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Home › Research › Topic

Genetics and APOE

933 studies in this group. A computer grouped them by what their titles and summaries are about, not by a hand-made list. The name describes most of the group, not every study in it.

Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.

Download bibliography of all 933 studies, highest score first: BibTeX (.bib) · RIS (.ris)

Highest usefulness score first. Studies without a score come last.

  1. Integrative in situ mapping of single-cell transcriptional states and tissue histopathology in a mouse model of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Nature neuroscience 2023-02-02 Genetics

    Complex diseases are characterized by spatiotemporal cellular and molecular changes that may be difficult to comprehensively capture.

  2. Identifying phenotype-associated subpopulations by integrating bulk and single-cell sequencing data

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Nature biotechnology 2021-11-11 Genetics

    Single-cell RNA sequencing (scRNA-seq) distinguishes cell types, states and lineages within the context of heterogeneous tissues.

  3. Experimental and real-world evidence supporting the computational repurposing of bumetanide for APOE4 -related Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Nature aging 2021-10-11 Digital health tools

    The evident genetic, pathological, and clinical heterogeneity of Alzheimer's disease (AD) poses challenges for traditional drug development.

  4. Single-nucleus chromatin accessibility and transcriptomic characterization of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Nature genetics 2021-07-08 Genetics

    The gene-regulatory landscape of the brain is highly dynamic in health and disease, coordinating a menagerie of biological processes across distinct cell types.

  5. Inclusion of African American/Black adults in a pilot brain proteomics study of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Neurobiology of disease 2020-10-10 Disparities

    Alzheimer's disease (AD) disproportionately affects certain racial and ethnic subgroups, such as African American/Black and Hispanic adults.

  6. Epigenome-wide analyses identify DNA methylation signatures of dementia risk

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Alzheimer's & dementia (Amsterdam, Netherlands) 2020-08-10 Genetics

    AD genetic risk and two dementia risk scores were associated with differential methylation.

  7. Large-scale proteomic analysis of Alzheimer's disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Nature medicine 2020-04-13 Tau biomarkers

    Our understanding of Alzheimer's disease (AD) pathophysiology remains incomplete.

  8. Interaction between APOE genotype and diabetes in cognitive decline

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Alzheimer's & dementia (Amsterdam, Netherlands) 2020-02-06 Genetics

    A significant interaction between diabetes and APOE genotype exists, where diabetes affected cognitive decline in APOE3 carriers and APOE2 carriers, but not APOE4 carriers.

  9. Brain cell type-specific enhancer-promoter interactome maps and disease - risk association

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Science (New York, N.Y.) 2019-11-14 Inflammation and the immune system

    Noncoding genetic variation is a major driver of phenotypic diversity, but functional interpretation is challenging.

  10. Genome-wide association study identifies SIAH3 locus influencing the rate of ventricular enlargement in non-demented elders

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Aging 2019-11-11 Genetics

    Ventricular enlargement occurs in several neurodegenerative and psychiatric diseases.

  11. Mutation profile of APP, PSEN1, and PSEN2 in Chinese familial Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Neurobiology of aging 2019-01-31 Risk genes beyond APOE

    Causative mutations in the genes encoding amyloid precursor protein (APP), presenilin 1 (PSEN1), or presenilin 2 (PSEN2) account for a majority of cases of familial Alzheimer disease (FAD) inherited in an autosomal-dominant pattern.

  12. Polygenic Risk Score Analysis of Alzheimer's Disease in Cases without APOE4 or APOE2 Alleles

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. The journal of prevention of Alzheimer's disease 2019 Genetics

    The We and others have previously shown that polygenic risk score analysis (PRS) has considerable predictive utility for identifying those at high risk of developing Alzheimer's disease (AD) with an area under the curve (AUC) of >0.8.

