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Home › Research › Topic

Inflammation, microglia and astrocytes

730 studies in this group. A computer grouped them by what their titles and summaries are about, not by a hand-made list. The name describes most of the group, not every study in it.

Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.

Highest usefulness score first. Studies without a score come last.

  1. [Inflammatory cerebral amyloid angiopathy]

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Brain and nerve = Shinkei kenkyu no shinpo 2015-03 Treatments

    Inflammatory cerebral amyloid angiopathy (CAA) typically affects older patients who present with acute or subacute cognitive decline, headache, behavioral change, seizures, and focal neurological deficits.

  2. Triggering receptor expressed on myeloid cells-2 is involved in prion-induced microglial activation but does not contribute to prion pathogenesis in mouse brains

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Neurobiology of aging 2015-02-27 TREM2 and immune genetics

    Dysfunctional variants of the innate immune cell surface receptor TREM2 (triggering receptor expressed on myeloid cells-2) were identified as major genetic risk factors for Alzheimer's disease and other neurodegenerative conditions.

  3. Different mechanisms of apolipoprotein E isoform-dependent modulation of prostaglandin E2 production and triggering receptor expressed on myeloid cells 2 (TREM2) expression after innate immune activation of microglia

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2015-01-15 TREM2 and immune genetics

    Several lines of evidence support immune response in brain as a mechanism of injury in Alzheimer disease (AD).

  4. Apolipoprotein E, amyloid-beta, and neuroinflammation in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Neuroscience bulletin 2014-03-20 Genetics

    Alzheimer's disease (AD) is characterized by the accumulation and deposition of amyloid-beta (Aβ) peptides in the brain.

  5. The triggering receptor expressed on myeloid cells 2: "TREM-ming" the inflammatory component associated with Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Oxidative medicine and cellular longevity 2013-03-06 TREM2 and immune genetics

    Alzheimer's disease (AD) is an age-related neurodegenerative disorder characterized by a progressive loss of memory and cognitive skills.

  6. Apolipoprotein e sets the stage: response to injury triggers neuropathology

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Neuron 2012-12-06 Genetics

    Apolipoprotein (apo) E4 is the major genetic risk factor for Alzheimer's disease and is associated with poor clinical outcome following traumatic brain injury and other neuropathological disorders.

  7. APOE genotype alters glial activation and loss of synaptic markers in mice

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Glia 2012-01-06 Genetics

    The ε4 allele of the Apolipoprotein E (APOE) gene is the strongest genetic risk factor for late-onset Alzheimer's disease (AD), and affects clinical outcomes of chronic and acute brain damages.

  8. Apolipoprotein E-specific innate immune response in astrocytes from targeted replacement mice

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Journal of neuroinflammation 2006-04-07 Genetics

    Here we showed that activation of primary astrocytes from TR APOE mice with LPS led to TR APOE-dependent differences in cytokine secretion that were greatest in TR APOE2 and that were associated with differences in NF-kappaB subunit activity.

  9. A dual role for apolipoprotein e in neuroinflammation: anti- and pro-inflammatory activity

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Journal of molecular neuroscience : MN 2004 Genetics

    Chronically activated glia associated with amyloid plaques might contribute to neuronal dysfunction in Alzheimer's disease (AD) through generation of neuroinflammatory molecules.

  10. Alzheimer disease and neuroinflammation

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Journal of neural transmission. Supplementum 2000 Inflammation and the immune system

    It is now generally accepted that the lesions of Alzheimer disease (AD) are associated with a host of inflammatory molecules, including complement proteins, as well as with many activated microglia.

  11. Matrix metalloproteinases in the brain and blood-brain barrier: Versatile breakers and makers

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2016-06-20 Vascular contributions

    Matrix metalloproteinases are versatile endopeptidases with many different functions in the body in health and disease.

  12. Nanoparticle-mediated brain drug delivery: Overcoming blood-brain barrier to treat neurodegenerative diseases

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of controlled release : official journal of the Controlled Release Society 2016-05-18 Inflammation and the immune system

    The blood-brain barrier (BBB) is a vital boundary between neural tissue and circulating blood.

