Home › Research › Brain tissue and pathology
A neurodevelopmental approach to the classification of schizophrenia
Murray RM, O'Callaghan E, Castle DJ, Lewis SW.. Schizophrenia bulletin, 1992-01-01
Topic: Risk, prevention and care in population studies
The conventional distinction between schizophrenia and manic depression has received little objective support from recent studies of phenomenology, outcome, or familial homotypy. Instead, much clinical, epidemiological, and morphological evidence suggests that within the broad range of Schneiderian schizophrenia there exists one form (congenital schizophrenia) that can be distinguished from other types, the manifestations of which are confined to adult life. We hypothesize that congenital schizophrenia is a consequence of aberrant brain development during fetal and neonatal life.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Murray, R. M., O'Callaghan, E., Castle, D. J., & Lewis, S. W. (1992). A neurodevelopmental approach to the classification of schizophrenia. Schizophrenia bulletin. https://doi.org/10.1093/schbul/18.2.319
Vancouver
Murray RM, O'Callaghan E, Castle DJ, Lewis SW. A neurodevelopmental approach to the classification of schizophrenia. Schizophrenia bulletin. 1992. doi:10.1093/schbul/18.2.319. PMID: 1377834.
BibTeX
@article{murray1992-1377834,
author = {Murray, R. M. and O'Callaghan, E. and Castle, D. J. and Lewis, S. W.},
title = {{A neurodevelopmental approach to the classification of schizophrenia}},
journal = {Schizophrenia bulletin},
year = {1992},
doi = {10.1093/schbul/18.2.319},
pmid = {1377834},
url = {https://doi.org/10.1093/schbul/18.2.319}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- Instead, much clinical, epidemiological, and morphological evidence suggests that within the broad range of Schneiderian schizophrenia there exists one form (congenital schizophrenia) that can be distinguished from other types, the manifestations of which are confined to adult life.
- We hypothesize that congenital schizophrenia is a consequence of aberrant brain development during fetal and neonatal life.
- Such patients show structural brain changes and cognitive impairment, and in their male predominance, early onset, and poor outcome, they reflect Kraepelin's original description of dementia praecox.
- We contend that adult-onset schizophrenia is itself heterogeneous.
Why it matters
This paper proposes that one form of schizophrenia may result from aberrant brain development during fetal and neonatal life. It is about schizophrenia, not Alzheimer's disease, and does not report a treatment, cure, or prevention.
Study details
- Evidence strengthLow
How this study scored 42/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on institution's track record, so that was left out: it earned 41 of the 97 points we could judge it on, which is 42 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Schizophrenia bulletin) |
| Journal's citation record | 3 / 4 | Schizophrenia Bulletin: journal h-index 298 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 1992 — older than 20 years, still counted |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 6 / 7 | Cited 521 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 14.5 citations a year over 36 year(s) since 1992 |
| Impact for its field and year | 4 / 6 | Cited 17.1× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 1 / 4 | Cited 7 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Shôn W. Lewis: h-index 91 (OpenAlex, whole career) |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 0 institution(s) in 0 countries — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 1377834) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 41 / 97 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 41 of the 97 points we could judge it on is 42 out of 100. |
| Total | 42 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
May need a subscription OpenAlex found no free copy of the full text (checked 6 Feb 1020), so the publisher may charge for it. The PubMed abstract is free.
Studies this one cites
Referenced by this study and also in the alzhub library, so you can read them here.
Related studies in Brain tissue and pathology
Also in Brain tissue and pathology
124 studies in the library are filed under Brain tissue and pathology with no topic tag they share with another; these are this study's neighbours in a fixed tour of them. The Brain tissue and pathology hub.