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Spectrum of human immunodeficiency virus-associated neocortical damage
Masliah E, Achim CL, Ge N, DeTeresa R, Terry RD, Wiley CA.. Annals of neurology, 1992-09-01
Topic: Brain proteins, microglia and lab models
A spectrum of neurocognitive defects, termed human immunodeficiency virus type 1 (HIV-1)-associated cognitive/motor complex, has been described in patients with acquired immunodeficiency syndrome (AIDS). AIDS dementia complex (ADC) is a severe form of this disease seen in 20 to 30% of terminally ill patients. The etiology of this complex is distinct from commonly observed opportunistic infections seen in brains of patients with AIDS and has been attributed to HIV infection within the brain.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Masliah, E., Achim, C. L., Ge, N., DeTeresa, R., Terry, R. D., & Wiley, C. A. (1992). Spectrum of human immunodeficiency virus-associated neocortical damage. Annals of neurology. https://doi.org/10.1002/ana.410320304
Vancouver
Masliah E, Achim CL, Ge N, DeTeresa R, Terry RD, Wiley CA. Spectrum of human immunodeficiency virus-associated neocortical damage. Annals of neurology. 1992. doi:10.1002/ana.410320304. PMID: 1416802.
BibTeX
@article{masliah1992-1416802,
author = {Masliah, E. and Achim, C. L. and Ge, N. and DeTeresa, R. and Terry, R. D. and Wiley, C. A.},
title = {{Spectrum of human immunodeficiency virus-associated neocortical damage}},
journal = {Annals of neurology},
year = {1992},
doi = {10.1002/ana.410320304},
pmid = {1416802},
url = {https://doi.org/10.1002/ana.410320304}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- AIDS dementia complex (ADC) is a severe form of this disease seen in 20 to 30% of terminally ill patients.
- The etiology of this complex is distinct from commonly observed opportunistic infections seen in brains of patients with AIDS and has been attributed to HIV infection within the brain.
- At autopsy, the brains of patients with ADC contain numerous HIV-infected macrophages/microglia with prominent subcortical damage, together termed HIV encephalitis.
- We retrospectively analyzed all 107 brains from a three-year period (1988-1990) of AIDS autopsies using immunocytochemistry to detect HIV.
Why it matters
This autopsy study describes brain damage and HIV-infected macrophages/microglia in AIDS dementia complex. It concerns HIV-associated dementia, not Alzheimer's disease, and reports no treatment or cure.
Study details
- Evidence strengthLow
How this study scored 46/100
Published in a leading specialty journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Annals of neurology) |
| Journal's citation record | 3 / 4 | Annals of Neurology: journal h-index 437 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 1992 — older than 20 years, still counted |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 6 / 7 | Cited 371 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 10.3 citations a year over 36 year(s) since 1992 |
| Impact for its field and year | 3 / 6 | Cited 6.8× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 8 other studies in this library |
| Still being cited | 1 / 4 | Cited 7 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Clayton A. Wiley: h-index 66 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University of California San Diego: institution h-index 1,852 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 1416802) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 46 / 100 | — |
What each of these 20 components measures, and what this score is not →
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