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Home › Research › Topic

Inflammation, microglia and astrocytes

730 studies in this group. A computer grouped them by what their titles and summaries are about, not by a hand-made list. The name describes most of the group, not every study in it.

Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.

Download bibliography of all 730 studies, highest score first: BibTeX (.bib) · RIS (.ris)

Highest usefulness score first. Studies without a score come last.

  1. Metabotropic P2Y1 receptor signalling mediates astrocytic hyperactivity in vivo in an Alzheimer's disease mouse model

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Nature communications 2014-11-19 Genetics

    Astrocytic network alterations have been reported in Alzheimer's disease (AD), but the underlying pathways have remained undefined.

  2. A Neurodegeneration-Specific Gene-Expression Signature of Acutely Isolated Microglia from an Amyotrophic Lateral Sclerosis Mouse Model

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Cell Reports 2013-07-01 Inflammation and the immune system

    Microglia are resident immune cells of the CNS that are activated by infection, neuronal injury, and inflammation.

  3. CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Nature immunology 2013-06-30 Risk factors

    Particulate ligands, including cholesterol crystals and amyloid fibrils, induce production of interleukin 1β (IL-1β) dependent on the cytoplasmic sensor NLRP3 in atherosclerosis, Alzheimer's disease and diabetes.

  4. Janus-faced microglia: beneficial and detrimental consequences of microglial phagocytosis

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Frontiers in cellular neuroscience 2013-01-30 Disease mechanisms

    Microglia are the resident brain macrophages and they have been traditionally studied as orchestrators of the brain inflammatory response during infections and disease.

  5. Nerve growth factor: from the early discoveries to the potential clinical use

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Journal of translational medicine 2012-11-29 Brain scans and imaging

    The physiological role of the neurotrophin nerve growth factor (NGF) has been characterized, since its discovery in the 1950s, first in the sensory and autonomic nervous system, then in central nervous, endocrine and immune systems.

  6. Deficiency in mural vascular cells coincides with blood-brain barrier disruption in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Brain pathology (Zurich, Switzerland) 2012-11-28 Vascular contributions

    Neurovascular dysfunction contributes to Alzheimer's disease (AD).

  7. Tight junctions at the blood brain barrier: physiological architecture and disease-associated dysregulation

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Fluids and barriers of the CNS 2012-11-09 Vascular contributions

    The Blood-brain barrier (BBB), present at the level of the endothelium of cerebral blood vessels, selectively restricts the blood-to-brain paracellular diffusion of compounds; it is mandatory for cerebral homeostasis and proper neuronal function.

  8. Astrocyte Senescence as a Component of Alzheimer’s Disease

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. PLoS ONE 2012-09-12 Disease mechanisms

    Aging is the main risk factor for Alzheimer's disease (AD); however, the aspects of the aging process that predispose the brain to the development of AD are largely unknown.

  9. An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Nature neuroscience 2012-06-01 Tau biomarkers

    Activation of innate immune receptors by host-derived factors exacerbates CNS damage, but the identity of these factors remains elusive.

  10. A review: inflammatory process in Alzheimer's disease, role of cytokines

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. TheScientificWorldJournal 2012-04-01 Brain tissue and pathology

    Alzheimer's disease (AD) is the most common neurodegenerative disorder to date.

  11. Prolonged oral cannabinoid administration prevents neuroinflammation, lowers β-amyloid levels and improves cognitive performance in Tg APP 2576 mice

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Journal of neuroinflammation 2012-01-16 Biomarkers

    We have shown that chronically administered cannabinoid showed marked beneficial effects concomitant with inflammation reduction and increased Aβ clearance.

  12. Identification and proteomic profiling of exosomes in human cerebrospinal fluid

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Journal of translational medicine 2012-01-05 Tau biomarkers

    Exosomes were identified in human CSF and their proteome is a potential new reservoir for biomarker discovery in neurological disorders such as Alzheimer's disease.

