Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
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MET-FINGER aims to test a FINGER 2.0 multimodal intervention, combining an updated FINGER multidomain lifestyle intervention with metformin, where appropriate, in an APOE ε4-enriched population of older adults (60-79 years) at increased risk of dementia.
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Portable, low‐field imaging could be useful for identifying moderate to severe WMHs.
Why it matters
Portable bedside MRI in the emergency department detected white matter hyperintensities with strong agreement between raters, and over half of enrolled patients had them. This is about detecting a marker linked to vascular cognitive impairment, not about treating or preventing Alzheimer's disease.
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Greater adherence to hPDI, MDS, RFS, and MIND was individually associated with larger brain volumes in specific regions.
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Numerous studies have investigated the impacts of common types of chronic pain (CP) on patients' cognitive function and observed that CP was associated with later dementia.
Why it matters
This study examined whether chronic pain at multiple body sites is associated with higher dementia risk, cognitive decline and hippocampal atrophy compared with single-site pain or no pain. It is observational and does not test any treatment or prevention.
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Nowadays, Artificial Intelligence (AI) and machine learning (ML) have successfully provided automated solutions to numerous real-world problems.
Why it matters
This systematic review of machine learning for dementia prediction found that image data driven models yielded promising results compared with clinical feature-based and voice data. It concerns automated diagnostic systems, not treating, curing, or preventing Alzheimer's disease.
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The association between patterns of physical/mental activity and dementia and how it is affected by disease susceptibility remains unknown.
Why it matters
This UK Biobank cohort followed 501,376 people without dementia, recruited in 2006-2010, until the end of 2019. It looked at whether everyday physical activity (leisure, housework, transport) and mental activity (intelligence, social contact, electronic-device use), each reported once by questionnaire, were associated with later dementia, and whether disease susceptibility changed that association. Its findings are associations from a single snapshot of habits, so they cannot show that any activity prevents dementia.
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62/100
Although recent studies have demonstrated the prognostic utility of plasma biomarkers of Alzheimer pathology or neurodegeneration, such as pTau-181 and NF-L, whether other plasma biomarkers can further improve prediction of cognitive decline is undetermined.
Why it matters
A machine learning model using plasma proteins linked to inflammation and vascular injury, along with age, sex, education and baseline cognition, was developed to distinguish people with mild cognitive impairment who progressed from those who stayed stable. This suggests a plasma profile could help predict cognitive decline, but it is a prognostic tool and not a treatment.
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Delirium is a distressing neurocognitive disorder recently linked to sleep disturbances.
Why it matters
This study found that poor sleep in middle and older age was linked to a higher risk of delirium during hospitalization. It is about delirium, not Alzheimer's disease, and does not test any treatment, cure, or prevention for dementia.
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This study showed that some deficits on IC domains, as measured by simple screening tests and questions, can be associated with higher healthcare costs.
Why it matters
This study found that certain deficits in intrinsic capacity domains, such as vision, locomotion and psychological capacity, were associated with higher healthcare costs in older adults. It is about healthcare costs and screening, not about treating, curing or preventing Alzheimer disease.
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Understanding the mental health consequences of child maltreatment at different life stages is important in accurately quantifying the burden of maltreatment.
Why it matters
This study investigated whether experiencing maltreatment as a child is linked to developing mental disorders in middle and older age. It also looked at what factors might explain or influence that connection, which is relevant to understanding long-term mental health risks.
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In tandem with the ever-increasing aging population in low and middle-income countries, the burden of dementia is rising on the African continent.
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The study consists of 25,186 patients (mean age = 63.0, interquartile range [IQR] of age = 15.1 years, male = 50%).
Why it matters
In diabetic patients, higher variability in HbA1c and lipid measures was associated with increased risks of complications including incident dementia. This identifies a possible risk marker, not a treatment, cure, or prevention for Alzheimer's disease.
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The global burden associated with physical inactivity is substantial.
Why it matters
This global analysis estimated that 8.1% of dementia cases could be attributed to physical inactivity if it were eliminated. This is an estimate of how much disease might be avoided, not proof that increasing activity prevents dementia.
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In the present study, higher adherence to MeDi was associated with a reduced risk for dementia and cognitive decline in a traditional Mediterranean population.
