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Home › Research › Topic

Inflammation, microglia and astrocytes

730 studies in this group. A computer grouped them by what their titles and summaries are about, not by a hand-made list. The name describes most of the group, not every study in it.

Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.

Highest usefulness score first. Studies without a score come last.

  1. Real-time imaging of single nerve cell apoptosis in retinal neurodegeneration

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. Proceedings of the National Academy of Sciences of the United States of America 2004-08-30 Brain scans and imaging

    Apoptotic nerve cell death is implicated in the pathogenesis of several devastating neurodegenerative conditions, including glaucoma and Alzheimer's and Parkinson's diseases.

  2. Human microglial transitions at the Aβ-tau inflection point associate with divergent pathways to dementia and resilience

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. Nature medicine 2026-06-04 Genetics

    Alzheimer's disease (AD) is not an inevitable outcome of pathology but a dynamic process shaped by how brain cells respond to amyloid-β (Aβ) and tau.

  3. Focused ultrasound-mediated APOE4 knockdown in mouse brain

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2025-07 Genetics

    FUS-enhanced delivery of AAV resulted in a 12.6% knockdown of APOE ε4 gene expression in the targeted hippocampus, accompanied by an over 20% decrease in apoE4 protein levels and significant reductions in astrocyte and microglia levels.

  4. APOE4/4 is linked to damaging lipid droplets in Alzheimer's disease microglia

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. Nature 2024-03-13 Genetics

    Several genetic risk factors for Alzheimer's disease implicate genes involved in lipid metabolism and many of these lipid genes are highly expressed in glial cells 1 .

  5. Multisensory gamma stimulation promotes glymphatic clearance of amyloid

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. Nature 2024-02-28 Disease mechanisms

    The glymphatic movement of fluid through the brain removes metabolic waste 1-4 .

  6. TREM2 expression in the brain and biological fluids in prion diseases

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. Acta neuropathologica 2021-04-21 TREM2 and immune genetics

    Triggering receptor expressed on myeloid cells 2 (TREM2) is an innate immune cell surface receptor that regulates microglial function and is involved in the pathophysiology of several neurodegenerative diseases.

  7. Photobiomodulation of immune crosstalk rescues neuroinflammation in Alzheimer's disease models

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Brain : a journal of neurology 2026-07-23 Inflammation and the immune system

    Peripheral immune cell infiltration and crosstalk with brain-resident cells critically drive Alzheimer's disease (AD)-associated neuroinflammation, highlighting its therapeutic potential.

  8. Semaglutide attenuates neuroinflammation in male mice

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Nature communications 2026-06-09 Drug development

    Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have shown promise in preclinical models of neurodegeneration, with emerging evidence suggesting these effects may be driven by modulation of neuroinflammation.

  9. Peripheral biomarkers of neuroinflammation in Alzheimer's disease and vascular dementia

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Biochemical pharmacology 2026-05-17 Inflammation and the immune system

    Alzheimer's disease (AD) and vascular dementia (VaD) are the two commonest causes of dementia in older adults and frequently coexist as mixed neurodegenerative-cerebrovascular pathology.

  10. Comprehensive single-cell transcriptomic atlas of microglia in Alzheimer's disease mouse models

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Molecular psychiatry 2026-03-21 Genetics

    Microglia are central mediators of neuroinflammation in Alzheimer's disease (AD), yet conserved microglial states and activation trajectories across AD mouse models remain incompletely defined.

  11. TREM2 in neurodegeneration and diseases

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Molecular psychiatry 2026-03-06 TREM2 and immune genetics

    Triggering receptor expressed on myeloid cells 2 (TREM2) is a cell surface transmembrane receptor from the TREM receptor family, predominantly expressed on the microglia in the central nervous system (CNS).

  12. HDAC6 regulates BACE1 stability and NLRP3 inflammasome activation in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Brain : a journal of neurology 2026-03-06 Inflammation and the immune system

    Alzheimer's disease (AD) is marked by amyloid-β (Aβ) accumulation, tau pathology, and neuroinflammation.