  13. Neurovascular dysfunction, inflammation and endothelial activation: implications for the pathogenesis of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Journal of neuroinflammation 2011-03-25 Costs and economics

    Alzheimer's disease (AD) is an age-related disorder characterized by progressive cognitive decline and dementia.

  14. Concomitant astroglial atrophy and astrogliosis in a triple transgenic animal model of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Glia 2010-05-01 Biomarkers

    Astrocytes are fundamental for brain homeostasis and are at the fulcrum of neurological diseases including Alzheimer's disease (AD).

  15. Pericyte-mediated regulation of capillary diameter: a component of neurovascular coupling in health and disease

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Frontiers in Neuroenergetics 2010-01-01 Vascular contributions

    Because regional blood flow increases in association with the increased metabolic demand generated by localized increases in neural activity, functional imaging researchers often assume that changes in blood flow are an accurate read-out of changes in underlying neural activity.

  16. Effect of quinolinic acid on human astrocytes morphology and functions: implications in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Journal of Neuroinflammation 2009-12-01 Biomarkers

    The excitotoxin quinolinic acid (QUIN) is synthesized through the kynurenine pathway (KP) by activated monocyte lineage cells.

  17. Does neuroinflammation fan the flame in neurodegenerative diseases?

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Molecular Neurodegeneration 2009-11-16 Inflammation and the immune system

    While peripheral immune access to the central nervous system (CNS) is restricted and tightly controlled, the CNS is capable of dynamic immune and inflammatory responses to a variety of insults.

  18. Glyburide inhibits the Cryopyrin/Nalp3 inflammasome

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. The Journal of cell biology 2009-10-01 Risk factors

    Inflammasomes activate caspase-1 for processing and secretion of the cytokines interleukin-1beta (IL-1beta) and IL-18.

  19. CD14 and Toll-Like Receptors 2 and 4 Are Required for Fibrillar Aβ-Stimulated Microglial Activation

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Journal of Neuroscience 2009-09-23 Inflammation and the immune system

    Microglia are the brain's tissue macrophages and are found in an activated state surrounding beta-amyloid plaques in the Alzheimer's disease brain.

  20. Neuroprotectin D1-mediated anti-inflammatory and survival signaling in stroke, retinal degenerations, and Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Journal of Lipid Research 2008-11-18 Brain scans and imaging

    Docosahexaenoic acid (DHA), the main omega-3 fatty acid, is concentrated and avidly retained in membrane phospholipids of the nervous system.

  21. Neurological and behavioral abnormalities, ventricular dilatation, altered cellular functions, inflammation, and neuronal injury in brains of mice due to common, persistent, parasitic infection

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Journal of neuroinflammation 2008-10-23 Biomarkers

    Twelve months after infection, a time equivalent to middle to early elderly ages, mice had behavioral and neurological deficits, and brain MRIs showed mild to moderate ventricular dilatation.

  22. TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Journal of neuroinflammation 2008-10-17 Inflammation and the immune system

    The role of tumor necrosis factor (TNF) as an immune mediator has long been appreciated but its function in the brain is still unclear.

  23. The ADAM metalloproteinases

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Molecular aspects of medicine 2008-08-15 Inflammation and the immune system

    The ADAMs (a disintegrin and metalloproteinase) are a fascinating family of transmembrane and secreted proteins with important roles in regulating cell phenotype via their effects on cell adhesion, migration, proteolysis and signalling.

  24. Toll-like receptor 4-dependent upregulation of cytokines in a transgenic mouse model of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Journal of neuroinflammation 2008-05-29 Biomarkers

    This is the first demonstration of TLR4-dependent upregulation of cytokines in an AD mouse model.

  25. Multiplicity of cerebrospinal fluid functions: New challenges in health and disease

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Cerebrospinal fluid research 2008-05-14 Tau biomarkers

    Accordingly the altered CSF composition in neurodegenerative diseases and senescence, because of adverse effects on neural processes and cognition, needs more effective clinical management.

From across this topic

10 of the 730 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.

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