Get help now — free helplines

You can call any of these for free. You do not need a diagnosis, an appointment, or a crisis to call — questions and plain exhaustion are reasons enough.

  • Alzheimer's Association 24/7 Helpline 800-272-3900 24 hours a day, 365 days a year Free, confidential support and information for people with dementia, caregivers, families and the public. Master's-level clinicians. Also Spanish.
  • 988 Suicide & Crisis Lifeline 988 24/7 Call or text 988, or chat at 988lifeline.org. For anyone in emotional distress or a mental-health crisis, including caregivers.
  • Alzheimer's Foundation of America (AFA) Helpline 866-232-8484 9:00 am - 9:00 pm ET, seven days a week Licensed social workers providing support, info and referrals. Also text message and web chat. Text: 646-586-5283

In a medical emergency, call 911. More numbers, and what each line does, on the help page.

Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.

Highest usefulness score first. Studies without a score come last.

  1. Vitamin and mineral supplementation for maintaining cognitive function in cognitively healthy people in mid and late life

    ✓ Peer-reviewed alzhub usefulness score 69 out of 100. The Cochrane database of systematic reviews 2018-12-17 Cognitive tests and assessment

    Vitamins and minerals play multiple functions within the central nervous system which may help to maintain brain health and optimal cognitive functioning.

    Why it matters

    This review evaluated whether vitamin and mineral supplements affect cognitive function in cognitively healthy people aged 40 or older. The provided text does not report the findings, so it is unknown whether supplementation helps maintain cognition or prevents dementia.

  2. Modifiable lifestyle risk factors have been identified as playing a major role in the development of dementia; hence, interventions addressing these risk factors represent a significant opportunity to reduce the number of people developing dementia.

  3. Early MoCA predicts long-term cognitive and functional outcome and mortality after stroke

    ✓ Peer-reviewed alzhub usefulness score 69 out of 100. Neurology 2018-10-17 Cognitive tests and assessment

    MoCA was administered to 274 patients from 2 prospective hospital-based cohort studies in Germany (n = 125) and France (n = 149).

    Why it matters

    This cohort study examined whether the Montreal Cognitive Assessment given within 7 days after stroke predicts long-term cognitive and functional outcome and mortality in 274 patients. It is about predicting outcomes after stroke and does not test any treatment, cure, or prevention for Alzheimer's disease.

  4. Twelve studies with 195 PwD and four with 53 PwMCI met the inclusion criteria.

  5. Quality of life of people with advanced dementia living in nursing homes is often suboptimal.

  6. Technology-based cognitive training and rehabilitation interventions for individuals with mild cognitive impairment: a systematic review

    ✓ Peer-reviewed alzhub usefulness score 69 out of 100. BMC geriatrics 2018-09-15 Prevention trials

    Technology-based cognitive training and rehabilitation interventions show promise, but the findings were inconsistent due to the variations in study design.

  7. Estimating the survival of elderly patients diagnosed with dementia in Taiwan: A longitudinal study

    ✓ Peer-reviewed alzhub usefulness score 69 out of 100. PloS one 2018-07-25 End-of-life care

    The survival prediction model demonstrated moderate accuracy for predicting mortality at 6 and 12 months before death in elderly patients with dementia.

  8. Effects of creative expression therapy for older adults with mild cognitive impairment at risk of Alzheimer's disease: a randomized controlled clinical trial

    ✓ Peer-reviewed alzhub usefulness score 69 out of 100. Clinical interventions in aging 2018-07-24 Prevention trials

    CrExp therapy has greater positive effects on cognitive functions and daily living ability than standard cognitive training.

  9. Interventions for subjective cognitive decline: systematic review and meta-analysis

    ✓ Peer-reviewed alzhub usefulness score 69 out of 100. BMJ open 2018-07-19 Prevention trials

    There is a lack of high-quality research in this field.

  10. Cognitive function trajectories and their determinants in older people: 8 years of follow-up in the English Longitudinal Study of Ageing

    ✓ Peer-reviewed alzhub usefulness score 69 out of 100. Journal of epidemiology and community health 2018-04-24 Risk factors

    The potential determinants of cognitive decline identified in this study, in particular modifiable risk factors, should be tested in the context of randomised controlled trials.

    Why it matters

    In over 10,000 older people followed for 8 years, women showed less cognitive decline than men, and poor physical function, physical inactivity and smoking were linked to faster decline in some cognitive domains. The study describes factors associated with cognitive decline but does not test any treatment or cure for Alzheimer's disease.

  11. Unrecognized Cardiovascular Emergencies Among Medicare Patients

    ✓ Peer-reviewed alzhub usefulness score 69 out of 100. JAMA internal medicine 2018-04-01 End-of-life care

    There were 1 561 940 patients, including 17 963 hospitalized for ruptured AAA, 304 980 for AMI, 1 181 648 for stroke, 19 675 for aortic dissection, and 37 674 for SAH.

  12. The Cost-Effectiveness of Using PARO, a Therapeutic Robotic Seal, to Reduce Agitation and Medication Use in Dementia: Findings from a Cluster-Randomized Controlled Trial

    ✓ Peer-reviewed alzhub usefulness score 69 out of 100. Journal of the American Medical Directors Association 2018-01-09 Digital health tools

    The plush toy used in this study offered marginally greater value for money than PARO in improving agitation.

