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Staging of alzheimer's disease-related neurofibrillary changes
Heiko Braak, Eva Braak. Neurobiology of Aging, 1995-05-01
Topic: Amyloid, tau and blood-test diagnosis
This study evaluated neuronal changes related to Alzheimer's disease using specific immunocytochemical methods (AT8) before the actual formation of neurofibrillary tangles and neuropil threads. It found that initial changes begin in the transentorhinal region and spread to the entorhinal region, Ammon's horn, and neocortex. The research also distinguished six stages of disease propagation based on the location of tangle-bearing neurons and the severity of changes.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Braak, H., & Braak, E. (1995). Staging of alzheimer's disease-related neurofibrillary changes. Neurobiology of Aging. https://doi.org/10.1016/0197-4580(95)00021-6
Vancouver
Braak H, Braak E. Staging of alzheimer's disease-related neurofibrillary changes. Neurobiology of Aging. 1995. doi:10.1016/0197-4580(95)00021-6. PMID: 7566337.
BibTeX
@article{braak1995-7566337,
author = {Braak, Heiko and Braak, Eva},
title = {{Staging of alzheimer's disease-related neurofibrillary changes}},
journal = {Neurobiology of Aging},
year = {1995},
doi = {10.1016/0197-4580(95)00021-6},
pmid = {7566337},
url = {https://doi.org/10.1016/0197-4580(95)00021-6}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- Specific immunocytochemical methods (AT8) permit evaluation of neuronal changes well before the actual formation of neurofibrillary tangles and neuropil threads.
- Initial changes are found in the transentorhinal region (temporal lobe).
- Six stages of disease propagation can be distinguished with respect to the location of the tangle-bearing neurons and the severity of changes
Why it matters
Describes staging of Alzheimer's disease-related neurofibrillary changes in the brain.
How this study scored 48/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it. We have no data on strength of evidence, so that was left out: it earned 46 of the 95 points we could judge it on, which is 48 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Neurobiology of Aging) |
| Journal's citation record | 3 / 4 | Neurobiology of Aging: journal h-index 263 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | — / 5 | No evidence rating recorded — left out of this score |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 1995 — older than 20 years, still counted |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 7 / 7 | Cited 2,366 times (OpenAlex, 2026-10-10) |
| Citations per year | 5 / 5 | 71.7 citations a year over 33 year(s) since 1995 |
| Impact for its field and year | 3 / 6 | Cited 7.4× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 4 / 4 | Cited 325 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Eva Braak: h-index 67 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Goethe University Frankfurt: institution h-index 958 (OpenAlex) |
| Multicenter collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 7566337) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 46 / 95 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 46 of the 95 points we could judge it on is 48 out of 100. |
| Total | 48 / 100 | — |
What each of these 20 components measures, and what this score is not →
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