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Newest in this topic

  1. Beyond Usual Pace: Quick Walking Speed and Brain Health Outcomes in the Framingham Heart Study 2026-10-15
  2. Long-term voluntary exercise reveals limited translation of hippocampal molecular responses into neuroprotection in 5xFAD mice 2026-09-24
  3. Exercise effects on balance confidence and concerns about falling in older adults with cognitive impairment: a construct-stratified meta-analysis 2026-09-14

Studies

125 studies carry this tag.

Date range

1996 to 2026

Top journals

  • Ageing research reviews 5
  • Journal of the American Geriatrics Society 5
  • Journal of Alzheimer's disease : JAD 4
  • Neurology 4
  • medRxiv 4

89 journals in all.

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. Physical Activity and Brain Health

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Genes 2019-09-17 Prevention trials

    Physical activity (PA) has been central in the life of our species for most of its history, and thus shaped our physiology during evolution.

  2. Functional and/or structural brain changes in response to resistance exercises and resistance training lead to cognitive improvements - a systematic review

    ✓ Peer-reviewed alzhub usefulness score 69 out of 100. European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity 2019-07-10 Prevention trials

    During the aging process, physical capabilities (e.g., muscular strength) and cognitive functions (e.g., memory) gradually decrease.

  3. Effect of aerobic exercise on white matter microstructure in the aging brain

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. Behavioural brain research 2019-07-04 Prevention trials

    Aging is associated with decline in white matter (WM) microstructure, decreased cognitive functioning, and increased risk of Alzheimer's disease and related dementias.

  4. Moderate- to high-intensity exercise does not modify cortical β-amyloid in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. Alzheimer's & dementia (New York, N. Y.) 2019-06-07 Prevention trials

    The intervention showed no effect on follow-up SUVRs in a covariance analysis with group allocation, baseline intervention SUVR, age, sex, and baseline Mini-Mental State Examination as predictors.

  5. Exercise as a prescription for patients with various diseases

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Journal of sport and health science 2019-04-18 Prevention trials

    A growing understanding of the benefits of exercise over the past few decades has prompted researchers to take an interest in the possibilities of exercise therapy.

  6. Multicomponent exercise and the hallmarks of frailty: Considerations on cognitive impairment and acute hospitalization

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Experimental gerontology 2019-04-14 Prevention trials

    Frailty syndrome encompasses several physical hallmarks such as loss of muscle strength, power output and mass, which leads to poor gait ability, fatigue, falls and overall difficulty to perform activities of daily living.

  7. Prescribing physical activity as a preventive measure for middle-aged Australians with dementia risk factors

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Australian journal of primary health 2019-04 Prevention trials

    Dementia is increasing in Australia in line with population ageing and is expected to peak by mid-century.

  8. Evidence-informed practical recommendations for increasing physical activity among persons living with HIV

    ✓ Peer-reviewed alzhub usefulness score 69 out of 100. AIDS 2019-02-01 Cognitive tests and assessment

    Non-ART polypharmacy is common among PLWH and associated with an increasing risk of hospitalization and mortality [1]; thus, nonpharmacologic management of comorbidities is critical for PLWH who may experience an earlier onset and a greater burden of comorbidities.

  9. Blood-brain barrier permeability and physical exercise

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Journal of neuroinflammation 2019-01-24 Prevention trials

    In this narrative review, a theoretical framework on the crosstalk between physical exercise and blood-brain barrier (BBB) permeability is presented.

  10. Exercise and retinal health

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Restorative neurology and neuroscience 2019 Brain scans and imaging

    Many ocular diseases (such as glaucoma, diabetic retinopathy, age-related macular degeneration, and traumatic eye injuries) can result in the degeneration of retinal cells and the subsequent loss of vision.

  11. Exercise and the Aging Brain: Considerations for Sex Differences

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Brain plasticity (Amsterdam, Netherlands) 2018-12-12 Prevention trials

    Engaging in targeted exercise interventions is a promising, non-pharmacological strategy to mitigate the deleterious effects of aging and disease on brain health.

  12. Exercise Improves Vascular Function, but does this Translate to the Brain?

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Brain plasticity (Amsterdam, Netherlands) 2018-12-12 Prevention trials

    The number of adults with Alzheimer's disease (AD) or related dementia is expected to increase exponentially.