    Why it matters

    This randomized controlled trial found no statistically significant between-group differences in agitation levels after using PARO, a plush toy, or usual care. PARO was $50.47 more expensive per resident than usual care, so it did not show a significant benefit for reducing agitation.

  13. Association of Long-Term Adherence to the MIND Diet with Cognitive Function and Cognitive Decline in American Women

    ✓ Peer-reviewed alzhub usefulness score 69 out of 100. The journal of nutrition, health & aging 2018-01-01 Prevention trials

    Long-term adherence to the MIND diet was moderately associated with better verbal memory in later life.

  14. Hospice Care for Patients With Dementia in the United States: A Longitudinal Cohort Study

    ✓ Peer-reviewed alzhub usefulness score 69 out of 100. Journal of the American Medical Directors Association 2017-11-16 End-of-life care

    Patients with dementia are significantly more likely to be disenrolled from hospice following a long enrollment period compared with patients without dementia.

  15. Cognitive Flexibility Training: A Large-Scale Multimodal Adaptive Active-Control Intervention Study in Healthy Older Adults

    ✓ Peer-reviewed alzhub usefulness score 69 out of 100. Frontiers in human neuroscience 2017-11-01 Prevention trials

    As aging is associated with cognitive decline, particularly in the executive functions, it is essential to effectively improve cognition in older adults.

  16. Intradialytic Cognitive and Exercise Training May Preserve Cognitive Function

    ✓ Peer-reviewed alzhub usefulness score 69 out of 100. Kidney international reports 2017-08-19 Prevention trials

    Preliminary findings of our pilot study suggested that cognitive decline in psychomotor speed and executive function is possibly prevented by intradialytic CT and ET.

  17. Mediterranean diet and cognitive health: Initial results from the Hellenic Longitudinal Investigation of Ageing and Diet

    ✓ Peer-reviewed alzhub usefulness score 69 out of 100. PloS one 2017-08-01 Prevention and risk

    Our results suggest that adherence to the MeDi is associated with better cognitive performance and lower dementia rates in Greek elders.

    Why it matters

    This longitudinal study found that each unit increase in the Mediterranean dietary score was associated with a lower likelihood of dementia and better performance in some cognitive domains. The findings support the Mediterranean diet as potentially protective against cognitive decline in a Greek population.

  18. Our findings suggest that older patients with reduced preoperative cognitive functions or who develop postoperative delirium are at risk of developing dementia within 5 years after cardiac surgery.

  19. Uric acid and incident dementia over 12 years of follow-up: a population-based cohort study

    ✓ Peer-reviewed alzhub usefulness score 69 out of 100. Annals of the rheumatic diseases 2017-07-28 Hippocampus size on brain scans

    Risk of dementia, especially vascular or mixed dementia, may be increased with high SUA levels in elderly people.

  20. A systematic review of the prevalence of comorbid cancer and dementia and its implications for cancer-related care

    ✓ Peer-reviewed alzhub usefulness score 69 out of 100. Aging & mental health 2017-07-18 End-of-life care

    There is a dearth of good-quality evidence investigating the cancer-dementia prevalence and its implications for successful cancer treatment.

  21. Effects of computerized cognitive training on neuroimaging outcomes in older adults: a systematic review

    ✓ Peer-reviewed alzhub usefulness score 69 out of 100. BMC geriatrics 2017-07-10 Prevention trials

    Of all studies included in this systematic review, results from the highest quality studies, which were two randomized controlled trials, demonstrated that multi-domain CCT could lead to increases in hippocampal functional connectivity.

  22. Depression as a modifiable factor to decrease the risk of dementia

    ✓ Peer-reviewed alzhub usefulness score 69 out of 100. Translational psychiatry 2017-05-02 Vascular contributions

    Depression is an accepted risk factor for dementia, but it is unclear if this relationship is causal.

  23. Virtual Reality for Management of Pain in Hospitalized Patients: Results of a Controlled Trial

    ✓ Peer-reviewed alzhub usefulness score 69 out of 100. JMIR mental health 2017-03-29 Vascular contributions

    Use of VR in hospitalized patients significantly reduces pain versus a control distraction condition.

  24. Dementia and delirium, the outcomes in elderly hip fracture patients

    ✓ Peer-reviewed alzhub usefulness score 69 out of 100. Clinical interventions in aging 2017-03-10 Clinical safety

    Elderly patients with a hip fracture are vulnerable for delirium, especially when the patient has dementia.

  25. Lifestyle for Brain Health (LIBRA): a new model for dementia prevention

    ✓ Peer-reviewed alzhub usefulness score 69 out of 100. International journal of geriatric psychiatry 2017-02-28 Prevention and risk

    Lifestyle for Brain Health (LIBRA) may help in identifying and monitoring risk status in dementia-prevention programmes, by targeting modifiable, lifestyle-related risk factors.

    Why it matters

    In 949 adults aged 50-81 from the Maastricht Ageing Study, followed for up to 16 years, each one-point rise in the LIBRA lifestyle-risk score was linked to a 19% higher risk of dementia and a 9% higher risk of cognitive impairment. The score predicted faster slowing of processing speed, but not decline in memory or executive function. The authors say it "may help in identifying and monitoring risk status" in prevention programmes. The study did not test whether changing these lifestyle factors lowers risk.

From across this topic

10 of the 7,967 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.

Other topics