Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
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Research into the role of the gut microbiome in modulating brain function has rapidly increased over the past 10 years, albeit chiefly in animal models.
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At baseline, subjects with normal vs. impaired cognition show no notable difference in microbiome diversity but several unique microbial signatures are detected in subjects with mild cognitive impairment.
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55/100
In recent years evidence has emerged that neurodegenerative diseases (NDs) are strongly associated with the microbiome composition in the gut.
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Patients with gout have a lower risk of developing dementia.
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The mean age of the participants was 70 years, and 55% were male.
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Along with mounting evidence that gut microbiota and their metabolites migrate endogenously to distal organs, the 'gut-lung axis,' 'gut-brain axis,' 'gut-liver axis' and 'gut-renal axis' have been established.
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IBS is associated with an increased risk of dementia, and this effect is obvious only in patients who are ≥50 years old.
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A total of 717 articles were identified, showing an upward trend in annual publications.
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Dementia was associated with dysbiosis characterized by differences in beta diversity and changes in taxonomic composition.
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This is the first study to show serum-based BA metabolites are associated with "A/T/N" AD biomarkers, providing further support for a role of BA pathways in AD pathophysiology.
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We report for the first time an association between altered BA profile, genetic variants implicated in AD, and cognitive changes in disease using a large multicenter study.
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Type 2 diabetes mellitus and Alzheimer's disease are both associated with increasing age, and each increases the risk of development of the other.
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52/100
Metformin use was associated with impaired cognitive performance.
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Nutritional supplementation is emerging as a promising strategy to support clinical management of early Alzheimer's disease (AD), partly through modulation of the intestinal microbiome via the microbiota-gut-brain axis.
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Recent studies have explored the impact of lifestyle, particularly diet, on cognitive decline and Alzheimer's disease (AD) risk.
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50/100
Increasing evidence suggests Alzheimer's disease (AD) pathophysiology is influenced by primary and secondary bile acids, the end product of cholesterol metabolism.
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50/100
These findings provide additional insight into gut microbial involvement in AD and add to the growing understanding of the gut-brain axis.
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The most common mental disorders that are currently prevalent in numerous countries are depression, bipolar disorder, schizophrenia, and obsessive-compulsive disorder (OCD).[2] The dietary intake pattern of the general population in many Asian and American countries reflects that they are often deficient in many nutrients, especially essential vitamins, minerals, and omega-3 fatty acids.[3] A notable feature of the diets of patients suffering from mental disorders is the severity of deficiency in these nutrients.[3] Studies have indicated that daily supplements of vital nutrients are often effective in reducing patients' symptoms.[4] Supplements containing amino acids have also been found to reduce symptoms, as they are converted to neurotransmitters which in turn alleviate depression and other mental health problems.[4] On the basis of accumulating scientific evidence, an effective therapeutic intervention is emerging, namely nutritional supplement/treatment.
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Cognitive decline is closely associated with biological aging and with interconnected processes, including chronic low-grade inflammation, oxidative stress, mitochondrial dysfunction, and cellular senescence.
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Metformin is the most widely used oral insulin-sensitizing agent.
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Alzheimer's disease (AD), is a chronic age-related progressive neurodegenerative disorder, characterized by neuroinflammation and extracellular aggregation of Aβ peptide.
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Diet is an important nonpharmacological risk-modifying factor for Alzheimer's disease (AD).
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Polyphenols, folate, vitamin D, omega-3 fatty acids, and β-carotene might decrease the risk of dementia.
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These constituents have shown a reduction in blood glucose levels.
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Age and comorbidities are key indicators of hospital admission, serious illness, and mortality in COVID-19 patients.
From across this topic
10 of the 1,048 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- Cardiorenal metabolic syndrome and diabetic cognopathy
- How Western Diet And Lifestyle Drive The Pandemic Of Obesity And Civilization Diseases
- GFAP mRNA increases with age in rat and human brain
- The modulatory effects of Hericium erinaceus and donepezil on amyloid accumulation and autophagy-associated clearance in Aβ 1-42 -induced N2a cells
- Oxidative stress, mitochondrial damage and neurodegenerative diseases
- Incretin-based therapy of metabolic disease
- Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline
- Microbiota-Gut-Brain Axis and Epilepsy: A Review on Mechanisms and Potential Therapeutics
- Gamma Linolenic Acid: An Antiinflammatory Omega-6 Fatty Acid
- The Microbiota-Gut-Brain Axis