% alzhub.org topic: Inflammation, microglia and astrocytes
% Source: https://alzhub.org/topic/microglia-inflammasome
% 730 entries, in the order the page lists them. Built from alzhub.org's own records.
% 0 entries have no readable author in the source record and carry no author field.

@article{brown2024-38629936,
  author  = {Brown, Robin B and Tozer, Daniel J and Loubière, Laurence and Harshfield, Eric L and Hong, Young T and Fryer, Tim D and Williams, Guy B and Graves, Martin J and others},
  title   = {{MINocyclinE to Reduce inflammation and blood-brain barrier leakage in small Vessel diseAse (MINERVA): A phase II, randomized, double-blind, placebo-controlled experimental medicine trial}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2024},
  doi     = {10.1002/alz.13830},
  pmid    = {38629936},
  url     = {https://doi.org/10.1002/alz.13830}
}

@article{koychev2024-39358806,
  author  = {Koychev, Ivan and Reid, Graham and Nguyen, Maggie and Mentz, Robert J and Joyce, Dan and Shah, Svati H and Holman, Rury R},
  title   = {{Inflammatory proteins associated with Alzheimer's disease reduced by a GLP1 receptor agonist: a post hoc analysis of the EXSCEL randomized placebo controlled trial}},
  journal = {Alzheimer's research \& therapy},
  year    = {2024},
  doi     = {10.1186/s13195-024-01573-x},
  pmid    = {39358806},
  url     = {https://doi.org/10.1186/s13195-024-01573-x}
}

@article{solopova2023-38086820,
  author  = {Solopova, E. and Romero-Fernandez, W. and Harmsen, H. and Ventura-Antunes, L. and Wang, E. and Shostak, A. and Maldonado, J. and Donahue, M. J. and others},
  title   = {{Fatal iatrogenic cerebral β-amyloid-related arteritis in a woman treated with lecanemab for Alzheimer's disease}},
  journal = {Nature communications},
  year    = {2023},
  doi     = {10.1038/s41467-023-43933-5},
  pmid    = {38086820},
  url     = {https://doi.org/10.1038/s41467-023-43933-5}
}

@article{ng2018-30104698,
  author  = {Ng, A. and Tam, W. W. and Zhang, M. W. and Ho, C. S. and Husain, S. F. and McIntyre, R. S. and Ho, R. C.},
  title   = {{IL-1β, IL-6, TNF- α and CRP in Elderly Patients with Depression or Alzheimer's disease: Systematic Review and Meta-Analysis}},
  journal = {Scientific reports},
  year    = {2018},
  doi     = {10.1038/s41598-018-30487-6},
  pmid    = {30104698},
  url     = {https://doi.org/10.1038/s41598-018-30487-6}
}

@article{bourdakou2023-37696195,
  author  = {Bourdakou, Marilena M and Fernández-Ginés, Raquel and Cuadrado, Antonio and Spyrou, George M},
  title   = {{Drug repurposing on Alzheimer's disease through modulation of NRF2 neighborhood}},
  journal = {Redox biology},
  year    = {2023},
  doi     = {10.1016/j.redox.2023.102881},
  pmid    = {37696195},
  url     = {https://doi.org/10.1016/j.redox.2023.102881}
}

@article{keddie2023-37435933,
  author  = {Keddie, S. and Smyth, D. and Keh, R. Y. S. and Chou, M. K. L. and Grant, D. and Surana, S. and Heslegrave, A. and Zetterberg, H. and others},
  title   = {{Peripherin is a biomarker of axonal damage in peripheral nervous system disease}},
  journal = {Brain : a journal of neurology},
  year    = {2023},
  doi     = {10.1093/brain/awad234},
  pmid    = {37435933},
  url     = {https://doi.org/10.1093/brain/awad234}
}

@article{podlesnydrabiniok2020-33127097,
  author  = {Podleśny-Drabiniok, A. and Marcora, E. and Goate, A. M.},
  title   = {{Microglial Phagocytosis: A Disease-Associated Process Emerging from Alzheimer's Disease Genetics}},
  journal = {Trends in neurosciences},
  year    = {2020},
  doi     = {10.1016/j.tins.2020.10.002},
  pmid    = {33127097},
  url     = {https://doi.org/10.1016/j.tins.2020.10.002}
}

@article{swardfager2010-20692646,
  author  = {Swardfager, W. and Lanctôt, K. and Rothenburg, L. and Wong, A. and Cappell, J. and Herrmann, N.},
  title   = {{A meta-analysis of cytokines in Alzheimer's disease}},
  journal = {Biological psychiatry},
  year    = {2010},
  doi     = {10.1016/j.biopsych.2010.06.012},
  pmid    = {20692646},
  url     = {https://doi.org/10.1016/j.biopsych.2010.06.012}
}

@article{haroon2015-26258401,
  author  = {Haroon, N. N. and Paterson, J. M. and Li, P. and Inman, R. D. and Haroon, N.},
  title   = {{Patients With Ankylosing Spondylitis Have Increased Cardiovascular and Cerebrovascular Mortality: A Population-Based Study}},
  journal = {Annals of internal medicine},
  year    = {2015},
  doi     = {10.7326/m14-2470},
  pmid    = {26258401},
  url     = {https://doi.org/10.7326/m14-2470}
}

@article{tiwari2021-33423653,
  author  = {Tiwari, Nidhi and Upadhyay, Jyoti and Ansari, Mohammad Nazam and Raza, Syed Shadab and Ahmad, Wasim and Ansari, Mohammad Azam},
  title   = {{Experimental Rodent Models of Vascular Dementia: A Systematic Review}},
  journal = {CNS \& neurological disorders drug targets},
  year    = {2021},
  doi     = {10.2174/1871527319666210108123438},
  pmid    = {33423653},
  url     = {https://doi.org/10.2174/1871527319666210108123438}
}

@article{jackson2022-34957486,
  author  = {Jackson, Rosemary J and Meltzer, Jonah C and Nguyen, Huong and Commins, Caitlin and Bennett, Rachel E and Hudry, Eloise and Hyman, Bradley T},
  title   = {{APOE4 derived from astrocytes leads to blood-brain barrier impairment}},
  journal = {Brain : a journal of neurology},
  year    = {2022},
  doi     = {10.1093/brain/awab478},
  pmid    = {34957486},
  url     = {https://doi.org/10.1093/brain/awab478}
}

@article{potter2021-33778150,
  author  = {Potter, H. and Woodcock, J. H. and Boyd, T. D. and Coughlan, C. M. and O'Shaughnessy, JR. and Borges, M. T. and Thaker, A. A. and Raj, B. A. and others},
  title   = {{Safety and efficacy of sargramostim (GM-CSF) in the treatment of Alzheimer's disease}},
  journal = {Alzheimer's \& dementia (New York, N. Y.)},
  year    = {2021},
  doi     = {10.1002/trc2.12158},
  pmid    = {33778150},
  url     = {https://doi.org/10.1002/trc2.12158}
}

@article{faura2020-31958084,
  author  = {Faura, J. and Bustamante, A. and Penalba, A. and Giralt, D. and Simats, A. and Martínez-Sáez, E. and Alcolea, D. and Fortea, J. and others},
  title   = {{CCL23: A Chemokine Associated with Progression from Mild Cognitive Impairment to Alzheimer's Disease}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2020},
  doi     = {10.3233/jad-190753},
  pmid    = {31958084},
  url     = {https://doi.org/10.3233/jad-190753}
}

@article{fan2017-28122877,
  author  = {Fan, Z. and Brooks, D. J. and Okello, A. and Edison, P.},
  title   = {{An early and late peak in microglial activation in Alzheimer's disease trajectory}},
  journal = {Brain : a journal of neurology},
  year    = {2017},
  doi     = {10.1093/brain/aww349},
  pmid    = {28122877},
  url     = {https://doi.org/10.1093/brain/aww349}
}

@article{ozlu2025-41442069,
  author  = {Özlü, Serap and Dyrba, Martin and Grazia, Alice and Brosseron, Frederic and Buerger, Katharina and Dechent, Peter and Düzel, Emrah and Ewers, Michael and others},
  title   = {{CSF biomarkers of neuroinflammation are associated with regional atrophy}},
  journal = {Journal of neurology},
  year    = {2025},
  doi     = {10.1007/s00415-025-13564-5},
  pmid    = {41442069},
  url     = {https://doi.org/10.1007/s00415-025-13564-5}
}

@article{martinsferreira2025-39820004,
  author  = {Martins-Ferreira, Ricardo and Calafell-Segura, Josep and Leal, Bárbara and Rodríguez-Ubreva, Javier and Martínez-Saez, Elena and Mereu, Elisabetta and Costa, Paulo Pinho E and Laguna, Ariadna and others},
  title   = {{The Human Microglia Atlas (HuMicA) unravels changes in disease-associated microglia subsets across neurodegenerative conditions}},
  journal = {Nature communications},
  year    = {2025},
  doi     = {10.1038/s41467-025-56124-1},
  pmid    = {39820004},
  url     = {https://doi.org/10.1038/s41467-025-56124-1}
}

@article{ramanan2015-26268530,
  author  = {Ramanan, Vijay K. and Risacher, Shannon L. and Nho, Kwangsik T. and Kim, Sungeun and Shen, Li and McDonald, Brenna C. and Yoder, Karmen K. and Hutchins, Gary D. and others},
  title   = {{GWAS of longitudinal amyloid accumulation on18F-florbetapir PET in Alzheimer’s disease implicates microglial activation geneIL1RAP}},
  journal = {Brain},
  year    = {2015},
  doi     = {10.1093/brain/awv231},
  pmid    = {26268530},
  url     = {https://doi.org/10.1093/brain/awv231}
}

@article{amin2022-35314318,
  author  = {Amin, Jay and Erskine, Daniel and Donaghy, Paul C and Surendranathan, Ajenthan and Swann, Peter and Kunicki, Amy P and Boche, Delphine and Holmes, Clive and others},
  title   = {{Inflammation in dementia with Lewy bodies}},
  journal = {Neurobiology of disease},
  year    = {2022},
  doi     = {10.1016/j.nbd.2022.105698},
  pmid    = {35314318},
  url     = {https://doi.org/10.1016/j.nbd.2022.105698}
}

@article{young2021-34083789,
  author  = {Young, A. M. H. and Kumasaka, N. and Calvert, F. and Hammond, T. R. and Knights, A. and Panousis, N. and Park, J. S. and Schwartzentruber, J. and others},
  title   = {{A map of transcriptional heterogeneity and regulatory variation in human microglia}},
  journal = {Nature genetics},
  year    = {2021},
  doi     = {10.1038/s41588-021-00875-2},
  pmid    = {34083789},
  url     = {https://doi.org/10.1038/s41588-021-00875-2}
}

@article{holmes2009-19738171,
  author  = {Holmes, C. and Cunningham, C. and Zotova, E. and Woolford, J. and Dean, C. and Kerr, S. and Culliford, D. and Perry, V. H.},
  title   = {{Systemic inflammation and disease progression in Alzheimer disease}},
  journal = {Neurology},
  year    = {2009},
  doi     = {10.1212/wnl.0b013e3181b6bb95},
  pmid    = {19738171},
  url     = {https://doi.org/10.1212/wnl.0b013e3181b6bb95}
}

@article{diazflores2009-19475537,
  author  = {Díaz‐Flores, Lucio and Gutiérrez, Ricardo and Madrid, Juan Francisco and Varela, H and Valladares, F. and Acosta, Elisa and Martı́n-Vasallo, Pablo and Díaz-Flores, L},
  title   = {{Pericytes. Morphofunction, interactions and pathology in a quiescent and activated mesenchymal cell niche}},
  journal = {PubMed},
  year    = {2009},
  doi     = {10.14670/hh-24.909},
  pmid    = {19475537},
  url     = {https://doi.org/10.14670/hh-24.909}
}

@article{vanwetering2024-38715119,
  author  = {van Wetering, Janna and Geut, Hanne and Bol, John J and Galis, Yvon and Timmermans, Evelien and Twisk, Jos W R and Hepp, Dagmar H and Morella, Martino L and others},
  title   = {{Neuroinflammation is associated with Alzheimer's disease co-pathology in dementia with Lewy bodies}},
  journal = {Acta neuropathologica communications},
  year    = {2024},
  doi     = {10.1186/s40478-024-01786-z},
  pmid    = {38715119},
  url     = {https://doi.org/10.1186/s40478-024-01786-z}
}

@article{watson2017-29017893,
  author  = {Watson, N. and Ding, B. and Zhu, X. and Frisina, R. D.},
  title   = {{Chronic inflammation - inflammaging - in the ageing cochlea: A novel target for future presbycusis therapy}},
  journal = {Ageing research reviews},
  year    = {2017},
  doi     = {10.1016/j.arr.2017.10.002},
  pmid    = {29017893},
  url     = {https://doi.org/10.1016/j.arr.2017.10.002}
}

@article{delvenne2023-35698882,
  author  = {Delvenne, Aurore and Gobom, Johan and Tijms, Betty and Bos, Isabelle and Reus, Lianne M and Dobricic, Valerija and Ten Kate, Mara and Verhey, Frans and others},
  title   = {{Cerebrospinal fluid proteomic profiling of individuals with mild cognitive impairment and suspected non-Alzheimer's disease pathophysiology}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2023},
  doi     = {10.1002/alz.12713},
  pmid    = {35698882},
  url     = {https://doi.org/10.1002/alz.12713}
}

@article{michaud2013-23792036,
  author  = {Michaud, M. and Balardy, L. and Moulis, G. and Gaudin, C. and Peyrot, C. and Vellas, B. and Cesari, M. and Nourhashemi, F.},
  title   = {{Proinflammatory cytokines, aging, and age-related diseases}},
  journal = {Journal of the American Medical Directors Association},
  year    = {2013},
  doi     = {10.1016/j.jamda.2013.05.009},
  pmid    = {23792036},
  url     = {https://doi.org/10.1016/j.jamda.2013.05.009}
}

@article{cordeiro2004-15340151,
  author  = {Cordeiro, M. F. and Guo, L. and Luong, V. and Harding, G. and Wang, W. and Jones, H. E. and Moss, S. E. and Sillito, A. M. and others},
  title   = {{Real-time imaging of single nerve cell apoptosis in retinal neurodegeneration}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2004},
  doi     = {10.1073/pnas.0405479101},
  pmid    = {15340151},
  url     = {https://doi.org/10.1073/pnas.0405479101}
}

@article{lu2026-42243549,
  author  = {Lu, Ashley and Chen, Wei-Ting and Dalby, Maria and Garcia, Diego Sainz and Vanheusden, Marisa and de Vries, Luuk E and van Lieshout, Veerle and Martirosyan, Araks and others},
  title   = {{Human microglial transitions at the Aβ-tau inflection point associate with divergent pathways to dementia and resilience}},
  journal = {Nature medicine},
  year    = {2026},
  doi     = {10.1038/s41591-026-04393-8},
  pmid    = {42243549},
  url     = {https://doi.org/10.1038/s41591-026-04393-8}
}

@article{zheng2025-40665471,
  author  = {Zheng, Kaiyuan and Tsitsos, Fotios N and Batts, Alec J and Ji, Robin and Nuriel, Tal and Konofagou, Elisa E and Leong, Kam W},
  title   = {{Focused ultrasound-mediated APOE4 knockdown in mouse brain}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2025},
  doi     = {10.1002/alz.70464},
  pmid    = {40665471},
  url     = {https://doi.org/10.1002/alz.70464}
}

@article{haney2024-38480892,
  author  = {Haney, M. S. and Pálovics, R. and Munson, C. N. and Long, C. and Johansson, P. K. and Yip, O. and Dong, W. and Rawat, E. and others},
  title   = {{APOE4/4 is linked to damaging lipid droplets in Alzheimer's disease microglia}},
  journal = {Nature},
  year    = {2024},
  doi     = {10.1038/s41586-024-07185-7},
  pmid    = {38480892},
  url     = {https://doi.org/10.1038/s41586-024-07185-7}
}

@article{murdock2024-38418876,
  author  = {Murdock, M. H. and Yang, C. Y. and Sun, N. and Pao, P. C. and Blanco-Duque, C. and Kahn, M. C. and Kim, T. and Lavoie, N. S. and others},
  title   = {{Multisensory gamma stimulation promotes glymphatic clearance of amyloid}},
  journal = {Nature},
  year    = {2024},
  doi     = {10.1038/s41586-024-07132-6},
  pmid    = {38418876},
  url     = {https://doi.org/10.1038/s41586-024-07132-6}
}

@article{diazlucena2021-33881612,
  author  = {Diaz-Lucena, Daniela and Kruse, Niels and Thüne, Katrin and Schmitz, Matthias and Villar-Piqué, Anna and da Cunha, Jose Eriton Gomes and Hermann, Peter and López-Pérez, Óscar and others},
  title   = {{TREM2 expression in the brain and biological fluids in prion diseases}},
  journal = {Acta neuropathologica},
  year    = {2021},
  doi     = {10.1007/s00401-021-02296-1},
  pmid    = {33881612},
  url     = {https://doi.org/10.1007/s00401-021-02296-1}
}

@article{shen2026-42489128,
  author  = {Shen, Qi and Chang, Haocai and Li, Junyu and Guo, Haoyun and Shi, Wenbin and Yan, Yihua and Ouyang, Wenwen and Zhang, Zhan and others},
  title   = {{Photobiomodulation of immune crosstalk rescues neuroinflammation in Alzheimer's disease models}},
  journal = {Brain : a journal of neurology},
  year    = {2026},
  doi     = {10.1093/brain/awag247},
  pmid    = {42489128},
  url     = {https://doi.org/10.1093/brain/awag247}
}

@article{belmontrausch2026-42265098,
  author  = {Belmont-Rausch, Dylan M and Ludwig, Mette Q and Bentsen, Marie A and Hansen, Stine N and Secher, Anna and Holst, Dorte and Moreno, Jaime and Das, Vivek and others},
  title   = {{Semaglutide attenuates neuroinflammation in male mice}},
  journal = {Nature communications},
  year    = {2026},
  doi     = {10.1038/s41467-026-74038-4},
  pmid    = {42265098},
  url     = {https://doi.org/10.1038/s41467-026-74038-4}
}

@article{ouyang2026-42150695,
  author  = {Ouyang, Xiaoxue and Chia, Rachel S L and Chai, Yuek Ling and Chong, Joyce R and Sim, Ming Ann and Jo, Dong-Gyu and Arumugam, Thiruma V and Sethi, Gautam and others},
  title   = {{Peripheral biomarkers of neuroinflammation in Alzheimer's disease and vascular dementia}},
  journal = {Biochemical pharmacology},
  year    = {2026},
  doi     = {10.1016/j.bcp.2026.118077},
  pmid    = {42150695},
  url     = {https://doi.org/10.1016/j.bcp.2026.118077}
}

@article{liu2026-41865123,
  author  = {Liu, Ping and Sun, Tingfang and Yang, Jie and Li, Hongrui and Min, Wanwan and Zhou, Xingyu and Xiong, Ruihan and Wu, Jing and others},
  title   = {{Comprehensive single-cell transcriptomic atlas of microglia in Alzheimer's disease mouse models}},
  journal = {Molecular psychiatry},
  year    = {2026},
  doi     = {10.1038/s41380-026-03529-z},
  pmid    = {41865123},
  url     = {https://doi.org/10.1038/s41380-026-03529-z}
}

@article{abdulkhaliq2026-41792456,
  author  = {Abdulkhaliq, Altaf A and Alasiri, Glowi and Kim, Bonglee and Khan, Johra and Ajoolabady, Amir and Yousof, Shimaa Mohammad and Ren, Jun and Tuomilehto, Jaakko and others},
  title   = {{TREM2 in neurodegeneration and diseases}},
  journal = {Molecular psychiatry},
  year    = {2026},
  doi     = {10.1038/s41380-026-03505-7},
  pmid    = {41792456},
  url     = {https://doi.org/10.1038/s41380-026-03505-7}
}

@article{lee2026-41789727,
  author  = {Lee, Jeongmi and Cho, Yongeun and Choi, Bo Youn and Kim, Hark Kyun and Lee, Yeongyeong and Kim, Eunae and Han, Jihoon and Sul, Jae Hoon and others},
  title   = {{HDAC6 regulates BACE1 stability and NLRP3 inflammasome activation in Alzheimer's disease}},
  journal = {Brain : a journal of neurology},
  year    = {2026},
  doi     = {10.1093/brain/awag089},
  pmid    = {41789727},
  url     = {https://doi.org/10.1093/brain/awag089}
}

@article{feiten2026-41580393,
  author  = {Feiten, Astrid F and Dahm, Kilian and Schlepckow, Kai and van Lengerich, Bettina and Suh, Jung H and Reifschneider, Anika and Wefers, Benedikt and Bartos, Laura M and others},
  title   = {{TREM2 expression level is critical for microglial state, metabolic capacity and efficacy of TREM2 agonism}},
  journal = {Nature communications},
  year    = {2026},
  doi     = {10.1038/s41467-026-68706-8},
  pmid    = {41580393},
  url     = {https://doi.org/10.1038/s41467-026-68706-8}
}

