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Pathological verification of ischemic score in differentiation of dementias
Rosen WG, Terry RD, Fuld PA, Katzman R, Peck A.. Annals of neurology, 1980-05-01
Topic: Risk, prevention and care in population studies
Fourteen case histories of persons who had a histological diagnosis of either senile dementia of the Alzheimer type, multiinfarct dementia, or a mixed dementia composed of these two types and who showed evidence of a moderate to severe dementia on psychological testing were rated for the presence of thirteen clinical features comprising Hachinski's Ischemic Score. These features are frequently considered primarily characteristic of vascular dementia. Persons with senile dementia of the Alzheimer type were clearly differentiable from persons with multiinfarct dementia and mixed dementia, while the latter two groups were indistinguishable from one another. In our sample, eight features were found to characterize those persons with vascular dementia. These data verify the usefulness of the Ischemic Score in differentiating between senile dementia of the Alzheimer type and vascular dementia.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Rosen, W. G., Terry, R. D., Fuld, P. A., Katzman, R., & Peck, A. (1980). Pathological verification of ischemic score in differentiation of dementias. Annals of neurology. https://doi.org/10.1002/ana.410070516
Vancouver
Rosen WG, Terry RD, Fuld PA, Katzman R, Peck A. Pathological verification of ischemic score in differentiation of dementias. Annals of neurology. 1980. doi:10.1002/ana.410070516. PMID: 7396427.
BibTeX
@article{rosen1980-7396427,
author = {Rosen, W. G. and Terry, R. D. and Fuld, P. A. and Katzman, R. and Peck, A.},
title = {{Pathological verification of ischemic score in differentiation of dementias}},
journal = {Annals of neurology},
year = {1980},
doi = {10.1002/ana.410070516},
pmid = {7396427},
url = {https://doi.org/10.1002/ana.410070516}
}
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Key findings
- Fourteen case histories of persons who had a histological diagnosis of either senile dementia of the Alzheimer type, multiinfarct dementia, or a mixed dementia composed of these two types and who showed evidence of a moderate to severe dementia on psychological testing were rated for the presence of thirteen clinical features comprising Hachinski's Ischemic Score.
- These features are frequently considered primarily characteristic of vascular dementia.
- Persons with senile dementia of the Alzheimer type were clearly differentiable from persons with multiinfarct dementia and mixed dementia, while the latter two groups were indistinguishable from one another.
- In our sample, eight features were found to characterize those persons with vascular dementia.
- These data verify the usefulness of the Ischemic Score in differentiating between senile dementia of the Alzheimer type and vascular dementia.
Why it matters
In 14 people whose dementia type was confirmed by examining brain tissue, researchers rated the case histories against the 13 features of Hachinski's Ischemic Score. People with "senile dementia of the Alzheimer type" could be told apart from those with multi-infarct or mixed dementia, but multi-infarct and mixed dementia "were indistinguishable from one another". The authors say this verifies the score's usefulness, but the study is small, covers only moderate-to-severe dementia, and does not address treatment or prevention.
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Study details
- Evidence strengthLow
How this study scored 49/100
Published in a leading specialty journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Annals of neurology) |
| Journal's citation record | 3 / 4 | Annals of Neurology: journal h-index 437 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 1980 — older than 20 years, still counted |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 7 / 7 | Cited 1,277 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 26.6 citations a year over 48 year(s) since 1980 |
| Impact for its field and year | 4 / 6 | Cited 10.3× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 4 / 6 | Cited by 83 other studies in this library |
| Still being cited | 2 / 4 | Cited 31 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 1 / 4 | Last-listed author Arthur Peck: h-index 12 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Albert Einstein College of Medicine: institution h-index 973 (OpenAlex) |
| Multicenter collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 7396427) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 49 / 100 | — |
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