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Home › Research › Topic

Gut, metabolism and diet

1,048 studies in this group. A computer grouped them by what their titles and summaries are about, not by a hand-made list. The name describes most of the group, not every study in it.

Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.

Highest usefulness score first. Studies without a score come last.

  1. Neurodegeneration onset with glucagon-like peptide-1 receptor agonists in people with type 2 diabetes: a real-world multinational cohort study

    ✓ Peer-reviewed alzhub usefulness score 63 out of 100. Cardiovascular diabetology 2025-11-07 Drug development

    Overall, 214,442 matched individuals initiated GLP-1 RAs or DPP4i (109,731 women, mean age 58.6 years [SD 12], and mean HbA1c 7.7% [1.4]).

  2. Relationship Between the Gut Microbiota and Alzheimer's Disease: A Systematic Review

    ✓ Peer-reviewed alzhub usefulness score 63 out of 100. Journal of Alzheimer's disease : JAD 2022 Disease mechanisms

    Eight observational studies were selected, carried out in humans and, therefore, suitable for inclusion in this review.

  3. Assessing potential glycemic overtreatment in persons at hypoglycemic risk

    ✓ Peer-reviewed alzhub usefulness score 62 out of 100. JAMA internal medicine 2014-02-01 Digital health tools

    We also assessed the rates in patients with other significant medical, neurologic, or mental comorbid illness.

  4. Mediterranean Diet, Alzheimer Disease, and Vascular Mediation

    ✓ Peer-reviewed alzhub usefulness score 62 out of 100. Archives of Neurology 2006-10-10 Risk factors

    Higher adherence to the MeDi was associated with lower risk for AD (odds ratio, 0.76; 95% confidence interval, 0.67-0.87; P<.001).

  5. The gut-brain axis in Alzheimer's disease: early detection, microbial metabolites, mechanisms, and therapeutic opportunities

    ✓ Peer-reviewed alzhub usefulness score 61 out of 100. Frontiers in molecular biosciences 2026-06-04 Disease mechanisms

    Alzheimer's disease (AD), the leading cause of dementia worldwide, imposes a growing clinical and societal burden, yet no therapies have been proven to alter its progression despite decades of intensive research.

  6. Microbiota-gut-brain axis and probiotics: potential therapeutic strategies for treating Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 61 out of 100. Nutritional neuroscience 2025-10-11 Disease mechanisms

    The gut-brain axis explains that changes in the intestinal microbiota influence Alzheimer's disease (AD).

  7. Effect of Probiotic Supplementation on Cognitive Function and Metabolic Status in Alzheimer's Disease: A Randomized, Double-Blind and Controlled Trial

    ✓ Peer-reviewed alzhub usefulness score 60 out of 100. Frontiers in aging neuroscience 2016-11-10 Clinical trials

    Alzheimer's disease (AD) is associated with severe cognitive impairments as well as some metabolic defects.

  8. Microbiota-gut-brain axis in neurodegenerative diseases: molecular mechanisms and therapeutic targets

    ✓ Peer-reviewed alzhub usefulness score 59 out of 100. Molecular biomedicine 2025-09-15 Disease mechanisms

    The microbiota-gut-brain axis (MGBA) is an intricate bidirectional communication network that links intestinal microbiota with the central nervous system (CNS) through immune, neural, endocrine, and metabolic pathways.

  9. Linking Metabolic Syndrome to Neurodegeneration Mechanisms and Potential Treatments

    ✓ Peer-reviewed alzhub usefulness score 59 out of 100. Molecular neurobiology 2025-04-24 Risk factors

    The global rise in both metabolic syndrome (MetS) and neurodegenerative diseases (NDs), particularly dementia and Alzheimer's disease (AD) poses a growing health and socioeconomic burden.

  10. Gut microbiome composition may be an indicator of preclinical Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 59 out of 100. Science translational medicine 2023-06-14 Disease mechanisms

    Alzheimer's disease (AD) pathology is thought to progress from normal cognition through preclinical disease and ultimately to symptomatic AD with cognitive impairment.

  11. Evaluating the effects of the novel GLP-1 analogue liraglutide in Alzheimer's disease: study protocol for a randomised controlled trial (ELAD study)

    ✓ Peer-reviewed alzhub usefulness score 59 out of 100. Trials 2019-04-03 Drug development

    Preclinical evidence in transgenic models of Alzheimer's disease suggests that liraglutide exerts neuroprotective effects by reducing amyloid oligomers, normalising synaptic plasticity and cerebral glucose uptake, and increasing the proliferation of neuronal progenitor cells.

  12. Promoting Successful Cognitive Aging: A Comprehensive Review

    ✓ Peer-reviewed alzhub usefulness score 59 out of 100. Journal of Alzheimer s Disease 2010-03-11 Drug development

    Promoting successful cognitive aging is a topic of major importance to individuals and the field of public health.

