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Leukoencephalopathy in normal and pathologic aging: 2. MRI of brain lucencies
George AE, de Leon MJ, Kalnin A, Rosner L, Goodgold A, Chase N.. AJNR. American journal of neuroradiology, 1986-07-01
Topic: Brain proteins, microglia and lab models
A pilot study was performed to test the ability of MR to evaluate the brain lucencies shown by CT in Alzheimer disease patients and in normal control subjects. Eight patients with presumed Alzheimer disease and 47 normal controls, 12 over the age of 45 years and 35 under age 45, were studied. Each group included subjects with and without CT evidence of leukoencephalopathy. Inversion recovery, saturation recovery, and spin-echo scans were obtained using a 0.3-T permanent magnet prototype unit. Results indicated that MR was more sensitive than CT to parenchymal disease. Seven of the eight patients with Alzheimer disease showed patches of increased signal intensity on SE scans; only three had lucencies on their CT studies. None of the normal subjects under the age of 45 showed periventricular patches of increased SE signal intensity. T2-weighted SE imaging was performed in nine of the 12 normal subjects over 45 years old. Eight of the nine demonstrated periventricular patches of increased SE signal intensity. Faint CT lucencies were present in only one of these. The configuration of the patches of increased signal intensity was similar for both the normal and Alzheimer groups, but the extent of white-matter involvement was greater in the Alzheimer group.
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APA 7th
George, A. E., de Leon, M. J., Kalnin, A., Rosner, L., Goodgold, A., & Chase, N. (1986). Leukoencephalopathy in normal and pathologic aging: 2. MRI of brain lucencies. AJNR. American journal of neuroradiology.
Vancouver
George AE, de Leon MJ, Kalnin A, Rosner L, Goodgold A, Chase N. Leukoencephalopathy in normal and pathologic aging: 2. MRI of brain lucencies. AJNR. American journal of neuroradiology. 1986. PMID: 3088934.
BibTeX
@article{george1986-3088934,
author = {George, A. E. and de Leon, M. J. and Kalnin, A. and Rosner, L. and Goodgold, A. and Chase, N.},
title = {{Leukoencephalopathy in normal and pathologic aging: 2. MRI of brain lucencies}},
journal = {AJNR. American journal of neuroradiology},
year = {1986},
pmid = {3088934}
}
Built from the record alzhub holds for this paper, not looked up. This record has no DOI, so the citation leaves it out. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- Results indicated that MR was more sensitive than CT to parenchymal disease.
- Eight of the nine demonstrated periventricular patches of increased SE signal intensity.
Why it matters
This small 1986 pilot study found that MRI was more sensitive than CT for detecting brain signal changes, with patches of increased signal intensity seen in seven of eight Alzheimer disease patients and in eight of nine normal subjects over 45. These are imaging observations only and provide no treatment, cure or prevention for Alzheimer's disease.
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Study details
- Evidence strengthLow
How this study scored 33/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 21 of the 64 points we could judge it on, which is 33 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (AJNR. American journal of neuroradiology) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 1986 — older than 20 years, still counted |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 3088934) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 21 / 64 | Scored on 12 of 20 parts. We have no data for the rest, so they are left out: 21 of the 64 points we could judge it on is 33 out of 100. |
| Total | 33 / 100 | — |
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