Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
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41/100
Parkinson's disease is characterized by accumulation of α-synuclein (αSyn).
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The central role of the resident innate immune cells of the brain (microglia) in neurodegeneration has become clear over the past few years largely through genome-wide association studies (GWAS), and has rapidly become an active area of research.
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Triggering receptor expressed on myeloid cells-2 (TREM2) and colony-stimulating factor 1 receptor (CSF1R) are crucial molecules for microgliopathy, which is characterized by microglia dysfunction and has recently been proposed as the neuropathological hallmark of neurological disorders.
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The prevalence of neurodegenerative disease has increased significantly in recent years, and with a rapidly aging global population, this trend is expected to continue.
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Excessive microglial activation might be a central pathological process in GRN-related frontotemporal dementia (FTD-GRN).
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Alzheimer's disease (AD) is the most common neurodegenerative disease worldwide.
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Neuroinflammation is a common feature in neurodegenerative diseases, modulated by the Alzheimer's disease risk factor, apolipoprotein E (APOE).
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Alzheimer's disease (AD) is a lethal neurodegenerative disorder primarily affecting the aged population.
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Inflammation plays important roles in the progress of neurodegenerative diseases, such as Parkinson's disease and Alzheimer's disease.
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Microglia, resident immune cells of the central nervous system (CNS), play a pivotal role in immune surveillance and maintenance of neuronal health.
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The expression of ABCA1 was significantly downregulated in AD models at both mRNA and protein levels.
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Alzheimer's Disease (AD) is the most prevalent form of dementia across the world.
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Alzheimer's disease (AD) is the most prevalent neurodegenerative disease commonly diagnosed among the elderly population.
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The innate immune system plays key roles in controlling Alzheimer's disease (AD), while secreting cytokines to eliminate pathogens and regulating brain homeostasis.
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Alzheimer's disease (AD) is the main cause of dementia worldwide.
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Alzheimer's disease (AD) is the most common form of dementia.
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Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary small vessel disease presenting with migraine, mood and cognitive disorders, focal neurological deficits, recurrent ischemic attacks, lacunar infarcts and brain white matter changes.
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Coronavirus Disease 2019 (COVID-19) pandemic-triggered mortality is significantly higher in older than in younger populations worldwide.
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Cerebrovascular pathologies occur in up to 80% of cases of Alzheimer's disease; however, the underlying mechanisms that lead to perivascular pathology and accompanying blood-brain barrier (BBB) disruption are still not fully understood.
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The triggering receptor expressed on myeloid cells 2 (TREM2) is an immune receptor expressed on myeloid-derived cell types.
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Neuroinflammation is associated with neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis.
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To maintain homeostasis, an organism must detect and resolve sterile tissue damage.
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Alogliptin treatment alleviated LPS-induced cognitive impairment as assessed by Morris water maze and novel object recognition tests.
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Alzheimer's disease (AD) is the most common form of dementia but has no effective treatment.
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41/100
Single-nucleus RNA sequencing (snRNA-seq) is used as an alternative to single-cell RNA-seq, as it allows transcriptomic profiling of frozen tissue.
From across this topic
10 of the 730 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- HIV-1 and Morphine Regulation of Autophagy in Microglia: Limited Interactions in the Context of HIV-1 Infection and Opioid Abuse
- A self-limiting, TREM2-dependent anabolic program confers microglial resilience in Alzheimer’s disease
- Microglial TREM2 promotes phagocytic clearance of damaged neurons after status epilepticus
- Astrocyte-Microglia Cross Talk through Complement Activation Modulates Amyloid Pathology in Mouse Models of Alzheimer's Disease
- In vivo direct reprogramming of reactive glial cells into functional neurons after brain injury and in an Alzheimer's disease model
- Prion Infection of Mouse Brain Reveals Multiple New Upregulated Genes Involved in Neuroinflammation or Signal Transduction
- Current Strategies for Brain Drug Delivery
- Acetylcholinesterase inhibitors reduce brain and blood interleukin-1beta production
- HMGB1 and RAGE in inflammation and cancer
- Mitochondrial Dysfunction, Oxidative Stress, and Neuroinflammation: Intertwined Roads to Neurodegeneration