@article{gaire2026-41571675,
  author  = {Gaire, Bhakta Prasad and Koronyo, Yosef and Vit, Jean-Philippe and Hutton, Alexandre and Subedi, Lalita and Fuchs, Dieu-Trang and Swerdlow, Natalie and Rentsendorj, Altan and others},
  title   = {{Identification of Chlamydia pneumoniae and NLRP3 inflammasome activation in Alzheimer's disease retina}},
  journal = {Nature communications},
  year    = {2026},
  doi     = {10.1038/s41467-026-68580-4},
  pmid    = {41571675},
  url     = {https://doi.org/10.1038/s41467-026-68580-4}
}

@article{shi2022-36408515,
  author  = {Shi, Xiaolei and Zhong, Xiaomei and Zhou, Huarong and Zhou, Nan and Hu, Yachun and Ning, Yuping and {Alzheimer's Disease Neuroimaging Initiative}},
  title   = {{The association between cerebrospinal ferritin and soluble triggering receptor expressed on myeloid cells 2 along Alzheimer's continuum}},
  journal = {Frontiers in neurology},
  year    = {2022},
  doi     = {10.3389/fneur.2022.961842},
  pmid    = {36408515},
  url     = {https://doi.org/10.3389/fneur.2022.961842}
}

@article{gate2021-34648304,
  author  = {Gate, D. and Tapp, E. and Leventhal, O. and Shahid, M. and Nonninger, T. J. and Yang, A. C. and Strempfl, K. and Unger, M. S. and others},
  title   = {{CD4 + T cells contribute to neurodegeneration in Lewy body dementia}},
  journal = {Science (New York, N.Y.)},
  year    = {2021},
  doi     = {10.1126/science.abf7266},
  pmid    = {34648304},
  url     = {https://doi.org/10.1126/science.abf7266}
}

@article{floresaguilar2020-33206953,
  author  = {Flores-Aguilar, L. and Iulita, M. F. and Kovecses, O. and Torres, M. D. and Levi, S. M. and Zhang, Y. and Askenazi, M. and Wisniewski, T. and others},
  title   = {{Evolution of neuroinflammation across the lifespan of individuals with Down syndrome}},
  journal = {Brain : a journal of neurology},
  year    = {2020},
  doi     = {10.1093/brain/awaa326},
  pmid    = {33206953},
  url     = {https://doi.org/10.1093/brain/awaa326}
}

@article{long2018-29193473,
  author  = {Long, Y. and Liang, J. and Xu, H. and Huang, Q. and Yang, J. and Gao, C. and Qiu, W. and Lin, S. and others},
  title   = {{Autoimmune glial fibrillary acidic protein astrocytopathy in Chinese patients: a retrospective study}},
  journal = {European journal of neurology},
  year    = {2018},
  doi     = {10.1111/ene.13531},
  pmid    = {29193473},
  url     = {https://doi.org/10.1111/ene.13531}
}

@article{yu2001-11220734,
  author  = {Yu, Zhiya and Kryzer, Thomas J. and Griesmann, Guy E. and Kim, Kwang-Kuk and Benarroch, Eduardo Elias and Lennon, Vanda A.},
  title   = {{CRMP-5 neuronal autoantibody: Marker of lung cancer and thymoma-related autoimmunity}},
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  title   = {{Pyroptosis in Alzheimer's disease: cell type-specific activation in microglia, astrocytes and neurons}},
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  year    = {2023},
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  pmid    = {36481964},
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}

@article{drieu2022-36352225,
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  title   = {{Parenchymal border macrophages regulate the flow dynamics of the cerebrospinal fluid}},
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@article{demiguel2021-34880498,
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  title   = {{Exercise plasma boosts memory and dampens brain inflammation via clusterin}},
  journal = {Nature},
  year    = {2021},
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  pmid    = {34880498},
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@article{lopezrodriguez2021-34080771,
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  title   = {{Acute systemic inflammation exacerbates neuroinflammation in Alzheimer's disease: IL-1β drives amplified responses in primed astrocytes and neuronal network dysfunction}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2021},
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  pmid    = {34080771},
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@article{kim2021-33382892,
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  title   = {{Gamma subunit of complement component 8 is a neuroinflammation inhibitor}},
  journal = {Brain : a journal of neurology},
  year    = {2021},
  doi     = {10.1093/brain/awaa425},
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@article{mallach2021-34704019,
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  title   = {{The influence of the R47H triggering receptor expressed on myeloid cells 2 variant on microglial exosome profiles}},
  journal = {Brain communications},
  year    = {2021},
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}

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  title   = {{Single cell RNA sequencing of human microglia uncovers a subset associated with Alzheimer's disease}},
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  year    = {2019},
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  title   = {{Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer's disease model}},
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  year    = {2019},
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  title   = {{A transcriptomic atlas of aged human microglia}},
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@article{liebner2018-29411111,
  author  = {Liebner, S. and Dijkhuizen, R. M. and Reiss, Y. and Plate, K. H. and Agalliu, D. and Constantin, G.},
  title   = {{Functional morphology of the blood-brain barrier in health and disease}},
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  year    = {2018},
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  pmid    = {29411111},
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}

@article{garg2025-41456076,
  author  = {Garg, Anjali and Vo, Sheeny and De Souza, Iara D and Brant, Ayslan Castro and Brase, Logan and Aladyeva, Ekaterina and Albanus, Ricardo D 'o and Nallapu, Aasritha and others},
  title   = {{Exploring cellular heterogeneity: single-cell and spatial transcriptomics of Alzheimer's disease brains and iPSC-derived microglia}},
  journal = {Alzheimer's research \& therapy},
  year    = {2025},
  doi     = {10.1186/s13195-025-01944-y},
  pmid    = {41456076},
  url     = {https://doi.org/10.1186/s13195-025-01944-y}
}

@article{gallo2025-41390810,
  author  = {Gallo, Carmela and Verrillo, Lucia and Manzo, Emiliano and Cauzzi, Emma and La Barbera, Livia and Sabatino, Giuseppina and De Paolis, Maria Luisa and Sciacca, Michele Francesco Maria and others},
  title   = {{Microglial clearance, neuroprotection and cognitive recovery via a novel synthetic sulfolipid in Alzheimer's disease}},
  journal = {Journal of neuroinflammation},
  year    = {2025},
  doi     = {10.1186/s12974-025-03634-w},
  pmid    = {41390810},
  url     = {https://doi.org/10.1186/s12974-025-03634-w}
}

@article{zhang2025-41462694,
  author  = {Zhang, Tiantian and Zhang, Shuangxi and Ma, Jiayang and Atiakshin, Dmitrii and Han, Shujun and Noda, Mami and Hiramatsu, Midori and Liu, Jiankang and others},
  title   = {{Luteolin in Safflower Leaves Suppresses Microglial Inflammation Through FOXO3-Mediated Trem2 Transcription}},
  journal = {Antioxidants (Basel, Switzerland)},
  year    = {2025},
  doi     = {10.3390/antiox14121495},
  pmid    = {41462694},
  url     = {https://doi.org/10.3390/antiox14121495}
}

@article{cho2025-41337883,
  author  = {Cho, Sungwoo and El Gaamouch, Farida and Upadhyay, Saurabh and Nada, Hossam and Kuncewicz, Katarzyna and Gabr, Moustafa T},
  title   = {{As48, a first-in-class dual-function TREM2 modulator: Receptor activation and shedding inhibition}},
  journal = {Biomedicine \& pharmacotherapy = Biomedecine \& pharmacotherapie},
  year    = {2025},
  doi     = {10.1016/j.biopha.2025.118862},
  pmid    = {41337883},
  url     = {https://doi.org/10.1016/j.biopha.2025.118862}
}

@article{ravichandran2025-41206011,
  author  = {Ravichandran, Kishore Aravind and Brosseron, Frederic and McManus, Róisín M and Ising, Christina and Görgen, Simon and Schmidt, Susanne V and Santarelli, Fracesco and Lee, Se Young and others},
  title   = {{Enhancing Tyro3 signaling ameliorates IL-1β production through STAT1 in Alzheimer's disease models}},
  journal = {Journal of leukocyte biology},
  year    = {2025},
  doi     = {10.1093/jleuko/qiaf157},
  pmid    = {41206011},
  url     = {https://doi.org/10.1093/jleuko/qiaf157}
}

@article{tsai2025-41307999,
  author  = {Tsai, Andy P and Henze, Douglas E and Lopez, Eduardo Ramirez and Haberberger, James and Dong, Chuanpeng and Lu, Nannan and Atkins, Micaiah and Costa, Emma K and others},
  title   = {{Spatial and single-cell transcriptomics reveal the reorganization of cerebellar microglia with aging}},
  journal = {Cell reports},
  year    = {2025},
  doi     = {10.1016/j.celrep.2025.116624},
  pmid    = {41307999},
  url     = {https://doi.org/10.1016/j.celrep.2025.116624}
}

@article{peng2025-41261263,
  author  = {Peng, Xiao-Qian and Yang, Zi-Kang and Guo, Hong-Song and Wu, Xiang-Yuan and Ruganzu, John Bosco and Liu, Zhong-Zhong and Wu, Song-Di and Yang, Wei-Na},
  title   = {{TREM2 Alleviates Neuroinflammation and Improves Neurogenesis in ApoE-/- Mice by Regulating M1/M2 Microglial Polarization}},
  journal = {Molecular neurobiology},
  year    = {2025},
  doi     = {10.1007/s12035-025-05449-5},
  pmid    = {41261263},
  url     = {https://doi.org/10.1007/s12035-025-05449-5}
}

@article{hayat2025-41877687,
  author  = {Hayat, Bushra and Alone, Debasmita Pankaj},
  title   = {{Unfolded proteins and aggregates: The role of proteostasis in pseudoexfoliation pathology}},
  journal = {Molecular vision},
  year    = {2025},
  pmid    = {41877687}
}

@article{yassine2025-41224653,
  author  = {Yassine, Hussein N and Hugo, Cristelle and O'Donovan, Bernadette and Stephens, Isaiah O and Johnson, Lance A and Cole, Gregory and Tcw, Julia and Johansson, Jan and others},
  title   = {{APOE-Targeted Therapeutics for Alzheimer's Disease}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2025},
  doi     = {10.1523/jneurosci.1388-25.2025},
  pmid    = {41224653},
  url     = {https://doi.org/10.1523/jneurosci.1388-25.2025}
}

@article{qi2025-41168805,
  author  = {Qi, Xiaoshan and Zhu, Kedong and Ke, Wei and Wang, Junjie and Mao, Shanping and Chen, Guiqin},
  title   = {{Roles of TREM2 in Alzheimer's disease}},
  journal = {Translational neurodegeneration},
  year    = {2025},
  doi     = {10.1186/s40035-025-00515-3},
  pmid    = {41168805},
  url     = {https://doi.org/10.1186/s40035-025-00515-3}
}

@article{sun2025-41173152,
  author  = {Sun, Zhao-Xin and Xie, Fang and Zhao, Yun and Wang, Xue and Sun, Zhao-Wei and Qian, Ling-Jia and Feng, Hong},
  title   = {{Exercise and the blood-brain barrier: Mechanistic insights and therapeutic implications}},
  journal = {Neurobiology of disease},
  year    = {2025},
  doi     = {10.1016/j.nbd.2025.107166},
  pmid    = {41173152},
  url     = {https://doi.org/10.1016/j.nbd.2025.107166}
}

@article{xu2025-41175591,
  author  = {Xu, Ziwei and Huang, Feijun and Wu, Zheming and Xu, Ke and Huang, Liping},
  title   = {{Syringin attenuates Alzheimer's disease-associated neuroinflammation by inhibiting NLRP3 inflammasome activation}},
  journal = {Phytomedicine : international journal of phytotherapy and phytopharmacology},
  year    = {2025},
  doi     = {10.1016/j.phymed.2025.157454},
  pmid    = {41175591},
  url     = {https://doi.org/10.1016/j.phymed.2025.157454}
}

@article{wang2025-41062518,
  author  = {Wang, Xiaoxuan and Tian, Haozhe and Chen, Shifei and Ying, Liangliang and Zheng, Juan and Song, Yaya and Xi, Jin and Zhang, Yuxin and others},
  title   = {{Probenecid relieves LPS-induced neuroinflammation by modulating the NLRP1 inflammasome pathway in BV2 cells}},
  journal = {Scientific reports},
  year    = {2025},
  doi     = {10.1038/s41598-025-19015-5},
  pmid    = {41062518},
  url     = {https://doi.org/10.1038/s41598-025-19015-5}
}

@article{njoku2025-41009633,
  author  = {Njoku, George Chigozie and Kanmogne, Georgette Djuidje},
  title   = {{Microglial Dysfunction and Amyloid-Beta Pathology in Alzheimer's Disease and HIV-Associated Neurocognitive Disorders}},
  journal = {International journal of molecular sciences},
  year    = {2025},
  doi     = {10.3390/ijms26189069},
  pmid    = {41009633},
  url     = {https://doi.org/10.3390/ijms26189069}
}

@article{zubillaga2025-40992081,
  author  = {Zubillaga, Marlene and Abadin, Xenia and Ivars, Elia and Puigròs, Margalida and Trullas, Ramon and Bellini, M José and Arnal, Nathalie and Colell, Anna},
  title   = {{Copper overload worsens the inflammatory response of microglia to amyloid beta (Aβ) by impairing phagocytosis and promoting mitochondrial DNA-mediated NLRP3 inflammasome activation}},
  journal = {Redox biology},
  year    = {2025},
  doi     = {10.1016/j.redox.2025.103872},
  pmid    = {40992081},
  url     = {https://doi.org/10.1016/j.redox.2025.103872}
}

@article{li2025-40940798,
  author  = {Li, Ling and Zheng, Xiaoxiao and Ma, Hongyue and Zhu, Mingxia and Li, Xiuli and Sun, Xiaodan and Feng, Xinhong},
  title   = {{TREM2 in Neurodegenerative Diseases: Mechanisms and Therapeutic Potential}},
  journal = {Cells},
  year    = {2025},
  doi     = {10.3390/cells14171387},
  pmid    = {40940798},
  url     = {https://doi.org/10.3390/cells14171387}
}

@article{wang2025-40847374,
  author  = {Wang, Jie and Ni, Hong and Wang, Yu and Wei, Luyao and Ding, Hanqing and Guo, Zhongzhao and Pan, Hao and Yu, Ying and others},
  title   = {{Cyclooxygenase-1 deletion in 5 × FAD mice protects against microglia-induced neuroinflammation and mitigates cognitive impairment}},
  journal = {Translational neurodegeneration},
  year    = {2025},
  doi     = {10.1186/s40035-025-00501-9},
  pmid    = {40847374},
  url     = {https://doi.org/10.1186/s40035-025-00501-9}
}

@article{kawatani2025-40796891,
  author  = {Kawatani, Keiji and Aikawa, Tomonori and Tabrizi, Zeynab and Pan, Yining and Ren, Yingxue and Wang, Ni and Kurti, Aishe and Nambara, Toshihiko and others},
  title   = {{Cerebrovascular p16INK4A expression induces cerebral small vessel disease-related phenotypes}},
  journal = {Acta neuropathologica communications},
  year    = {2025},
  doi     = {10.1186/s40478-025-02085-x},
  pmid    = {40796891},
  url     = {https://doi.org/10.1186/s40478-025-02085-x}
}

@article{he2025-40803604,
  author  = {He, Zihua and Liu, Shengyi and Shi, Wenyan and Yang, Yi and Wang, Jierui and Wang, Jiaqi and Yin, Jianqiong and Shen, Sisi and others},
  title   = {{Single-cell transcriptome analysis reveals dysregulation of microglial iron homeostasis in temporal lobe epilepsy}},
  journal = {Brain research},
  year    = {2025},
  doi     = {10.1016/j.brainres.2025.149885},
  pmid    = {40803604},
  url     = {https://doi.org/10.1016/j.brainres.2025.149885}
}

@article{arcosencarnacion2025-40537787,
  author  = {Arcos-Encarnación, Bolivar and Cortes-Flores, Eladio and Barón-Mendoza, Isabel and Almazán, Jorge Luis and Valle-García, David and de León-Guerrero, Sol Díaz and Hovan, Ladislav and Meza-Sosa, Karla F and others},
  title   = {{KChIP3 fosters neuroinflammation and synaptic dysfunction in the 5XFAD mouse model of Alzheimer's disease}},
  journal = {Journal of neuroinflammation},
  year    = {2025},
  doi     = {10.1186/s12974-025-03426-2},
  pmid    = {40537787},
  url     = {https://doi.org/10.1186/s12974-025-03426-2}
}

@article{guo2025-40541122,
  author  = {Guo, Minsong and Wang, Zhengqin and Zhou, Xiaogang and Yu, Chonglin and Wu, Jianming and Yu, Lu and Mi, Jianing and Ren, Fang and others},
  title   = {{Ciliatoside A attenuates neuroinflammation in Alzheimer's disease by activating mitophagy and inhibiting NLRP3 inflammasome activation}},
  journal = {Phytomedicine : international journal of phytotherapy and phytopharmacology},
  year    = {2025},
  doi     = {10.1016/j.phymed.2025.156928},
  pmid    = {40541122},
  url     = {https://doi.org/10.1016/j.phymed.2025.156928}
}

@article{han2025-40400619,
  author  = {Han, Jialin and Zhang, Zhi and Zhang, Pengfei and Yu, Qian and Cheng, Qian and Lu, Zhiming and Zong, Shuai},
  title   = {{The roles of microglia and astrocytes in neuroinflammation of Alzheimer's disease}},
  journal = {Frontiers in neuroscience},
  year    = {2025},
  doi     = {10.3389/fnins.2025.1575453},
  pmid    = {40400619},
  url     = {https://doi.org/10.3389/fnins.2025.1575453}
}

@article{butovsky2025-40324382,
  author  = {Butovsky, Oleg and Rosenzweig, Neta},
  title   = {{Alzheimer's disease and age-related macular degeneration: Shared and distinct immune mechanisms}},
  journal = {Immunity},
  year    = {2025},
  doi     = {10.1016/j.immuni.2025.04.013},
  pmid    = {40324382},
  url     = {https://doi.org/10.1016/j.immuni.2025.04.013}
}

@article{olejnik2025-40405515,
  author  = {Olejnik, Beata and Ferens-Sieczkowska, Mirosława},
  title   = {{Lectins and neurodegeneration: A glycobiologist's perspective}},
  journal = {Advances in clinical and experimental medicine : official organ Wroclaw Medical University},
  year    = {2025},
  doi     = {10.17219/acem/204107},
  pmid    = {40405515},
  url     = {https://doi.org/10.17219/acem/204107}
}

@article{chen2025-40305572,
  author  = {Chen, Dadian and Wang, Chen and Chen, Xi and Li, Jiayu and Chen, Shuai and Li, Yanzhong and Ma, Fangling and Li, Tingting and others},
  title   = {{Brain-wide microglia replacement using a nonconditioning strategy ameliorates pathology in mouse models of neurological disorders}},
  journal = {Science translational medicine},
  year    = {2025},
  doi     = {10.1126/scitranslmed.ads6111},
  pmid    = {40305572},
  url     = {https://doi.org/10.1126/scitranslmed.ads6111}
}

@article{besin2025-40951730,
  author  = {Besin, Valentinus and Humardani, Farizky Martriano and Yudiarto, Fenny Lanawati and Ong, Paulus Anam and Putra, Sulistyo Emantoko Dwi and Ningrum, Ratih Asmana},
  title   = {{Amyloid-Related Imaging Abnormality (ARIA) Beyond the APOE-ε4 Allele}},
  journal = {Chronic diseases and translational medicine},
  year    = {2025},
  doi     = {10.1002/cdt3.70006},
  pmid    = {40951730},
  url     = {https://doi.org/10.1002/cdt3.70006}
}

@article{chen2025-40258814,
  author  = {Chen, Junru and Chen, Haibing and Wei, Qinjun and Lu, Yajie and Wang, Tianming and Pang, Xiuhong and Xing, Guangqian and Chen, Zhibin and others},
  title   = {{APOE4 impairs macrophage lipophagy and promotes demyelination of spiral ganglion neurons in mouse cochleae}},
  journal = {Cell death discovery},
  year    = {2025},
  doi     = {10.1038/s41420-025-02454-4},
  pmid    = {40258814},
  url     = {https://doi.org/10.1038/s41420-025-02454-4}
}

@article{li2025-40260242,
  author  = {Li, Zhitao and Gong, Chunrong},
  title   = {{NLRP3 inflammasome in Alzheimer's disease: molecular mechanisms and emerging therapies}},
  journal = {Frontiers in immunology},
  year    = {2025},
  doi     = {10.3389/fimmu.2025.1583886},
  pmid    = {40260242},
  url     = {https://doi.org/10.3389/fimmu.2025.1583886}
}

