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Home › Research › Topic

Inflammation, microglia and astrocytes

730 studies in this group. A computer grouped them by what their titles and summaries are about, not by a hand-made list. The name describes most of the group, not every study in it.

Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.

Highest usefulness score first. Studies without a score come last.

  1. Cellular and molecular influencers of neuroinflammation in Alzheimer's disease: Recent concepts & roles

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Neurochemistry international 2021-10-14 Inflammation and the immune system

    Alzheimer's disease (AD), an extremely common neurodegenerative disorder of the older generation, is one of the leading causes of death globally.

  2. Donepezil Regulates LPS and Aβ-Stimulated Neuroinflammation through MAPK/NLRP3 Inflammasome/STAT3 Signaling

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. International journal of molecular sciences 2021-09-30 Inflammation and the immune system

    The acetylcholinesterase inhibitors donepezil and rivastigmine have been used as therapeutic drugs for Alzheimer's disease (AD), but their effects on LPS- and Aβ-induced neuroinflammatory responses and the underlying molecular pathways have not been studied in detail in vitro and in vivo.

  3. Reduced TREM2 activation in microglia of patients with Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. FEBS open bio 2021-09-28 TREM2 and immune genetics

    Loss-of-function variants of triggering receptor expressed on myeloid cells 2 (TREM2) increase the risk of developing Alzheimer's disease (AD).

  4. NAD+ supplementation reduces neuroinflammation and cell senescence in a transgenic mouse model of Alzheimer's disease via cGAS-STING

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Proceedings of the National Academy of Sciences of the United States of America 2021-09-14 Inflammation and the immune system

    Alzheimer's disease (AD) is a progressive and fatal neurodegenerative disorder.

  5. Neurovascular Alterations in Vascular Dementia: Emphasis on Risk Factors

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Frontiers in aging neuroscience 2021-09-10 Vascular contributions

    Vascular dementia (VaD) constitutes the second most prevalent cause of dementia in the world after Alzheimer's disease (AD).

  6. APOE4 Affects Basal and NMDAR-Mediated Protein Synthesis in Neurons by Perturbing Calcium Homeostasis

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. The Journal of neuroscience : the official journal of the Society for Neuroscience 2021-09-02 Genetics

    Here, we report that the acute exposure of primary cortical neurons or synaptoneurosomes to APOE4 leads to a significant decrease in global protein synthesis.

  7. Microglial TREM2 at the Intersection of Brain Aging and Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry 2021-09-02 TREM2 and immune genetics

    As resident immune cells of the brain, microglia serve pivotal roles in regulating neuronal function under both physiological and pathological conditions, including aging and the most prevalent neurodegenerative disease, Alzheimer's disease (AD).

  8. APOE4-carrying human astrocytes oversupply cholesterol to promote neuronal lipid raft expansion and Aβ generation

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Stem cell reports 2021-08-26 Genetics

    The ε4 allele of APOE-encoding apolipoprotein (ApoE) is one of the strongest genetic risk factors for Alzheimer's disease (AD).

  9. Differential interaction with TREM2 modulates microglial uptake of modified Aβ species

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Glia 2021-08-24 TREM2 and immune genetics

    Rare coding variants of the microglial triggering receptor expressed on myeloid cells 2 (TREM2) confer an increased risk for Alzheimer's disease (AD) characterized by the progressive accumulation of aggregated forms of amyloid β peptides (Aβ).

  10. BAD-mediated neuronal apoptosis and neuroinflammation contribute to Alzheimer's disease pathology

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. iScience 2021-08-04 Inflammation and the immune system

    Alzheimer's disease (AD) is the most common progressive neurodegenerative disease.

  11. Inflammation and Alzheimer's Disease: Mechanisms and Therapeutic Implications by Natural Products

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Mediators of inflammation 2021-07-31 Inflammation and the immune system

    Alzheimer's disease (AD) is a neurodegenerative disorder with no clear causative event making the disease difficult to diagnose and treat.

  12. Exploring ER stress response in cellular aging and neuroinflammation in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Ageing research reviews 2021-07-31 Disease mechanisms

    One evident hallmark of Alzheimer's disease (AD) is the irregular accumulation of proteins due to changes in proteostasis involving endoplasmic reticulum (ER) stress.