  13. TREM2 expression level is critical for microglial state, metabolic capacity and efficacy of TREM2 agonism

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Nature communications 2026-01-24 TREM2 and immune genetics

    Triggering receptor expressed on myeloid cells 2 (TREM2) is a central regulator of microglial activity and loss-of-function coding variants are major risk factors for late onset Alzheimer's disease (LOAD).

  14. Identification of Chlamydia pneumoniae and NLRP3 inflammasome activation in Alzheimer's disease retina

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Nature communications 2026-01-22 Inflammation and the immune system

    Chlamydia pneumoniae is an intracellular bacterium implicated in Alzheimer's disease (AD), but its role in retinal pathology and disease progression is unclear.

  15. The association between cerebrospinal ferritin and soluble triggering receptor expressed on myeloid cells 2 along Alzheimer's continuum

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Frontiers in neurology 2022-11-03 TREM2 and immune genetics

    Brain iron accumulation, which is indicated in the cerebrospinal fluid (CSF) ferritin, is associated with the development of Alzheimer's Disease (AD).

  16. CD4 + T cells contribute to neurodegeneration in Lewy body dementia

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Science (New York, N.Y.) 2021-10-14 Genetics

    Recent studies indicate that the adaptive immune system plays a role in Lewy body dementia (LBD).

  17. Evolution of neuroinflammation across the lifespan of individuals with Down syndrome

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Brain : a journal of neurology 2020-12-01 Down syndrome and Alzheimer's

    Epidemiological and experimental studies suggest that a disease-aggravating neuroinflammatory process is present at preclinical stages of Alzheimer's disease.

  18. Autoimmune glial fibrillary acidic protein astrocytopathy in Chinese patients: a retrospective study

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. European journal of neurology 2018-01-19 Biomarkers

    The present patients with positive GFAP-immunoglobulin G are highly similar to autoimmune GFAP astrocytopathy, described in a recent report.

  19. CRMP-5 neuronal autoantibody: Marker of lung cancer and thymoma-related autoimmunity

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Annals of Neurology 2001-01-01 Disease mechanisms

    We have defined a new paraneoplastic immunoglobulin G (IgG) autoantibody specific for CRMP-5, a previously unknown 62-kd neuronal cytoplasmic protein of the collapsin response-mediator family.

  20. Multiple sclerosis

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Lancet (London, England) 2023-11-07 Mild cognitive impairment

    Multiple sclerosis remains one of the most common causes of neurological disability in the young adult population (aged 18-40 years).

  21. Perivascular cells induce microglial phagocytic states and synaptic engulfment via SPP1 in mouse models of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Nature neuroscience 2023-02-06 Genetics

    Alzheimer's disease (AD) is characterized by synaptic loss, which can result from dysfunctional microglial phagocytosis and complement activation.

  22. Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Nature communications 2022-04-12 Genetics

    Activation of microglia is a prominent pathological feature in tauopathies, including Alzheimer's disease.

  23. Transcriptional signature in microglia associated with Aβ plaque phagocytosis

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Nature communications 2021-05-21 Genetics

    The role of microglia cells in Alzheimer's disease (AD) is well recognized, however their molecular and functional diversity remain unclear.

  24. Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Nature 2020-01-08 Tau biomarkers

    Alzheimer's disease is an incurable neurodegenerative disorder in which neuroinflammation has a critical function 1 .

  25. IL-1β, IL-6, IL-10, and TNFα Single Nucleotide Polymorphisms in Human Influence the Susceptibility to Alzheimer's Disease Pathology

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Journal of Alzheimer's disease : JAD 2020-01-01 Biomarkers

    These results suggest that persons carrying certain genotypes in IL10 (-1082G/A), IL1β (1473C/G), IL6 (-174C/G), and TNFIα (-308A/G) could be more vulnerable to development of neuroinflammation, and consequently of AD.

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