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Vascular risk factors and leuko-araiosis
Inzitari D, Diaz F, Fox A, Hachinski VC, Steingart A, Lau C, Donald A, Wade J et al.. Archives of neurology, 1987-01-01
Topic: Brain proteins, microglia and lab models
Leuko-araiosis was found in 49 of 140 demented patients compared with 12 out of 110 control subjects. Thirty-one of 95 patients with dementia of the Alzheimer's type had leuko-araiosis. A history of stroke was four times more frequent in patients with leuko-araiosis than in those without leuko-araiosis (17.4% and 4.4%, respectively). It occurred in 25% of controls with leuko-araiosis compared with only 2% of those without leuko-araiosis. Mean systolic blood pressure was associated with leuko-araiosis. No association was found for diastolic blood pressure, myocardial infarction, angina, diabetes, or carotid bruits. On logistic regression analysis, the strong association between dementia and leuko-araiosis was mainly explained by a history of stroke. There are common factors in leuko-araiosis and stroke, but stroke alone does not account for leuko-araiosis.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Inzitari, D., Diaz, F., Fox, A., Hachinski, V. C., Steingart, A., Lau, C., et al. (1987). Vascular risk factors and leuko-araiosis. Archives of neurology. https://doi.org/10.1001/archneur.1987.00520130034014
Vancouver
Inzitari D, Diaz F, Fox A, Hachinski VC, Steingart A, Lau C, et al. Vascular risk factors and leuko-araiosis. Archives of neurology. 1987. doi:10.1001/archneur.1987.00520130034014. PMID: 3800721.
BibTeX
@article{inzitari1987-3800721,
author = {Inzitari, D. and Diaz, F. and Fox, A. and Hachinski, V. C. and Steingart, A. and Lau, C. and Donald, A. and Wade, J. and others},
title = {{Vascular risk factors and leuko-araiosis}},
journal = {Archives of neurology},
year = {1987},
doi = {10.1001/archneur.1987.00520130034014},
pmid = {3800721},
url = {https://doi.org/10.1001/archneur.1987.00520130034014}
}
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Key findings
- Leuko-araiosis was found in 49 of 140 demented patients compared with 12 out of 110 control subjects.
- It occurred in 25% of controls with leuko-araiosis compared with only 2% of those without leuko-araiosis.
- Mean systolic blood pressure was associated with leuko-araiosis.
Study details
- Participants95
- Effect size17.4%; 4.4%
- Evidence strengthLow
How this study scored 47/100
Published in a peer-reviewed journal. Scored zero for study design and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 27 of the 58 points we could judge it on, which is 47 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Archives of neurology) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 1987 — older than 20 years, still counted |
| Sample size | 1 / 4 | 95 participants |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 3800721) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 27 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 27 of the 58 points we could judge it on is 47 out of 100. |
| Total | 47 / 100 | — |
What each of these 20 components measures, and what this score is not →
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