@article{bassal2025-40164781,
  author  = {Bassal, Rawan and Rivkin-Natan, Maria and Rabinovich, Alon and Michaelson, Daniel Moris and Frenkel, Dan and Pinkas-Kramarski, Ronit},
  title   = {{APOE4 impairs autophagy and Aβ clearance by microglial cells}},
  journal = {Inflammation research : official journal of the European Histamine Research Society ... [et al.]},
  year    = {2025},
  doi     = {10.1007/s00011-025-02016-5},
  pmid    = {40164781},
  url     = {https://doi.org/10.1007/s00011-025-02016-5}
}

@article{chen2025-40122810,
  author  = {Chen, Kai and Li, Fuyao and Zhang, Shuwen and Chen, Yixing and Ikezu, Tadafumi C and Li, Zonghua and Martens, Yuka A and Qiao, Wenhui and others},
  title   = {{Enhancing TREM2 expression activates microglia and modestly mitigates tau pathology and neurodegeneration}},
  journal = {Journal of neuroinflammation},
  year    = {2025},
  doi     = {10.1186/s12974-025-03420-8},
  pmid    = {40122810},
  url     = {https://doi.org/10.1186/s12974-025-03420-8}
}

@article{xu2025-40075143,
  author  = {Xu, Wen and Huang, Yi and Zhou, Rongbin},
  title   = {{NLRP3 inflammasome in neuroinflammation and central nervous system diseases}},
  journal = {Cellular \& molecular immunology},
  year    = {2025},
  doi     = {10.1038/s41423-025-01275-w},
  pmid    = {40075143},
  url     = {https://doi.org/10.1038/s41423-025-01275-w}
}

@article{cai2025-39945772,
  author  = {Cai, Zhangying and Wang, Shoutang and Cao, Siyan and Chen, Yun and Penati, Silvia and Peng, Vincent and Yuede, Carla M and Beatty, Wandy L and others},
  title   = {{Loss of ATG7 in microglia impairs UPR, triggers ferroptosis, and weakens amyloid pathology control}},
  journal = {The Journal of experimental medicine},
  year    = {2025},
  doi     = {10.1084/jem.20230173},
  pmid    = {39945772},
  url     = {https://doi.org/10.1084/jem.20230173}
}

@article{iadecola2025-39813992,
  author  = {Iadecola, Costantino and Anrather, Josef},
  title   = {{The immunology of stroke and dementia}},
  journal = {Immunity},
  year    = {2025},
  doi     = {10.1016/j.immuni.2024.12.008},
  pmid    = {39813992},
  url     = {https://doi.org/10.1016/j.immuni.2024.12.008}
}

@article{kremer2025-39743557,
  author  = {Kremer, Ronja and Williams, Anna and Wardlaw, Joanna},
  title   = {{Endothelial cells as key players in cerebral small vessel disease}},
  journal = {Nature reviews. Neuroscience},
  year    = {2025},
  doi     = {10.1038/s41583-024-00892-0},
  pmid    = {39743557},
  url     = {https://doi.org/10.1038/s41583-024-00892-0}
}

@article{han2024-39641002,
  author  = {Han, Hohyeon and Lee, Sooyeon and Gao, Ge and Yi, Hee-Gyeong and Paek, Sun Ha and Jang, Jinah},
  title   = {{Cerebrovascular-Specific Extracellular Matrix Bioink Promotes Blood-Brain Barrier Properties}},
  journal = {Biomaterials research},
  year    = {2024},
  doi     = {10.34133/bmr.0115},
  pmid    = {39641002},
  url     = {https://doi.org/10.34133/bmr.0115}
}

@article{ning2024-39522311,
  author  = {Ning, Zhenqiu and Zhong, Xiaoqin and Wang, Yu and Hu, Dafeng and Tang, Xialin and Deng, Minzhen},
  title   = {{Cerebral ischemic injury impairs autophagy and exacerbates cognitive impairment in APP/PS1 mice}},
  journal = {International immunopharmacology},
  year    = {2024},
  doi     = {10.1016/j.intimp.2024.113581},
  pmid    = {39522311},
  url     = {https://doi.org/10.1016/j.intimp.2024.113581}
}

@article{preman2024-39528861,
  author  = {Preman, Pranav and Moechars, Daan and Fertan, Emre and Wolfs, Leen and Serneels, Lutgarde and Shah, Disha and Lamote, Jochen and Poovathingal, Suresh and others},
  title   = {{APOE from astrocytes restores Alzheimer's Aβ-pathology and DAM-like responses in APOE deficient microglia}},
  journal = {EMBO molecular medicine},
  year    = {2024},
  doi     = {10.1038/s44321-024-00162-7},
  pmid    = {39528861},
  url     = {https://doi.org/10.1038/s44321-024-00162-7}
}

@article{zhu2024-39475571,
  author  = {Zhu, Biqing and Park, Jae-Min and Coffey, Sarah R and Russo, Anthony and Hsu, I-Uen and Wang, Jiawei and Su, Chang and Chang, Rui and others},
  title   = {{Single-cell transcriptomic and proteomic analysis of Parkinson's disease brains}},
  journal = {Science translational medicine},
  year    = {2024},
  doi     = {10.1126/scitranslmed.abo1997},
  pmid    = {39475571},
  url     = {https://doi.org/10.1126/scitranslmed.abo1997}
}

@article{kempuraj2024-39526043,
  author  = {Kempuraj, Duraisamy and Dourvetakis, Kirk D and Cohen, Jessica and Valladares, Daniel Seth and Joshi, Rhitik Samir and Kothuru, Sai Puneeth and Anderson, Tristin and Chinnappan, Baskaran and others},
  title   = {{Neurovascular unit, neuroinflammation and neurodegeneration markers in brain disorders}},
  journal = {Frontiers in cellular neuroscience},
  year    = {2024},
  doi     = {10.3389/fncel.2024.1491952},
  pmid    = {39526043},
  url     = {https://doi.org/10.3389/fncel.2024.1491952}
}

@article{ding2024-39394110,
  author  = {Ding, Yunfeng and Palecek, Sean P and Shusta, Eric V},
  title   = {{iPSC-derived blood-brain barrier modeling reveals APOE isoform-dependent interactions with amyloid beta}},
  journal = {Fluids and barriers of the CNS},
  year    = {2024},
  doi     = {10.1186/s12987-024-00580-2},
  pmid    = {39394110},
  url     = {https://doi.org/10.1186/s12987-024-00580-2}
}

@article{shojaei2024-39431020,
  author  = {Shojaei, Monireh and Schaefer, Rebecca and Schlepckow, Kai and Kunze, Lea H and Struebing, Felix L and Brunner, Bettina and Willem, Michael and Bartos, Laura M and others},
  title   = {{PET imaging of microglia in Alzheimer's disease using copper-64 labeled TREM2 antibodies}},
  journal = {Theranostics},
  year    = {2024},
  doi     = {10.7150/thno.97149},
  pmid    = {39431020},
  url     = {https://doi.org/10.7150/thno.97149}
}

@article{bosco2025-39353548,
  author  = {Bosco, Dale B and Kremen, Vaclav and Haruwaka, Koichiro and Zhao, Shunyi and Wang, Lingxiao and Ebner, Blake A and Zheng, Jiaying and Xie, Manling and others},
  title   = {{Microglial TREM2 promotes phagocytic clearance of damaged neurons after status epilepticus}},
  journal = {Brain, behavior, and immunity},
  year    = {2025},
  doi     = {10.1016/j.bbi.2024.09.034},
  pmid    = {39353548},
  url     = {https://doi.org/10.1016/j.bbi.2024.09.034}
}

@article{zhang2024-39276310,
  author  = {Zhang, Zhengrong and Lin, Weiwei and Gan, Qini and Lei, Maohua and Gong, Bin and Zhang, Chao and Henrique, Jessica Salles and Han, Jingyan and others},
  title   = {{The influences of ApoE isoforms on endothelial adherens junctions and actin cytoskeleton responding to mCRP}},
  journal = {Angiogenesis},
  year    = {2024},
  doi     = {10.1007/s10456-024-09946-4},
  pmid    = {39276310},
  url     = {https://doi.org/10.1007/s10456-024-09946-4}
}

@article{joshi2024-39215356,
  author  = {Joshi, Radhika and Brezani, Veronika and Mey, Gabrielle M and Guixé-Muntet, Sergi and Ortega-Ribera, Marti and Zhuang, Yuan and Zivny, Adam and Werneburg, Sebastian and others},
  title   = {{IRF3 regulates neuroinflammatory responses and the expression of genes associated with Alzheimer's disease}},
  journal = {Journal of neuroinflammation},
  year    = {2024},
  doi     = {10.1186/s12974-024-03203-7},
  pmid    = {39215356},
  url     = {https://doi.org/10.1186/s12974-024-03203-7}
}

@article{serradas2024-39272998,
  author  = {Serradas, Maria L and Ding, Yingying and Martorell, Paula V and Kulińska, Ida and Castro-Gomez, Sergio},
  title   = {{Therapeutic Targets in Innate Immunity to Tackle Alzheimer's Disease}},
  journal = {Cells},
  year    = {2024},
  doi     = {10.3390/cells13171426},
  pmid    = {39272998},
  url     = {https://doi.org/10.3390/cells13171426}
}

@article{lu2025-39153159,
  author  = {Lu, Mengru and Li, Jiaxin and Huang, Qi and Mao, Daniel and Yang, Grace and Lan, Yating and Zeng, Jingyi and Pan, Mika and others},
  title   = {{Single-Nucleus Landscape of Glial Cells and Neurons in Alzheimer's Disease}},
  journal = {Molecular neurobiology},
  year    = {2025},
  doi     = {10.1007/s12035-024-04428-6},
  pmid    = {39153159},
  url     = {https://doi.org/10.1007/s12035-024-04428-6}
}

@article{lee2024-39201439,
  author  = {Lee, Dong-Hun and Lee, Eun Chae and Park, Sang-Won and Lee, Ji Young and Lee, Man Ryul and Oh, Jae Sang},
  title   = {{Pathogenesis of Cerebral Small Vessel Disease: Role of the Glymphatic System Dysfunction}},
  journal = {International journal of molecular sciences},
  year    = {2024},
  doi     = {10.3390/ijms25168752},
  pmid    = {39201439},
  url     = {https://doi.org/10.3390/ijms25168752}
}

@article{shahidehpour2024-38997773,
  author  = {Shahidehpour, Ryan K and Nelson, Peter T and Bachstetter, Adam D},
  title   = {{A pathologic study of Perivascular pTDP-43 Lin bodies in LATE-NC}},
  journal = {Acta neuropathologica communications},
  year    = {2024},
  doi     = {10.1186/s40478-024-01826-8},
  pmid    = {38997773},
  url     = {https://doi.org/10.1186/s40478-024-01826-8}
}

@article{sun2024-39062547,
  author  = {Sun, Zhongqing and Zhang, Xin and So, Kwok-Fai and Jiang, Wen and Chiu, Kin},
  title   = {{Targeting Microglia in Alzheimer's Disease: Pathogenesis and Potential Therapeutic Strategies}},
  journal = {Biomolecules},
  year    = {2024},
  doi     = {10.3390/biom14070833},
  pmid    = {39062547},
  url     = {https://doi.org/10.3390/biom14070833}
}

@article{firdous2024-38832985,
  author  = {Firdous, Sayed Mohammed and Khan, Sahabaj Ali and Maity, Amritangshu},
  title   = {{Oxidative stress-mediated neuroinflammation in Alzheimer's disease}},
  journal = {Naunyn-Schmiedeberg's archives of pharmacology},
  year    = {2024},
  doi     = {10.1007/s00210-024-03188-3},
  pmid    = {38832985},
  url     = {https://doi.org/10.1007/s00210-024-03188-3}
}

@article{wang2024-38831312,
  author  = {Wang, Xueting and Xie, Yuqi and Fan, Xiaoyang and Wu, Xiaomei and Wang, Dan and Zhu, Li},
  title   = {{Intermittent hypoxia training enhances Aβ endocytosis by plaque associated microglia via VPS35-dependent TREM2 recycling in murine Alzheimer's disease}},
  journal = {Alzheimer's research \& therapy},
  year    = {2024},
  doi     = {10.1186/s13195-024-01489-6},
  pmid    = {38831312},
  url     = {https://doi.org/10.1186/s13195-024-01489-6}
}

@article{lee2024-38741048,
  author  = {Lee, Che Yu and Riffle, Dylan and Xiong, Yifeng and Momtaz, Nadia and Lei, Yutong and Pariser, Joseph M and Sikdar, Diptanshu and Hwang, Ahyeon and others},
  title   = {{Characterizing dysregulations via cell-cell communications in Alzheimer's brains using single-cell transcriptomes}},
  journal = {BMC neuroscience},
  year    = {2024},
  doi     = {10.1186/s12868-024-00867-y},
  pmid    = {38741048},
  url     = {https://doi.org/10.1186/s12868-024-00867-y}
}

@article{vandermeulen2024-38654375,
  author  = {Vandermeulen, Lina and Geric, Ivana and Fumagalli, Laura and Kreir, Mohamed and Lu, Ashley and Nonneman, Annelies and Premereur, Jessie and Wolfs, Leen and others},
  title   = {{Regulation of human microglial gene expression and function via RNAase-H active antisense oligonucleotides in vivo in Alzheimer's disease}},
  journal = {Molecular neurodegeneration},
  year    = {2024},
  doi     = {10.1186/s13024-024-00725-9},
  pmid    = {38654375},
  url     = {https://doi.org/10.1186/s13024-024-00725-9}
}

@article{aldalahmah2024-38626772,
  author  = {Al-Dalahmah, Osama and Lam, Matti and McInvale, Julie J and Qu, Wenhui and Nguyen, Trang and Mun, Jeong-Yeon and Kwon, Sam and Ifediora, Nkechime and others},
  title   = {{Osteopontin drives neuroinflammation and cell loss in MAPT-N279K frontotemporal dementia patient neurons}},
  journal = {Cell stem cell},
  year    = {2024},
  doi     = {10.1016/j.stem.2024.03.013},
  pmid    = {38626772},
  url     = {https://doi.org/10.1016/j.stem.2024.03.013}
}

@article{ramakrishnan2024-38613944,
  author  = {Ramakrishnan, Gautham S and Berry, William L and Pacherille, Angela and Kerr, William G and Chisholm, John D and Pedicone, Chiara and Humphrey, Mary Beth},
  title   = {{SHIP inhibition mediates select TREM2-induced microglial functions}},
  journal = {Molecular immunology},
  year    = {2024},
  doi     = {10.1016/j.molimm.2024.04.002},
  pmid    = {38613944},
  url     = {https://doi.org/10.1016/j.molimm.2024.04.002}
}

@article{qin2024-38577947,
  author  = {Qin, Pei and Sun, Ye and Li, Liya},
  title   = {{Mitochondrial dysfunction in chronic neuroinflammatory diseases (Review)}},
  journal = {International journal of molecular medicine},
  year    = {2024},
  doi     = {10.3892/ijmm.2024.5371},
  pmid    = {38577947},
  url     = {https://doi.org/10.3892/ijmm.2024.5371}
}

@article{verma2024-38507186,
  author  = {Verma, Ambika and Azhar, Gohar and Patyal, Pankaj and Zhang, Wei and Zhang, Xiaomin and Wei, Jeanne Y},
  title   = {{Proteomic analysis of P. gingivalis-Lipopolysaccharide induced neuroinflammation in SH-SY5Y and HMC3 cells}},
  journal = {GeroScience},
  year    = {2024},
  doi     = {10.1007/s11357-024-01117-z},
  pmid    = {38507186},
  url     = {https://doi.org/10.1007/s11357-024-01117-z}
}

@article{wu2024-38417710,
  author  = {Wu, Liu-Yun and Chai, Yuek Ling and Cheah, Irwin K and Chia, Rachel S L and Hilal, Saima and Arumugam, Thiruma V and Chen, Christopher P and Lai, Mitchell K P},
  title   = {{Blood-based biomarkers of cerebral small vessel disease}},
  journal = {Ageing research reviews},
  year    = {2024},
  doi     = {10.1016/j.arr.2024.102247},
  pmid    = {38417710},
  url     = {https://doi.org/10.1016/j.arr.2024.102247}
}

@article{yin2024-38347225,
  author  = {Yin, Tao and Yesiltepe, Metin and D'Adamio, Luciano},
  title   = {{Functional BRI2-TREM2 interactions in microglia: implications for Alzheimer's and related dementias}},
  journal = {EMBO reports},
  year    = {2024},
  doi     = {10.1038/s44319-024-00077-x},
  pmid    = {38347225},
  url     = {https://doi.org/10.1038/s44319-024-00077-x}
}

@article{ghosh2024-38396791,
  author  = {Ghosh, Shamasree and Tamilselvi, Shanmugam and Williams, Chloe and Jayaweera, Sanduni W and Iashchishyn, Igor A and Šulskis, Darius and Gilthorpe, Jonathan D and Olofsson, Anders and others},
  title   = {{ApoE Isoforms Inhibit Amyloid Aggregation of Proinflammatory Protein S100A9}},
  journal = {International journal of molecular sciences},
  year    = {2024},
  doi     = {10.3390/ijms25042114},
  pmid    = {38396791},
  url     = {https://doi.org/10.3390/ijms25042114}
}

@article{zgorzynska2024-38244651,
  author  = {Zgorzynska, Emilia},
  title   = {{TREM2 in Alzheimer's disease: Structure, function, therapeutic prospects, and activation challenges}},
  journal = {Molecular and cellular neurosciences},
  year    = {2024},
  doi     = {10.1016/j.mcn.2024.103917},
  pmid    = {38244651},
  url     = {https://doi.org/10.1016/j.mcn.2024.103917}
}

@article{cadiz2024-38226975,
  author  = {Cadiz, Mika P and Gibson, Katelin A and Todd, Kennedi T and Nascari, David G and Massa, Nashali and Lilley, Meredith T and Olney, Kimberly C and Al-Amin, Md Mamun and others},
  title   = {{Aducanumab anti-amyloid immunotherapy induces sustained microglial and immune alterations}},
  journal = {The Journal of experimental medicine},
  year    = {2024},
  doi     = {10.1084/jem.20231363},
  pmid    = {38226975},
  url     = {https://doi.org/10.1084/jem.20231363}
}

@article{ang2024-38198946,
  author  = {Ang, Phillip S and Zhang, Douglas M and Azizi, Saara-Anne and de Matos, Salvador A Norton and Brorson, James R},
  title   = {{The glymphatic system and cerebral small vessel disease}},
  journal = {Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association},
  year    = {2024},
  doi     = {10.1016/j.jstrokecerebrovasdis.2024.107557},
  pmid    = {38198946},
  url     = {https://doi.org/10.1016/j.jstrokecerebrovasdis.2024.107557}
}

@article{chiang2024-38592304,
  author  = {Chiang, Yi-Kuan and Lin, Yung-Shuan and Chen, Chun-Yu and Lirng, Jiing-Feng and Yang, Yu-Hsiu and Lee, Wei-Ju and Fuh, Jong-Ling},
  title   = {{Different Splice Isoforms of Peripheral Triggering Receptor Expressed on Myeloid Cells 2 mRNA Expressions are Associated With Cognitive Decline in Mild Dementia Due to Alzheimer's Disease and Reflect Central Neuroinflammation}},
  journal = {American journal of Alzheimer's disease and other dementias},
  year    = {2024},
  doi     = {10.1177/15333175241243183},
  pmid    = {38592304},
  url     = {https://doi.org/10.1177/15333175241243183}
}

@article{li2024-38043010,
  author  = {Li, Yunfeng and Chen, Xiongjin and Zhou, Mulan and Feng, Sifan and Peng, Xiaoping and Wang, Yan},
  title   = {{Microglial TLR4/NLRP3 Inflammasome Signaling in Alzheimer's Disease}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2024},
  doi     = {10.3233/jad-230273},
  pmid    = {38043010},
  url     = {https://doi.org/10.3233/jad-230273}
}

@article{banerjee2024-38427250,
  author  = {Banerjee, Sayani and Banerjee, Sugato},
  title   = {{Amyloid Beta-Mediated Neurovascular Toxicity in Alzheimer's Disease}},
  journal = {Methods in molecular biology (Clifton, N.J.)},
  year    = {2024},
  doi     = {10.1007/978-1-0716-3662-6_26},
  pmid    = {38427250},
  url     = {https://doi.org/10.1007/978-1-0716-3662-6_26}
}

@article{anzovino2023-38132159,
  author  = {Anzovino, A. and Canepa, E. and Alves, M. and Lemon, N. L. and Carare, R. O. and Fossati, S.},
  title   = {{Amyloid Beta Oligomers Activate Death Receptors and Mitochondria-Mediated Apoptotic Pathways in Cerebral Vascular Smooth Muscle Cells; Protective Effects of Carbonic Anhydrase Inhibitors}},
  journal = {Cells},
  year    = {2023},
  doi     = {10.3390/cells12242840},
  pmid    = {38132159},
  url     = {https://doi.org/10.3390/cells12242840}
}

