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Home › Research › Topic

Inflammation, microglia and astrocytes

730 studies in this group. A computer grouped them by what their titles and summaries are about, not by a hand-made list. The name describes most of the group, not every study in it.

Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.

Highest usefulness score first. Studies without a score come last.

  1. If amyloid drives Alzheimer disease, why have anti-amyloid therapies not yet slowed cognitive decline?

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. PLoS biology 2022-07-21 Treatments

    Strong genetic evidence supports an imbalance between production and clearance of amyloid β-protein (Aβ) in people with Alzheimer disease (AD).

  2. Microglia Phenotypes in Aging and Neurodegenerative Diseases

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Cells 2022-06-30 Genetics

    Neuroinflammation is a hallmark of many neurodegenerative diseases (NDs) and plays a fundamental role in mediating the onset and progression of disease.

  3. A shared disease-associated oligodendrocyte signature among multiple CNS pathologies

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Nature neuroscience 2022-06-27 Genetics

    Alzheimer's disease (AD) is a complex neurodegenerative disease, perturbing neuronal and non-neuronal cell populations.

  4. Microglial amyloid beta clearance is driven by PIEZO1 channels

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Journal of neuroinflammation 2022-06-15 Genetics

    These results indicate that the compromised function of microglia in AD could be improved by controlled activation of PIEZO1 channels resulting in alleviated Aβ burden.

  5. Innate Immune Cell Death in Neuroinflammation and Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Cells 2022-06-10 End-of-life care

    Alzheimer's disease (AD) is a neurodegenerative disorder molecularly characterized by the formation of amyloid β (Aβ) plaques and type 2 microtubule-associated protein (Tau) abnormalities.

  6. Real-time whole-brain imaging of hemodynamics and oxygenation at micro-vessel resolution with ultrafast wide-field photoacoustic microscopy

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Light, science & applications 2022-05-17 Digital health tools

    High-speed high-resolution imaging of the whole-brain hemodynamics is critically important to facilitating neurovascular research.

  7. Microglia regulation of synaptic plasticity and learning and memory

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Neural regeneration research 2022-04-01 Brain scans and imaging

    Microglia are the resident macrophages of the central nervous system.

  8. Microglia Polarization From M1 to M2 in Neurodegenerative Diseases

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Frontiers in aging neuroscience 2022-02-16 Inflammation and the immune system

    Microglia-mediated neuroinflammation is a common feature of neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS).

  9. Exosomes derived from bone-marrow mesenchymal stem cells alleviate cognitive decline in AD-like mice by improving BDNF-related neuropathology

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Journal of neuroinflammation 2022-02-07 Biomarkers

    Lateral ventricle administration, but not caudal vein injection of BMSC-exos improved AD-like behaviors in the STZ-injected mouse model, as indicated by the increased number of rearing, increased frequency to the central area, and increased duration and distance traveled in the central area in the OFT, and improved preference index of the novel object in the NOR.

  10. The Impact of Systemic Inflammation on Alzheimer's Disease Pathology

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Frontiers in immunology 2022-01-06 Treatments

    Alzheimer's disease (AD) is a devastating age-related neurodegenerative disorder with an alarming increasing prevalence.

  11. Microglia in Neuroinflammation and Neurodegeneration: From Understanding to Therapy

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Frontiers in neuroscience 2021-09-24 Genetics

    Microglia are the resident macrophages of the central nervous system (CNS) acting as the first line of defense in the brain by phagocytosing harmful pathogens and cellular debris.

  12. Beyond Activation: Characterizing Microglial Functional Phenotypes

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Cells 2021-08-28 Genetics

    Classically, the following three morphological states of microglia have been defined: ramified, amoeboid and phagocytic.

  13. Microglia in Alzheimer's disease at single-cell level. Are there common patterns in humans and mice?

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. The Journal of experimental medicine 2021-07-22 Genetics

    Alzheimer's disease (AD) is characterized by extracellular aggregates of amyloid β peptides, intraneuronal tau aggregates, and neuronal death.

  14. Mesenchymal stem cell-derived extracellular vesicles ameliorate Alzheimer's disease-like phenotypes in a preclinical mouse model

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Theranostics 2021-07-13 Biomarkers

    The data revealed that 5XFAD mice that received hMSC-EV treatment behaved significantly better in cognitive tests than saline treated 5XFAD mice, with no significant change between EV-treated 5XFAD mice and NT mice.

  15. Molecular mechanisms of cell death in neurological diseases

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Cell death and differentiation 2021-06-07 Disease mechanisms

    Tightly orchestrated programmed cell death (PCD) signalling events occur during normal neuronal development in a spatially and temporally restricted manner to establish the neural architecture and shaping the CNS.

  16. The sTREM2 Concentrations in the Blood: A Marker of Neurodegeneration?

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Frontiers in molecular biosciences 2021-03-09 TREM2 and immune genetics

    Microglia performs a variety of functions during brain development designed to maintain brain homeostasis.

  17. Amyloid β oligomers constrict human capillaries in Alzheimer's disease via signaling to pericytes

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Science (New York, N.Y.) 2019-06-20 Vascular contributions

    Cerebral blood flow is reduced early in the onset of Alzheimer's disease (AD).

  18. Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Nature 2017-12-01 Risk genes beyond APOE

    The spreading of pathology within and between brain areas is a hallmark of neurodegenerative disorders.

  19. Clearance of beta-amyloid is facilitated by apolipoprotein E and circulating high-density lipoproteins in bioengineered human vessels

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. eLife 2017-10-10 Genetics

    Amyloid plaques, consisting of deposited beta-amyloid (Aβ), are a neuropathological hallmark of Alzheimer's Disease (AD).

  20. Microglia emerge as central players in brain disease

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Nature medicine 2017-09-01 Inflammation and the immune system

    There has been an explosion of new findings recently giving us insights into the involvement of microglia in central nervous system (CNS) disorders.

  21. Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer's disease in rodent models

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Nature communications 2016-08-11 Drug development

    Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit cyclooxygenase-1 (COX-1) and COX-2 enzymes.

  22. Untangling the brain's neuroinflammatory and neurodegenerative transcriptional responses

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Nature communications 2016-04-21 Genetics

    A common approach to understanding neurodegenerative disease is comparing gene expression in diseased versus healthy tissues.

  23. Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Brain 2015-03-31 Inflammation and the immune system

    Pathological aggregation of tau is a hallmark of Alzheimer’s disease and related tauopathies.

  24. Mutations in the colony stimulating factor 1 receptor (CSF1R) gene cause hereditary diffuse leukoencephalopathy with spheroids

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Nature genetics 2011-12-25 Risk factors

    Hereditary diffuse leukoencephalopathy with spheroids (HDLS) is an autosomal-dominant central nervous system white-matter disease with variable clinical presentations, including personality and behavioral changes, dementia, depression, parkinsonism, seizures and other phenotypes.

  25. Mild hypoxia enhances proliferation and multipotency of human neural stem cells

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. PloS one 2010-01-05 Biomarkers

    These findings raise the possibility that reduced oxygen levels occurring in neuronal disorders like cerebral ischemia transiently lead to NSC remaining in a state of quiescence.

From across this topic

9 of the 730 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 9. The same 9 appear here every time.

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