  13. A rare loss-of-function variant of ADAM17 is associated with late-onset familial Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Molecular psychiatry 2018-07-09 Genetics

    Common variants of about 20 genes contributing to AD risk have so far been identified through genome-wide association studies (GWAS).

  14. A decade in psychiatric GWAS research

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Molecular psychiatry 2018-06-25 Genetics

    After more than 10 years of accumulated efforts, genome-wide association studies (GWAS) have led to many findings, most of which have been deposited into the GWAS Catalog.

  15. Evaluation of Apolipoprotein E Fragmentation as a Biomarker for Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Journal of neurology and neurological disorders 2017-07-31 Genetics

    Recent studies have supported a role for the proteolytic cleavage of apolipoprotein E4 (APOE4) as a potential mechanism for the enhanced dementia risk associated with Alzheimer's disease.

  16. ApoE isoforms differentially regulates cleavage and secretion of BDNF

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Molecular brain 2017-06-01 Genetics

    Apolipoprotein E4 (ApoE4) is a major genetic risk factor for sporadic or late onset Alzheimer's disease (AD).

  17. Two novel loci, COBL and SLC10A2, for Alzheimer's disease in African Americans

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2016-10-20 Genetics

    Two SNPs at novel loci, rs112404845 (P = 3.8 × 10-8), upstream of COBL, and rs16961023 (P = 4.6 × 10-8), downstream of SLC10A2, obtained genome-wide significant evidence of association with the posterior liability.

  18. Evolution of prodromal clinical markers of Parkinson disease in a GBA mutation-positive cohort

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. JAMA neurology 2015-02-01 Brain scans and imaging

    This study indicates that, as a group, GBA mutation-positive individuals show a deterioration in clinical markers consistent with the prodrome of PD.

  19. A novel PSEN1 mutation (I238M) associated with early-onset Alzheimer's disease in an African-American woman

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Journal of Alzheimer's disease : JAD 2014 Risk genes beyond APOE

    Mutations in PSEN1 are the most common cause of autosomal dominant familial Alzheimer's disease (FAD).

  20. Global changes in DNA methylation and hydroxymethylation in Alzheimer's disease human brain

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Neurobiology of aging 2013-12-04 Genetics

    DNA methylation (5-methylcytosine [5mC]) is one of several epigenetic markers altered in Alzheimer's disease (AD) brain.

  21. SQSTM1 mutations in French patients with frontotemporal dementia or frontotemporal dementia with amyotrophic lateral sclerosis

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. JAMA neurology 2013-11-01 Genetics

    Although the frequency of the mutations is low in our series (4 of 188 patients [2%]), our results, similar to those already reported, support a direct pathogenic role of p62 in different types of FTD.

  22. Mutations in DNMT1 cause hereditary sensory neuropathy with dementia and hearing loss

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Nature genetics 2011-05-01 Genetics

    DNA methyltransferase 1 (DNMT1) is crucial for maintenance of methylation, gene regulation and chromatin stability.

  23. How citation distortions create unfounded authority: analysis of a citation network

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. BMJ (Clinical research ed.) 2009-07-20 Drug development

    Citation is both an impartial scholarly method and a powerful form of social communication.

  24. Alcohol drinking in middle age and subsequent risk of mild cognitive impairment and dementia in old age: a prospective population based study

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. BMJ 2004-08-10 Prevention and risk

    Participants who drank no alcohol at midlife and those who drank alcohol frequently were both twice as likely to have mild cognitive impairment in old age as those participants who drank alcohol infrequently.

  25. Incipient Alzheimer's disease: microarray correlation analyses reveal major transcriptional and tumor suppressor responses

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Proceedings of the National Academy of Sciences of the United States of America 2004-02-09 Cognitive tests and assessment

    The pathogenesis of incipient Alzheimer's disease (AD) has been resistant to analysis because of the complexity of AD and the overlap of its early-stage markers with normal aging.

From across this topic

9 of the 933 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 9. The same 9 appear here every time.

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