  13. Comparison of multiple interventions for older adults with Alzheimer disease or mild cognitive impairment: A PRISMA-compliant network meta-analysis

    ✓ Peer-reviewed alzhub usefulness score 83 out of 100. Medicine 2018-05-01 Cognitive tests and assessment

    As the first NMA comparing different interventions for AD and MCI, our study suggests that PE and CCT might have a significant improvement in cognition and neuropsychiatric symptoms respectively.

  14. Routine Assessment and Promotion of Physical Activity in Healthcare Settings: A Scientific Statement From the American Heart Association

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Circulation 2018-04-04 Prevention trials

    Physical inactivity is one of the most prevalent major health risk factors, with 8 in 10 US adults not meeting aerobic and muscle-strengthening guidelines, and is associated with a high burden of cardiovascular disease.

  15. Can Exercise Improve Cognitive Symptoms of Alzheimer's Disease?

    ✓ Peer-reviewed alzhub usefulness score 82 out of 100. Journal of the American Geriatrics Society 2018-01-24 Prevention trials

    Exercise interventions were performed 3.4 ± 1.4 days per week at moderate intensity (3.7 ± 0.6 metabolic equivalents) for 45.2 ± 17.0 minutes per session for 18.6 ± 10.0 weeks and consisted primarily of aerobic exercise (65%).

  16. Effects of Resistance Exercise Training on Cognitive Function and Physical Performance in Cognitive Frailty: A Randomized Controlled Trial

    ✓ Peer-reviewed alzhub usefulness score 79 out of 100. The journal of nutrition, health & aging 2018-01-01 Digital health tools

    Our findings indicate that high-speed resistance exercise training approaches are effective in improving cognitive function and physical performance in older adults with cognitive frailty.

  17. Positive effects of combined cognitive and physical exercise training on cognitive function in older adults with mild cognitive impairment or dementia: A meta-analysis

    ✓ Peer-reviewed alzhub usefulness score 66 out of 100. Ageing research reviews 2017-09-12 Prevention trials

    Combined cognitive and physical exercise interventions have potential to elicit cognitive benefits in older adults with mild cognitive impairment (MCI) or dementia.

  18. Motor function deficits in the 12 month-old female 5xFAD mouse model of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Behavioural brain research 2017-09-07 Risk factors

    Motor problems occur early in some patients with Alzheimer's disease (AD) and as the disease progresses many patients develop motor dysfunction.

  19. Practical applications of physical activity for successful cognitive aging

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. JAAPA : official journal of the American Academy of Physician Assistants 2017-08 Prevention trials

    As patients lose cognitive function, they lose autonomy and increasingly use fiscal, social, and medical resources.

  20. Physical Activity and Alzheimer's Disease: A Systematic Review

    ✓ Peer-reviewed alzhub usefulness score 66 out of 100. The journals of gerontology. Series A, Biological sciences and medical sciences 2017-06-01 Prevention trials

    The current literature includes several studies investigating the association between physical activity and risk of Alzheimer's disease (AD).

  21. Physical Activity, Brain Volume, and Dementia Risk: The Framingham Study

    ✓ Peer-reviewed alzhub usefulness score 69 out of 100. The journals of gerontology. Series A, Biological sciences and medical sciences 2017-06-01 Prevention trials

    Low physical activity is associated with a higher risk for dementia in older individuals, suggesting that a reduced risk of dementia and higher brain volumes may be additional health benefits of maintaining physical activity into old age.

  22. Impact of Physical Activity on Cognitive Decline, Dementia, and Its Subtypes: Meta-Analysis of Prospective Studies

    ✓ Peer-reviewed alzhub usefulness score 69 out of 100. BioMed research international 2017-02-07 Prevention trials

    The association of physical activity with dementia and its subtypes has remained controversial in the literature and has continued to be a subject of debate among researchers.

  23. The concurrent validity and reliability of the Leg Motion system for measuring ankle dorsiflexion range of motion in older adults

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. PeerJ 2017-01-03 Cognitive tests and assessment

    Dorsiflexion ROM limitation is associated with ankle injuries, foot pain, lower limb disorders, loss of balance, gait control disorders and fall risk in older adults.