@article{vilella2024-37967665,
  author  = {Vilella, Antonietta and Bodria, Martina and Papotti, Bianca and Zanotti, Ilaria and Zimetti, Francesca and Remaggi, Giulia and Elviri, Lisa and Potì, Francesco and others},
  title   = {{PCSK9 ablation attenuates Aβ pathology, neuroinflammation and cognitive dysfunctions in 5XFAD mice}},
  journal = {Brain, behavior, and immunity},
  year    = {2024},
  doi     = {10.1016/j.bbi.2023.11.008},
  pmid    = {37967665},
  url     = {https://doi.org/10.1016/j.bbi.2023.11.008}
}

@article{windham2024-37805344,
  author  = {Windham, Ian A and Cohen, Sarah},
  title   = {{The cell biology of APOE in the brain}},
  journal = {Trends in cell biology},
  year    = {2024},
  doi     = {10.1016/j.tcb.2023.09.004},
  pmid    = {37805344},
  url     = {https://doi.org/10.1016/j.tcb.2023.09.004}
}

@article{jia2024-37905869,
  author  = {Jia, Ruxue and Solé-Guardia, Gemma and Kiliaan, Amanda J},
  title   = {{Blood-brain barrier pathology in cerebral small vessel disease}},
  journal = {Neural regeneration research},
  year    = {2024},
  doi     = {10.4103/1673-5374.385864},
  pmid    = {37905869},
  url     = {https://doi.org/10.4103/1673-5374.385864}
}

@article{gazestani2023-37774681,
  author  = {Gazestani, V. and Kamath, T. and Nadaf, N. M. and Dougalis, A. and Burris, S. J. and Rooney, B. and Junkkari, A. and Vanderburg, C. and others},
  title   = {{Early Alzheimer's disease pathology in human cortex involves transient cell states}},
  journal = {Cell},
  year    = {2023},
  doi     = {10.1016/j.cell.2023.08.005},
  pmid    = {37774681},
  url     = {https://doi.org/10.1016/j.cell.2023.08.005}
}

@article{taylor2023-37649100,
  author  = {Taylor, X. and Clark, I. M. and Fitzgerald, G. J. and Oluoch, H. and Hole, J. T. and DeMattos, R. B. and Wang, Y. and Pan, F.},
  title   = {{Amyloid-β (Aβ) immunotherapy induced microhemorrhages are associated with activated perivascular macrophages and peripheral monocyte recruitment in Alzheimer's disease mice}},
  journal = {Molecular neurodegeneration},
  year    = {2023},
  doi     = {10.1186/s13024-023-00649-w},
  pmid    = {37649100},
  url     = {https://doi.org/10.1186/s13024-023-00649-w}
}

@article{zhang2023-37433768,
  author  = {Zhang, W. and Xiao, D. and Mao, Q. and Xia, H.},
  title   = {{Role of neuroinflammation in neurodegeneration development}},
  journal = {Signal transduction and targeted therapy},
  year    = {2023},
  doi     = {10.1038/s41392-023-01486-5},
  pmid    = {37433768},
  url     = {https://doi.org/10.1038/s41392-023-01486-5}
}

@article{braatz2024-36799439,
  author  = {Braatz, Charlotte and Komes, Max P and Ravichandran, Kishore Aravind and de Fragas, Matheus Garcia and Griep, Angelika and Schwartz, Stephanie and McManus, Róisín M and Heneka, Michael T},
  title   = {{NLRP3-directed antisense oligonucleotides reduce microglial immunoactivities in vitro}},
  journal = {Journal of neurochemistry},
  year    = {2024},
  doi     = {10.1111/jnc.15778},
  pmid    = {36799439},
  url     = {https://doi.org/10.1111/jnc.15778}
}

@article{yang2022-36353359,
  author  = {Yang, J. and Ran, M. and Li, H. and Lin, Y. and Ma, K. and Yang, Y. and Fu, X. and Yang, S.},
  title   = {{New insight into neurological degeneration: Inflammatory cytokines and blood-brain barrier}},
  journal = {Frontiers in molecular neuroscience},
  year    = {2022},
  doi     = {10.3389/fnmol.2022.1013933},
  pmid    = {36353359},
  url     = {https://doi.org/10.3389/fnmol.2022.1013933}
}

@article{haass2022-35862308,
  author  = {Haass, C. and Selkoe, D.},
  title   = {{If amyloid drives Alzheimer disease, why have anti-amyloid therapies not yet slowed cognitive decline?}},
  journal = {PLoS biology},
  year    = {2022},
  doi     = {10.1371/journal.pbio.3001694},
  pmid    = {35862308},
  url     = {https://doi.org/10.1371/journal.pbio.3001694}
}

@article{wendimu2022-35805174,
  author  = {Wendimu, M. Y. and Hooks, S. B.},
  title   = {{Microglia Phenotypes in Aging and Neurodegenerative Diseases}},
  journal = {Cells},
  year    = {2022},
  doi     = {10.3390/cells11132091},
  pmid    = {35805174},
  url     = {https://doi.org/10.3390/cells11132091}
}

@article{kenigsbuch2022-35760863,
  author  = {Kenigsbuch, M. and Bost, P. and Halevi, S. and Chang, Y. and Chen, S. and Ma, Q. and Hajbi, R. and Schwikowski, B. and others},
  title   = {{A shared disease-associated oligodendrocyte signature among multiple CNS pathologies}},
  journal = {Nature neuroscience},
  year    = {2022},
  doi     = {10.1038/s41593-022-01104-7},
  pmid    = {35760863},
  url     = {https://doi.org/10.1038/s41593-022-01104-7}
}

@article{jantti2022-35706029,
  author  = {Jäntti, H. and Sitnikova, V. and Ishchenko, Y. and Shakirzyanova, A. and Giudice, L. and Ugidos, I. F. and Gómez-Budia, M. and Korvenlaita, N. and others},
  title   = {{Microglial amyloid beta clearance is driven by PIEZO1 channels}},
  journal = {Journal of neuroinflammation},
  year    = {2022},
  doi     = {10.1186/s12974-022-02486-y},
  pmid    = {35706029},
  url     = {https://doi.org/10.1186/s12974-022-02486-y}
}

@article{rajesh2022-35741014,
  author  = {Rajesh, Y. and Kanneganti, T. D.},
  title   = {{Innate Immune Cell Death in Neuroinflammation and Alzheimer's Disease}},
  journal = {Cells},
  year    = {2022},
  doi     = {10.3390/cells11121885},
  pmid    = {35741014},
  url     = {https://doi.org/10.3390/cells11121885}
}

@article{zhu2022-35577780,
  author  = {Zhu, X. and Huang, Q. and DiSpirito, A. and Vu, T. and Rong, Q. and Peng, X. and Sheng, H. and Shen, X. and others},
  title   = {{Real-time whole-brain imaging of hemodynamics and oxygenation at micro-vessel resolution with ultrafast wide-field photoacoustic microscopy}},
  journal = {Light, science \& applications},
  year    = {2022},
  doi     = {10.1038/s41377-022-00836-2},
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@article{zhang2023-37926352,
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  title   = {{Role of trigger receptor 2 expressed on myeloid cells in neuroinflammation－neglected multidimensional regulation of microglia}},
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  title   = {{The Pathogenesis in Alzheimer's Disease: TREM2 as a Potential Target}},
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  title   = {{Border-associated macrophages promote cerebral amyloid angiopathy and cognitive impairment through vascular oxidative stress}},
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@article{han2023-37725102,
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  title   = {{Role of NLRP3 inflammasome-mediated neuronal pyroptosis and neuroinflammation in neurodegenerative diseases}},
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  title   = {{Glycogen Synthase Kinase-3β, NLRP3 Inflammasome, and Alzheimer's Disease}},
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@article{mamsa2023-37652164,
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  title   = {{Crosstalk between NLRP3 inflammasome and calpain in Alzheimer's disease}},
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@article{das2023-37591465,
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  title   = {{Alzheimer risk-increasing TREM2 variant causes aberrant cortical synapse density and promotes network hyperexcitability in mouse models}},
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  title   = {{Trem2 Enhances Demyelination in the Csf1r+/- Mouse Model of Leukoencephalopathy}},
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  pmid    = {37626591},
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}

@article{alshamrani2023-37366656,
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  title   = {{Recent Trends in Active and Passive Immunotherapies of Alzheimer's Disease}},
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  year    = {2023},
  doi     = {10.3390/antib12020041},
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}

@article{gao2023-37328043,
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  title   = {{Tetrahydroxy stilbene glycoside ameliorates neuroinflammation for Alzheimer's disease via cGAS-STING}},
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@article{nott2023-37359515,
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  title   = {{Genetic insights into immune mechanisms of Alzheimer's and Parkinson's disease}},
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@article{lyu2023-37130227,
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  title   = {{The triggering receptor expressed on myeloid cells 2-apolipoprotein E signaling pathway in diseases}},
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@article{zhou2023-37268807,
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  title   = {{Complement C3 Enhances LPS-Elicited Neuroinflammation and Neurodegeneration Via the Mac1/NOX2 Pathway}},
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  title   = {{TREM2 Expression and Amyloid-Beta Phagocytosis in Alzheimer's Disease}},
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  title   = {{The involvement of NLRP3 inflammasome in CUMS-induced AD-like pathological changes and related cognitive decline in mice}},
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@article{chernyaeva2023-37155564,
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  title   = {{Reduced binding of apoE4 to complement factor H promotes amyloid-β oligomerization and neuroinflammation}},
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@article{faiq2023-36255004,
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  title   = {{Ocular manifestations of central insulin resistance}},
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@article{fu2023-37190607,
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  title   = {{The TREM2 H157Y Variant Influences Microglial Phagocytosis, Polarization, and Inflammatory Cytokine Release}},
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  year    = {2023},
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  title   = {{Circadian Rhythms and Astrocytes: The Good, the Bad, and the Ugly}},
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@article{xiong2023-36922879,
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  title   = {{Astrocytic APOE4 removal confers cerebrovascular protection despite increased cerebral amyloid angiopathy}},
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  year    = {2023},
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@article{dedios2023-36895045,
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  title   = {{Inflammasome activation under high cholesterol load triggers a protective microglial phenotype while promoting neuronal pyroptosis}},
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@article{ishikawa2023-36883344,
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  title   = {{A brief overview of a mouse model of cerebral hypoperfusion by bilateral carotid artery stenosis}},
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  year    = {2023},
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@article{chen2023-36018184,
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  title   = {{β2-Microglobulin exacerbates neuroinflammation, brain damage, and cognitive impairment after stroke in rats}},
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  year    = {2023},
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  pmid    = {36018184},
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}

@article{andjelkovic2023-36848419,
  author  = {Andjelkovic, Anuska V and Situ, Muyu and Citalan-Madrid, Ali Francisco and Stamatovic, Svetlana M and Xiang, Jianming and Keep, Richard F},
  title   = {{Blood-Brain Barrier Dysfunction in Normal Aging and Neurodegeneration: Mechanisms, Impact, and Treatments}},
  journal = {Stroke},
  year    = {2023},
  doi     = {10.1161/strokeaha.122.040578},
  pmid    = {36848419},
  url     = {https://doi.org/10.1161/strokeaha.122.040578}
}

@article{shu2023-36800288,
  author  = {Shu, Xiaoqiu and Wei, Chen and Tu, Wen-Yo and Zhong, Keke and Qi, Shuyuan and Wang, Ailian and Bai, Lei and Zhang, Shan-Xin and others},
  title   = {{Negative regulation of TREM2-mediated C9orf72 poly-GA clearance by the NLRP3 inflammasome}},
  journal = {Cell reports},
  year    = {2023},
  doi     = {10.1016/j.celrep.2023.112133},
  pmid    = {36800288},
  url     = {https://doi.org/10.1016/j.celrep.2023.112133}
}

@article{bohlson2023-36750318,
  author  = {Bohlson, Suzanne S and Tenner, Andrea J},
  title   = {{Complement in the Brain: Contributions to Neuroprotection, Neuronal Plasticity, and Neuroinflammation}},
  journal = {Annual review of immunology},
  year    = {2023},
  doi     = {10.1146/annurev-immunol-101921-035639},
  pmid    = {36750318},
  url     = {https://doi.org/10.1146/annurev-immunol-101921-035639}
}

@article{fang2023-36769234,
  author  = {Fang, Yao-Ching and Hsieh, Yi-Chen and Hu, Chaur-Jong and Tu, Yong-Kwang},
  title   = {{Endothelial Dysfunction in Neurodegenerative Diseases}},
  journal = {International journal of molecular sciences},
  year    = {2023},
  doi     = {10.3390/ijms24032909},
  pmid    = {36769234},
  url     = {https://doi.org/10.3390/ijms24032909}
}

@article{qiao2023-36721205,
  author  = {Qiao, Wenhui and Chen, Yixing and Zhong, Jun and Madden, Benjamin J and Charlesworth, Cristine M and Martens, Yuka A and Liu, Chia-Chen and Knight, Joshua and others},
  title   = {{Trem2 H157Y increases soluble TREM2 production and reduces amyloid pathology}},
  journal = {Molecular neurodegeneration},
  year    = {2023},
  doi     = {10.1186/s13024-023-00599-3},
  pmid    = {36721205},
  url     = {https://doi.org/10.1186/s13024-023-00599-3}
}

@article{asiedu2023-36641840,
  author  = {Asiedu, Kofi and Krishnan, Arun V and Kwai, Natalie and Poynten, Ann and Markoulli, Maria},
  title   = {{Conjunctival microcirculation in ocular and systemic microvascular disease}},
  journal = {Clinical \& experimental optometry},
  year    = {2023},
  doi     = {10.1080/08164622.2022.2151872},
  pmid    = {36641840},
  url     = {https://doi.org/10.1080/08164622.2022.2151872}
}

@article{chu2023-37525057,
  author  = {Chu, Yung Ning and Akahori, Aika and Takatori, Sho and Tomita, Taisuke},
  title   = {{Pathological Roles of INPP5D in Alzheimer's Disease}},
  journal = {Advances in experimental medicine and biology},
  year    = {2023},
  doi     = {10.1007/978-3-031-31978-5_30},
  pmid    = {37525057},
  url     = {https://doi.org/10.1007/978-3-031-31978-5_30}
}

@article{shibly2022-36672558,
  author  = {Shibly, Abu Zaffar and Sheikh, Abdullah Md and Michikawa, Makoto and Tabassum, Shatera and Azad, Abul Kalam and Zhou, Xiaojing and Zhang, Yuchi and Yano, Shozo and others},
  title   = {{Analysis of Cerebral Small Vessel Changes in AD Model Mice}},
  journal = {Biomedicines},
  year    = {2022},
  doi     = {10.3390/biomedicines11010050},
  pmid    = {36672558},
  url     = {https://doi.org/10.3390/biomedicines11010050}
}

@article{katsumoto2022-36389767,
  author  = {Katsumoto, Atsuko and Kokiko-Cochran, Olga N and Bemiller, Shane M and Xu, Guixiang and Ransohoff, Richard M and Lamb, Bruce T},
  title   = {{Triggering receptor expressed on myeloid cells 2 deficiency exacerbates injury-induced inflammation in a mouse model of tauopathy}},
  journal = {Frontiers in immunology},
  year    = {2022},
  doi     = {10.3389/fimmu.2022.978423},
  pmid    = {36389767},
  url     = {https://doi.org/10.3389/fimmu.2022.978423}
}

@article{yu2023-36318443,
  author  = {Yu, Chao-Ji and Wang, Meng and Li, Rui-Yang and Wei, Tao and Yang, Han-Chen and Yin, Yun-Si and Mi, Ying-Xin and Qin, Qi and others},
  title   = {{TREM2 and Microglia Contribute to the Synaptic Plasticity: from Physiology to Pathology}},
  journal = {Molecular neurobiology},
  year    = {2023},
  doi     = {10.1007/s12035-022-03100-1},
  pmid    = {36318443},
  url     = {https://doi.org/10.1007/s12035-022-03100-1}
}

@article{ayyubova2023-36302379,
  author  = {Ayyubova, Gunel},
  title   = {{Dysfunctional microglia and tau pathology in Alzheimer's disease}},
  journal = {Reviews in the neurosciences},
  year    = {2023},
  doi     = {10.1515/revneuro-2022-0087},
  pmid    = {36302379},
  url     = {https://doi.org/10.1515/revneuro-2022-0087}
}

@article{merighi2022-36361780,
  author  = {Merighi, Stefania and Nigro, Manuela and Travagli, Alessia and Gessi, Stefania},
  title   = {{Microglia and Alzheimer's Disease}},
  journal = {International journal of molecular sciences},
  year    = {2022},
  doi     = {10.3390/ijms232112990},
  pmid    = {36361780},
  url     = {https://doi.org/10.3390/ijms232112990}
}

@article{chen2022-36353622,
  author  = {Chen, Yu and Peng, Fu and Xing, Ziwei and Chen, Junren and Peng, Cheng and Li, Dan},
  title   = {{Beneficial effects of natural flavonoids on neuroinflammation}},
  journal = {Frontiers in immunology},
  year    = {2022},
  doi     = {10.3389/fimmu.2022.1006434},
  pmid    = {36353622},
  url     = {https://doi.org/10.3389/fimmu.2022.1006434}
}

@article{bandow2022-36283335,
  author  = {Bandow, Kenjiro and Smith, Avi and Garlick, Jonathan},
  title   = {{Soluble triggering receptor expressed on myeloid cells 2 (sTREM2) positively regulates lipopolysaccharide-induced expression of CXC chemokine ligand 10 and 11 in mouse macrophages}},
  journal = {Biochemical and biophysical research communications},
  year    = {2022},
  doi     = {10.1016/j.bbrc.2022.10.048},
  pmid    = {36283335},
  url     = {https://doi.org/10.1016/j.bbrc.2022.10.048}
}

@article{lu2022-36262883,
  author  = {Lu, Ranran and Zhang, Lijie and Yang, Xinling},
  title   = {{Interaction between autophagy and the NLRP3 inflammasome in Alzheimer's and Parkinson's disease}},
  journal = {Frontiers in aging neuroscience},
  year    = {2022},
  doi     = {10.3389/fnagi.2022.1018848},
  pmid    = {36262883},
  url     = {https://doi.org/10.3389/fnagi.2022.1018848}
}

@article{kosyreva2022-36138973,
  author  = {Kosyreva, Anna Mikhailovna and Sentyabreva, Alexandra Vladislavovna and Tsvetkov, Ivan Sergeevich and Makarova, Olga Vasilievna},
  title   = {{Alzheimer's Disease and Inflammaging}},
  journal = {Brain sciences},
  year    = {2022},
  doi     = {10.3390/brainsci12091237},
  pmid    = {36138973},
  url     = {https://doi.org/10.3390/brainsci12091237}
}

@article{traub2022-36142218,
  author  = {Traub, Jan and Grondey, Katja and Gassenmaier, Tobias and Schmitt, Dominik and Fette, Georg and Frantz, Stefan and Boivin-Jahns, Valérie and Jahns, Roland and others},
  title   = {{Sustained Increase in Serum Glial Fibrillary Acidic Protein after First ST-Elevation Myocardial Infarction}},
  journal = {International journal of molecular sciences},
  year    = {2022},
  doi     = {10.3390/ijms231810304},
  pmid    = {36142218},
  url     = {https://doi.org/10.3390/ijms231810304}
}

@article{wolf2022-36119485,
  author  = {Wolf, Elysa M and Fingleton, Barbara and Hasty, Alyssa H},
  title   = {{The therapeutic potential of TREM2 in cancer}},
  journal = {Frontiers in oncology},
  year    = {2022},
  doi     = {10.3389/fonc.2022.984193},
  pmid    = {36119485},
  url     = {https://doi.org/10.3389/fonc.2022.984193}
}

@article{gao2022-36034144,
  author  = {Gao, Yue and Li, Di and Lin, Jianwen and Thomas, Aline M and Miao, Jianyu and Chen, Dong and Li, Shen and Chu, Chengyan},
  title   = {{Cerebral small vessel disease: Pathological mechanisms and potential therapeutic targets}},
  journal = {Frontiers in aging neuroscience},
  year    = {2022},
  doi     = {10.3389/fnagi.2022.961661},
  pmid    = {36034144},
  url     = {https://doi.org/10.3389/fnagi.2022.961661}
}

@article{barczuk2022-36012243,
  author  = {Barczuk, Julia and Siwecka, Natalia and Lusa, Weronika and Rozpędek-Kamińska, Wioletta and Kucharska, Ewa and Majsterek, Ireneusz},
  title   = {{Targeting NLRP3-Mediated Neuroinflammation in Alzheimer's Disease Treatment}},
  journal = {International journal of molecular sciences},
  year    = {2022},
  doi     = {10.3390/ijms23168979},
  pmid    = {36012243},
  url     = {https://doi.org/10.3390/ijms23168979}
}

