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Newest in this topic

  1. Pathway-specific polygenic risk scores reveal underlying mechanisms of cerebral small vessel disease 2026-09-14
  2. Cerebral Small Vessel Disease and Risk of Cardiovascular Events and All-Cause Mortality: The Framingham Heart Study 2026-09-07
  3. Regional Distribution of Mineralized Blood Vessels in Alzheimer Disease and Clinicopathological Associations: A Multicenter Autopsy Study 2026-09-01

Studies

903 studies carry this tag.

Date range

1975 to 2026

Top journals

  • Neurology 93
  • Stroke 61
  • Alzheimer s & Dementia 31
  • Brain : a journal of neurology 20
  • Annals of neurology 19

342 journals in all.

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. Relation between age-related decline in intelligence and cerebral white-matter hyperintensities in healthy octogenarians: a longitudinal study

    ✓ Peer-reviewed alzhub usefulness score 66 out of 100. Lancet (London, England) 2000-08-01 Vascular contributions

    Scores for periventricular hyperintensities in this sample included all possible degrees of severity, but no participant scored more than 75% of maximum for deep white-matter hyperintensities.

  2. Alzheimer's disease comorbidity in normal pressure hydrocephalus: prevalence and shunt response

    ✓ Peer-reviewed alzhub usefulness score 42 out of 100. Journal of neurology, neurosurgery, and psychiatry 2000-06-01 Cognitive tests and assessment

    The clinical impact of Alzheimer's disease pathology at biopsy was investigated in 56 cognitively impaired patients undergoing shunt surgery for idiopathic normal pressure hydrocephalus (NPH).

  3. The ectodomain of the Notch3 receptor accumulates within the cerebrovasculature of CADASIL patients

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The Journal of clinical investigation 2000-03-01 Vascular contributions

    Mutations in Notch3 cause CADASIL (cerebral autosomal dominant adult onset arteriopathy), which leads to stroke and dementia in humans.

  4. Membrane breakdown in acute and chronic neurodegeneration: focus on choline-containing phospholipids

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of neural transmission (Vienna, Austria : 1996) 2000-01-01 Vascular contributions

    Breakdown of cellular membranes is a characteristic feature of neuronal degeneration in acute (stroke) and chronic (senile dementia) neurological disorders.

  5. Midlife blood pressure and neuritic plaques, neurofibrillary tangles, and brain weight at death: the HAAS. Honolulu-Asia aging Study

    ✓ Peer-reviewed alzhub usefulness score 61 out of 100. Neurobiology of aging 2000-01-01 How common it is

    Midlife hypertension is associated with later development of cognitive impairment, vascular dementia (VsD), and possibly Alzheimer's disease (AD).

  6. Prevalence and outcomes of vascular cognitive impairment. Vascular Cognitive Impairment Investigators of the Canadian Study of Health and Aging

    ✓ Peer-reviewed alzhub usefulness score 66 out of 100. Neurology 2000-01-01 Caregiving

    Failure to consider vascular cognitive impairment without dementia underestimates the prevalence of impairment and the risk for adverse outcomes associated with vascular cognitive impairment.

  7. Research criteria for subcortical vascular dementia in clinical trials

    ✓ Peer-reviewed alzhub usefulness score 49 out of 100. Journal of neural transmission. Supplementum 2000-01-01 How common it is

    Vascular dementia (VaD) incorporate different vascular mechanisms and changes in the brain, and have different causes and clinical manifestations.

  8. The Oregon brain aging study: neuropathology accompanying healthy aging in the oldest old

    ✓ Peer-reviewed alzhub usefulness score 54 out of 100. Neurology 2000-01-01 Cognitive tests and assessment

    Nondemented individuals without cardiovascular or other age-associated diseases of age > or =85 years were followed until death.

  9. Specific patterns of cognitive impairment in patients with idiopathic normal pressure hydrocephalus and Alzheimer's disease: a pilot study

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Journal of neurology, neurosurgery, and psychiatry 1999-12-01 Cognitive tests and assessment

    Eleven patients with idiopathic normal pressure hydrocephalus (NPH) were selected from an initial cohort of 43 patients.

  10. The role of microglia and macrophages in the pathophysiology of the CNS

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Progress in neurobiology 1999-06-01 Inflammation and the immune system

    Microglia are a major ghal component of the central nervous system (CNS) and are extremely sessile.

