trisomic and euploid iPSCs to define the cellular, functional, and molecular consequences of trisomy 21 during early brain development.
Trisomic organoids exhibited an early growth delay, reduced oligodendroglial specification, and impaired oligodendrocyte maturation, resulting in decreased myelination.
These defects were accompanied by increased astroglial output and delayed neuronal maturation.

Why it matters

This laboratory study using brain organoids from trisomic and euploid cells found early growth delay, reduced oligodendroglial specification, and impaired maturation in Down syndrome. It is early in-vitro work with no treatment or prevention findings.

Study details

Evidence strengthLow

How this study scored 16/100

Preprint — not yet peer-reviewed. It scored 18 on the same rubric, but non-peer-reviewed sources are capped at 16, so it shows as 16. Scored zero for study design, sample size, effect reported and randomised / blinded because the record does not state it. We have no data on impact for its field and year and senior author's track record, so those were left out: it earned 16 of the 90 points we could judge it on, which is 18 out of 100.

Component	Points	Why
Journal tier	2 / 10	Tier 4 — not a peer-reviewed journal (bioRxiv)
Journal's citation record	0 / 4	Not a journal article, so the journal's record does not count
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	4 / 10	Preprint — not yet peer-reviewed. Hosted on a preprint server.
How recent	5 / 5	2026 — within 1 year(s) of the newest study here
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	0 / 3	Laboratory or animal study (title names “organoids”) — scores zero
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	0 / 7	Cited 0 times (OpenAlex, 2026-10-10)
Citations per year	0 / 5	0.0 citations a year over 2 year(s) since 2026
Impact for its field and year	— / 6	No field-weighted citation impact (OpenAlex has none yet) — left out of this score
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	0 / 4	Cited 0 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	— / 4	OpenAlex's profile for last-listed author Mohammed R. Shaker holds only 4 work(s), too few to judge a track record — left out of this score
Institution's track record	2 / 3	The University of Queensland: institution h-index 1,516 (OpenAlex)
Multi-centre collaboration	1 / 3	OpenAlex lists 3 institution(s) in 2 countries
Indexed in PubMed	1 / 2	Not in PubMed, but has a DOI
Free to read	0 / 2	Behind a paywall — scores zero
Points	16 / 90	Scored on 18 of 20 parts. We have no data for the rest, so they are left out: 16 of the 90 points we could judge it on is 18 out of 100.
Total	18 / 100	Capped to 16 because this is not a peer-reviewed article.

What each of these 20 components measures, and what this score is not →

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Studies this one cites

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