  13. Gut Microbial Metabolism as a Dynamic Interface in Neurodegenerative Diseases

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Metabolites 2026-08-07 Disease mechanisms

    Gut microbial metabolites serve as functional mediators of gut–brain communication, linking microbial alterations to neurodegenerative pathology.

  14. Acute effects of lactate infusion on metabolism, AD biomarkers, and cognition: The LEAN study

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2025-12 Biomarkers

    Lactate metabolic clearance rate did not differ between CH and CI subjects (p = 0.988).

  15. MIND Diet Impact on Multiple Sclerosis Patients: Biochemical Changes after Nutritional Intervention

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. International journal of molecular sciences 2024-09-17 Prevention and risk

    There is substantial evidence supporting the neuroprotective effects of the MIND diet in neurodegenerative diseases like Parkinson's and Alzheimer's. Our aim was to evaluate the impact of a nutritional intervention (NI) with this diet on multiple sclerosis (MS) patients.

  16. Brain-gut-microbiota axis in Parkinson's disease: A historical review and future perspective

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Brain research bulletin 2022-03-01 Disease mechanisms

    Parkinson's disease (PD) is the second most common degenerative disease of the central nervous system (CNS) after Alzheimer's disease.

  17. Dysfunction of the Microbiota-Gut-Brain Axis in Neurodegenerative Disease: The Promise of Therapeutic Modulation With Prebiotics, Medicinal Herbs, Probiotics, and Synbiotics

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Journal of Evidence-Based Integrative Medicine 2020-01-01 Disease mechanisms

    Recent data suggest gut microbiota dysbiosis as a contributing factor in neurodegenerative diseases, such as Parkinson's Disease (PD) and Alzheimer's Disease (AD), and these pathologies may manifest via the microbiota-gut-brain-axis, which comprises bidirectional communication through neuroimmune, neuroendocrine, and direct neural pathways such as the vagus nerve.

  18. Association between circadian rhythms and neurodegenerative diseases

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. The Lancet. Neurology 2019-02-12 Risk factors

    Dysfunction in 24-h circadian rhythms is a common occurrence in ageing adults; however, circadian rhythm disruptions are more severe in people with age-related neurodegenerative diseases, including Alzheimer's disease and related dementias, and Parkinson's disease.

  19. Gut microbiota changes in the extreme decades of human life: a focus on centenarians

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Cellular and molecular life sciences : CMLS 2017-10-14 Disease mechanisms

    The gut microbiota (GM) is a complex, evolutionarily molded ecological system, which contributes to a variety of physiological functions.

  20. In Alzheimer's Disease, 6-Month Treatment with GLP-1 Analog Prevents Decline of Brain Glucose Metabolism: Randomized, Placebo-Controlled, Double-Blind Clinical Trial

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Frontiers in aging neuroscience 2016-05-24 Drug development

    In animal models, the incretin hormone GLP-1 affects Alzheimer's disease (AD).

  21. PON-1 and ferroxidase activities in older patients with mild cognitive impairment, late onset Alzheimer’s disease or vascular dementia

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Clinical Chemistry and Laboratory Medicine (CCLM) 2015-01-01 Mild cognitive impairment

    A large body of evidence suggests that not only cerebral but also systemic oxidative stress (OxS) might be involved in the pathogenesis of late onset Alzheimer’s disease (LOAD) and vascular dementia (VAD), as well as of the prodromal phase of dementia, the so-called mild cognitive impairment (MCI).

  22. Oral curcumin for Alzheimer's disease: tolerability and efficacy in a 24-week randomized, double blind, placebo-controlled study

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Alzheimer's research & therapy 2012-10-29 Biomarkers

    Mean age of completers (n = 30) was 73.5 years and mean Mini-Mental Status Examination (MMSE) score was 22.5.

  23. Association of dietary and nutritional factors with cognitive decline, dementia, and depressive symptomatology in older individuals according to a neurogenesis-centred biological susceptibility to brain ageing

    ✓ Peer-reviewed alzhub usefulness score 56 out of 100. Age and ageing 2024-05-11 Prevention and risk

    Hippocampal neurogenesis (HN) occurs throughout the life course and is important for memory and mood.

  24. The 25-Year Evolution of Lithium as a Disease-Modifying Agent in Dementia: A Narrative Review

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. JAMA psychiatry 2026-09-01 Drug development

    These convergent data support a prospective clinical trial of low-dose lithium orotate to slow disease progression in MCI.

  25. Compositional and functional gut microbiota alterations in mild cognitive impairment: links to Alzheimer's disease pathology

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. Alzheimer's research & therapy 2025-05-30 Disease mechanisms

    We identified 59 key microbial species linked to MCI and AD biomarkers.

From across this topic

9 of the 1,048 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 9. The same 9 appear here every time.

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