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Reduced amounts of immunoreactive somatostatin in the temporal cortex in senile dementia of Alzheimer type
Rossor MN, Emson PC, Mountjoy CQ, Roth M, Iversen LL.. Neuroscience letters, 1980-12-01
Topic: Brain proteins, microglia and lab models
Post-mortem brain tissue from 15 patients dying with a diagnosis of senile dementia of Alzheimer type (SDAT) was compared with tissue obtained from 16 control patients at routine post-mortem. A significant fall in choline acetyltransferase (ChAT) activity was observed in the cortex, hippocampus and amygdala of the SDAT cases and was maximal in the temporal cortex. The fall in ChAT activity observed in the temporal cortex was accompanied by a significant reduction (47%) in immunoreactive somatostatin.
Key findings
- Post-mortem brain tissue from 15 patients dying with a diagnosis of senile dementia of Alzheimer type (SDAT) was compared with tissue obtained from 16 control patients at routine post-mortem.
- A significant fall in choline acetyltransferase (ChAT) activity was observed in the cortex, hippocampus and amygdala of the SDAT cases and was maximal in the temporal cortex.
- The fall in ChAT activity observed in the temporal cortex was accompanied by a significant reduction (47%) in immunoreactive somatostatin.
Why it matters
In post-mortem brain tissue from 15 people with senile dementia of Alzheimer type, this study found reduced choline acetyltransferase activity and a 47% reduction in immunoreactive somatostatin in the temporal cortex. It describes brain changes found after death and does not test any treatment, cure, or prevention.
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Study details
- Participants15
- Evidence strengthLow
How this study scored 47/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Neuroscience letters) |
| Journal's citation record | 3 / 4 | Neuroscience Letters: journal h-index 267 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 1980 — older than 20 years, still counted |
| Sample size | 1 / 4 | 15 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 6 / 7 | Cited 433 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 9.0 citations a year over 48 year(s) since 1980 |
| Impact for its field and year | 4 / 6 | Cited 15.0× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 4 other studies in this library |
| Still being cited | 1 / 4 | Cited 5 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author L L Iversen: h-index 36 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Addenbrooke's Hospital: institution h-index 1,025 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 6108540) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 47 / 100 | — |
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Read the original
May need a subscription OpenAlex found no free copy of the full text (checked 6 Feb 1020), so the publisher may charge for it. The PubMed abstract is free.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Rossor, M. N., Emson, P. C., Mountjoy, C. Q., Roth, M., & Iversen, L. L. (1980). Reduced amounts of immunoreactive somatostatin in the temporal cortex in senile dementia of Alzheimer type. Neuroscience letters. https://doi.org/10.1016/0304-3940(80)90177-9
Vancouver
Rossor MN, Emson PC, Mountjoy CQ, Roth M, Iversen LL. Reduced amounts of immunoreactive somatostatin in the temporal cortex in senile dementia of Alzheimer type. Neuroscience letters. 1980. doi:10.1016/0304-3940(80)90177-9. PMID: 6108540.
BibTeX
@article{rossor1980-6108540,
author = {Rossor, M. N. and Emson, P. C. and Mountjoy, C. Q. and Roth, M. and Iversen, L. L.},
title = {{Reduced amounts of immunoreactive somatostatin in the temporal cortex in senile dementia of Alzheimer type}},
journal = {Neuroscience letters},
year = {1980},
doi = {10.1016/0304-3940(80)90177-9},
pmid = {6108540},
url = {https://doi.org/10.1016/0304-3940(80)90177-9}
}
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