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Sleep, EEG and mental function changes in senile dementia of the Alzheimer's type
Prinz PN, Vitaliano PP, Vitiello MV, Bokan J, Raskind M, Peskind E, Gerber C.. Neurobiology of aging, 1982-01-01
Topic: Risk, prevention and care in population studies
Sleep, EEG and mental function variables were studied in 44 subjects diagnosed as having probable senile dementia of the Alzheimer's type (SDAT) and 22 controls matched for age and minimal depression. Results indicate that sleep, EEG and mental function variables all undergo significant change even in the early, mild stage of SDAT, with further change in the moderate and severe stages of dementia. Mental function variables also underwent significant decline across levels of dementia. Sleep and mental function variables had strong power in correctly classifying subjects into control vs. mild dementia groups (90 and 100%, respectively). Dominant occipital rhythm frequency, a clinical EEG measure, also discriminate as well (75%). The results indicate that sleep and EEG variables discriminate well for early, mild SDAT in minimally depressed aged individuals.
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APA 7th
Prinz, P. N., Vitaliano, P. P., Vitiello, M. V., Bokan, J., Raskind, M., Peskind, E., et al. (1982). Sleep, EEG and mental function changes in senile dementia of the Alzheimer's type. Neurobiology of aging. https://doi.org/10.1016/0197-4580(82)90024-0
Vancouver
Prinz PN, Vitaliano PP, Vitiello MV, Bokan J, Raskind M, Peskind E, et al. Sleep, EEG and mental function changes in senile dementia of the Alzheimer's type. Neurobiology of aging. 1982. doi:10.1016/0197-4580(82)90024-0. PMID: 7170052.
BibTeX
@article{prinz1982-7170052,
author = {Prinz, P. N. and Vitaliano, P. P. and Vitiello, M. V. and Bokan, J. and Raskind, M. and Peskind, E. and Gerber, C.},
title = {{Sleep, EEG and mental function changes in senile dementia of the Alzheimer's type}},
journal = {Neurobiology of aging},
year = {1982},
doi = {10.1016/0197-4580(82)90024-0},
pmid = {7170052},
url = {https://doi.org/10.1016/0197-4580(82)90024-0}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
Key findings
- Results indicate that sleep, EEG and mental function variables all undergo significant change even in the early, mild stage of SDAT, with further change in the moderate and severe stages of dementia.
- Mental function variables also underwent significant decline across levels of dementia.
- The results indicate that sleep and EEG variables discriminate well for early, mild SDAT in minimally depressed aged individuals.
Why it matters
In 44 people with probable senile dementia of the Alzheimer's type and 22 controls, sleep, EEG and mental function measures changed even in early mild dementia and worsened with severity. The study shows these measures can help classify early dementia but does not test any treatment or cure.
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Study details
- Participants44
- Evidence strengthLow
How this study scored 47/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Neurobiology of aging) |
| Journal's citation record | 3 / 4 | Neurobiology of Aging: journal h-index 263 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 1982 — older than 20 years, still counted |
| Sample size | 1 / 4 | 44 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 6 / 7 | Cited 325 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 7.1 citations a year over 46 year(s) since 1982 |
| Impact for its field and year | 2 / 6 | Cited 1.9× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 3 / 6 | Cited by 14 other studies in this library |
| Still being cited | 2 / 4 | Cited 24 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 1 / 4 | Last-listed author Carl J. Gerber: h-index 12 (OpenAlex, whole career) |
| Institution's track record | 3 / 3 | University of Washington: institution h-index 3,540 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 7170052) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 47 / 100 | — |
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