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Liver-Specific Polygenic Risk Score Is Associated with Alzheimer's Disease Diagnosis
Daniel J Panyard, Yuetiva K Deming, Burcu F Darst, Carol A Van Hulle, Henrik Zetterberg, Kaj Blennow, Gwendlyn Kollmorgen, Ivonne Suridjan et al.. Journal of Alzheimer's disease : JAD, 2023
Topic: Genetics and APOE
The AD PRS model that was most predictive of AD diagnosis (even without APOE) was the liver AD PRS: n = 1,115; odds ratio = 2.15 (1.67-2.78), p = 3.62×10-9. The liver AD PRS was also statistically significantly associated with cerebrospinal fluid biomarker evidence of amyloid-β (Aβ42:Aβ40 ratio, p = 3.53×10-6) and the phosphorylated tau:amyloid-β ratio (p = 1.45×10-5). These findings provide further evidence of the role of the liver-functional genome in AD and the benefits of incorporating functional annotation into genomic research.
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APA 7th
Panyard, D. J., Deming, Y. K., Darst, B. F., Van Hulle, C. A., Zetterberg, H., Blennow, K., et al. (2023). Liver-Specific Polygenic Risk Score Is Associated with Alzheimer's Disease Diagnosis. Journal of Alzheimer's disease : JAD. https://doi.org/10.3233/jad-220599
Vancouver
Panyard DJ, Deming YK, Darst BF, Van Hulle CA, Zetterberg H, Blennow K, et al. Liver-Specific Polygenic Risk Score Is Associated with Alzheimer's Disease Diagnosis. Journal of Alzheimer's disease : JAD. 2023. doi:10.3233/jad-220599. PMID: 36744333.
BibTeX
@article{panyard2023-36744333,
author = {Panyard, Daniel J and Deming, Yuetiva K and Darst, Burcu F and Van Hulle, Carol A and Zetterberg, Henrik and Blennow, Kaj and Kollmorgen, Gwendlyn and Suridjan, Ivonne and others},
title = {{Liver-Specific Polygenic Risk Score Is Associated with Alzheimer's Disease Diagnosis}},
journal = {Journal of Alzheimer's disease : JAD},
year = {2023},
doi = {10.3233/jad-220599},
pmid = {36744333},
url = {https://doi.org/10.3233/jad-220599}
}
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Key findings
- The AD PRS model that was most predictive of AD diagnosis (even without APOE) was the liver AD PRS: n = 1,115; odds ratio = 2.15 (1.67-2.78), p = 3.62×10-9.
- The liver AD PRS was also statistically significantly associated with cerebrospinal fluid biomarker evidence of amyloid-β (Aβ42:Aβ40 ratio, p = 3.53×10-6) and the phosphorylated tau:amyloid-β ratio (p = 1.45×10-5).
- These findings provide further evidence of the role of the liver-functional genome in AD and the benefits of incorporating functional annotation into genomic research.
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Study details
- Study designcohort study
- Participants1,115
- Evidence strengthModerate
How this study scored 68/100
Published in a peer-reviewed journal, and it is a cohort study following people over time. Scored zero for effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 38 of the 56 points we could judge it on, which is 68 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of Alzheimer's disease : JAD) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 7 / 12 | A cohort study following people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2023 — within 6 year(s) of the newest study here |
| Sample size | 3 / 4 | 1,115 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 36744333) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 38 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 38 of the 56 points we could judge it on is 68 out of 100. |
| Total | 68 / 100 | — |
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