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Home › Research › Topic

Inflammation, microglia and astrocytes

730 studies in this group. A computer grouped them by what their titles and summaries are about, not by a hand-made list. The name describes most of the group, not every study in it.

Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.

Highest usefulness score first. Studies without a score come last.

  1. C-terminal truncations in human 3'-5' DNA exonuclease TREX1 cause autosomal dominant retinal vasculopathy with cerebral leukodystrophy

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Nature genetics 2007-07-29 Brain scans and imaging

    Autosomal dominant retinal vasculopathy with cerebral leukodystrophy is a microvascular endotheliopathy with middle-age onset.

  2. Inflammatory markers and the risk of Alzheimer disease: the Framingham Study

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Neurology 2007-05-01 Long-term cohort studies

    Higher spontaneous production of interleukin 1 or tumor necrosis factor alpha by peripheral blood mononuclear cells may be a marker of future risk of Alzheimer disease (AD) in older individuals.

  3. Central and Systemic Endotoxin Challenges Exacerbate the Local Inflammatory Response and Increase Neuronal Death during Chronic Neurodegeneration

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Journal of Neuroscience 2005-10-05 Inflammation and the immune system

    The contribution of inflammation to the progression of neurodegenerative diseases such as Alzheimer's, Parkinson's, and prion diseases is poorly understood.

  4. Acetylcholinesterase inhibitors reduce brain and blood interleukin-1beta production

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Annals of neurology 2005-05-01 Drug development

    Overproduction of interleukin-1 within the brain is associated with Alzheimer's disease and other neurological conditions.

  5. Microglia and neuroinflammation: a pathological perspective

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Journal of neuroinflammation 2004-07-30 Inflammation and the immune system

    Microglia make up the innate immune system of the central nervous system and are key cellular mediators of neuroinflammatory processes.

  6. Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Abeta-induced cell death

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. The Journal of cell biology 2004-05-03 Disease mechanisms

    Recent studies have suggested that neuronal death in Alzheimer's disease or ischemia could arise from dysfunction of the endoplasmic reticulum (ER).

  7. Cannabinoid CB2Receptors and Fatty Acid Amide Hydrolase Are Selectively Overexpressed in Neuritic Plaque-Associated Glia in Alzheimer's Disease Brains

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Journal of Neuroscience 2003-12-03 Inflammation and the immune system

    The endocannabinoid system is still poorly understood.

  8. β-Amyloid Stimulation of Microglia and Monocytes Results in TNFα-Dependent Expression of Inducible Nitric Oxide Synthase and Neuronal Apoptosis

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Journal of Neuroscience 2001-02-15 Inflammation and the immune system

    Reactive microglia associated with the beta-amyloid plaques in Alzheimer's disease (AD) brains initiate a sequence of inflammatory events integral to the disease process.

  9. Increased Peroxynitrite Activity in AIDS Dementia Complex: Implications for the Neuropathogenesis of HIV-1 Infection

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. The Journal of Immunology 1999-04-01 Biomarkers

    Oxidative stress is suggested to be involved in several neurodegenerative diseases.

  10. Microglial response to amyloid plaques in APPsw transgenic mice

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Europe PMC (PubMed Central) 1998-01-01 Inflammation and the immune system

    Microglial activation is central to the inflammatory response in Alzheimer's Disease (AD).

  11. Microglial Cells Internalize Aggregates of the Alzheimer's Disease Amyloid β-Protein Via a Scavenger Receptor

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Neuron 1996-09-01 Inflammation and the immune system

    Microglia are immune system cells associated with Alzheimer's disease plaques containing beta-amyloid (A beta).

  12. Increased cytokine production in mononuclear cells of healthy elderly people

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. European Journal of Immunology 1993-09-01 Inflammation and the immune system

    The production of cytokines during aging, except interleukin (IL)-2, has been neglected in humans.

