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Statins for the prevention of dementia
McGuinness B, Craig D, Bullock R, Passmore P.. The Cochrane database of systematic reviews, 2016-01-04
Topic: Risk, prevention and care in population studies
Main results We included two trials with 26,340 participants aged 40 to 82 years of whom 11,610 were aged 70 or older. Both studies assessed cognitive function, but at different times using different scales, so we judged the results unsuitable for a meta-analysis.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
McGuinness, B., Craig, D., Bullock, R., & Passmore, P. (2016). Statins for the prevention of dementia. The Cochrane database of systematic reviews. https://doi.org/10.1002/14651858.cd003160.pub3
Vancouver
McGuinness B, Craig D, Bullock R, Passmore P. Statins for the prevention of dementia. The Cochrane database of systematic reviews. 2016. doi:10.1002/14651858.cd003160.pub3. PMID: 26727124.
BibTeX
@article{mcguinness2016-26727124,
author = {McGuinness, B. and Craig, D. and Bullock, R. and Passmore, P.},
title = {{Statins for the prevention of dementia}},
journal = {The Cochrane database of systematic reviews},
year = {2016},
doi = {10.1002/14651858.cd003160.pub3},
pmid = {26727124},
url = {https://doi.org/10.1002/14651858.cd003160.pub3}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- Main results We included two trials with 26,340 participants aged 40 to 82 years of whom 11,610 were aged 70 or older.
- Both studies assessed cognitive function, but at different times using different scales, so we judged the results unsuitable for a meta-analysis.
Why it matters
This review included two trials with 26,340 participants but judged the results unsuitable for meta-analysis because the studies assessed cognitive function at different times using different scales. It does not provide evidence that statins prevent dementia.
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Study details
- Study designmeta-analysis
- Participants26,340
- Effect sizeOR 0.94
- Evidence strengthHigh
How this study scored 79/100
Published in a leading specialty journal, and it is a meta-analysis pooling many studies. We have no data on times cited, citations per year, impact for its field and year, cited by studies here and still being cited, so those were left out: it earned 57 of the 72 points we could judge it on, which is 79 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (The Cochrane database of systematic reviews) |
| Journal's citation record | 3 / 4 | Cochrane Database of Systematic Reviews: journal h-index 468 (OpenAlex, 2026-10-29) |
| Study design | 12 / 12 | A meta-analysis pooling many studies |
| Strength of evidence | 5 / 5 | Rated “high” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2016 — within 20 year(s) of the newest study here |
| Sample size | 4 / 4 | 26,340 participants |
| Effect reported | 3 / 3 | Effect reported with a statistic (interval, p-value, ratio or similar) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | A review of other studies — randomisation is not credited here |
| Times cited | — / 7 | Citation count not trusted: 10 of 31 library studies citing it were published more than a year before it - a sign OpenAlex merged several works under this DOI — left out of this score |
| Citations per year | — / 5 | Citation count not trusted (see above) — left out of this score |
| Impact for its field and year | — / 6 | Citation count not trusted (see above) — left out of this score |
| Cited by studies here | — / 6 | Library citations not trusted (see above) — left out of this score |
| Still being cited | — / 4 | Citation count not trusted (see above) — left out of this score |
| Senior author's track record | 3 / 4 | Last-listed author Peter Passmore: h-index 57 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Queen's University Belfast: institution h-index 712 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 3 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 26727124) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 57 / 72 | Scored on 15 of 20 parts. We have no data for the rest, so they are left out: 57 of the 72 points we could judge it on is 79 out of 100. |
| Total | 79 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1002/14651858.cd003160.pub3
- PubMed: 26727124
- Original source →
- Free full text: PubMed Central →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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