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Home › Research › Topic

Genetics and APOE

933 studies in this group. A computer grouped them by what their titles and summaries are about, not by a hand-made list. The name describes most of the group, not every study in it.

Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.

Highest usefulness score first. Studies without a score come last.

  1. [Early-onset familial Alzheimer's disease with spastic paraparesis associated with PSEN1 gene]

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 2023 Risk genes beyond APOE

    A familial case of a rare autosomal dominant Alzheimer's disease (AD), related to PSEN1 gene (AD3, OMIM 607822), differing from common multifactorial form by earlier onset and, in part of cases, by accompanying neurological signs, spastic paraparesis particularly, is presented.

  2. Common human genetic variants of APOE impact murine COVID-19 mortality

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. Nature 2022-09-21 Genetics

    Clinical outcomes of severe acute respiratory syndrome 2 (SARS-CoV-2) infection are highly heterogeneous, ranging from asymptomatic infection to lethal coronavirus disease 2019 (COVID-19).

  3. A polygenic risk score predicts mosaic loss of chromosome Y in circulating blood cells

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. Cell & bioscience 2021-12-12 Genetics

    We calculated a PRS for LOY in 5131 men aged 70 years and older.

  4. Exploring the genetic relationship between hearing impairment and Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. Alzheimer's & dementia (Amsterdam, Netherlands) 2020-09-25 Genetics

    We found a significant genetic overlap between hearing impairment and AD and a polygenic risk score for AD was able to significantly predict hearing loss in an independent cohort.

  5. Presenilin 1 and APP Gene Mutations in Early-Onset AD Families from a Southeast Region of China

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. Current Alzheimer research 2020 Risk genes beyond APOE

    A splice mutation (p.S290C) in PSEN1 and a missense mutation (p.V717I) in APP were identified.

  6. A combined miRNA-piRNA signature to detect Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. Translational psychiatry 2019-10-07 Biomarkers

    Alzheimer's disease (AD) is the most common neurodegenerative disorder causing huge emotional and economic burden to our societies.

  7. APP, PSEN1, and PSEN2 Mutations in Asian Patients with Early-Onset Alzheimer Disease

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. International journal of molecular sciences 2019-09-25 Risk genes beyond APOE

    The number of patients with Alzheimer's disease (AD) is rapidly increasing in Asia.

  8. Genetic analyses of early-onset Alzheimer's disease using next generation sequencing

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. Scientific reports 2019-06-10 Risk genes beyond APOE

    Alzheimer's disease (AD) is the most common type of neurodegenerative dementia, but the cause of AD remained poorly understood.

  9. Drug repositioning for diabetes based on 'omics' data mining

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. PloS one 2015-05-06 Drug development

    Drug repositioning has shorter developmental time, lower cost and less safety risk than traditional drug development process.

  10. Apolipoprotein E and familial dysbetalipoproteinemia: clinical, biochemical, and genetic aspects

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. Seminars in vascular medicine 2004-08 Genetics

    In humans, apolipoprotein E (apoE) is a polymorphic protein of which three common isoforms can be distinguished, designated apoE2, apoE3, and apoE4.

  11. Very early onset AD with a de novo mutation in the presenilin 1 gene (Met 233 Leu)

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. Neurology 2003-10-28 Risk genes beyond APOE

    The authors describe a 28-year-old woman with histopathologically confirmed early onset Alzheimer disease characterized by severe frontal lobe involvement associated with a de novo mutation in the presenilin 1 gene (PSEN1).

  12. Exceptional Longevity Modifying Allele APOE2 Promotes DNA Signaling Pathways Resisting Cellular Senescence in Human Neurons

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Aging cell 2026-05 Genetics

    Genome-wide association studies (GWAS) have identified APOE2 allele as linked to exceptional longevity, with carriers exhibiting a reduced risk of Alzheimer's disease (AD).

  13. Alzheimer's Disease Risk Factor APOE4 Exerts Dimorphic Effects on Female Bone

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026-04-13 Genetics

    Individuals with Alzheimer's disease (AD) are at an increased risk of bone fracture, while osteoporosis in women is one of the earliest predictors of AD.

  14. Genetic risk in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. NPJ systems biology and applications 2026-02-14 Genetics

    Alzheimer's disease (AD) has a strong genetic predisposition.

  15. Protective ApoE variants support neuronal function by effluxing oxidized phospholipids

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Neuron 2025-12-02 Genetics

    Apolipoprotein E (ApoE) mediates the bidirectional transport of lipids between cells.

  16. A blood biomarker of the pace of aging is associated with brain structure: replication across three cohorts

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Neurobiology of aging 2024-01-24 Biomarkers

    Biological aging is the correlated decline of multi-organ system integrity central to the etiology of many age-related diseases.

  17. Novel Alzheimer's disease genes and epistasis identified using machine learning GWAS platform

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Scientific reports 2023-10-17 Genetics

    Alzheimer's disease (AD) is a complex genetic disease, and variants identified through genome-wide association studies (GWAS) explain only part of its heritability.

  18. A comparative atlas of single-cell chromatin accessibility in the human brain

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Science (New York, N.Y.) 2023-10-13 Genetics

    Recent advances in single-cell transcriptomics have illuminated the diverse neuronal and glial cell types within the human brain.

  19. Divergent single cell transcriptome and epigenome alterations in ALS and FTD patients with C9orf72 mutation

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Nature communications 2023-09-15 Genetics

    A repeat expansion in the C9orf72 (C9) gene is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).

  20. Key variants via Alzheimer's Disease Sequencing Project whole genome sequence data

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2023-08-29 Genetics

    Seventeen variants were significantly associated with AD within five genomic regions implicating the genes OARD1/NFYA/TREML1, JAZF1, FERMT2, and SLC24A4.

  21. Educational attainment, structural brain reserve and Alzheimer's disease: a Mendelian randomization analysis

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Brain : a journal of neurology 2023-05-02 Risk factors

    Higher educational attainment is observationally associated with lower risk of Alzheimer's disease.

  22. Neuropathology-based APOE genetic risk score better quantifies Alzheimer's risk

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2023-02-16 Tau biomarkers

    The APOE-npscore explained more variance and provided a better model fit for all three CSF measures than APOE ε4-carrier status and ε4 allele count.

  23. Aberrant splicing of PSEN2, but not PSEN1, in individuals with sporadic Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Brain : a journal of neurology 2023-02-13 Risk genes beyond APOE

    Alzheimer's disease is the most common neurodegenerative disease, characterized by dementia and premature death.

  24. APOE2 Exacerbates TDP-43 Related Toxicity in the Absence of Alzheimer Pathology

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Annals of neurology 2023-01-10 Genetics

    We found that TDP-43 overexpression induced motor function deficits, neuronal loss, and gliosis in the motor cortex, especially in APOE2 mice, with much milder or absent effects in APOE3, APOE4, or Apoe-KO mice.

  25. APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Nature 2022-11-16 Genetics

    APOE4 is the strongest genetic risk factor for Alzheimer's disease 1-3 .

From across this topic

10 of the 933 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.

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