  13. Identification of lymphotoxin and tumor necrosis factor in multiple sclerosis lesions

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Journal of Clinical Investigation 1991-03-01 Inflammation and the immune system

    Multiple sclerosis (MS) brain tissue, spleen, and PBMC were studied using immunocytochemistry and FACS for immunoreactivity for lymphotoxin (LT) and TNF.

  14. Tumor necrosis factor identified in multiple sclerosis brain

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. The Journal of Experimental Medicine 1989-08-01 Inflammation and the immune system

    Frozen brain specimens from patients with multiple sclerosis (MS) and other neurologic diseases were analyzed using immunocytochemical techniques for the presence of TNF.

  15. Repositioning of Immunomodulators: A Ray of Hope for Alzheimer's Disease?

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Frontiers in neuroscience 2020-12-04 Drug development

    Alzheimer's disease (AD) is the most common age-related neurodegenerative disorder characterized by cognitive decline and by the presence of amyloid β plaques and neurofibrillary tangles in the brain.

  16. Locus Coeruleus Modulates Neuroinflammation in Parkinsonism and Dementia

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. International journal of molecular sciences 2020-11-16 Inflammation and the immune system

    Locus Coeruleus (LC) is the main noradrenergic nucleus of the central nervous system, and its neurons widely innervate the whole brain.

  17. Interaction between genetic factors, Porphyromonas gingivalis and microglia to promote Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Journal of oral microbiology 2020-09-16 TREM2 and immune genetics

    In late-onset Alzheimer disease (AD) pathogenesis, genes, infections and immunity could be significant factors.

  18. Neuroinflammation, microglial activation, and glucose metabolism in neurodegenerative diseases

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. International review of neurobiology 2020-07-24 Risk factors

    Alzheimer's disease is characterized by aggregated amyloid beta plaques and neurofibrillary tangles.

  19. Key Mechanisms and Potential Targets of the NLRP3 Inflammasome in Neurodegenerative Diseases

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Frontiers in integrative neuroscience 2020-07-24 Inflammation and the immune system

    Neurodegenerative diseases are neuronal disorders characterized by the loss of a large number of neurons in the human brain.

  20. Neurovascular Inflammaging in Health and Disease

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Cells 2020-07-04 Inflammation and the immune system

    Aging is characterized by a chronic low-grade sterile inflammation dubbed as inflammaging, which in part originates from accumulating cellular debris.

  21. Apolipoprotein E isoforms differentially regulate matrix metallopeptidase 9 function in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Neurobiology of aging 2020-07-03 Genetics

    Apolipoprotein E (APOE) has been shown to influence amyloid-β (Aβ) clearance from the brain in an isoform-specific manner.

  22. Triggering receptor expressed on myeloid cells 2 activation downregulates toll-like receptor 4 expression and ameliorates cognitive impairment in the Aβ1-42 -induced Alzheimer's disease mouse model

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Synapse (New York, N.Y.) 2020-06-12 TREM2 and immune genetics

    Increasing evidence suggests that changes in the triggering receptor expressed on myeloid cells 2 (TREM2) is closely correlated with the pathological development of Alzheimer's disease (AD).

  23. TREM2 Overexpression Attenuates Cognitive Deficits in Experimental Models of Vascular Dementia

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Neural plasticity 2020-06-12 TREM2 and immune genetics

    Neuroinflammation plays a prominent role in the pathogenesis of vascular dementia (VD).

  24. Understanding the Pathophysiology of Cerebral Amyloid Angiopathy

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. International journal of molecular sciences 2020-05-13 Vascular contributions

    Cerebral amyloid angiopathy (CAA), one of the main types of cerebral small vessel disease, is a major cause of spontaneous intracerebral haemorrhage and an important contributor to cognitive decline in elderly patients.

  25. Clinical Features and Experimental Models of Cerebral Small Vessel Disease

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Frontiers in aging neuroscience 2020-05-05 Vascular contributions

    Cerebral small vessel disease (SVD) refers to a group of disease conditions affecting the cerebral small vessels, which include the small arteries, arterioles, capillaries, and postcapillary venules in the brain.

From across this topic

10 of the 730 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.

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