This page is alzhub.org's plain-English summary of a published study, not the paper itself. It is generated from the record we hold for this study, sourced and linked below — check the original for the full text and methods.

46/100

✓ Peer-reviewed alzhub usefulness score 46 out of 100. Getting a diagnosis

Topic: Risk, prevention and care in population studies

We used cross-sectional data from the NHANES (National Health and Nutrition Examination Survey) from 1999 to 2018 linked to National Death Index records. We included participants with available data on self-reported and measured hypertension, hypercholesterolemia, diabetes, kidney disease, hearing impairment and overweight. Reliability was assessed using F1 scores, and used survey-weighted Cox-proportional hazards models evaluated associations with stroke- or dementia-related mortality. Reliability of self-reported risk factors was highest in overweight (F1 score 0.81, sensitivity 76%, specificity 77%) and diabetes (F1 score 0.71, sensitivity 77%, specificity 97%) and lowest for kidney disease (F1 score 0.25, sensitivity 16%, specificity 98%). Self-reported hypertension (hazard ratio [HR], 1.49 [95% CI, 1.14-1.94]) and diabetes (HR, 1.58 [95% CI, 1.18-2.12]) were associated with stroke-related mortality, comparable to measured risk factors. For dementia-related mortality, only measured hearing impairment (all dementia cases had hearing impairment at baseline) and both self-reported (HR, 0.50 [95% CI, 0.37-0.68]) and measured overweight (HR, 0.70 [95% CI, 0.52-0.93]) were associated. In conclusion, the reliability and validity of self-reported risk factors for stroke and dementia differ between risk factors. Although self-reported measures vary in their reliability, they perform equally as well as objective metrics for evaluating the risk of stroke- and dementia-related mortality.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Tack, R. W. P., Senff, J. R., Kimball, T. N., Prapiadou, S., Tan, B. Y., Yechoor, N., et al. (2025). Reliability and Validity of Self‐Reported Risk Factors for Stroke and Dementia. Journal of the American Heart Association. https://doi.org/10.1161/jaha.124.038730

Vancouver

Tack RWP, Senff JR, Kimball TN, Prapiadou S, Tan BY, Yechoor N, et al. Reliability and Validity of Self‐Reported Risk Factors for Stroke and Dementia. Journal of the American Heart Association. 2025. doi:10.1161/jaha.124.038730. PMID: 40118792.

BibTeX

@article{tack2025-40118792,
  author  = {Tack, Reinier W. P. and Senff, Jasper Rudolf and Kimball, Tamara N. and Prapiadou, Savvina and Tan, Benjamin Yong‐Qiang and Yechoor, Nirupama and Rosand, Jonathan M. and Singh, Sanjula and others},
  title   = {{Reliability and Validity of Self‐Reported Risk Factors for Stroke and Dementia}},
  journal = {Journal of the American Heart Association},
  year    = {2025},
  doi     = {10.1161/jaha.124.038730},
  pmid    = {40118792},
  url     = {https://doi.org/10.1161/jaha.124.038730}
}

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.

Key findings

We used cross-sectional data from the NHANES (National Health and Nutrition Examination Survey) from 1999 to 2018 linked to National Death Index records.
We included participants with available data on self-reported and measured hypertension, hypercholesterolemia, diabetes, kidney disease, hearing impairment and overweight.
Reliability was assessed using F1 scores, and used survey-weighted Cox-proportional hazards models evaluated associations with stroke- or dementia-related mortality.
Reliability of self-reported risk factors was highest in overweight (F1 score 0.81, sensitivity 76%, specificity 77%) and diabetes (F1 score 0.71, sensitivity 77%, specificity 97%) and lowest for kidney disease (F1 score 0.25, sensitivity 16%, specificity 98%).
Self-reported hypertension (hazard ratio [HR], 1.49 [95% CI, 1.14-1.94]) and diabetes (HR, 1.58 [95% CI, 1.18-2.12]) were associated with stroke-related mortality, comparable to measured risk factors.

Why it matters

This study examined the reliability and validity of self-reported risk factors for stroke and dementia-related mortality. It found that reliability varies between risk factors, and it does not report any treatment, cure, or prevention for Alzheimer's disease.

New to this subject? Start with our plain-English guide: Getting a diagnosis →

Study details

Study designcross-sectional
Evidence strengthLow

How this study scored 46/100

Published in a peer-reviewed journal, and it is a snapshot of people at one point in time. Scored zero for sample size, effect reported, studied in people and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Journal of the American Heart Association)
Journal's citation record	2 / 4	Journal of the American Heart Association: journal h-index 200 (OpenAlex, 2026-10-29)
Study design	4 / 12	A snapshot of people at one point in time
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	0 / 3	Not stated whether this was studied in people — scores zero (not stated in the record — scored 0)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	2 / 7	Cited 6 times (OpenAlex, 2026-10-10)
Citations per year	1 / 5	2.0 citations a year over 3 year(s) since 2025
Impact for its field and year	3 / 6	Cited 3.9× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	1 / 4	Cited 6 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	3 / 4	Last-listed author Christopher D. Anderson: h-index 65 (OpenAlex, whole career)
Institution's track record	3 / 3	Broad Institute: institution h-index 2,541 (OpenAlex)
Multi-centre collaboration	1 / 3	OpenAlex lists 3 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 40118792)
Free to read	2 / 2	Free to read
Total	46 / 100	—

What each of these 20 components measures, and what this score is not →

Read the original

Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).

Studies this one cites

Referenced by this study and also in the alzhub library, so you can read them here.

Related studies in Getting a diagnosis

Also tagged “biobank”

1,084 studies in the library carry the topic tag “biobank”; these are this study's neighbours in a fixed, alphabetical-by-hash tour of them, not the closest in content. All 1,084 tagged studies.

Similar studies

More on Getting a diagnosis

See all studies in Getting a diagnosis →