  11. The role of excitotoxicity in neurodegenerative disease: implications for therapy

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Pharmacology & therapeutics 1999-03-01 Vascular contributions

    Several clinical trials have evaluated the potential of antiglutamate drugs to improve outcome following acute ischaemic stroke, but to date, the results of these have been disappointing.

  12. HIV encephalitis, proviral load and dementia in drug users and homosexuals with AIDS. Effect of neocortical involvement

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. Brain : a journal of neurology 1998-11-01 Inflammation and the immune system

    In this consecutive autopsy study, the pathological evidence of HIV encephalitis, which included the presence of giant cells and/or HIV p24 immunopositivity, was found more frequently in drug users (25 of 45; 56%) than in homosexual men (6 of 35; 17%) with AIDS (P < 0.01).

  13. Patterns of MRI lesions in CADASIL

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Neurology 1998-08-01 Vascular contributions

    Our results suggest that different subcortical areas have different vulnerabilities to ischemia in CADASIL.

  14. Cerebral infarcts in patients with autopsy-proven Alzheimer's disease: CERAD, part XVIII. Consortium to Establish a Registry for Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. Neurology 1998-07-01 Cognitive tests and assessment

    Prior studies report that subjects with neuropathologic evidence of AD and concomitant brain infarcts had poorer cognitive function and higher frequency of dementia than those with AD alone.

  15. Natural history and survival of 14 patients with corticobasal degeneration confirmed at postmortem examination

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Journal of neurology, neurosurgery, and psychiatry 1998-02-01 Disparities

    The results confirm that unilateral parkinsonism unresponsive to levodopa and limb ideomotor apraxia are the clinical hallmarks of corticobasal degeneration, and only a minority of patients with corticobasal degeneration present with dementia.

  16. Relationship between ApoE, MRI findings, and cognitive function in the Cardiovascular Health Study

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Stroke 1998-02-01 Disparities

    We determined the relationship between apolipoprotein (Apo)E, MRI, and low cognitive scores.

  17. Cerebellar degeneration associated with human immunodeficiency virus infection

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Neurology 1998-01-01 Digital health tools

    Cerebellar disorders associated with HIV infection are typically the result of discrete cerebellar lesions resulting from opportunistic infections such as toxoplasmosis and progressive multifocal leukoencephalopathy or primary CNS lymphoma.

  18. Diagnosis of intracranial vasculitis: a multi-disciplinary approach

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Journal of neuropathology and experimental neurology 1998-01-01 Brain scans and imaging

    Intracranial vasculitis, or primary angiitis of the central nervous system (PACNS), is an uncommon, often fatal disorder that frequently responds to aggressive immunosuppressive therapy.

  19. Nitric oxide in neurodegeneration

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Progress in brain research 1998-01-01 Vascular contributions

    Nitric oxide (NO) is a unique biological messenger molecule which mediates diverse physiologic roles.

  20. Neuropathological assessment of the lesions of significance in vascular dementia

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of neurology, neurosurgery, and psychiatry 1997-12-01 Vascular contributions

    Microvascular disease, not macroscopic infarction, was the chief substrate of vascular dementia in this series of cases.

  21. Meta-analysis of the Hachinski Ischemic Score in pathologically verified dementias

    ✓ Peer-reviewed alzhub usefulness score 79 out of 100. Neurology 1997-10-01 Vascular contributions

    Our objectives were to investigate the utility of the Hachinski Ischemic Score (HIS) in differentiating patients with pathologically verified Alzheimer's disease (AD), multi-infarct dementia (MID), and "mixed" (AD plus cerebrovascular disease) dementia, and to identify the specific items of the HIS that best discriminate those dementia subtypes.

  22. Distinctive pattern of Bergmann glial pathology in human hepatic encephalopathy

    ✓ Peer-reviewed alzhub usefulness score 31 out of 100. Molecular and chemical neuropathology 1997-08-01 Biomarkers

    Alzheimer type II astrocytosis is the pathological hallmark of hepatic encephalopathy.

  23. A model for monocyte migration through the blood-brain barrier during HIV-1 encephalitis

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Journal of immunology (Baltimore, Md. : 1950) 1997-04-01 Inflammation and the immune system

    HIV-1 invades the central nervous system early during viral infection, but neurologic impairment usually occurs years later.

  24. Clinical correlates of white matter findings on cranial magnetic resonance imaging of 3301 elderly people. The Cardiovascular Health Study

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. Stroke 1996-08-01 Vascular contributions

    White matter findings were significantly associated with age, silent stroke, hypertension, FEV1, and income.