  13. Role of TREM2 in Alzheimer's Disease: A Long Road Ahead

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Molecular neurobiology 2021-07-18 TREM2 and immune genetics

    Alzheimer's disease (AD) is a neurodegenerative disease characterized by an increasing deterioration of memory, which is concomitant with additional cognitive deficits.

  14. Chronic colitis exacerbates NLRP3-dependent neuroinflammation and cognitive impairment in middle-aged brain

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Journal of neuroinflammation 2021-07-06 Inflammation and the immune system

    Administration of DSS induced colitis, impaired spatial and recognition memory, activated microglia, and increased A1-like astrocyte numbers.

  15. Autophagy deficiency modulates microglial lipid homeostasis and aggravates tau pathology and spreading

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Proceedings of the National Academy of Sciences of the United States of America 2021-07-06 Inflammation and the immune system

    The autophagy-lysosomal pathway plays a critical role in intracellular clearance and metabolic homeostasis.

  16. NLRP3 and Infections: β-Amyloid in Inflammasome beyond Neurodegeneration

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. International journal of molecular sciences 2021-06-29 Inflammation and the immune system

    Amyloid beta (Aβ)-induced abnormal neuroinflammation is recognized as a major pathological feature of Alzheimer's disease (AD), which results in memory impairment.

  17. Potential Repositioning of Anti-cancer EGFR Inhibitors in Alzheimer's Disease: Current Perspectives and Challenging Prospects

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Neuroscience 2021-06-15 Drug development

    Clinical trials of new drugs for Alzheimer's disease (AD) have ended with disappointing results, with tremendous resources and time.

  18. The Unfolded Protein Response in Immune Cells as an Emerging Regulator of Neuroinflammation

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Frontiers in aging neuroscience 2021-06-11 Disease mechanisms

    Immune surveillance is an essential process that safeguards the homeostasis of a healthy brain.

  19. Metformin, Macrophage Dysfunction and Atherosclerosis

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Frontiers in immunology 2021-06-07 Drug development

    Metformin is one of the most widely prescribed hypoglycemic drugs and has the potential to treat many diseases.

  20. Sensorineural hearing loss may lead to dementia-related pathological changes in hippocampal neurons

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Neurobiology of disease 2021-05-31 Risk factors

    Presbycusis contributes to cognitive decline and Alzheimer's disease.

  21. Hemostasis components in cerebral amyloid angiopathy and Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 2021-05-27 Vascular contributions

    Increased cerebrovascular amyloid-β (Aβ) deposition represents the main pathogenic mechanisms characterizing Alzheimer's disease (AD) and cerebral amyloid angiopathy (CAA).

  22. Cerebral microbleeds in vascular dementia from clinical aspects to host-microbial interaction

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Neurochemistry international 2021-05-25 Vascular contributions

    Vascular dementia is the second leading cause of dementia after Alzheimer's disease in the elderly population worldwide.

  23. TREM2 promotes natural killer cell development in CD3-CD122+NK1.1+ pNK cells

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. BMC immunology 2021-05-12 TREM2 and immune genetics

    Here, we demonstrated for the first time that CD3-CD122+NK1.1+ precursor NK (pNK) cells expressed TREM2 and their population increased in TREM2-overexpressing transgenic (TREM2-TG) mice compared with that in female C57BL/6 J wild type (WT) mice.

  24. VEGF counteracts amyloid-β-induced synaptic dysfunction

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Cell reports 2021-05-11 Disease mechanisms

    The vascular endothelial growth factor (VEGF) pathway regulates key processes in synapse function, which are disrupted in early stages of Alzheimer's disease (AD) by toxic-soluble amyloid-beta oligomers (Aβo).

  25. Role of triggering receptor expressed on myeloid cells 2 (TREM2) in neurodegenerative dementias

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. The European journal of neuroscience 2021-04-26 TREM2 and immune genetics

    Neurodegeneration is a debilitating condition that causes nerve cell degeneration or death.

From across this topic

10 of the 730 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.

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