@article{gong2022-36017373,
  author  = {Gong, Ting and Chen, Qi and Mao, Hongchen and Zhang, Yao and Ren, Huan and Xu, Mengmeng and Chen, Hong and Yang, Deqin},
  title   = {{Outer membrane vesicles of Porphyromonas gingivalis trigger NLRP3 inflammasome and induce neuroinflammation, tau phosphorylation, and memory dysfunction in mice}},
  journal = {Frontiers in cellular and infection microbiology},
  year    = {2022},
  doi     = {10.3389/fcimb.2022.925435},
  pmid    = {36017373},
  url     = {https://doi.org/10.3389/fcimb.2022.925435}
}

@article{susjanleite2022-35979366,
  author  = {Sušjan-Leite, Petra and Ramuta, Taja Železnik and Boršić, Elvira and Orehek, Sara and Hafner-Bratkovič, Iva},
  title   = {{Supramolecular organizing centers at the interface of inflammation and neurodegeneration}},
  journal = {Frontiers in immunology},
  year    = {2022},
  doi     = {10.3389/fimmu.2022.940969},
  pmid    = {35979366},
  url     = {https://doi.org/10.3389/fimmu.2022.940969}
}

@article{deng2022-35851991,
  author  = {Deng, Wenjun and Guo, Shuzhen and van Veluw, Susanne J and Yu, Zhanyang and Chan, Su Jing and Takase, Hajime and Arai, Ken and Ning, MingMing and others},
  title   = {{Effects of cerebral amyloid angiopathy on the brain vasculome}},
  journal = {Aging cell},
  year    = {2022},
  doi     = {10.1111/acel.13503},
  pmid    = {35851991},
  url     = {https://doi.org/10.1111/acel.13503}
}

@article{freitag2022-35780157,
  author  = {Freitag, Kiara and Sterczyk, Nele and Wendlinger, Sarah and Obermayer, Benedikt and Schulz, Julia and Farztdinov, Vadim and Mülleder, Michael and Ralser, Markus and others},
  title   = {{Spermidine reduces neuroinflammation and soluble amyloid beta in an Alzheimer's disease mouse model}},
  journal = {Journal of neuroinflammation},
  year    = {2022},
  doi     = {10.1186/s12974-022-02534-7},
  pmid    = {35780157},
  url     = {https://doi.org/10.1186/s12974-022-02534-7}
}

@article{schwarz2022-35752274,
  author  = {Schwarz, Hannah and Bässler, Sarah and Balta, Denise and Socher, Eileen and Zunke, Friederike and Arnold, Philipp},
  title   = {{The role of triggering receptor expressed on myeloid cells 2 in Parkinson's disease and other neurodegenerative disorders}},
  journal = {Behavioural brain research},
  year    = {2022},
  doi     = {10.1016/j.bbr.2022.113977},
  pmid    = {35752274},
  url     = {https://doi.org/10.1016/j.bbr.2022.113977}
}

@article{situ2022-35813502,
  author  = {Situ, Muyu and Citalan-Madrid, Ali Francisco and Stamatovic, Svetlana M and Keep, Richard F and Andjelkovic, Anuska V},
  title   = {{Transcriptomic Profile of Blood-Brain Barrier Remodeling in Cerebral Amyloid Angiopathy}},
  journal = {Frontiers in cellular neuroscience},
  year    = {2022},
  doi     = {10.3389/fncel.2022.931247},
  pmid    = {35813502},
  url     = {https://doi.org/10.3389/fncel.2022.931247}
}

@article{essex2022-35575023,
  author  = {Essex, Alyson L and Huot, Joshua R and Deosthale, Padmini and Wagner, Alison and Figueras, Jorge and Davis, Azaria and Damrath, John and Pin, Fabrizio and others},
  title   = {{Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) R47H Variant Causes Distinct Age- and Sex-Dependent Musculoskeletal Alterations in Mice}},
  journal = {Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year    = {2022},
  doi     = {10.1002/jbmr.4572},
  pmid    = {35575023},
  url     = {https://doi.org/10.1002/jbmr.4572}
}

@article{moccia2022-35526818,
  author  = {Moccia, Francesco and Negri, Sharon and Faris, Pawan and Angelone, Tommaso},
  title   = {{Targeting endothelial ion signalling to rescue cerebral blood flow in cerebral disorders}},
  journal = {Vascular pharmacology},
  year    = {2022},
  doi     = {10.1016/j.vph.2022.106997},
  pmid    = {35526818},
  url     = {https://doi.org/10.1016/j.vph.2022.106997}
}

@article{jung2022-35474599,
  author  = {Jung, Eun Sun and Suh, Kyujin and Han, Jihui and Kim, Heyyoung and Kang, Hyung-Sik and Choi, Won-Seok and Mook-Jung, Inhee},
  title   = {{Amyloid-β activates NLRP3 inflammasomes by affecting microglial immunometabolism through the Syk-AMPK pathway}},
  journal = {Aging cell},
  year    = {2022},
  doi     = {10.1111/acel.13623},
  pmid    = {35474599},
  url     = {https://doi.org/10.1111/acel.13623}
}

@article{vandenbrink2023-35311609,
  author  = {van den Brink, Hilde and Doubal, Fergus N and Duering, Marco},
  title   = {{Advanced MRI in cerebral small vessel disease}},
  journal = {International journal of stroke : official journal of the International Stroke Society},
  year    = {2023},
  doi     = {10.1177/17474930221091879},
  pmid    = {35311609},
  url     = {https://doi.org/10.1177/17474930221091879}
}

@article{zhou2022-35382554,
  author  = {Zhou, Haoyue and Gao, Feng and Yang, Xiaoli and Lin, Tingting and Li, Zhenxing and Wang, Qiong and Yao, Yang and Li, Lei and others},
  title   = {{Endothelial BACE1 Impairs Cerebral Small Vessels via Tight Junctions and eNOS}},
  journal = {Circulation research},
  year    = {2022},
  doi     = {10.1161/circresaha.121.320183},
  pmid    = {35382554},
  url     = {https://doi.org/10.1161/circresaha.121.320183}
}

@article{moretti2022-35408867,
  author  = {Moretti, Rita and Caruso, Paola},
  title   = {{Small Vessel Disease: Ancient Description, Novel Biomarkers}},
  journal = {International journal of molecular sciences},
  year    = {2022},
  doi     = {10.3390/ijms23073508},
  pmid    = {35408867},
  url     = {https://doi.org/10.3390/ijms23073508}
}

@article{davis2022-36324401,
  author  = {Davis, Judianne and Xu, Feng and Zhu, Xiaoyue and Van Nostrand, William E},
  title   = {{rTg-D: A novel transgenic rat model of cerebral amyloid angiopathy Type-2}},
  journal = {Cerebral circulation - cognition and behavior},
  year    = {2022},
  doi     = {10.1016/j.cccb.2022.100133},
  pmid    = {36324401},
  url     = {https://doi.org/10.1016/j.cccb.2022.100133}
}

@article{xin2022-35229660,
  author  = {Xin, Yue-Yang and Wang, Jin-Xu and Xu, Ai-Jun},
  title   = {{Electroacupuncture ameliorates neuroinflammation in animal models}},
  journal = {Acupuncture in medicine : journal of the British Medical Acupuncture Society},
  year    = {2022},
  doi     = {10.1177/09645284221076515},
  pmid    = {35229660},
  url     = {https://doi.org/10.1177/09645284221076515}
}

@article{fetoni2022-35197842,
  author  = {Fetoni, Anna Rita and Pisani, Anna and Rolesi, Rolando and Paciello, Fabiola and Viziano, Andrea and Moleti, Arturo and Sisto, Renata and Troiani, Diana and others},
  title   = {{Early Noise-Induced Hearing Loss Accelerates Presbycusis Altering Aging Processes in the Cochlea}},
  journal = {Frontiers in aging neuroscience},
  year    = {2022},
  doi     = {10.3389/fnagi.2022.803973},
  pmid    = {35197842},
  url     = {https://doi.org/10.3389/fnagi.2022.803973}
}

@article{olufunmilayo2022-35120968,
  author  = {Olufunmilayo, Edward O and Holsinger, R M Damian},
  title   = {{Variant TREM2 Signaling in Alzheimer's Disease}},
  journal = {Journal of molecular biology},
  year    = {2022},
  doi     = {10.1016/j.jmb.2022.167470},
  pmid    = {35120968},
  url     = {https://doi.org/10.1016/j.jmb.2022.167470}
}

@article{jonas2022-35078351,
  author  = {Jonas, Lauren A and Jain, Tanya and Li, Yue-Ming},
  title   = {{Functional insight into LOAD-associated microglial response genes}},
  journal = {Open biology},
  year    = {2022},
  doi     = {10.1098/rsob.210280},
  pmid    = {35078351},
  url     = {https://doi.org/10.1098/rsob.210280}
}

@article{brahadeeswaran2022-35066762,
  author  = {Brahadeeswaran, Subhashini and Sivagurunathan, Narmadhaa and Calivarathan, Latchoumycandane},
  title   = {{Inflammasome Signaling in the Aging Brain and Age-Related Neurodegenerative Diseases}},
  journal = {Molecular neurobiology},
  year    = {2022},
  doi     = {10.1007/s12035-021-02683-5},
  pmid    = {35066762},
  url     = {https://doi.org/10.1007/s12035-021-02683-5}
}

@article{poh2022-35000611,
  author  = {Poh, Luting and Sim, Wei Liang and Jo, Dong-Gyu and Dinh, Quynh Nhu and Drummond, Grant R and Sobey, Christopher G and Chen, Christopher Li-Hsian and Lai, Mitchell K P and others},
  title   = {{The role of inflammasomes in vascular cognitive impairment}},
  journal = {Molecular neurodegeneration},
  year    = {2022},
  doi     = {10.1186/s13024-021-00506-8},
  pmid    = {35000611},
  url     = {https://doi.org/10.1186/s13024-021-00506-8}
}

@article{chappie2022-35059124,
  author  = {Chappie, Thomas A and Abdelmessih, Mario and Ambroise, Claude W and Boehm, Markus and Cai, Mi and Green, Michael and Guilmette, Edward and Steppan, Claire M and others},
  title   = {{Discovery of Small-Molecule CD33 Pre-mRNA Splicing Modulators}},
  journal = {ACS medicinal chemistry letters},
  year    = {2022},
  doi     = {10.1021/acsmedchemlett.1c00396},
  pmid    = {35059124},
  url     = {https://doi.org/10.1021/acsmedchemlett.1c00396}
}

@article{weller2022-36213995,
  author  = {Weller, Andrew E and Ferraro, Thomas N and Doyle, Glenn A and Reiner, Benjamin C and Crist, Richard C and Berrettini, Wade H},
  title   = {{Single Nucleus Transcriptome Data from Alzheimer's Disease Mouse Models Yield New Insight into Pathophysiology}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2022},
  doi     = {10.3233/jad-220391},
  pmid    = {36213995},
  url     = {https://doi.org/10.3233/jad-220391}
}

@article{ravichandran2021-34846519,
  author  = {Ravichandran, Kishore Aravind and Heneka, Michael T},
  title   = {{Inflammasome activation in neurodegenerative diseases}},
  journal = {Essays in biochemistry},
  year    = {2021},
  doi     = {10.1042/ebc20210021},
  pmid    = {34846519},
  url     = {https://doi.org/10.1042/ebc20210021}
}

@article{shah2021-34948444,
  author  = {Shah, Akash and Kishore, Uday and Shastri, Abhishek},
  title   = {{Complement System in Alzheimer's Disease}},
  journal = {International journal of molecular sciences},
  year    = {2021},
  doi     = {10.3390/ijms222413647},
  pmid    = {34948444},
  url     = {https://doi.org/10.3390/ijms222413647}
}

@article{oluwole2022-34993346,
  author  = {Oluwole, Oluwafemi Gabriel and James, Kili and Yalcouye, Abdoulaye and Wonkam, Ambroise},
  title   = {{Hearing loss and brain disorders: A review of multiple pathologies}},
  journal = {Open medicine (Warsaw, Poland)},
  year    = {2022},
  doi     = {10.1515/med-2021-0402},
  pmid    = {34993346},
  url     = {https://doi.org/10.1515/med-2021-0402}
}

@article{koh2021-34884940,
  author  = {Koh, Han Seok and Lee, SangJoon and Lee, Hyo Jin and Min, Jae-Woong and Iwatsubo, Takeshi and Teunissen, Charlotte E and Cho, Hyun-Jeong and Ryu, Jin-Hyeob},
  title   = {{Targeting MicroRNA-485-3p Blocks Alzheimer's Disease Progression}},
  journal = {International journal of molecular sciences},
  year    = {2021},
  doi     = {10.3390/ijms222313136},
  pmid    = {34884940},
  url     = {https://doi.org/10.3390/ijms222313136}
}

@article{wang2021-34881076,
  author  = {Wang, Hai-Ling and Zhang, Chun-Lin and Qiu, Yan-Mei and Chen, An-Qi and Li, Ya-Nan and Hu, Bo},
  title   = {{Dysfunction of the Blood-brain Barrier in Cerebral Microbleeds: from Bedside to Bench}},
  journal = {Aging and disease},
  year    = {2021},
  doi     = {10.14336/ad.2021.0514},
  pmid    = {34881076},
  url     = {https://doi.org/10.14336/ad.2021.0514}
}

@article{catalasolsona2021-34880728,
  author  = {Català-Solsona, Judit and Miñano-Molina, Alfredo J and Rodríguez-Álvarez, José},
  title   = {{Nr4a2 Transcription Factor in Hippocampal Synaptic Plasticity, Memory and Cognitive Dysfunction: A Perspective Review}},
  journal = {Frontiers in molecular neuroscience},
  year    = {2021},
  doi     = {10.3389/fnmol.2021.786226},
  pmid    = {34880728},
  url     = {https://doi.org/10.3389/fnmol.2021.786226}
}

@article{ghosh2021-34656693,
  author  = {Ghosh, Powsali and Singh, Ravi and Ganeshpurkar, Ankit and Pokle, Ankit Vyankatrao and Singh, Ravi Bhushan and Singh, Sushil Kumar and Kumar, Ashok},
  title   = {{Cellular and molecular influencers of neuroinflammation in Alzheimer's disease: Recent concepts \& roles}},
  journal = {Neurochemistry international},
  year    = {2021},
  doi     = {10.1016/j.neuint.2021.105212},
  pmid    = {34656693},
  url     = {https://doi.org/10.1016/j.neuint.2021.105212}
}

@article{kim2021-34638977,
  author  = {Kim, Jieun and Lee, Hyun-Ju and Park, Seon Kyeong and Park, Jin-Hee and Jeong, Ha-Ram and Lee, Soojung and Lee, Heeyong and Seol, Eunyoung and others},
  title   = {{Donepezil Regulates LPS and Aβ-Stimulated Neuroinflammation through MAPK/NLRP3 Inflammasome/STAT3 Signaling}},
  journal = {International journal of molecular sciences},
  year    = {2021},
  doi     = {10.3390/ijms221910637},
  pmid    = {34638977},
  url     = {https://doi.org/10.3390/ijms221910637}
}

@article{okuzono2021-34523252,
  author  = {Okuzono, Yuumi and Sakuma, Hiroyuki and Miyakawa, Shuuichi and Ifuku, Masataka and Lee, Jonghun and Das, Debashree and Banerjee, Antara and Zhao, Yang and others},
  title   = {{Reduced TREM2 activation in microglia of patients with Alzheimer's disease}},
  journal = {FEBS open bio},
  year    = {2021},
  doi     = {10.1002/2211-5463.13300},
  pmid    = {34523252},
  url     = {https://doi.org/10.1002/2211-5463.13300}
}

@article{hou2021-34497121,
  author  = {Hou, Yujun and Wei, Yong and Lautrup, Sofie and Yang, Beimeng and Wang, Yue and Cordonnier, Stephanie and Mattson, Mark P and Croteau, Deborah L and others},
  title   = {{NAD+ supplementation reduces neuroinflammation and cell senescence in a transgenic mouse model of Alzheimer's disease via cGAS-STING}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2021},
  doi     = {10.1073/pnas.2011226118},
  pmid    = {34497121},
  url     = {https://doi.org/10.1073/pnas.2011226118}
}

@article{lecordier2021-34566627,
  author  = {Lecordier, Sarah and Manrique-Castano, Daniel and El Moghrabi, Yara and ElAli, Ayman},
  title   = {{Neurovascular Alterations in Vascular Dementia: Emphasis on Risk Factors}},
  journal = {Frontiers in aging neuroscience},
  year    = {2021},
  doi     = {10.3389/fnagi.2021.727590},
  pmid    = {34566627},
  url     = {https://doi.org/10.3389/fnagi.2021.727590}
}

@article{ramakrishna2021-34475200,
  author  = {Ramakrishna, Sarayu and Jhaveri, Vishwaja and Konings, Sabine C and Nawalpuri, Bharti and Chakraborty, Sumita and Holst, Bjørn and Schmid, Benjamin and Gouras, Gunnar K and others},
  title   = {{APOE4 Affects Basal and NMDAR-Mediated Protein Synthesis in Neurons by Perturbing Calcium Homeostasis}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2021},
  doi     = {10.1523/jneurosci.0435-21.2021},
  pmid    = {34475200},
  url     = {https://doi.org/10.1523/jneurosci.0435-21.2021}
}

@article{qu2023-34470515,
  author  = {Qu, Wenhui and Li, Ling},
  title   = {{Microglial TREM2 at the Intersection of Brain Aging and Alzheimer's Disease}},
  journal = {The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry},
  year    = {2023},
  doi     = {10.1177/10738584211040786},
  pmid    = {34470515},
  url     = {https://doi.org/10.1177/10738584211040786}
}

@article{lee2021-34450034,
  author  = {Lee, Se-In and Jeong, Woojin and Lim, Heejin and Cho, Sukhee and Lee, Hyein and Jang, Yonghee and Cho, Joonho and Bae, Simsung and others},
  title   = {{APOE4-carrying human astrocytes oversupply cholesterol to promote neuronal lipid raft expansion and Aβ generation}},
  journal = {Stem cell reports},
  year    = {2021},
  doi     = {10.1016/j.stemcr.2021.07.017},
  pmid    = {34450034},
  url     = {https://doi.org/10.1016/j.stemcr.2021.07.017}
}

@article{joshi2021-34427354,
  author  = {Joshi, Pranav and Riffel, Florian and Satoh, Kanayo and Enomoto, Masahiro and Qamar, Seema and Scheiblich, Hannah and Villacampa, Nàdia and Kumar, Sathish and others},
  title   = {{Differential interaction with TREM2 modulates microglial uptake of modified Aβ species}},
  journal = {Glia},
  year    = {2021},
  doi     = {10.1002/glia.24077},
  pmid    = {34427354},
  url     = {https://doi.org/10.1002/glia.24077}
}

@article{zhang2021-34430820,
  author  = {Zhang, Liansheng and Qian, Yun and Li, Jie and Zhou, Xuan and Xu, He and Yan, Jie and Xiang, Jialing and Yuan, Xiang and others},
  title   = {{BAD-mediated neuronal apoptosis and neuroinflammation contribute to Alzheimer's disease pathology}},
  journal = {iScience},
  year    = {2021},
  doi     = {10.1016/j.isci.2021.102942},
  pmid    = {34430820},
  url     = {https://doi.org/10.1016/j.isci.2021.102942}
}

@article{rather2021-34381308,
  author  = {Rather, Mashoque Ahmad and Khan, Andleeb and Alshahrani, Saeed and Rashid, Hina and Qadri, Marwa and Rashid, Summya and Alsaffar, Rana M and Kamal, Mohammad Amjad and others},
  title   = {{Inflammation and Alzheimer's Disease: Mechanisms and Therapeutic Implications by Natural Products}},
  journal = {Mediators of inflammation},
  year    = {2021},
  doi     = {10.1155/2021/9982954},
  pmid    = {34381308},
  url     = {https://doi.org/10.1155/2021/9982954}
}

@article{uddin2021-34339860,
  author  = {Uddin, Md Sahab and Yu, Wing Shan and Lim, Lee Wei},
  title   = {{Exploring ER stress response in cellular aging and neuroinflammation in Alzheimer's disease}},
  journal = {Ageing research reviews},
  year    = {2021},
  doi     = {10.1016/j.arr.2021.101417},
  pmid    = {34339860},
  url     = {https://doi.org/10.1016/j.arr.2021.101417}
}

@article{kulkarni2021-34275100,
  author  = {Kulkarni, Bhargavi and Kumar, Dileep and Cruz-Martins, Natália and Sellamuthu, Satheeshkumar},
  title   = {{Role of TREM2 in Alzheimer's Disease: A Long Road Ahead}},
  journal = {Molecular neurobiology},
  year    = {2021},
  doi     = {10.1007/s12035-021-02477-9},
  pmid    = {34275100},
  url     = {https://doi.org/10.1007/s12035-021-02477-9}
}