  24. Exercise Training and Functional Connectivity Changes in Mild Cognitive Impairment and Healthy Elders

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Journal of Alzheimer's disease : JAD 2017 Brain scans and imaging

    A linear mixed effects model revealed a significant interaction in the right parietal lobe: the MCI group showed increased connectivity while the healthy elders showed decreased connectivity.

  25. Personalising exercise recommendations for brain health: considerations and future directions

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. British journal of sports medicine 2016-11-17 Prevention trials

    The societal value of strategies that delay the onset and progression of dementia cannot be overstated.

  26. Neuroplasticity and Clinical Practice: Building Brain Power for Health

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Frontiers in psychology 2016-07-26 Cognitive tests and assessment

    The focus of this review is on driving neuroplasticity in a positive direction using evidence-based interventions that also have the potential to improve general health.

  27. [Exercise and Physical Activity for Dementia Prevention]

    ✓ Peer-reviewed alzhub usefulness score 54 out of 100. Brain and nerve = Shinkei kenkyu no shinpo 2016-07 Prevention trials

    The effects of exercise and physical activity on cognitive function and brain health have been established by longitudinal and intervention studies.

  28. Exercise for Individuals with Lewy Body Dementia: A Systematic Review

    ✓ Peer-reviewed alzhub usefulness score 77 out of 100. PloS one 2016-06-03 Prevention trials

    111,485 articles were initially retrieved; 288 full articles were reviewed and 89.6% subsequently deemed ineligible due to exclusion of participants with co-existence of dementia and Parkinsonism.

  29. Gait variability in people with neurological disorders: A systematic review and meta-analysis

    ✓ Peer-reviewed alzhub usefulness score 72 out of 100. Human movement science 2016-03-26 Digital health tools

    There has been growing evidence showing gait variability provides unique information about gait characteristics in neurological disorders.

  30. Poor Gait Performance and Prediction of Dementia: Results From a Meta-Analysis

    ✓ Peer-reviewed alzhub usefulness score 69 out of 100. Journal of the American Medical Directors Association 2016-02-04 Digital health tools

    This meta-analysis provides evidence that poor gait performance predicts dementia.

  31. Moderate-to-High Intensity Physical Exercise in Patients with Alzheimer's Disease: A Randomized Controlled Trial

    ✓ Peer-reviewed alzhub usefulness score 72 out of 100. Journal of Alzheimer's disease : JAD 2016-01-01 Prevention trials

    This is the first randomized controlled trial with supervised moderate-to-high intensity exercise in patients with mild AD.

  32. Motor-Cognitive Dual-Task Training in Persons With Neurologic Disorders: A Systematic Review

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Journal of neurologic physical therapy : JNPT 2015-07-01 Digital health tools

    The inclusion criteria of the studies reviewed limited the diagnostic groups included.

  33. Protective Effects of Physical Exercise in Alzheimer's Disease and Parkinson's Disease: A Narrative Review

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Journal of clinical neurology (Seoul, Korea) 2015-07-01 Prevention trials

    Alzheimer's disease (AD) and Parkinson's disease (PD) are devastating, frequent, and still incurable neurodegenerative diseases that manifest as cognitive and motor disorders.

  34. Cognitive-motor dual-task training was more beneficial than single-task training alone in improving broader domains of cognitive functions of elderly persons, and the improvement was not directly due to modulating Aβ metabolism.

  35. Voluntary Running Attenuates Memory Loss, Decreases Neuropathological Changes and Induces Neurogenesis in a Mouse Model of A lzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Brain Pathology 2015-03-11 Biomarkers

    Alzheimer's disease (AD) is a neurodegenerative disorder characterized by loss of memory and cognitive abilities, and the appearance of amyloid plaques composed of the amyloid-β peptide (Aβ) and neurofibrillary tangles formed of tau protein.

  36. Pain and decreased cognitive function negatively impact physical functioning in older adults with knee osteoarthritis

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Pain medicine (Malden, Mass.) 2014-07-08 Cognitive tests and assessment

    Worse pain scores and executive function scores were associated with worse physical function in older adults with painful knee OA.

