Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
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In this meta-analysis, the usage of hearing restorative devices by participants with hearing loss was associated with a 19% decrease in hazards of long-term cognitive decline.
Why it matters
This meta-analysis of 31 studies with 137,484 participants found that hearing aid and cochlear implant use was associated with a 19% decrease in hazards of long-term cognitive decline and a 3% improvement in short-term cognitive test scores. It suggests hearing restoration may help reduce cognitive decline, but it does not show a treatment or cure for dementia.
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Despite older racial and ethnic minorities (REMs) being more likely to develop dementia they are underrepresented in clinical trials focused on neurological disorders.
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Early identification and management of OD should consider geriatric syndromes and neurogenic comorbidities to prevent malnutrition and pneumonia and reduce mortality in adults aged 60 years and older.
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Overall, mental and neurological disorders were associated with a significant high risk of infection (pre-existing mental: OR 1·67, 95% CI 1·12-2·49; and pre-existing neurological: 2·05, 1·58-2·67), illness severity (mental: pre-existing, 1·40, 1·25-1·57; sequelae, 4·85, 2·53-9·32; neurological: pre-existing, 1·43, 1·09-1·88; sequelae, 2·17, 1·45-3·24), and mortality (mental: pre-existing, 1·47, 1·26-1·72; neurological: pre-existing, 2·08, 1·61-2·69; sequelae, 2·03, 1·66-2·49) from COVID-19.
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The CAIDE (Cardiovascular Risk Factors, Aging and Dementia) Risk Score is a validated tool estimating dementia risk.
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Backgrounds To investigate the efficacy of a community group-based intervention among community-dwelling older adults with physio-cognitive decline syndrome (PCDS).
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This project will be part of the World-Wide FINGERS (Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability) Network, of which common identifiable data will be shared and harmonized among the consortia.
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WMH were associated with increased risk of cognitive dysfunction and could become a neuroimaging indicator of dementia.
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Our results revealed that both TMS and tDCS elicit a small trans-diagnostic effect on working memory, tDCS also improved attention/vigilance across diagnoses.
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We found no data on our primary outcome of global cognitive function.
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Our educational intervention increased ACP initiation, and the number of nonmedical and medical preferences discussed.
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We found no studies on our primary outcome of global cognitive function.
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Low cognitive and brain reserve and limited cognitive stimulation are associated with increased risk of dementia.
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Emergency department (ED)-initiated palliative care has been shown to improve patient-centred outcomes in older adults with serious, life-limiting illnesses.
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Twenty-three articles were included in the systematic review, and 21 in the meta-analysis.
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Of 2846 articles identified, 94 studies were eligible, with up to 14 529 participants for WMH, 16 012 participants for BI, 15 693 participants for CMB, and 4587 participants for PVS.
Why it matters
This 2019 systematic review and meta-analysis pooled 94 prospective cohort studies to ask whether four MRI signs of "covert" vascular brain injury (white matter hyperintensities, covert brain infarcts, microbleeds and perivascular spaces) predict later stroke, dementia or death. The one result kept in alzhub's copy is that extensive white matter hyperintensity burden went with a higher rate of stroke (hazard ratio 2.45; 95% CI 1.93–3.12), and the authors conclude the markers "have major clinical significance". The studies were observational and no treatment was tested, so it does not show that preventing these scan changes prevents stroke or dementia.
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Alzheimer's disease is the most common cause of dementia in older people.
Why it matters
This Cochrane review, "an updated version of a review first published in 1998", set out to assess the "clinical efficacy and safety of donepezil in people with mild, moderate or severe dementia due to Alzheimer's disease", to compare doses, and to assess effects on "healthcare resource use and costs". Donepezil is a cholinesterase inhibitor, which the review describes as a "symptomatic treatment" that boosts the brain chemical acetylcholine; it is not presented as a cure or prevention. The record we hold contains only the review's background and aims, not its results, so see the original for what it found.
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White matter hyperintensities are associated with an increased risk of all-dementia and Alzheimer's disease in the general population.
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451 (11%) of 4241 beds in ten hospitals were included in the analyses.
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Data collection and analysis Two review authors independently assessed for inclusion all the potential studies we identified as a result of the search strategy.
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A nurse-led, multidomain intervention did not result in a reduced incidence of all-cause dementia in an unselected population of older people.
Why it matters
This randomised controlled trial found that a nurse-led, multidomain vascular care intervention did not reduce the incidence of all-cause dementia in an unselected population of older people. The intervention did not work for preventing dementia in this trial.
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MCR is associated with an increased risk of falls.
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Main results We included two trials with 26,340 participants aged 40 to 82 years of whom 11,610 were aged 70 or older.
Why it matters
This review included two trials with 26,340 participants but judged the results unsuitable for meta-analysis because the studies assessed cognitive function at different times using different scales. It does not provide evidence that statins prevent dementia.
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Though still small, the current body of RCT evidence indicates that CT is safe and modestly effective on cognition in patients with mild to moderate PD.
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Lower intakes of nutrient-dense foods and higher intakes of unhealthy foods are each independently associated with smaller left hippocampal volume.
From across this topic
10 of the 7,967 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- Impact of fee-revision policy for gastrostomy on its implementation among older adults with dementia in Japan
- Damage to lipids, proteins, DNA, and RNA in mild cognitive impairment
- Summary of the evidence on modifiable risk factors for cognitive decline and dementia: A population-based perspective
- Choice of Received Long-Term Care – Individual Responses to Regional Nursing Home Provisions
- Eating patterns are associated with cognitive function in the elderly at risk of metabolic syndrome from rural areas
- New criteria for frontotemporal dementia syndromes: clinical and pathological diagnostic implications
- P3‐509: FEASIBILITY OF A DEMENTIA VILLAGE IN SINGAPORE
- Down syndrome: A curative prospect?
- Post-stroke cognitive impairment: epidemiology, mechanisms and management
- Evidenzlage zu Advance Care Planning bei Menschen mit Demenz – Ein systematisches Review (2017–2023)