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Home › Research › Topic

Gut, metabolism and diet

1,048 studies in this group. A computer grouped them by what their titles and summaries are about, not by a hand-made list. The name describes most of the group, not every study in it.

Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.

Highest usefulness score first. Studies without a score come last.

  1. Gut microbiota and its metabolites in Alzheimer's disease: from pathogenesis to treatment

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. PeerJ 2024-03-13 Disease mechanisms

    Regulating the gut flora ecological balance upregulates neurotrophic factor expression, regulates the microbiota-gut-brain (MGB) axis, and suppresses the inflammatory responses.

  2. Ketogenic diet and BHB rescue the fall of long-term potentiation in an Alzheimer's mouse model and stimulates synaptic plasticity pathway enzymes

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Communications biology 2024-02-16 Disease mechanisms

    The Ketogenic Diet (KD) improves memory and longevity in aged C57BL/6 mice.

  3. Reconsidering repurposing: long-term metformin treatment impairs cognition in Alzheimer's model mice

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Translational psychiatry 2024-01-18 Drug development

    Metformin, a primary anti-diabetic medication, has been anticipated to provide benefits for Alzheimer's disease (AD), also known as "type 3 diabetes".

  4. The contribution of age-related changes in the gut-brain axis to neurological disorders

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Gut microbes 2024-01-18 Disease mechanisms

    Trillions of microbes live symbiotically in the host, specifically in mucosal tissues such as the gut.

  5. GLP-1 derivatives with functional sequences transit and migrate through trigeminal neurons

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 2024-01-06 Drug development

    Patients with dementia are increasing with the aging of the population, and dementia has become a disease with high unmet medical needs.

  6. Gut microbiota, circulating cytokines and dementia: a Mendelian randomization study

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Journal of neuroinflammation 2024-01-04 Genetics

    There were 20 positive and 16 negative causal effects between genetic liability in the gut microbiota and dementia.

  7. Gut Microbiome in Alzheimer's Disease: from Mice to Humans

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Current neuropharmacology 2024 Disease mechanisms

    Alzheimer's disease (AD) is the most prevalent type of dementia, but its etiopathogenesis is not yet fully understood.

  8. Intestinal Barrier Function and Neurodegenerative Disease

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. CNS & neurological disorders drug targets 2024 Disease mechanisms

    Neurodegenerative diseases are caused by the loss of neurons and/or their myelin sheaths, which deteriorate over time and become dysfunctional.

  9. Impact of Obesity on Atrial Fibrillation Pathogenesis and Treatment Options

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Journal of the American Heart Association 2023-12-29 Risk factors

    Atrial fibrillation (AF) is the most common cardiac arrhythmia.

  10. Magnesium-L-threonate treats Alzheimer's disease by modulating the microbiota-gut-brain axis

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Neural regeneration research 2023-12-21 Disease mechanisms

    JOURNAL/nrgr/04.03/01300535-202410000-00029/figure1/v/2024-02-06T055622Z/r/image-tiff Disturbances in the microbiota-gut-brain axis may contribute to the development of Alzheimer's disease.

  11. Pathways linking microbiota-gut-brain axis with neuroinflammatory mechanisms in Alzheimer's pathophysiology

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Microbiome research reports 2023-12-06 Disease mechanisms

    Disturbances in the local and peripheral immune systems are closely linked to a wide range of diseases.

  12. The Role of Cortisol in Chronic Stress, Neurodegenerative Diseases, and Psychological Disorders

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Cells 2023-11-29 Risk factors

    Cortisol, a critical glucocorticoid hormone produced by the adrenal glands, plays a pivotal role in various physiological processes.

  13. The role of nutrition in the prevention of cognitive decline

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Current opinion in clinical nutrition and metabolic care 2023-11-25 Prevention and risk

    Dementia is a growing concern and underscores the urgent need for effective preventive measures targeting modifiable risk factors.

  14. Exercise training improves long-term memory in obese mice

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Life metabolism 2023-11-15 Prevention trials

    Obesity has been linked to a range of pathologies, including dementia.

  15. The role of Lactobacillus in inflammatory bowel disease: from actualities to prospects

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Cell death discovery 2023-09-29 Disease mechanisms

    Inflammatory Bowel Disease (IBD), a chronic nonspecific intestinal inflammatory disease, is comprised of Ulcerative Colitis (UC) and Crohn's Disease (CD).

  16. Targeting redox imbalance in neurodegeneration: characterizing the role of GLP-1 receptor agonists

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Theranostics 2023-09-04 Drug development

    Reactive oxygen species (ROS) have emerged as essential signaling molecules regulating cell survival, death, inflammation, differentiation, growth, and immune response.

  17. The gut microbiota-brain axis in neurological disorder

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Frontiers in neuroscience 2023-08-04 Disease mechanisms

    The gut microbiota (GM) plays an important role in the physiology and pathology of the host.

  18. Metformin: A Review of Potential Mechanism and Therapeutic Utility Beyond Diabetes

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Drug design, development and therapy 2023-06-26 Drug development

    Metformin has been designated as one of the most crucial first-line therapeutic agents in the management of type 2 diabetes mellitus.

  19. The potential role of human islet amyloid polypeptide in type 2 diabetes mellitus and Alzheimer's diseases

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Diabetology & metabolic syndrome 2023-05-13 Drug development

    Human Islet amyloid polypeptide (hIAPP) from pancreatic β cells in the islet of Langerhans has different physiological functions including inhibiting the release of insulin and glucagon.

  20. Mitochondria: It is all about energy

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Frontiers in physiology 2023-04-25 Disease mechanisms

    Mitochondria play a key role in both health and disease.

  21. The mechanism and efficacy of GLP-1 receptor agonists in the treatment of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Frontiers in endocrinology 2022-11-17 Drug development

    Since type 2 diabetes mellitus (T2DM) is a risk factor for Alzheimer's disease (AD) and both have the same pathogenesis (e.g., insulin resistance), drugs used to treat T2DM have been gradually found to reduce the progression of AD in AD models.

  22. The importance of estradiol for body weight regulation in women

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Frontiers in endocrinology 2022-11-07 Drug development

    Obesity in women of reproductive age has a number of adverse metabolic effects, including Type II Diabetes (T2D), dyslipidemia, and cardiovascular disease.

  23. Gut microbiome and human health: Exploring how the probiotic genus Lactobacillus modulate immune responses

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Frontiers in pharmacology 2022-10-24 Disease mechanisms

    The highest density of microbes resides in human gastrointestinal tract, known as "Gut microbiome".

  24. Acetylcholinesterase Inhibitory Activities of Essential Oils from Vietnamese Traditional Medicinal Plants

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Molecules 2022-10-20 Risk factors

    Essential oils are promising as environmentally friendly and safe sources of pesticides for human use.

  25. The neuroprotective effects of glucagon-like peptide 1 in Alzheimer's and Parkinson's disease: An in-depth review

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Frontiers in neuroscience 2022-09-01 Treatments

    Currently, there is no disease-modifying treatment available for Alzheimer's and Parkinson's disease (AD and PD) and that includes the highly controversial approval of the Aβ-targeting antibody aducanumab for the treatment of AD.

From across this topic

10 of the 1,048 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.

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