  37. Does physical activity prevent cognitive decline and dementia?: A systematic review and meta-analysis of longitudinal studies

    ✓ Peer-reviewed alzhub usefulness score 72 out of 100. BMC public health 2014-05-27 Prevention trials

    Longitudinal observational studies show an association between higher levels of physical activity and a reduced risk of cognitive decline and dementia.

  38. Effects of combined cognitive and exercise interventions on cognition in older adults with and without cognitive impairment: a systematic review

    ✓ Peer-reviewed alzhub usefulness score 64 out of 100. Ageing research reviews 2014-03-12 Prevention trials

    Global concern on the potential impact of dementia is mounting.

  39. A review of the effects of physical activity and exercise on cognitive and brain functions in older adults

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. Journal of aging research 2013-09-11 Prevention trials

    Studies supporting the notion that physical activity and exercise can help alleviate the negative impact of age on the body and the mind abound.

  40. Bridging animal and human models of exercise-induced brain plasticity

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Trends in cognitive sciences 2013-09-09 Prevention trials

    Significant progress has been made in understanding the neurobiological mechanisms through which exercise protects and restores the brain.

  41. The effect of exercise training on cognitive function in older adults with mild cognitive impairment: a meta-analysis of randomized controlled trials

    ✓ Peer-reviewed alzhub usefulness score 74 out of 100. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 2013-07-03 Prevention trials

    There is very limited evidence that exercise improves cognitive function in individuals with MCI, although published research is of moderate quality and inconclusive due to low statistical power.

  42. Professional fighters brain health study: rationale and methods

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. American journal of epidemiology 2013-06-04 Cognitive tests and assessment

    Repetitive head trauma is a risk factor for Alzheimer's disease and is the primary cause of chronic traumatic encephalopathy.

  43. Physical activity, brain plasticity, and Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. Archives of medical research 2012-10-16 Prevention trials

    In this review we summarize the epidemiological, cross-sectional, and interventional studies examining the association between physical activity and brain volume, function, and risk for Alzheimer's disease.

  44. Physical activity and amyloid-β plasma and brain levels: results from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. Molecular psychiatry 2012-08-14 Prevention trials

    Previous studies suggest physical activity improves cognition and lowers Alzheimer's disease (AD) risk.

  45. Exercise counteracts declining hippocampal function in aging and Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neurobiology of disease 2012-06-30 Prevention trials

    Alzheimer's disease (AD) afflicts more than 5.4 million Americans and ranks as the most common type of dementia (Thies and Bleiler, 2011), yet effective pharmacological treatments have not been identified.

  46. Association of lifetime cognitive engagement and low β-amyloid deposition

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Archives of neurology 2012-05-01 Brain scans and imaging

    Individuals with greater early- and middle-life cognitive activity had lower [(11)C]PiB uptake.

  47. Gait and cognition: the relationship between gait stability and variability with executive function in persons with and without dementia

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Gait & posture 2011-10-02 Digital health tools

    Besides cognitive decline, dementia is characterized by gait changes and increased fall risk, also in early stages of the disease.

  48. Gait assessment in mild cognitive impairment and Alzheimer's disease: the effect of dual-task challenges across the cognitive spectrum

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Gait & posture 2011-09-22 Digital health tools

    Gait impairment is a prominent falls risk factor and a prevalent feature among older adults with cognitive impairment.

  49. Six-month walking program changes cognitive and ADL performance in patients with Alzheimer

    ✓ Peer-reviewed alzhub usefulness score 64 out of 100. American journal of Alzheimer's disease and other dementias 2011-08-17 Health systems and care delivery

    Motor inactivity is typical in the later stages of Alzheimer's disease although there is evidence that physical exercise can reduce depression and enhance performance of daily activities.

  50. Associations between physical performance and executive function in older adults with mild cognitive impairment: gait speed and the timed "up & go" test

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Physical therapy 2011-05-26 Digital health tools

    Physical performance speed was associated with executive function after adjusting for age, sex, and age-related factors in sedentary older adults with aMCI.

From across this tag

6 of the 125 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 6. The same 6 appear here every time.

All topic tags with their study counts