Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
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The development of a multicellular organism involves a delicate balance among the processes of proliferation, differentiation and death.
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There appears to be a new syndrome in this family that is characterized by recurrent subcortical strokelike episodes, leukoencephalopathy, immunologic anomalies, muscular lipidosis, and an autosomal dominant pattern of transmission.
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Protease nexin-II (PN-II) [amyloid beta-protein precursor (APP)] and the amyloid beta-protein are major constituents of neuritic plaques and cerebrovascular deposits in individuals with Alzheimer's disease and Down syndrome.
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Altered microglial states affect neuroinflammation, neurodegeneration, and disease but remain poorly understood.
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Spatial molecular profiling of complex tissues is essential to investigate cellular function in physiological and pathological states.
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Adult neurogenesis occurs mainly in the subgranular zone of the hippocampal dentate gyrus and the subventricular zone of the lateral ventricles.
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Traditionally, lymphocytic interferon γ (IFN-γ) was considered to be a simple 'booster' of proinflammatory responses by microglia (brain-resident macrophages) during bacterial or viral infection.
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Microglia are critical in brain development and Alzheimer's disease (AD) etiology.
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The pro-inflammatory activation of microglia is a hallmark of Alzheimer's disease (AD), and this process involves a switch from oxidative phosphorylation (OXPHOS) toward glycolysis.
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The NLRP3 inflammasome is a cytosolic multiprotein complex composed of the innate immune receptor protein NLRP3, adapter protein ASC, and inflammatory protease caspase-1 that responds to microbial infection, endogenous danger signals, and environmental stimuli.
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The apolipoprotein E (APOE) gene is the strongest genetic risk factor for Alzheimer's disease and directly influences tauopathy and tau-mediated neurodegeneration.
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There is growing evidence that excessive microglial phagocytosis of neurons and synapses contributes to multiple brain pathologies.
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The ε4 allele of the apolipoprotein E ( APOE ) gene is the strongest genetic risk factor for late-onset Alzheimer's disease (AD) and greatly influences the development of amyloid-β (Aβ) pathology.
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40/100
The concept of the inflammasome, a macromolecular complex sensing cell stress or danger signals and initiating inflammation, was first introduced approximately a decade ago.
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Vascular cognitive impairment is the second most common form of dementia.
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Several attempts have been made to treat Alzheimer's disease (AD) using anti-amyloid strategies with disappointing results.
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Pericytes are vascular mural cells embedded in the basement membrane of blood microvessels.
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In addition to amyloid-β plaque and tau neurofibrillary tangle deposition, neuroinflammation is considered a key feature of Alzheimer's disease pathology.
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Increasing evidence supports a role of neuroinflammation in the pathogenesis of Alzheimer's disease (AD).
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Patients with chronic inflammation are often associated with the emergence of depression symptoms, while diagnosed depressed patients show increased levels of circulating cytokines.
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The neurone-centred view of the past disregarded or downplayed the role of astroglia as a primary component in the pathogenesis of neurological diseases.
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Amyloid-related imaging abnormalities (ARIA) represent the major severe side effect of amyloid-beta (Aβ) immunotherapy for Alzheimer's disease (AD).
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The extracellular matrix (ECM) is a critical regulator of neural network development and plasticity.
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Neuroinflammation and mitochondrial dysfunction are common features of chronic neurodegenerative diseases of the central nervous system.
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40/100
The glucose transporter GLUT1 at the blood-brain barrier (BBB) mediates glucose transport into the brain.
From across this topic
10 of the 730 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- Spatial and single-cell transcriptomics reveal the reorganization of cerebellar microglia with aging
- APOE4 reduction in vascular-associated fibroblasts decreases cerebral amyloid angiopathy and associated vascular dysfunction
- New insight into neurological degeneration: Inflammatory cytokines and blood-brain barrier
- Neurovascular Alterations in Vascular Dementia: Emphasis on Risk Factors
- Triggering receptor expressed on myeloid cells 2 activation downregulates toll-like receptor 4 expression and ameliorates cognitive impairment in the Aβ1-42 -induced Alzheimer's disease mouse model
- Alzheimer’s disease phospholipase C-gamma-2 (PLCG2) protective variant is a functional hypermorph
- Inhibition of Neuroinflammation by Synthetic Androstene Derivatives Incorporating Amino Acid Methyl Esters on Activated BV‐2 Microglia
- Role of TREM2 in neuroinflammation
- Apolipoprotein E promotes subretinal mononuclear phagocyte survival and chronic inflammation in age‐related macular degeneration
- Trem2 H157Y increases soluble TREM2 production and reduces amyloid pathology