Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
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Familial Alzheimer's disease (FAD), despite representing a rare condition, is attracting a growing interest in the scientific community.
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We found that common variation at the CR1 locus has a broad impact on cognition and that this effect is largely mediated by an individual's amyloid plaque burden.
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Among 463,447 TPMI participants, 4381 PD patients and 43,810 controls were analysed.
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64/100
No variant passed the genome-wide significance threshold (p = 5 × 10- 8) in the case-control GWAS.
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Genetic variation in sulfonylurea targets was associated with a lower risk of AD, and future studies are warranted to clarify the underlying mechanistic pathways between sulfonylureas and AD.
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PheMap significantly streamlines the process of extracting research-quality phenotype information from EHRs, with comparable or better performance to current phenotyping approaches.
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Variants in GBA, encoding the enzyme glucocerebrosidase, are associated with Lewy body diseases such as Parkinson's disease and Lewy body dementia.
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Effective interventions in diet, medications, biochemical exposures, psychological condition, pre-existing disease and lifestyle may decrease new incidence of AD.
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Recent studies have found an association between a variant in triggering receptor expressed on myeloid cells 2 (TREM2) (rs75932628-T) and both Alzheimer's disease (AD) and cognitive function in individuals aged 80-100 years.
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Obesity and diabetes significantly and independently increase risk for AD.
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The genetic underpinnings of Alzheimer's disease (AD) remain largely elusive despite early successes in identifying three genes that cause early-onset familial AD (those that encode amyloid precursor protein (APP) and the presenilins (PSEN1 and PSEN2)), and one genetic risk factor for late-onset AD (the gene that encodes apolipoprotein E (APOE)).
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Genome-wide significant loci were identified for all biomarkers, including DACT1-DAAM1 (pTau217), KCNJ3 (pTau181), KLHDC4 (NfL), SLC10A7 (GFAP), and PPP4R2 (composite score).
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Nine female-specific associations were identified and replicated, involving ADGRV1, OR3A3, IFI27L1, LYRM1, STAP2, TSTD2, PDYN, and TMEM50B. We observed the preponderance of protective female-specific associations in neurons.
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Plasma levels of glial fibrillary acidic protein (GFAP) and neurofilament light (NEFL) are key dementia biomarkers.
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Chronological age offers an imperfect estimate of the molecular changes that occur with aging.
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Approximately 40% of dementia cases could be prevented or delayed by modifiable risk factors related to lifestyle and environment.
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Rich data from large biobanks, coupled with increasingly accessible association statistics from genome-wide association studies (GWAS), provide great opportunities to dissect the complex relationships among human traits and diseases.
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Alzheimer's disease (AD) is the most common form of dementia, characterized by progressive cognitive impairment and neurodegeneration.
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Through this approach, we identified 103 ARGs validated by various levels of pathobiological evidence in AD.
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There were interactions between the dietary patterns and APOE ε4 status in relation to incident dementia (interaction p value threshold of < 0.1), while no evidence of interactions were found between the dietary patterns and the AD-PRSs.
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Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder and the most common form of dementia in the elderly.
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63/100
To examine the association between blood cholesterol concentrations and Alzheimer's disease (AD) in the Chinese elderly.
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Animal studies show aging varies between individuals as well as between organs within an individual 1-4 , but whether this is true in humans and its effect on age-related diseases is unknown.
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Alzheimer's disease (AD) is a common neurodegenerative disease characterized by amyloid plaques and impaired brain metabolism.
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We used within-group locally estimated scatterplot smoothing models to compare the trajectory of biomarker changes with age in females versus males, as well as by apolipoprotein ɛ4 carriership.
From across this topic
10 of the 933 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- Autosomal dominant cerebellar phenotypes
- Genome-wide association analysis reveals putative Alzheimer's disease susceptibility loci in addition to APOE
- Evolution of prodromal clinical markers of Parkinson disease in a GBA mutation-positive cohort
- Cockayne syndrome in adults: review with clinical and pathologic study of a new case
- Early-onset familial Alzheimer's disease (EOFAD)
- A Proteotranscriptomic-Based Computational Drug-Repositioning Method for Alzheimer's Disease
- DNA Methylation Biomarkers in Aging and Age-Related Diseases
- A Genome-Wide Association Study of 2304 Extreme Longevity Cases Identifies Novel Longevity Variants
- Disease prediction using graph convolutional networks: Application to Autism Spectrum Disorder and Alzheimer's disease
- APOE and Alzheimer's disease: advances in genetics, pathophysiology, and therapeutic approaches