Home › Research › Inflammation and the immune system
A model for monocyte migration through the blood-brain barrier during HIV-1 encephalitis
Persidsky Y, Stins M, Way D, Witte MH, Weinand M, Kim KS, Bock P, Gendelman HE et al.. Journal of immunology (Baltimore, Md. : 1950), 1997-04-01
Topic: Brain proteins, microglia and lab models
HIV-1 invades the central nervous system early during viral infection, but neurologic impairment usually occurs years later. The strongest predictor for clinical dementia is the absolute numbers of immunocompetent brain macrophages. Thus, how monocytes penetrate the brain during disease remains critical for understanding the neuropathogenic mechanisms of HIV-1 encephalitis.
Key findings
- The strongest predictor for clinical dementia is the absolute numbers of immunocompetent brain macrophages.
- Thus, how monocytes penetrate the brain during disease remains critical for understanding the neuropathogenic mechanisms of HIV-1 encephalitis.
- To these ends, we constructed an artificial blood-brain barrier (BBB) consisting of a matrix-coated membrane with brain microvascular endothelial cells (BMVEC) on one side and astrocytes on the other.
- Astrocyte endfeet contacted the monolayer of BMVEC that formed tight junctions.
Why it matters
This laboratory study built an artificial blood-brain barrier model to study how monocytes migrate into the brain during HIV-1 encephalitis, a condition different from Alzheimer's disease. It does not provide evidence about treating, curing, or preventing Alzheimer's disease.
Study details
- Evidence strengthLow
How this study scored 43/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of immunology (Baltimore, Md. : 1950)) |
| Journal's citation record | 4 / 4 | The Journal of Immunology: journal h-index 531 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 1997 — older than 20 years, still counted |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 6 / 7 | Cited 317 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 10.2 citations a year over 31 year(s) since 1997 |
| Impact for its field and year | 4 / 6 | Cited 12.4× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 2 other studies in this library |
| Still being cited | 1 / 4 | Cited 10 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Milan Fiala: h-index 48 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | University of Nebraska Medical Center: institution h-index 666 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 9120312) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 43 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
May need a subscription OpenAlex found no free copy of the full text (checked 6 Feb 1020), so the publisher may charge for it. The PubMed abstract is free.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Persidsky, Y., Stins, M., Way, D., Witte, M. H., Weinand, M., Kim, K. S., et al. (1997). A model for monocyte migration through the blood-brain barrier during HIV-1 encephalitis. Journal of immunology (Baltimore, Md. : 1950). https://doi.org/10.4049/jimmunol.158.7.3499
Vancouver
Persidsky Y, Stins M, Way D, Witte MH, Weinand M, Kim KS, et al. A model for monocyte migration through the blood-brain barrier during HIV-1 encephalitis. Journal of immunology (Baltimore, Md. : 1950). 1997. doi:10.4049/jimmunol.158.7.3499. PMID: 9120312.
BibTeX
@article{persidsky1997-9120312,
author = {Persidsky, Y. and Stins, M. and Way, D. and Witte, M. H. and Weinand, M. and Kim, K. S. and Bock, P. and Gendelman, H. E. and others},
title = {{A model for monocyte migration through the blood-brain barrier during HIV-1 encephalitis}},
journal = {Journal of immunology (Baltimore, Md. : 1950)},
year = {1997},
doi = {10.4049/jimmunol.158.7.3499},
pmid = {9120312},
url = {https://doi.org/10.4049/jimmunol.158.7.3499}
}
Later studies that cite this one
2 studies in the alzhub library list this one in their references.
Related studies in Inflammation and the immune system
Also tagged “cerebral”
900 studies in the library carry the topic tag “cerebral”; these are this study's neighbours in a fixed, alphabetical-by-hash tour of them, not the closest in content. All 900 tagged studies.