@article{he2021-34229722,
  author  = {He, Xiao-Fei and Li, Li-Li and Xian, Wen-Biao and Li, Ming-Yue and Zhang, Li-Ying and Xu, Jing-Hui and Pei, Zhong and Zheng, Hai-Qing and others},
  title   = {{Chronic colitis exacerbates NLRP3-dependent neuroinflammation and cognitive impairment in middle-aged brain}},
  journal = {Journal of neuroinflammation},
  year    = {2021},
  doi     = {10.1186/s12974-021-02199-8},
  pmid    = {34229722},
  url     = {https://doi.org/10.1186/s12974-021-02199-8}
}

@article{xu2021-34187889,
  author  = {Xu, Yin and Propson, Nicholas E and Du, Shuqi and Xiong, Wen and Zheng, Hui},
  title   = {{Autophagy deficiency modulates microglial lipid homeostasis and aggravates tau pathology and spreading}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2021},
  doi     = {10.1073/pnas.2023418118},
  pmid    = {34187889},
  url     = {https://doi.org/10.1073/pnas.2023418118}
}

@article{sita2021-34209586,
  author  = {Sita, Giulia and Graziosi, Agnese and Hrelia, Patrizia and Morroni, Fabiana},
  title   = {{NLRP3 and Infections: β-Amyloid in Inflammasome beyond Neurodegeneration}},
  journal = {International journal of molecular sciences},
  year    = {2021},
  doi     = {10.3390/ijms22136984},
  pmid    = {34209586},
  url     = {https://doi.org/10.3390/ijms22136984}
}

@article{mansour2021-34139302,
  author  = {Mansour, Heba M and Fawzy, Hala M and El-Khatib, Aiman S and Khattab, Mahmoud M},
  title   = {{Potential Repositioning of Anti-cancer EGFR Inhibitors in Alzheimer's Disease: Current Perspectives and Challenging Prospects}},
  journal = {Neuroscience},
  year    = {2021},
  doi     = {10.1016/j.neuroscience.2021.06.013},
  pmid    = {34139302},
  url     = {https://doi.org/10.1016/j.neuroscience.2021.06.013}
}

@article{fernandez2021-34177557,
  author  = {Fernández, Dominique and Geisse, Antonia and Bernales, Jose Ignacio and Lira, Alonso and Osorio, Fabiola},
  title   = {{The Unfolded Protein Response in Immune Cells as an Emerging Regulator of Neuroinflammation}},
  journal = {Frontiers in aging neuroscience},
  year    = {2021},
  doi     = {10.3389/fnagi.2021.682633},
  pmid    = {34177557},
  url     = {https://doi.org/10.3389/fnagi.2021.682633}
}

@article{feng2021-34163481,
  author  = {Feng, Xiaojun and Chen, Wenxu and Ni, Xiayun and Little, Peter J and Xu, Suowen and Tang, Liqin and Weng, Jianping},
  title   = {{Metformin, Macrophage Dysfunction and Atherosclerosis}},
  journal = {Frontiers in immunology},
  year    = {2021},
  doi     = {10.3389/fimmu.2021.682853},
  pmid    = {34163481},
  url     = {https://doi.org/10.3389/fimmu.2021.682853}
}

@article{shen2021-34082124,
  author  = {Shen, Yilin and Hu, Haixia and Fan, Cui and Wang, Quan and Zou, Tianyuan and Ye, Bin and Xiang, Mingliang},
  title   = {{Sensorineural hearing loss may lead to dementia-related pathological changes in hippocampal neurons}},
  journal = {Neurobiology of disease},
  year    = {2021},
  doi     = {10.1016/j.nbd.2021.105408},
  pmid    = {34082124},
  url     = {https://doi.org/10.1016/j.nbd.2021.105408}
}

@article{ziliotto2021-34041636,
  author  = {Ziliotto, Nicole and Bernardi, Francesco and Piazza, Fabrizio},
  title   = {{Hemostasis components in cerebral amyloid angiopathy and Alzheimer's disease}},
  journal = {Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology},
  year    = {2021},
  doi     = {10.1007/s10072-021-05327-7},
  pmid    = {34041636},
  url     = {https://doi.org/10.1007/s10072-021-05327-7}
}

@article{tonomura2021-34048844,
  author  = {Tonomura, Shuichi and Gyanwali, Bibek},
  title   = {{Cerebral microbleeds in vascular dementia from clinical aspects to host-microbial interaction}},
  journal = {Neurochemistry international},
  year    = {2021},
  doi     = {10.1016/j.neuint.2021.105073},
  pmid    = {34048844},
  url     = {https://doi.org/10.1016/j.neuint.2021.105073}
}

@article{lee2021-33980160,
  author  = {Lee, Hwa-Youn and Lee, Eun-Hee and Yi, Jawoon and Ji, Kon-Young and Kim, Su-Man and Choi, Ha-Rim and Yee, Su-Min and Kang, Hyung-Sik and others},
  title   = {{TREM2 promotes natural killer cell development in CD3-CD122+NK1.1+ pNK cells}},
  journal = {BMC immunology},
  year    = {2021},
  doi     = {10.1186/s12865-021-00420-0},
  pmid    = {33980160},
  url     = {https://doi.org/10.1186/s12865-021-00420-0}
}

@article{martin2021-33979625,
  author  = {Martin, Laurent and Bouvet, Pauline and Chounlamountri, Naura and Watrin, Chantal and Besançon, Roger and Pinatel, Delphine and Meyronet, David and Honnorat, Jérôme and others},
  title   = {{VEGF counteracts amyloid-β-induced synaptic dysfunction}},
  journal = {Cell reports},
  year    = {2021},
  doi     = {10.1016/j.celrep.2021.109121},
  pmid    = {33979625},
  url     = {https://doi.org/10.1016/j.celrep.2021.109121}
}

@article{shafi2021-33786894,
  author  = {Shafi, Sadat and Singh, Archu and Ibrahim, Abdallah Mohammad and Alhajri, Noora and Izneid, Tareq Abu and Pottoo, Faheem Hyder},
  title   = {{Role of triggering receptor expressed on myeloid cells 2 (TREM2) in neurodegenerative dementias}},
  journal = {The European journal of neuroscience},
  year    = {2021},
  doi     = {10.1111/ejn.15215},
  pmid    = {33786894},
  url     = {https://doi.org/10.1111/ejn.15215}
}

@article{trudler2021-33833060,
  author  = {Trudler, Dorit and Nazor, Kristopher L and Eisele, Yvonne S and Grabauskas, Titas and Dolatabadi, Nima and Parker, James and Sultan, Abdullah and Zhong, Zhenyu and others},
  title   = {{Soluble α-synuclein-antibody complexes activate the NLRP3 inflammasome in hiPSC-derived microglia}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2021},
  doi     = {10.1073/pnas.2025847118},
  pmid    = {33833060},
  url     = {https://doi.org/10.1073/pnas.2025847118}
}

@article{magno2021-33823896,
  author  = {Magno, Lorenza and Bunney, Tom D and Mead, Emma and Svensson, Fredrik and Bictash, Magda N},
  title   = {{TREM2/PLCγ2 signalling in immune cells: function, structural insight, and potential therapeutic modulation}},
  journal = {Molecular neurodegeneration},
  year    = {2021},
  doi     = {10.1186/s13024-021-00436-5},
  pmid    = {33823896},
  url     = {https://doi.org/10.1186/s13024-021-00436-5}
}

@article{cheng2021-33841415,
  author  = {Cheng, Baoying and Li, Xin and Dai, Kai and Duan, Shengshun and Rong, Zhouyi and Chen, Yingmin and Lü, Liangcheng and Liu, Zhaoji and others},
  title   = {{Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) Interacts With Colony-Stimulating Factor 1 Receptor (CSF1R) but Is Not Necessary for CSF1/CSF1R-Mediated Microglial Survival}},
  journal = {Frontiers in immunology},
  year    = {2021},
  doi     = {10.3389/fimmu.2021.633796},
  pmid    = {33841415},
  url     = {https://doi.org/10.3389/fimmu.2021.633796}
}

@article{holbrook2021-33776778,
  author  = {Holbrook, Jonathan A and Jarosz-Griffiths, Heledd H and Caseley, Emily and Lara-Reyna, Samuel and Poulter, James A and Williams-Gray, Caroline H and Peckham, Daniel and McDermott, Michael F},
  title   = {{Neurodegenerative Disease and the NLRP3 Inflammasome}},
  journal = {Frontiers in pharmacology},
  year    = {2021},
  doi     = {10.3389/fphar.2021.643254},
  pmid    = {33776778},
  url     = {https://doi.org/10.3389/fphar.2021.643254}
}

@article{vanderende2021-33896652,
  author  = {van der Ende, Emma L and Morenas-Rodriguez, Estrella and McMillan, Corey and Grossman, Murray and Irwin, David and Sanchez-Valle, Raquel and Graff, Caroline and Vandenberghe, Rik and others},
  title   = {{CSF sTREM2 is elevated in a subset in GRN-related frontotemporal dementia}},
  journal = {Neurobiology of aging},
  year    = {2021},
  doi     = {10.1016/j.neurobiolaging.2021.02.024},
  pmid    = {33896652},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2021.02.024}
}

@article{sotorojas2021-33670754,
  author  = {Soto-Rojas, Luis O and Pacheco-Herrero, Mar and Martínez-Gómez, Paola A and Campa-Córdoba, B Berenice and Apátiga-Pérez, Ricardo and Villegas-Rojas, Marcos M and Harrington, Charles R and de la Cruz, Fidel and others},
  title   = {{The Neurovascular Unit Dysfunction in Alzheimer's Disease}},
  journal = {International journal of molecular sciences},
  year    = {2021},
  doi     = {10.3390/ijms22042022},
  pmid    = {33670754},
  url     = {https://doi.org/10.3390/ijms22042022}
}

@article{lanfranco2021-33556209,
  author  = {Lanfranco, Maria Fe and Sepulveda, Jordy and Kopetsky, Gregory and Rebeck, G William},
  title   = {{Expression and secretion of apoE isoforms in astrocytes and microglia during inflammation}},
  journal = {Glia},
  year    = {2021},
  doi     = {10.1002/glia.23974},
  pmid    = {33556209},
  url     = {https://doi.org/10.1002/glia.23974}
}

@article{xue2021-33557250,
  author  = {Xue, Feng and Du, Heng},
  title   = {{TREM2 Mediates Microglial Anti-Inflammatory Activations in Alzheimer's Disease: Lessons Learned from Transcriptomics}},
  journal = {Cells},
  year    = {2021},
  doi     = {10.3390/cells10020321},
  pmid    = {33557250},
  url     = {https://doi.org/10.3390/cells10020321}
}

@article{lei2021-33641782,
  author  = {Lei, Li-Yan and Wang, Rui-Cheng and Pan, Ya-Lei and Yue, Zheng-Gang and Zhou, Rui and Xie, Pei and Tang, Zhi-Shu},
  title   = {{Mangiferin inhibited neuroinflammation through regulating microglial polarization and suppressing NF-κB, NLRP3 pathway}},
  journal = {Chinese journal of natural medicines},
  year    = {2021},
  doi     = {10.1016/s1875-5364(21)60012-2},
  pmid    = {33641782},
  url     = {https://doi.org/10.1016/s1875-5364(21)60012-2}
}

@article{sandhu2021-33499208,
  author  = {Sandhu, Jagdeep K and Kulka, Marianna},
  title   = {{Decoding Mast Cell-Microglia Communication in Neurodegenerative Diseases}},
  journal = {International journal of molecular sciences},
  year    = {2021},
  doi     = {10.3390/ijms22031093},
  pmid    = {33499208},
  url     = {https://doi.org/10.3390/ijms22031093}
}

@article{zhu2021-34334400,
  author  = {Zhu, Min and Jia, Longfei and Jia, Jianping},
  title   = {{Inhibition of miR-96-5p May Reduce Aβ42/Aβ40 Ratio via Regulating ATP-binding cassette transporter A1}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2021},
  doi     = {10.3233/jad-210411},
  pmid    = {34334400},
  url     = {https://doi.org/10.3233/jad-210411}
}

@article{liang2021-34749609,
  author  = {Liang, Xinyan and Wu, Haijian and Colt, Mark and Guo, Xinying and Pluimer, Brock and Zeng, Jianxiong and Dong, Shupeng and Zhao, Zhen},
  title   = {{Microglia and its Genetics in Alzheimer's Disease}},
  journal = {Current Alzheimer research},
  year    = {2021},
  doi     = {10.2174/1567205018666211105140732},
  pmid    = {34749609},
  url     = {https://doi.org/10.2174/1567205018666211105140732}
}

@article{vanzeller2021-34366341,
  author  = {Van Zeller, Mariana and Dias, Diogo and Sebastião, Ana M and Valente, Cláudia A},
  title   = {{NLRP3 Inflammasome: A Starring Role in Amyloid-β- and Tau-Driven Pathological Events in Alzheimer's Disease}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2021},
  doi     = {10.3233/jad-210268},
  pmid    = {34366341},
  url     = {https://doi.org/10.3233/jad-210268}
}

@article{lee2021-34668411,
  author  = {Lee, SangJoon and Cho, Hyun-Jeong and Ryu, Jin-Hyeob},
  title   = {{Innate Immunity and Cell Death in Alzheimer's Disease}},
  journal = {ASN neuro},
  year    = {2021},
  doi     = {10.1177/17590914211051908},
  pmid    = {34668411},
  url     = {https://doi.org/10.1177/17590914211051908}
}

@article{toscano2021-34530705,
  author  = {Toscano, Eliana C de Brito and Rocha, Natalia P and Lopes, Beatriz N A and Suemoto, Claudia K and Teixeira, Antonio L},
  title   = {{Neuroinflammation in Alzheimer's Disease: Focus on NLRP1 and NLRP3 Inflammasomes}},
  journal = {Current protein \& peptide science},
  year    = {2021},
  doi     = {10.2174/1389203722666210916141436},
  pmid    = {34530705},
  url     = {https://doi.org/10.2174/1389203722666210916141436}
}

@article{golzarisorkheh2021-34569958,
  author  = {Golzari-Sorkheh, Mahdieh and Brown, Carla E and Weaver, Donald F and Reed, Mark A},
  title   = {{The NLRP3 Inflammasome in the Pathogenesis and Treatment of Alzheimer's Disease}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2021},
  doi     = {10.3233/jad-210660},
  pmid    = {34569958},
  url     = {https://doi.org/10.3233/jad-210660}
}

@article{ruchoux2021-34950895,
  author  = {Ruchoux, Marie-Magdeleine and Kalaria, Raj N and Román, Gustavo C},
  title   = {{The pericyte: A critical cell in the pathogenesis of CADASIL}},
  journal = {Cerebral circulation - cognition and behavior},
  year    = {2021},
  doi     = {10.1016/j.cccb.2021.100031},
  pmid    = {34950895},
  url     = {https://doi.org/10.1016/j.cccb.2021.100031}
}

@article{rangon2020-33532701,
  author  = {Rangon, C. M. and Krantic, S. and Moyse, E. and Fougère, B.},
  title   = {{The Vagal Autonomic Pathway of COVID-19 at the Crossroad of Alzheimer's Disease and Aging: A Review of Knowledge}},
  journal = {Journal of Alzheimer's disease reports},
  year    = {2020},
  doi     = {10.3233/adr-200273},
  pmid    = {33532701},
  url     = {https://doi.org/10.3233/adr-200273}
}

@article{delaney2021-33350588,
  author  = {Delaney, Conor and Farrell, Michael and Doherty, Colin P and Brennan, Kiva and O'Keeffe, Eoin and Greene, Chris and Byrne, Kieva and Kelly, Eoin and others},
  title   = {{Attenuated CSF-1R signalling drives cerebrovascular pathology}},
  journal = {EMBO molecular medicine},
  year    = {2021},
  doi     = {10.15252/emmm.202012889},
  pmid    = {33350588},
  url     = {https://doi.org/10.15252/emmm.202012889}
}

@article{ibach2021-33314333,
  author  = {Ibach, Melanie and Mathews, Mona and Linnartz-Gerlach, Bettina and Theil, Sandra and Kumar, Sathish and Feederle, Regina and Brüstle, Oliver and Neumann, Harald and others},
  title   = {{A reporter cell system for the triggering receptor expressed on myeloid cells 2 reveals differential effects of disease-associated variants on receptor signaling and activation by antibodies against the stalk region}},
  journal = {Glia},
  year    = {2021},
  doi     = {10.1002/glia.23953},
  pmid    = {33314333},
  url     = {https://doi.org/10.1002/glia.23953}
}

@article{kwon2020-33239064,
  author  = {Kwon, H. S. and Koh, S. H.},
  title   = {{Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes}},
  journal = {Translational neurodegeneration},
  year    = {2020},
  doi     = {10.1186/s40035-020-00221-2},
  pmid    = {33239064},
  url     = {https://doi.org/10.1186/s40035-020-00221-2}
}

@article{milner2021-33181351,
  author  = {Milner, Mark T and Maddugoda, Madhavi and Götz, Jürgen and Burgener, Sabrina S and Schroder, Kate},
  title   = {{The NLRP3 inflammasome triggers sterile neuroinflammation and Alzheimer's disease}},
  journal = {Current opinion in immunology},
  year    = {2021},
  doi     = {10.1016/j.coi.2020.10.011},
  pmid    = {33181351},
  url     = {https://doi.org/10.1016/j.coi.2020.10.011}
}

@article{elsahar2020-33125461,
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  title   = {{A Therapeutic Strategy for Alzheimer's Disease Focused on Immune-inflammatory Modulation}},
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  year    = {2019},
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  pmid    = {31297134},
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}

@article{takatori2019-30747419,
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  year    = {2019},
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}

@article{gussago2019-30997915,
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@article{larosa2019-31594217,
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  title   = {{Stavudine Reduces NLRP3 Inflammasome Activation and Modulates Amyloid-β Autophagy}},
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  year    = {2019},
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@article{kalaria2019-30888663,
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@article{parodirullan2019-31306129,
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  title   = {{Endothelial Mitochondrial Dysfunction in Cerebral Amyloid Angiopathy and Alzheimer's Disease}},
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  year    = {2019},
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@article{salmina2019-31147877,
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@article{robison2019-30580011,
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  title   = {{Molecular Mechanisms of Synaptotoxicity and Neuroinflammation in Alzheimer's Disease}},
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  title   = {{Inflammasome-derived cytokine IL18 suppresses amyloid-induced seizures in Alzheimer-prone mice}},
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@article{kao2018-30096777,
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  title   = {{miRNA-34c Overexpression Causes Dendritic Loss and Memory Decline}},
  journal = {International journal of molecular sciences},
  year    = {2018},
  doi     = {10.3390/ijms19082323},
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@article{deming2018-29889572,
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  title   = {{Triggering receptor expressed on myeloid cells 2 (TREM2): a potential therapeutic target for Alzheimer disease?}},
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  year    = {2018},
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@article{dansokho2018-29273951,
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  year    = {2018},
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  title   = {{Triggering Receptor Expressed on Myeloid Cells 2 Overexpression Inhibits Proinflammatory Cytokines in Lipopolysaccharide-Stimulated Microglia}},
  journal = {Mediators of inflammation},
  year    = {2017},
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@article{torres2018-28965914,
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  title   = {{Dendritic spine pathology and thrombospondin-1 deficits in Down syndrome}},
  journal = {Free radical biology \& medicine},
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@article{yamazaki2017-28902142,
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  title   = {{Blood-Brain Barrier Dysfunction and the Pathogenesis of Alzheimer's Disease}},
  journal = {International journal of molecular sciences},
  year    = {2017},
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@article{silva2017-28666746,
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  title   = {{MicroRNAs as Important Regulators of Exercise Adaptation}},
  journal = {Progress in cardiovascular diseases},
  year    = {2017},
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@article{singh2017-28299411,
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@article{heneka2017-28019679,
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  year    = {2017},
  doi     = {10.1111/bpa.12483},
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@article{gao2017-28393702,
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  title   = {{TREM2 and the Progression of Alzheimer's Disease}},
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  year    = {2017},
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  year    = {2017},
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@article{pennisi2017-27862176,
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  title   = {{Inflammasomes, hormesis, and antioxidants in neuroinflammation: Role of NRLP3 in Alzheimer disease}},
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@article{herrerogarcia2017-27746143,
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  year    = {2017},
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  title   = {{TREM2 Overexpression has No Improvement on Neuropathology and Cognitive Impairment in Aging APPswe/PS1dE9 Mice}},
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  year    = {2017},
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  title   = {{TLR9 signalling in microglia attenuates seizure-induced aberrant neurogenesis in the adult hippocampus}},
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@article{madore2020-31924476,
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  year    = {2020},
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@article{fotuhi2020-32538857,
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  title   = {{Neurobiology of COVID-19}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2020},
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@article{vanveluw2020-31810839,
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  title   = {{Vasomotion as a Driving Force for Paravascular Clearance in the Awake Mouse Brain}},
  journal = {Neuron},
  year    = {2020},
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@article{geirsdottir2019-31835035,
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  title   = {{Cross-Species Single-Cell Analysis Reveals Divergence of the Primate Microglia Program}},
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  pmid    = {31835035},
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@article{baik2019-31257151,
  author  = {Baik, S. H. and Kang, S. and Lee, W. and Choi, H. and Chung, S. and Kim, J. I. and Mook-Jung, I.},
  title   = {{A Breakdown in Metabolic Reprogramming Causes Microglia Dysfunction in Alzheimer's Disease}},
  journal = {Cell metabolism},
  year    = {2019},
  doi     = {10.1016/j.cmet.2019.06.005},
  pmid    = {31257151},
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@article{subhramanyam2019-31077796,
  author  = {Subhramanyam, C. S. and Wang, C. and Hu, Q. and Dheen, S. T.},
  title   = {{Microglia-mediated neuroinflammation in neurodegenerative diseases}},
  journal = {Seminars in cell \& developmental biology},
  year    = {2019},
  doi     = {10.1016/j.semcdb.2019.05.004},
  pmid    = {31077796},
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@article{martorell2019-30879788,
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  title   = {{Multi-sensory Gamma Stimulation Ameliorates Alzheimer's-Associated Pathology and Improves Cognition}},
  journal = {Cell},
  year    = {2019},
  doi     = {10.1016/j.cell.2019.02.014},
  pmid    = {30879788},
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@article{mcintosh2019-30661261,
  author  = {McIntosh, A. and Mela, V. and Harty, C. and Minogue, A. M. and Costello, D. A. and Kerskens, C. and Lynch, M. A.},
  title   = {{Iron accumulation in microglia triggers a cascade of events that leads to altered metabolism and compromised function in APP/PS1 mice}},
  journal = {Brain pathology (Zurich, Switzerland)},
  year    = {2019},
  doi     = {10.1111/bpa.12704},
  pmid    = {30661261},
  url     = {https://doi.org/10.1111/bpa.12704}
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@article{sweeney2019-30280653,
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  title   = {{Blood-Brain Barrier: From Physiology to Disease and Back}},
  journal = {Physiological reviews},
  year    = {2019},
  doi     = {10.1152/physrev.00050.2017},
  pmid    = {30280653},
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}