  25. Localization of HIV-1 in human brain using polymerase chain reaction/in situ hybridization and immunocytochemistry

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Annals of neurology 1996-06-01 Disparities

    Human immunodeficiency virus type 1 (HIV-1) infects the brains of a majority of patients with the acquired immunodeficiency syndrome (AIDS), and has been linked to the development of a progressive dementia termed "HIV-associated dementia."

  26. Cortical synaptic changes and gliosis in normal aging, Alzheimer's disease and frontal lobe degeneration

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Dementia (Basel, Switzerland) 1996-05-01 Disease mechanisms

    The most important new development during recent years in the field of degenerative dementia concerns synaptic pathology.

  27. Inter- and intraobserver reproducibility of cerebral atrophy assessment on MRI scans with hemispheric infarcts

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. European neurology 1996-01-01 How common it is

    Cerebral atrophy (CA) in stroke patients is associated with poststroke dementia and may reflect underlying neurodegenerative pathology.

  28. Immunocytochemical quantitation of human immunodeficiency virus in the brain: correlations with dementia

    ✓ Peer-reviewed alzhub usefulness score 54 out of 100. Annals of neurology 1995-11-01 Inflammation and the immune system

    The pathogenesis of human immunodeficiency virus (HIV)-associated dementia is unclear, and the underlying pathological substrate has been a matter of debate.

  29. Clinical spectrum of CADASIL: a study of 7 families. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Lancet (London, England) 1995-10-01 Getting a diagnosis

    Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an inherited arterial disease of the brain recently mapped to chromosome 19.

  30. Corticonigral degeneration with neuronal achromasia presenting with primary progressive aphasia: ultrastructural and immunocytochemical studies

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Journal of the neurological sciences 1994-12-01 Drug development

    We describe a clinico-pathological variant of a degenerative disorder involving Broca's, Wernicke's, and supplementary motor areas, which presented as primary progressive aphasia, dysarthria, bucco-facial apraxia, and hearing loss as initial symptoms, followed by organic personality changes.

  31. Cognitive correlates of ventricular enlargement and cerebral white matter lesions on magnetic resonance imaging. The Rotterdam Study

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. Stroke 1994-06-01 Long-term cohort studies

    Ventricular enlargement and white matter lesions are frequent findings on cerebral magnetic resonance imaging scans of elderly subjects.

  32. The clinical spectrum of cerebral amyloid angiopathy: presentations without lobar hemorrhage

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. Neurology 1993-10-01 Brain tissue and pathology

    Cerebral amyloid angiopathy is a common cause of spontaneous lobar hemorrhage in elderly patients.

  33. Cerebral white matter changes in acquired immunodeficiency syndrome dementia: alterations of the blood-brain barrier

    ✓ Peer-reviewed alzhub usefulness score 51 out of 100. Annals of neurology 1993-09-01 Brain tissue and pathology

    The cause of acquired immunodeficiency syndrome (AIDS) dementia, which is a frequent late manifestation of human immunodeficiency virus (HIV) infection, is unknown but radiological and pathological studies have implicated alterations in subcortical white matter.

  34. Functional roles of microglia in the brain

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neuroscience research 1993-08-01 Inflammation and the immune system

    It has been suggested that microglia, a type of glial cells in the central nervous system, play various important roles in normal and pathologic brains.

  35. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy maps to chromosome 19q12

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Nature genetics 1993-03-01 Risk factors

    Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) has been recently reported as a cause of stroke.

  36. Vascular dementia: diagnostic criteria for research studies. Report of the NINDS-AIREN International Workshop

    ✓ Peer-reviewed alzhub usefulness score 61 out of 100. Neurology 1993-02-01 Getting a diagnosis

    Criteria for the diagnosis of vascular dementia (VaD) that are reliable, valid, and readily applicable in a variety of settings are urgently needed for both clinical and research purposes.

  37. Autosomal dominant leukoencephalopathy and subcortical ischemic stroke. A clinicopathological study

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Stroke 1993-01-01 Vascular contributions

    The underlying lesion of this hereditary disorder is located in the small arteries and is of unknown etiology.

  38. Leukoaraiosis and dementia in hypertensive patients

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Stroke 1992-11-01 Digital health tools

    Hypertension-caused arteriosclerotic changes of the long penetrating medullary arteries may cause misery perfusion and later ischemic damage in the periventricular white matter.