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Compared with 2000, the adjusted odds ratio (AOR) for the increase in NIV use was 2.63 (95% CI, 2.46-2.82; % receipt: 0.8% vs 2.0%) for 2005 and 11.84 (95% CI, 11.11-12.61; % receipt: 0.8% vs 7.1%) for 2017.
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Importance and objective Conducting advance care planning (ACP) conversations with people with dementia and their relatives contributes to providing care according to their preferences.
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Interventions had, on average, a significant, small-to-moderate effect on the improvement of ability/knowledge, subjective well-being, burden, depression, and the caregiver's anxiety as well as symptoms of the care recipient.
Why it matters
This meta-analysis of 282 controlled studies found that dementia caregiver interventions had small-to-moderate effects on ability and knowledge, subjective well-being, burden, depression, caregiver anxiety, and care recipient symptoms. No mean effect was found for reducing the risk of institutionalization.
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The testing conditions and the accessibility of telemedicine yield inconclusive results as to whether telemedicine can improve the management of dementia in geriatric individuals.
Why it matters
This systematic review found mixed results on whether cognitive test performance differs between in-person and telemedicine assessment for rural patients with dementia, though patients and physicians generally reported satisfaction. It addresses how care is delivered, not whether Alzheimer's disease can be treated, cured, or prevented.
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At the beginning of June 2020, there were nearly 7 million reported cases of coronavirus disease 2019 (COVID-19) worldwide and over 400,000 deaths in people with COVID-19.
Why it matters
This study examined which other medical conditions were linked to death in adults with COVID-19. It does not address Alzheimer's disease treatment, cure or prevention.
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The Namaste Care Family program is dominant over usual care and, thus, cost-effective, although statistical uncertainty was considerable.
Why it matters
The Namaste Care Family programme for nursing home residents with advanced dementia was more effective than usual care on some quality-of-life measures, but the confidence intervals included no difference. This concerns quality of life and cost, not curing or preventing Alzheimer's disease.
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Healthy lifestyles are promising targets for prevention of cognitive aging, yet the optimal time windows for interventions remain unclear.
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This text discusses the characterisation of subjective cognitive decline (SCD), a term conceived in 2014 to describe cognitively unimpaired individuals who are concerned about reduced cognitive function and seek medical help.
Why it matters
Discusses the characterisation of subjective cognitive decline.
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62/100
Understanding how dementia risk is impacted by timing of smoking cessation has public health implications for prevention efforts.
Why it matters
In the Atherosclerosis Risk in Communities study, researchers investigated how cigarette smoking and the timing of quitting relate to dementia risk and cognitive decline in 13,002 men and women aged 52 to 75. The study examined whether when a person quits smoking affects their later risk of dementia.
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Benefit-finding reduces depressive symptoms as well as global burden in the long-term and increases psychological well-being in the medium-term.
Why it matters
In this trial of 129 family caregivers of people with mild-to-moderate Alzheimer disease, a group benefit-finding intervention reduced depressive symptoms, with a strong initial effect that leveled out but was maintained up to 10 months compared with two forms of psychoeducation. This addresses caregiver well-being rather than treating, curing, or preventing Alzheimer's disease itself.
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The most common reasons for hospitalization in LBD are potentially modifiable.
From across this topic
10 of the 7,967 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- Problem-Solving Therapy in the Elderly
- Validation of the new interpretive guidelines for the clinical dementia rating scale sum of boxes score in the national Alzheimer's coordinating center database
- Age at diabetes diagnosis, genetic susceptibility and dementia risk: a prospective study of 13,126 participants from the UK Biobank
- Early MoCA predicts long-term cognitive and functional outcome and mortality after stroke
- Improving Early Detection of Dementia: Extra Trees-Based Classification Model Using Inter-Relation-Based Features and K-Means Synthetic Minority Oversampling Technique
- Longitudinal change of biomarkers in cognitive decline
- Risk of dementia in elderly patients with the use of proton pump inhibitors
- Quantitative gait dysfunction and risk of cognitive decline and dementia
- Readability of AI-Generated Patient Information Leaflets on Alzheimer’s, Vascular Dementia, and Delirium
- Feasibility and Preliminary Efficacy of an Intervention to Support Long-Distance Family Caregivers of Older Adults with Dementia