@article{chua2019-30488149,
  author  = {Chua, C. E. L. and Tang, B. L.},
  title   = {{miR-34a in Neurophysiology and Neuropathology}},
  journal = {Journal of molecular neuroscience : MN},
  year    = {2019},
  doi     = {10.1007/s12031-018-1231-y},
  pmid    = {30488149},
  url     = {https://doi.org/10.1007/s12031-018-1231-y}
}

@article{thawkar2019-30502599,
  author  = {Thawkar, B. S. and Kaur, G.},
  title   = {{Inhibitors of NF-κB and P2X7/NLRP3/Caspase 1 pathway in microglia: Novel therapeutic opportunities in neuroinflammation induced early-stage Alzheimer's disease}},
  journal = {Journal of neuroimmunology},
  year    = {2019},
  doi     = {10.1016/j.jneuroim.2018.11.010},
  pmid    = {30502599},
  url     = {https://doi.org/10.1016/j.jneuroim.2018.11.010}
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@article{michetti2019-30144068,
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  title   = {{The S100B story: from biomarker to active factor in neural injury}},
  journal = {Journal of neurochemistry},
  year    = {2019},
  doi     = {10.1111/jnc.14574},
  pmid    = {30144068},
  url     = {https://doi.org/10.1111/jnc.14574}
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@article{litvinchuk2018-30415998,
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  title   = {{Complement C3aR Inactivation Attenuates Tau Pathology and Reverses an Immune Network Deregulated in Tauopathy Models and Alzheimer's Disease}},
  journal = {Neuron},
  year    = {2018},
  doi     = {10.1016/j.neuron.2018.10.031},
  pmid    = {30415998},
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}

@article{damesquita2018-30359603,
  author  = {Da Mesquita, S. and Fu, Z. and Kipnis, J.},
  title   = {{The Meningeal Lymphatic System: A New Player in Neurophysiology}},
  journal = {Neuron},
  year    = {2018},
  doi     = {10.1016/j.neuron.2018.09.022},
  pmid    = {30359603},
  url     = {https://doi.org/10.1016/j.neuron.2018.09.022}
}

@article{stephenson2018-29513402,
  author  = {Stephenson, J. and Nutma, E. and van der Valk, P. and Amor, S.},
  title   = {{Inflammation in CNS neurodegenerative diseases}},
  journal = {Immunology},
  year    = {2018},
  doi     = {10.1111/imm.12922},
  pmid    = {29513402},
  url     = {https://doi.org/10.1111/imm.12922}
}

@article{toyama2018-29650692,
  author  = {Toyama, K. and Spin, J. M. and Deng, A. C. and Huang, T. T. and Wei, K. and Wagenhäuser, M. U. and Yoshino, T. and Nguyen, H. and others},
  title   = {{MicroRNA-Mediated Therapy Modulating Blood-Brain Barrier Disruption Improves Vascular Cognitive Impairment}},
  journal = {Arteriosclerosis, thrombosis, and vascular biology},
  year    = {2018},
  doi     = {10.1161/atvbaha.118.310822},
  pmid    = {29650692},
  url     = {https://doi.org/10.1161/atvbaha.118.310822}
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@article{fricker2018-29488822,
  author  = {Fricker, M. and Tolkovsky, A. M. and Borutaite, V. and Coleman, M. and Brown, G. C.},
  title   = {{Neuronal Cell Death}},
  journal = {Physiological reviews},
  year    = {2018},
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  pmid    = {29488822},
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}

@article{rajendran2018-29563239,
  author  = {Rajendran, L. and Paolicelli, R. C.},
  title   = {{Microglia-Mediated Synapse Loss in Alzheimer's Disease}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2018},
  doi     = {10.1523/jneurosci.1136-17.2017},
  pmid    = {29563239},
  url     = {https://doi.org/10.1523/jneurosci.1136-17.2017}
}

@article{mrdjen2018-29426702,
  author  = {Mrdjen, D. and Pavlovic, A. and Hartmann, F. J. and Schreiner, B. and Utz, S. G. and Leung, B. P. and Lelios, I. and Heppner, F. L. and others},
  title   = {{High-Dimensional Single-Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease}},
  journal = {Immunity},
  year    = {2018},
  doi     = {10.1016/j.immuni.2018.01.011},
  pmid    = {29426702},
  url     = {https://doi.org/10.1016/j.immuni.2018.01.011}
}

@article{friedman2018-29346778,
  author  = {Friedman, B. A. and Srinivasan, K. and Ayalon, G. and Meilandt, W. J. and Lin, H. and Huntley, M. A. and Cao, Y. and Lee, S. H. and others},
  title   = {{Diverse Brain Myeloid Expression Profiles Reveal Distinct Microglial Activation States and Aspects of Alzheimer's Disease Not Evident in Mouse Models}},
  journal = {Cell reports},
  year    = {2018},
  doi     = {10.1016/j.celrep.2017.12.066},
  pmid    = {29346778},
  url     = {https://doi.org/10.1016/j.celrep.2017.12.066}
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@article{kisler2017-28515434,
  author  = {Kisler, K. and Nelson, A. R. and Montagne, A. and Zlokovic, B. V.},
  title   = {{Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease}},
  journal = {Nature reviews. Neuroscience},
  year    = {2017},
  doi     = {10.1038/nrn.2017.48},
  pmid    = {28515434},
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}

@article{shi2017-28566429,
  author  = {Shi, Q. and Chowdhury, S. and Ma, R. and Le, K. X. and Hong, S. and Caldarone, B. J. and others},
  title   = {{Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice}},
  journal = {Science translational medicine},
  year    = {2017},
  doi     = {10.1126/scitranslmed.aaf6295},
  pmid    = {28566429},
  url     = {https://doi.org/10.1126/scitranslmed.aaf6295}
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  title   = {{Neurodegeneration severity can be predicted from early microglia alterations monitored in vivo in a mouse model of chronic glaucoma}},
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  title   = {{Inhibition of Neuroinflammation by Synthetic Androstene Derivatives Incorporating Amino Acid Methyl Esters on Activated BV‐2 Microglia}},
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  title   = {{GFAP and vimentin deficiency alters gene expression in astrocytes and microglia in wild‐type mice and changes the transcriptional response of reactive glia in mouse model for A lzheimer's disease}},
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@article{heneka2015-25689443,
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@article{brown2015-602808b8,
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@article{kim2015-25690731,
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@article{carretrebillat2015-79617690,
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  title   = {{Neuroinflammation and Aβ Accumulation Linked To Systemic Inflammation Are Decreased By Genetic PKR Down-Regulation}},
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@article{biesmans2015-5f2cd130,
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  title   = {{Effect of stress and peripheral immune activation on astrocyte activation in transgenic bioluminescent Gfap‐luc mice}},
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@article{carroll2015-a3cc5d37,
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@article{haim2015-fb6262b5,
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@article{mellak2015-3e43caee,
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  title   = {{Angiotensin II Mobilizes Spleen Monocytes to Promote the Development of Abdominal Aortic Aneurysm in Apoe −/− Mice}},
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  title   = {{A Peptide Antagonist of Thrombospondin-1 Promotes Abdominal Aortic Aneurysm Progression in the Angiotensin II–Infused Apolipoprotein-E–Deficient Mouse}},
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@article{cox2015-0d3a0b26,
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  title   = {{DNA sensors are expressed in astrocytes and microglia in vitro and are upregulated during gliosis in neurodegenerative disease}},
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@article{tang2016-25598354,
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@article{levy2015-4d2d615e,
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  title   = {{Apolipoprotein E promotes subretinal mononuclear phagocyte survival and chronic inflammation in age‐related macular degeneration}},
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@article{elhage2015-84bbe974,
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  title   = {{HIV-1 and Morphine Regulation of Autophagy in Microglia: Limited Interactions in the Context of HIV-1 Infection and Opioid Abuse}},
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}

@article{zott2026-90b7bcf3,
  author  = {Zott, B. and Unger, F. and Wolf, C. and Schlepckow, K. and Ulmer, N. and Rossignol, P. and Pousinha, P. and Chen, L. and others},
  title   = {{Soluble TREM2 suppresses neuronal activity}},
  journal = {Research Square},
  year    = {2026},
  doi     = {10.21203/rs.3.rs-11388834/v1},
  url     = {https://doi.org/10.21203/rs.3.rs-11388834/v1}
}

@article{devlin2026-50f6f595,
  author  = {Devlin, M. and Rodstrom, K. and Benkerdagh, C. and Ber, S. and Ramsden, N. and Rowlett, M. and Cordeiro, S. and Hayre, M. and others},
  title   = {{A Binding Site for CVN293 Reveals a Mechanism for Allosteric Control of THIK-1 K2P Channel Gating}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.10.27.761881},
  url     = {https://doi.org/10.64898/2026.10.27.761881}
}

@article{danhash2026-f606cf98,
  author  = {Danhash, E. P. and Verbeck, A. C. and Iyer, A. K. and Karch, C. M.},
  title   = {{Ms4a4a loss preferentially remodels microglia with limited, compartment-specific effects across central and peripheral immune compartments in 5xFAD mice}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.10.26.762005},
  url     = {https://doi.org/10.64898/2026.10.26.762005}
}

@article{wong2026-d98194dd,
  author  = {Wong, K. K.},
  title   = {{CEP-IP with CMRF in SEA-AD Microglia: A Mitochondrial Co-expression Module Linked to Cognition}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.10.22.761284},
  url     = {https://doi.org/10.64898/2026.10.22.761284}
}

@article{quang2026-09848cb6,
  author  = {Quang, D. and Summers, R. and Dooling, B. R. and Esquer, H. and Zhou, Q. and LaBarbera, D. V. and Vergara, M. N. and Chial, H. J. and others},
  title   = {{High-content imaging of live microglia-containing Alzheimer’s disease brain organoids}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.10.26.761970},
  url     = {https://doi.org/10.64898/2026.10.26.761970}
}

@article{venturaantunes2026-4f28fca6,
  author  = {Ventura-Antunes, L. and Janve, V. A. and Womble, N. and Weasler, C. J. and Hai, S. A. and Brula, H. and Mobley, B. C. and Hohman, T. J. and others},
  title   = {{Serpin A3 is Increased in Cerebral Amyloid Angiopathy and ARIA}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.10.19.759840},
  url     = {https://doi.org/10.64898/2026.10.19.759840}
}

@article{miao2026-b8fc93ce,
  author  = {Miao, C. and Wang, Z. and Zhang, X. and Li, Y. and Fu, X. and Zhou, Y. and Tian, J. and Cheng, S. and others},
  title   = {{GPR6 Protects Medial Entorhinal Cortex in 5×FAD Mice from Early Pathology in Alzheimer’s Disease}},
  journal = {Research Square},
  year    = {2026},
  doi     = {10.21203/rs.3.rs-10817939/v1},
  url     = {https://doi.org/10.21203/rs.3.rs-10817939/v1}
}

@article{tu2026-39d431f5,
  author  = {Tu, A. and Liu, S.},
  title   = {{Function-oriented microglial transcriptional scores in Alzheimer’s disease: resolving terminal functions beyond activation states}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.10.14.759278},
  url     = {https://doi.org/10.64898/2026.10.14.759278}
}

@article{riaz2026-1fe6b0f9,
  author  = {Riaz, H. A. and Soman, S. K. and Devlin, J. F. and Kumar, G. and Lee, Y. and Morrow, E. M.},
  title   = {{Longitudinal single-cell transcriptional profiling identifies dynamic neurodegenerative mechanisms in Christianson Syndrome rat}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.10.14.756427},
  url     = {https://doi.org/10.64898/2026.10.14.756427}
}

@article{ghosh2026-549141c1,
  author  = {Ghosh, B. and Wang, S. and Qi, C. and Ghosh, A. and Comerota, M. and Rajpurohit, C. S. and Zeldin, D. C. and Zheng, H.},
  title   = {{Astrocytic sEH–EET signaling regulates microglial lysosomal function and suppresses the STING–Type I interferon pathway in Alzheimer’s disease}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.10.16.759679},
  url     = {https://doi.org/10.64898/2026.10.16.759679}
}

@article{juardar2026-b4b52380,
  author  = {Juardar, P. P. and George, K. and Roy, R. K.},
  title   = {{Protective or Pathogenic? Microglial Responses at the Intersection of Amyloid-β, Tau, and Neuroinflammation in Alzheimer’s Disease}},
  journal = {Preprints.org},
  year    = {2026},
  doi     = {10.20944/preprints202610.1771.v1},
  url     = {https://doi.org/10.20944/preprints202610.1771.v1}
}

@article{da2026-559eb37f,
  author  = {Da, J. and Zhang, R. and Xu, L. and Wu, R. and Zhang, S. and Wang, H. and Baazaoui, N. and Shi, J. and others},
  title   = {{NADPH attenuates tau pathology and disease-associated microglial phenotype in a truncated tau- induced mouse model}},
  journal = {Research Square},
  year    = {2026},
  doi     = {10.21203/rs.3.rs-11151367/v1},
  url     = {https://doi.org/10.21203/rs.3.rs-11151367/v1}
}

@article{cox2026-d503604f,
  author  = {Cox, J. E. and Poljanska, E. and Ray, S. and Forsgren, M. and Ko, S. and Swiergiel, P. and Wright, Z. and Thomas, M. A. and others},
  title   = {{Female microglia show heightened responses to aging and amyloid pathology in mice and humans}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.10.13.758897},
  url     = {https://doi.org/10.64898/2026.10.13.758897}
}

@article{tan2026-437238a8,
  author  = {Tan, Q. and Xie, A. and Chen, J. and Wei, S. and Guo, Y. and Liu, G. and Wang, L. and Liu, X. and others},
  title   = {{Electroacupuncture alleviate cognitive impairment via activation of TREM2-positive microglia in APP/PS1 mice}},
  journal = {Research Square},
  year    = {2026},
  doi     = {10.21203/rs.3.rs-11138446/v1},
  url     = {https://doi.org/10.21203/rs.3.rs-11138446/v1}
}

@article{kumar2026-ed611fa0,
  author  = {Kumar, A. and Zhang, J. and Harvey, J. and Guenter, R. and Chkheidze, R. and Sethu, P. and Beck, A. W. and Ren, B.},
  title   = {{Endothelial CD36 links arteriolar remodeling to metabolic and immune alterations in Alzheimer’s disease}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.10.13.758947},
  url     = {https://doi.org/10.64898/2026.10.13.758947}
}

@article{aggarwal2026-715fc47c,
  author  = {Aggarwal, G. and Banerjee, S. and Bhadra, A. K. and Hwang, J. J. and Malabana, D. A. O. and Nagarajan, N. and Smith, D. M. and Kollarapu, J. and others},
  title   = {{Progranulin deficiency promotes neuroinflammation through cathepsin B-mediated activation of the NLRP3 inflammasome}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.10.11.758389},
  url     = {https://doi.org/10.64898/2026.10.11.758389}
}

@article{merour2026-4bfc6db9,
  author  = {Merour, E. and Ghatage, T. and Corbett, C. and DeBerge, M. and Kunjamma, R. and Steckler, I. and Heidari, M. and Sorond, F. A. and others},
  title   = {{Oligodendrocyte stress response as a driver of vascular dementia}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.10.12.758545},
  url     = {https://doi.org/10.64898/2026.10.12.758545}
}

@article{liu2026-6e29bce4,
  author  = {Liu, X. and Liu, Z. and Lv, Z. and Lei, Y. and Zhou, Z. and Xu, Z. and Duan, J. and Xing, W. and others},
  title   = {{Mechanistic study of PHLDA1 in cognitive dysfunction of Alzheimer’s disease model mice via FoxO1‑mediated neuroinflammation}},
  journal = {Research Square},
  year    = {2026},
  doi     = {10.21203/rs.3.rs-10948741/v1},
  url     = {https://doi.org/10.21203/rs.3.rs-10948741/v1}
}

@article{lee2026-ce9e4ee2,
  author  = {Lee, H. and Peppler, G. B. and Sewell, M. and Münch, A. and Podleśny-Drabiniok, A. and Kim, J. J. and Orrick, J. and Marcora, E. and others},
  title   = {{A rapid, genetically-tractable human iPSC-derived model for studying tissue-resident macrophage biology in Alzheimer’s and other diseases}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.10.08.757653},
  url     = {https://doi.org/10.64898/2026.10.08.757653}
}

@article{leon2026-1faaf0d8,
  author  = {Leon, J. and Yoshinaga, S. and Koya, I. and Palafox, G. and Ando, Y. and Kubo, K. and Moody, J. and Takao, M. and others},
  title   = {{DAP12-deficient microglia adopt a TREM2-independent antigen-presenting state with a glial-to-neuronal cascade in Nasu-Hakola disease}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.10.07.757387},
  url     = {https://doi.org/10.64898/2026.10.07.757387}
}

@article{thakur2026-ca6358d7,
  author  = {Thakur, K. and Péladeau, C. and Hewitt, M. and Baumann, K. and Cai, D. and Woulfe, J. M. and Tomlinson, J. J. and Schlossmacher, M. G. and others},
  title   = {{ASC specks and α-synuclein amplify microglial NLRP3 inflammasome activation and co-localize with Lewy body pathology}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.10.02.756339},
  url     = {https://doi.org/10.64898/2026.10.02.756339}
}

@article{zhu2026-08a4bdbf,
  author  = {Zhu, Y. and Yang, D. and Chen, J. and Wang, Q. and Xiong, W. and Wang, J. and Chen, H. and Verkhratsky, A. and others},
  title   = {{Disease stage-sensitive MFSD2A-caveolae axis insigates hippocampal blood–brain barrier disruption in Alzheimer’s disease}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.09.30.755839},
  url     = {https://doi.org/10.64898/2026.09.30.755839}
}

@article{zhang2026-7247d7cc,
  author  = {Zhang, A. and Shen, W. and Yan, S. and Chen, J. and Liu, X. and Zou, J. and Li, S. and Hu, S. and others},
  title   = {{Cross-Tissue Inflammatory Convergence Supports a Putative Muscle–Brain Axis in Alzheimer’s Disease}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.10.07.751107},
  url     = {https://doi.org/10.64898/2026.10.07.751107}
}

@article{kim2026-376fe0f8,
  author  = {Kim, N. and Jeong, D. S. and Lee, Y. and Oh, C.},
  title   = {{Human multiscale transcriptomics identifies the NLRP3 inflammasome as a convergent druggable target in Alzheimer’s disease: validation with dimethyl itaconate in 5xFAD mice}},
  journal = {Research Square},
  year    = {2026},
  doi     = {10.21203/rs.3.rs-11103693/v1},
  url     = {https://doi.org/10.21203/rs.3.rs-11103693/v1}
}

@article{huang2026-f63e9b8e,
  author  = {Huang, E. and Lu, R. and Choi, J. and Jahan, N. and Imhof, I. and Collo, S. and Eguiguren, S. and Zhang, J. and others},
  title   = {{TLR7-mediated autoimmunity targets Robo3 to drive astrogliosis in frontotemporal dementia}},
  journal = {Research Square},
  year    = {2026},
  doi     = {10.21203/rs.3.rs-11236688/v1},
  url     = {https://doi.org/10.21203/rs.3.rs-11236688/v1}
}