  13. The role of interleukin-6 signaling in nervous tissue

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Biochimica et biophysica acta 2016-03-23 Brain scans and imaging

    The cytokine interleukin-6 (IL-6) plays a critical role in the pathogenesis of inflammatory disorders and in the physiological homeostasis of neural tissue.

  14. Cerebrospinal Fluid Markers of Alzheimer's Disease Pathology and Microglial Activation are Associated with Altered White Matter Microstructure in Asymptomatic Adults at Risk for Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of Alzheimer's disease : JAD 2016-01-01 Biomarkers

    Inflammation may play a role in neural damage in preclinical AD.

  15. Hypertension enhances Aβ-induced neurovascular dysfunction, promotes β-secretase activity, and leads to amyloidogenic processing of APP

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2016-01-01 Biomarkers

    Hypertension (HTN) doubles the risk of Alzheimer’s disease (AD), but the mechanisms remain unclear.

  16. Accelerated pericyte degeneration and blood-brain barrier breakdown in apolipoprotein E4 carriers with Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2016-01-01 Genetics

    The blood–brain barrier (BBB) limits the entry of neurotoxic blood-derived products and cells into the brain that is required for normal neuronal functioning and information processing.

  17. New insights on the role of microglia in synaptic pruning in health and disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Current opinion in neurobiology 2015-12-30 Genetics

    Recent genome-wide association studies implicate microglia in Alzheimer's disease (AD) pathogenesis; however, their biological significance remains poorly understood.

  18. Establishment and Dysfunction of the Blood-Brain Barrier

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Cell 2015-11-01 Vascular contributions

    Structural and functional brain connectivity, synaptic activity, and information processing require highly coordinated signal transduction between different cell types within the neurovascular unit and intact blood-brain barrier (BBB) functions.

  19. Depression as a microglial disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Trends in neurosciences 2015-10-01 Risk factors

    Despite decades of intensive research, the biological mechanisms that causally underlie depression are still unclear, and therefore the development of novel effective antidepressant treatments is hindered.

  20. Role of pro-inflammatory cytokines released from microglia in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Annals of translational medicine 2015-06-01 Inflammation and the immune system

    Alzheimer's disease (AD) is a progressive neurodegenerative disorder of the brain, which is characterized by the formation of extracellular amyloid plaques (or senile plaques) and intracellular neurofibrillary tangles.

  21. Neurodegeneration severity can be predicted from early microglia alterations monitored in vivo in a mouse model of chronic glaucoma

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Disease Models & Mechanisms 2015-05-01 Inflammation and the immune system

    Microglia serve key homeostatic roles, and respond to neuronal perturbation and decline with a high spatiotemporal resolution.

  22. APOE ‐modulated Aβ‐induced neuroinflammation in Alzheimer's disease: current landscape, novel data, and future perspective

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of Neurochemistry 2015-03-18 Inflammation and the immune system

    Chronic glial activation and neuroinflammation induced by the amyloid‐β peptide (Aβ) contribute to Alzheimer's disease ( AD ) pathology.

  23. Inhibition of Neuroinflammation by Synthetic Androstene Derivatives Incorporating Amino Acid Methyl Esters on Activated BV‐2 Microglia

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. ChemMedChem 2015-03-04 Inflammation and the immune system

    Androstene derivatives incorporating amino acid methyl esters were prepared, and their anti‐inflammatory effects were evaluated in lipopolysaccharide (LPS)‐activated BV‐2 microglial cells.

  24. GFAP and vimentin deficiency alters gene expression in astrocytes and microglia in wild‐type mice and changes the transcriptional response of reactive glia in mouse model for A lzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Glia 2015-03-02 Inflammation and the immune system

    Reactive astrocytes with an increased expression of intermediate filament (IF) proteins Glial Fibrillary Acidic Protein (GFAP) and Vimentin (VIM) surround amyloid plaques in Alzheimer's disease (AD).

  25. Innate immunity in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Nature immunology 2015-03-01 Inflammation and the immune system

    Alzheimer's disease (AD) is the world's most common dementing illness, affecting over 150 million patients.

From across this topic

10 of the 730 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.

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