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Role of glucose in regulating the brain and cognition
Gold PE.. The American journal of clinical nutrition, 1995-04-01
Topic: Gut, metabolism and diet
Extensive evidence indicates that relatively modest increases in circulating glucose concentrations enhance learning and memory processes in rodents and humans. In rats, systemic injections of glucose enhance learning and memory under many conditions. When microinjected into specific brain sites, glucose has selective behavioral and pharmacological effects, with behavioral effects that are specific to the brain site injected and pharmacological effects that are largely specific to interactions with opiate agonists. Recent evidence suggests that glucose may attenuate opiate inhibition of acetylcholine release in the hippocampus. The relative safety of glucose has permitted tests of glucose effects on cognitive functions in humans. Glucose also enhances learning and memory in healthy aged humans and enhances several other cognitive functions in subjects with severe cognitive pathologies, including individuals with Alzheimer's disease and Down syndrome. Thus, increases in circulating glucose concentrations have robust and broad influences on brain functions that span many neural and behavioral measures and cross readily from rodents to humans.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Gold, P. E. (1995). Role of glucose in regulating the brain and cognition. The American journal of clinical nutrition. https://doi.org/10.1093/ajcn/61.4.987s
Vancouver
Gold PE. Role of glucose in regulating the brain and cognition. The American journal of clinical nutrition. 1995. doi:10.1093/ajcn/61.4.987s. PMID: 7900698.
BibTeX
@article{gold1995-7900698,
author = {Gold, P. E.},
title = {{Role of glucose in regulating the brain and cognition}},
journal = {The American journal of clinical nutrition},
year = {1995},
doi = {10.1093/ajcn/61.4.987s},
pmid = {7900698},
url = {https://doi.org/10.1093/ajcn/61.4.987s}
}
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Key findings
- Extensive evidence indicates that relatively modest increases in circulating glucose concentrations enhance learning and memory processes in rodents and humans.
- Recent evidence suggests that glucose may attenuate opiate inhibition of acetylcholine release in the hippocampus.
Study details
- Evidence strengthLow
How this study scored 36/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 21 of the 58 points we could judge it on, which is 36 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (The American journal of clinical nutrition) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 1995 — older than 20 years, still counted |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 7900698) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 21 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 21 of the 58 points we could judge it on is 36 out of 100. |
| Total | 36 / 100 | — |
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