@article{anand2026-d39ea5ab,
  author  = {Anand, A. and Natarajan, E.},
  title   = {{Cross-Dataset Reanalysis of Mouse Alzheimer Disease Single-Cell RNA-Sequencing Data Reveals a Reproducible Innate Immune Activation Signature}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.09.30.755581},
  url     = {https://doi.org/10.64898/2026.09.30.755581}
}

@article{choi2026-a92521b4,
  author  = {Choi, M. and Kim, K. and Kim, I. and Jung, M. K. and Kim, D.},
  title   = {{Brain-wide Cerebrospinal Fluid Recirculation Collapse in Alzheimer’s Disease}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.10.01.755971},
  url     = {https://doi.org/10.64898/2026.10.01.755971}
}

@article{saadi2026-e9af705a,
  author  = {Saadi, F. and Cho, Y. and Katritch, IV. and Lugo, B. and Wu, Y. and Smyth, L. C. and Bosch, M. and Telfer, K. A. and others},
  title   = {{APOE4 reduction in vascular-associated fibroblasts decreases cerebral amyloid angiopathy and associated vascular dysfunction}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.10.02.756327},
  url     = {https://doi.org/10.64898/2026.10.02.756327}
}

@article{onken2026-b6aeedca,
  author  = {Onken, M. D. and Cooper, J. A.},
  title   = {{The Alzheimer’s Disease-associated gene CD2AP regulates permeability of endothelial cells and transendothelial migration of immune cells}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.10.01.755982},
  url     = {https://doi.org/10.64898/2026.10.01.755982}
}

@article{li2026-66649645,
  author  = {Li, H. and Cheng, Y. and Lin, X. and Feng, Y. and Du, B. and Dou, B. and Sheng, Z. and Xu, F. and others},
  title   = {{PDE2A Modulation Attenuates Aβ-Induced Neuronal Injury and Associated Oxidative, Inflammatory, and Apoptotic Responses}},
  journal = {Research Square},
  year    = {2026},
  doi     = {10.21203/rs.3.rs-10975363/v1},
  url     = {https://doi.org/10.21203/rs.3.rs-10975363/v1}
}

@article{vanschaik2026-b4bfc569,
  author  = {van Schaik, M. and Lai, K. O. and Shapiro, N. L. and Jäck, A. and Goddard, J. and Crook, H. and Frohn, R. and Jones, P. S. and others},
  title   = {{Plasma immune signatures associate with neurodegeneration in frontotemporal lobar degeneration}},
  journal = {medRxiv},
  year    = {2026},
  doi     = {10.64898/2026.09.28.26364155},
  url     = {https://doi.org/10.64898/2026.09.28.26364155}
}

@article{nortley2026-211812a0,
  author  = {Nortley, R. and Anderle, S. and Sideris-Lampretsas, G. and Davis, H. and Sethi, H. and Alasaadi, D. N. and Acton, S. and Attwell, D.},
  title   = {{Neurodegeneration-inducing macromolecules exit the brain via nanovascular conduits formed by reticular fibroblasts}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.09.21.752863},
  url     = {https://doi.org/10.64898/2026.09.21.752863}
}

@article{sharma2026-c554220d,
  author  = {Sharma, A. and Aylar, D. and Lapin, D. and Marambaud, P. and Wang, P.},
  title   = {{Extracellular CIRP induces neurotoxic astrocytes via TREM-1 in Alzheimer’s disease}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.09.18.752724},
  url     = {https://doi.org/10.64898/2026.09.18.752724}
}

@article{bhatt2026-94d50e55,
  author  = {Bhatt, N. N. and Tabrizi, Z. and Janulis, J. and Chakraborty, S. and Weick, M. and Franciosa, S. A. and Rodriguez Moore, G. and Agatemor, C. and others},
  title   = {{Reducing Neutrophil Sialic Acid Residues Alleviates Cerebral Hypoperfusion in Alzheimer’s Models}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.09.23.753660},
  url     = {https://doi.org/10.64898/2026.09.23.753660}
}

@article{lin2026-703e2eb0,
  author  = {Lin, D. and Atkinson, JR. and Wu, W. and Chen, M. and Jayasekara, S. and Segal, B. M. and Ma, A. and Gao, J.},
  title   = {{A self-limiting, TREM2-dependent anabolic program confers microglial resilience in Alzheimer’s disease}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.09.16.752098},
  url     = {https://doi.org/10.64898/2026.09.16.752098}
}

@article{voloviceva2026-7b70684b,
  author  = {Voloviceva, E. and Goetze, S. and Hausler, S. and Abukar, S. H. and Jagels, A. and Othman, A. and von Eckardstein, A. and Robert, J.},
  title   = {{The protein and lipid compositions of brain apolipoprotein E particles are cell type-specific}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.09.07.749850},
  url     = {https://doi.org/10.64898/2026.09.07.749850}
}

@article{antonbarros2026-0ceb195a,
  author  = {Antón-Barros, C. and Villarejo-Zori, B. and Carmona-Lorenzo, S. and Barbero-Paredes, J. M. and González-Díaz, D. and Uceda, M. and Fernàndez-Bernal, A. and Portero-Otín, M. and others},
  title   = {{A sphingomyelin-cholesterol complex regulates TLR4 activation in microglia}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.09.10.750647},
  url     = {https://doi.org/10.64898/2026.09.10.750647}
}

@article{gergian2026-bd7ce9bb,
  author  = {Gergian, C. and Urbanaviciute, P. and Wells, P. M. and Transfeld, J. L. and Askarova, A. and Yaa, R. M. and Wu, Y. and Ziegler, K. C. and others},
  title   = {{Cell type-specific histone acetylation landscape in Alzheimer’s disease reveals a putative role of MITF in microglia}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.09.09.750356},
  url     = {https://doi.org/10.64898/2026.09.09.750356}
}

@article{gray2026-95944ba3,
  author  = {Gray, C. and Hu, K. and Tse, D. H. and Dieterle, K. and Simpson, S. and Ruhl, T. and Duff, K. and Kim, D. and others},
  title   = {{High frame rate in vivo two-photon microscopy to quantify murine cerebrospinal fluid flow heterogeneity}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.09.04.749497},
  url     = {https://doi.org/10.64898/2026.09.04.749497}
}

@article{algamal2026-005bc584,
  author  = {Algamal, M. and Yokomizo, S. and Ndambakuwa, W. and Abdallah, S. and Sanchez-Mico, M. V. and Gillani, R. and da Silva, P. and Rajput, A. and others},
  title   = {{Brain-resident myeloid cells promote rapid leukocyte adhesion in leptomeningeal vessels after anti-Aβ immunotherapy}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.09.07.749938},
  url     = {https://doi.org/10.64898/2026.09.07.749938}
}

@article{xu2026-ac98f5b7,
  author  = {Xu, Z. and Chen, J. and Yu, J. and Duan, J. and Xie, Y. and Gong, Y. and Wang, P. and Lei, X. and others},
  title   = {{Transthyretin Contributes to Hippocampal Blood-Brain Barrier Recovery Following Intestinal Inflammation, with Reduced Expression in Alzheimer’s Disease}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.09.01.748473},
  url     = {https://doi.org/10.64898/2026.09.01.748473}
}

@article{chiarella2026-eb5bfb2c,
  author  = {Chiarella, L. S. and Acar, L. and Dahmann, S. and Jin, L. and Otto, T. and Marschall, U. and Nzomo, M. M. and Hirsch, T. and others},
  title   = {{Reduced Dementia Incidence Following Neck Dissection: A Population-based Matched Cohort Study}},
  journal = {Research Square},
  year    = {2026},
  doi     = {10.21203/rs.3.rs-10718409/v1},
  url     = {https://doi.org/10.21203/rs.3.rs-10718409/v1}
}

@article{lin2026-160e62d4,
  author  = {Lin, S. and Li, M. and Wang, S. and Li, E. and Sun, H. and Li, L.},
  title   = {{Public-Data Reanalysis Links MS4A4A to M2-like Human Myeloid States and Supports a Predicted Four-Pass Transmembrane Fold}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.08.19.745820},
  url     = {https://doi.org/10.64898/2026.08.19.745820}
}

@article{unaran2026-73b99cce,
  author  = {Unaran, E. and Adebiyi, O. and Krishnan, M. R. and Bussey, T. J. and Saksida, L. M. and Prado, M. A. and Prado, V. F. and Menon, R. S.},
  title   = {{Myelin maturation failure and oligodendrocyte precursor loss underlie default mode network disruption in a humanized APP knock-in model of Alzheimer’s disease}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.08.12.744193},
  url     = {https://doi.org/10.64898/2026.08.12.744193}
}

@article{an2026-91a40936,
  author  = {An, X. and Chen, Y.},
  title   = {{Rhabdomyolysis Secondary to Reactivated Herpes Simplex Virus Type 1 Coinfected with Klebsiella pneumoniae in an Elderly Patient: A Case Report}},
  journal = {Research Square},
  year    = {2026},
  doi     = {10.21203/rs.3.rs-10288569/v1},
  url     = {https://doi.org/10.21203/rs.3.rs-10288569/v1}
}

@article{kuhnau2026-4fd9d702,
  author  = {Kuhnau, L. and Jimenez, G. A. and Hack, W. and Varada, S. and Gladen-Kolarsky, N. and Kim, S. and Klein, F. and Banerji, T. and others},
  title   = {{The TREM2 targeting small molecule Sob-AM2 improves cognition independent of Aβ plaque alteration in 5xFAD mice}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.07.31.741838},
  url     = {https://doi.org/10.64898/2026.07.31.741838}
}

@article{rodriguez2026-ef1dd141,
  author  = {Rodríguez, E. M. and Zaragoza-Ballester, P. and Alcolea, D. and Esteller-Gauxax, D. and Nuscher, B. and Chacón, S. and Á, Fernández-León and Í, Rodríguez-Baz and others},
  title   = {{APOEε4 attenuates early TREM2-mediated microglial responses and influences disease trajectories in dementia with Lewy bodies}},
  journal = {Research Square},
  year    = {2026},
  doi     = {10.21203/rs.3.rs-10429506/v1},
  url     = {https://doi.org/10.21203/rs.3.rs-10429506/v1}
}

@article{carriquiriborde2026-c605517a,
  author  = {Carriquiriborde, V. and Yue, J. and Cheng, W. H. and Yildirim, T. and Fan, J. and Tok, S. and Kelly, M. and Wellington, C. L. and others},
  title   = {{Repeated mild traumatic brain injury does not affect sleep or epileptiform activity one-month post-injury in a knock-in mouse model of Alzheimer’s disease}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.07.24.740449},
  url     = {https://doi.org/10.64898/2026.07.24.740449}
}

@article{krunic2026-ec5a997c,
  author  = {Krunic, A. and Umesh Ganesh, N. and Coskun, U. and Brennan, W. and Patel, C. and Joshi, O. and Lee, J. and Gu, T. S. and others},
  title   = {{MicroRNA-223 Enhances Microglia-Dependent Clearance of Amyloid Beta Plaques and Ameliorates Behavioral Deficits in a Mouse Model of Alzheimer’s Disease}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.07.20.738977},
  url     = {https://doi.org/10.64898/2026.07.20.738977}
}

@article{srikanth2026-e12d5e2b,
  author  = {Srikanth, M. and Jiang, S. and Wellman, S. M. and Sarkar, S. and Lorman, D. E. and Lantin, T. and Runyan, A. M. and Kumar, M. and others},
  title   = {{Immunoproteasome Deficiency Impairs Microglial Clearance and Worsens Tau and Amyloid Pathology}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.07.14.738427},
  url     = {https://doi.org/10.64898/2026.07.14.738427}
}

@article{chen2026-b03c3c29,
  author  = {Chen, X. and Munoz-Mayorga, D. and Lyu, X. and Jati, S. and Zhang, J. and Rossitto, L. and Tao, Y. and Zhao, S. and others},
  title   = {{A non-canonical androgen signaling pathway drives microglial activation and tau pathology in females}},
  journal = {Research Square},
  year    = {2026},
  doi     = {10.21203/rs.3.rs-10286730/v1},
  url     = {https://doi.org/10.21203/rs.3.rs-10286730/v1}
}

@article{c2026-e330dfe2,
  author  = {Ç, Özkurt},
  title   = {{Single-cell gene networks nominate IKZF1 as an Alzheimer’s microglial regulator}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.07.14.738463},
  url     = {https://doi.org/10.64898/2026.07.14.738463}
}

@article{qiao2026-7155c963,
  author  = {Qiao, M. and Bhattarai, P. and Yilmaz, E. and Rookyard, A. W. and Das, L. and Jain, A. and Reyes-Dumeyer, D. and Lee, A. J. and others},
  title   = {{Biomarker-informed CSF proteomics reveals ENPP2–LPA lipid signaling associated with Alzheimer’s disease}},
  journal = {medRxiv},
  year    = {2026},
  doi     = {10.64898/2026.07.08.26357565},
  url     = {https://doi.org/10.64898/2026.07.08.26357565}
}

@article{balistreri2026-20d3f448,
  author  = {Balistreri, A. and Gomulinski, M. and Chapman, M. R. and Kelly, J. W.},
  title   = {{The Microglial Protein sTREM2 Inhibits the Bacterial Functional Amyloid CsgA and Suppresses Amyloid-Dependent Biofilm Formation}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.07.03.736422},
  url     = {https://doi.org/10.64898/2026.07.03.736422}
}

@article{fuchs2026-87ec3a14,
  author  = {Fuchs, U. and Schröder, S. and Pena, T. and Krüger, D. M. and Burkhardt, S. and Schütz, A. and Hempel, N. and Gisa, V. and others},
  title   = {{Loss of the lncRNA SOX1-OT promotes p53-dependent cell-cycle arrest in astrocytes}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.07.03.736275},
  url     = {https://doi.org/10.64898/2026.07.03.736275}
}

@article{pallerla2026-922ec944,
  author  = {Pallerla, A. V. and Lucido, C. C. and Saito, K. and Nolt, G. L. and Arbones-Mainar, J. M. and Funnell, J. L. and Satish, D. and Smith, L. M. and others},
  title   = {{Anti-amyloid immunotherapy drives APOE4 specific increases in glial reactivity, perivascular immune activation, and ARIA-like events}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.06.26.734793},
  url     = {https://doi.org/10.64898/2026.06.26.734793}
}

@article{pikus2026-5846ffcd,
  author  = {Pikus, P. and Healey, G. S. and Xia, E. and Shautidze, G. and Siddapureddy, N. and Lee, Y. and Albanese, C. and Rodriguez, O. and others},
  title   = {{Intravenous anti-Aβ immunotherapy acutely increases cerebral amyloid angiopathy and vascular damages in APOE4 mice}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.02.09.704876},
  url     = {https://doi.org/10.64898/2026.02.09.704876}
}

@article{tuunanen2026-63f1c5a1,
  author  = {Tuunanen, J. and Hautamäki, K. and Väyrynen, T. and Järvelä, M. and Korhonen, V. and Huotari, N. and Kaakinen, M. and Kananen, J. and others},
  title   = {{Vasomechanic treatment increases efflux of human brain proteins}},
  journal = {medRxiv},
  year    = {2026},
  doi     = {10.64898/2026.01.22.26344377},
  url     = {https://doi.org/10.64898/2026.01.22.26344377}
}

@article{rausch2026-a2d21860,
  author  = {Rausch, D. M. and Ludwig, M. Q. and Bentsen, M. A. and Hansen, S. N. and Secher, A. and Holst, D. and Moreno, J. and Das, V. and others},
  title   = {{Semaglutide Attenuates Neuroinflammation in Mice}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.01.10.698763},
  url     = {https://doi.org/10.64898/2026.01.10.698763}
}

@article{abel2025-41446157,
  author  = {Abel, Tamar R and Pandey, Ravi S and Haber, Annat and Garceau, Dylan and Sasner, Michael and Kotredes, Kevin P and Cary, Gregory A and Oblak, Adrian and others},
  title   = {{Trem2R47H and reduced TREM2 expression both mimic human Alzheimer's disease signatures in mice}},
  journal = {bioRxiv : the preprint server for biology},
  year    = {2025},
  doi     = {10.64898/2025.12.17.694758},
  pmid    = {41446157},
  url     = {https://doi.org/10.64898/2025.12.17.694758}
}

@article{philippe2025-41394664,
  author  = {Philippe, Tristan J and Avey, Denis R and Kearns, Nicola A and Vyas, Himanshu and De Tissera, Sashini and Xu, Jishu and Ng, Bernard and Saunders, Devin M and others},
  title   = {{A Multi-omic Atlas of Human Choroid Plexus in Alzheimer's Disease}},
  journal = {bioRxiv : the preprint server for biology},
  year    = {2025},
  doi     = {10.1101/2025.11.23.690014},
  pmid    = {41394664},
  url     = {https://doi.org/10.1101/2025.11.23.690014}
}

@article{lopepiedrafita2025-343d96ed,
  author  = {Lope-Piedrafita, S. and Serra-Mir, G. and Melón, P. and Bonaterra, A. and Hernández-Guillamon, M. and Villegas, S.},
  title   = {{ScFv-h3D6 Prevents Bapineuzumab-Induced Hemorrhagic Events in the APP23 Mouse Model of Alzheimer’s Disease}},
  journal = {Preprints.org},
  year    = {2025},
  doi     = {10.20944/preprints202511.0180.v1},
  url     = {https://doi.org/10.20944/preprints202511.0180.v1}
}

@article{zhang2025-41278621,
  author  = {Zhang, Mengqi and Letian, Anudari and Mohl, Gregory A and Kroke, Brynn and Arkelius, Kajsa and Clelland, Claire D and Goldberg, Emily L and Singhal, Neel S},
  title   = {{PCSK9 and High-Fat Diet Synergistically Induce Neurovascular Dysfunction and Neuroinflammation}},
  journal = {bioRxiv : the preprint server for biology},
  year    = {2025},
  doi     = {10.1101/2025.10.29.685380},
  pmid    = {41278621},
  url     = {https://doi.org/10.1101/2025.10.29.685380}
}

@article{schuldt2025-40964350,
  author  = {Schuldt, Braxton R and Haworth-Staines, Dominic and Perez-Arevalo, Andrea and Broekaart, Diede W M and Wang, Leon and Gallagher, Georgia and Rabinowitz, Grace and Goate, Alison M and others},
  title   = {{APOE4 promotes cerebrovascular fibrosis and amyloid deposition via a pericyte-to-myofibroblast transition}},
  journal = {bioRxiv : the preprint server for biology},
  year    = {2025},
  doi     = {10.1101/2025.09.04.674192},
  pmid    = {40964350},
  url     = {https://doi.org/10.1101/2025.09.04.674192}
}

@article{kansakar2025-40166284,
  author  = {Kansakar, Sahan Bs and Sterben, Sydney P and Anamala, Charitha C and Thielen, Mitchell D and Liaudanskaya, Volha},
  title   = {{The Silent Saboteur: How Mitochondria Shape the Long-Term Fate of the Injured Brain}},
  journal = {bioRxiv : the preprint server for biology},
  year    = {2025},
  doi     = {10.1101/2025.03.19.644244},
  pmid    = {40166284},
  url     = {https://doi.org/10.1101/2025.03.19.644244}
}

@article{bosco2024-38260601,
  author  = {Bosco, Dale B and Kremen, Vaclav and Haruwaka, Koichiro and Zhao, Shunyi and Wang, Lingxiao and Ebner, Blake A and Zheng, Jiaying and Dheer, Aastha and others},
  title   = {{Impaired microglial phagocytosis promotes seizure development}},
  journal = {bioRxiv : the preprint server for biology},
  year    = {2024},
  doi     = {10.1101/2023.12.31.573794},
  pmid    = {38260601},
  url     = {https://doi.org/10.1101/2023.12.31.573794}
}

@article{chou2023-36865139,
  author  = {Chou, Vicky and Fancher, Seeley B and Pearse, Richard V and Lee, Hyo and Lam, Matti and Seyfried, Nicholas T and Bennett, David A and De Jager, Phillip L and others},
  title   = {{INPP5D/SHIP1 regulates inflammasome activation in human microglia}},
  journal = {bioRxiv : the preprint server for biology},
  year    = {2023},
  doi     = {10.1101/2023.02.25.530025},
  pmid    = {36865139},
  url     = {https://doi.org/10.1101/2023.02.25.530025}
}

@article{cao2019-31185010,
  author  = {Cao, Yongliang and Xu, Haochen and Zhu, Yuanbo and Shi, Mei-Juan and Wei, Lixiang and Zhang, Jin and Cheng, Shuo and Shi, Yiqian and others},
  title   = {{ADAMTS13 maintains cerebrovascular integrity to ameliorate Alzheimer-like pathology}},
  journal = {PLoS biology},
  year    = {2019},
  doi     = {10.1371/journal.pbio.3000313},
  pmid    = {31185010},
  url     = {https://doi.org/10.1371/journal.pbio.3000313}
}