  39. Spectrum of human immunodeficiency virus-associated neocortical damage

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. Annals of neurology 1992-09-01 Inflammation and the immune system

    A spectrum of neurocognitive defects, termed human immunodeficiency virus type 1 (HIV-1)-associated cognitive/motor complex, has been described in patients with acquired immunodeficiency syndrome (AIDS).

  40. Criteria for the diagnosis of ischemic vascular dementia proposed by the State of California Alzheimer's Disease Diagnostic and Treatment Centers

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. Neurology 1992-03-01 Getting a diagnosis

    Accurate diagnosis of vascular dementia is important for the recognition of underlying pathophysiology and the institution of appropriate therapy.

  41. Cerebral blood flow and oxygen metabolism in patients with vascular dementia of the Binswanger type

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Stroke 1990-12-01 Digital health tools

    We performed clinical and neuroradiologic studies, including positron emission tomography, in five patients with vascular dementia of the Binswanger type.

  42. Brain microglia constitutively express beta-2 integrins

    ✓ Peer-reviewed alzhub usefulness score 44 out of 100. Journal of neuroimmunology 1990-11-01 Inflammation and the immune system

    Localization of beta-2 integrins in normal and Alzheimer disease temporal cortex was studied immunohistochemically.

  43. Slowly progressive aphasia: three cases with language, memory, CT and PET data

    ✓ Peer-reviewed alzhub usefulness score 44 out of 100. Journal of neurology, neurosurgery, and psychiatry 1990-11-01 Digital health tools

    Three cases of slowly progressive speech and language disturbance were studied at various points post onset (three, five and 15 years respectively).

  44. Late neurological complications after prophylactic cranial irradiation in patients with small-cell lung cancer: the Toronto experience

    ✓ Peer-reviewed alzhub usefulness score 44 out of 100. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1990-02-01 Disparities

    We retrospectively analyzed the charts of 58 long-term survivors of small-cell lung cancer (SCLC) (greater than 2 years) for neurological complications and their impact on the well-being of these patients.

  45. The brain in AIDS: central nervous system HIV-1 infection and AIDS dementia complex

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. Science (New York, N.Y.) 1988-02-01 Brain tissue and pathology

    Infection with human immunodeficiency virus type 1 (HIV-1) is frequently complicated in its late stages by the AIDS dementia complex, a neurological syndrome characterized by abnormalities in cognition, motor performance, and behavior.

  46. Incidental subcortical lesions identified on magnetic resonance imaging in the elderly. I. Correlation with age and cerebrovascular risk factors

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Stroke 1986-11-01 Getting a diagnosis

    Patchy subcortical foci of increased signal intensity are frequently identified on magnetic resonance imaging (MRI) in the elderly.

  47. Leukoencephalopathy in normal and pathologic aging: 2. MRI of brain lucencies

    ✓ Peer-reviewed alzhub usefulness score 33 out of 100. AJNR. American journal of neuroradiology 1986-07-01 Brain scans and imaging

    A pilot study was performed to test the ability of MR to evaluate the brain lucencies shown by CT in Alzheimer disease patients and in normal control subjects.

  48. Hypoxic-ischemic brain lesions found in asphyxiating neonates

    ✓ Peer-reviewed alzhub usefulness score 27 out of 100. Acta pathologica japonica 1986-04-01 Biomarkers

    Early hypoxic-ischemic brain lesions were examined regarding 26 autopsy cases which had severe asphyxia at birth and died within the first week.

  49. Cerebral blood flow changes in benign aging and cerebrovascular disease

    ✓ Peer-reviewed alzhub usefulness score 59 out of 100. Neurology 1984-07-01 Vascular contributions

    Cross-sectional analysis of CBF values was carried out among 668 volunteers and patients.

  50. Loss of neurons of origin of the adrenergic projection to cerebral cortex (nucleus locus ceruleus) in senile dementia

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. Neurology 1982-02-01 Getting a diagnosis

    To examine the possibility that senile dementia may be associated with a loss of noradrenergic neurons that innervate the cerebral cortex, we used a Quantimet 720 image analyzer to estimate the number of neurons in the nucleus locus ceruleus in elderly patients with the clinical diagnosis of senile dementia.

From across this tag

9 of the 902 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 9. The same 9 appear here every time.

All topic tags with their study counts