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Genetically distinct neurodegenerative proteinopathies engage overlapping proteostasis components
Yarlagadda B, Kumar V.. bioRxiv, 2026-10-04
Topic: Disease mechanisms in lab and animal studies
Neurodegenerative proteinopathies are defined by distinct proteins whose folding, trafficking and clearance depend on shared proteostasis machinery. Whether these disorders engage common components or only common processes has been unresolved. We mapped 16 disease proteins from 12 disorders onto a fixed 990-protein proteostasis network. Across the 12 disorders, the neighborhoods of these proteins shared specific proteins beyond expectations from process composition and connectivity. The same held for the two disorders defined by more than one protein. Nine proteins contributed disproportionately, and only autophagy’s removal significantly reduced similarity. Removing PRKN, HSPA8 or UBQLN2 in silico reduced path efficiency, marking them candidate shared network vulnerabilities. In human brain proteomes, Alzheimer’s disease-zone proteins showed greater abundance remodeling in the insoluble fraction; recurrence across disorders showed no such association. The result is a component-level architecture prioritizing network-derived candidates for cross-disease functional testing.
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APA 7th
Yarlagadda, B., & Kumar, V. (2026). Genetically distinct neurodegenerative proteinopathies engage overlapping proteostasis components. bioRxiv. https://doi.org/10.64898/2026.09.28.753000
Vancouver
Yarlagadda B, Kumar V. Genetically distinct neurodegenerative proteinopathies engage overlapping proteostasis components. bioRxiv. 2026. doi:10.64898/2026.09.28.753000.
BibTeX
@article{yarlagadda2026-02a60d50,
author = {Yarlagadda, B. and Kumar, V.},
title = {{Genetically distinct neurodegenerative proteinopathies engage overlapping proteostasis components}},
journal = {bioRxiv},
year = {2026},
doi = {10.64898/2026.09.28.753000},
url = {https://doi.org/10.64898/2026.09.28.753000}
}
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Key findings
- Nine proteins contributed disproportionately, and only autophagy’s removal significantly reduced similarity.
- The result is a component-level architecture prioritizing network-derived candidates for cross-disease functional testing.
Study details
- Evidence strengthLow
How this study scored 16/100
Preprint — not yet peer-reviewed. It scored 21 on the same rubric, but non-peer-reviewed sources are capped at 16, so it shows as 16. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 13 of the 62 points we could judge it on, which is 21 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 2 / 10 | Tier 4 — not a peer-reviewed journal (bioRxiv) |
| Journal's citation record | 0 / 4 | Not a journal article, so the journal's record does not count |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 4 / 10 | Preprint — not yet peer-reviewed. Hosted on a preprint server. |
| How recent | 5 / 5 | 2026 — within 1 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 1 / 2 | Not in PubMed, but has a DOI |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 13 / 62 | Scored on 12 of 20 parts. We have no data for the rest, so they are left out: 13 of the 62 points we could judge it on is 21 out of 100. |
| Total | 21 / 100 | Capped to 16 because this is not a peer-reviewed article. |
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