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Gene expression profiling in human neurodegenerative disease
Cooper-Knock J, Kirby J, Ferraiuolo L, Heath PR, Rattray M, Shaw PJ.. Nature reviews. Neurology, 2012-08-14
Topic: Brain proteins, microglia and lab models
Transcriptome study in neurodegenerative disease has advanced considerably in the past 5 years. Increasing scientific rigour and improved analytical tools have led to more-reproducible data. Many transcriptome analysis platforms assay the expression of the entire genome, enabling a complete biological context to be captured.
Key findings
- Increasing scientific rigour and improved analytical tools have led to more-reproducible data.
- Many transcriptome analysis platforms assay the expression of the entire genome, enabling a complete biological context to be captured.
- Gene expression profiling (GEP) is, therefore, uniquely placed to discover pathways of disease pathogenesis, potential therapeutic targets, and biomarkers.
- This Review summarizes microarray human GEP studies in the common neurodegenerative diseases amyotrophic lateral sclerosis (ALS), Parkinson disease (PD) and Alzheimer disease (AD).
Why it matters
This review summarizes gene expression profiling studies in common neurodegenerative diseases and how such studies may reveal disease pathways, therapeutic targets and biomarkers. It reports no new treatment or prevention and is a summary of existing research rather than a clinical trial.
Study details
- Evidence strengthLow
How this study scored 42/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Nature reviews. Neurology) |
| Journal's citation record | 3 / 4 | Nature Reviews Neurology: journal h-index 269 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2012 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 224 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 14.0 citations a year over 16 year(s) since 2012 |
| Impact for its field and year | 2 / 6 | Cited 2.9× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 2 other studies in this library |
| Still being cited | 2 / 4 | Cited 17 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Pamela J. Shaw: h-index 116 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | University of Sheffield: institution h-index 1,017 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 22890216) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 42 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1038/nrneurol.2012.156
- PubMed: 22890216
- Original source →
- Free full text: Nature Reviews Neurology →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Cooper-Knock, J., Kirby, J., Ferraiuolo, L., Heath, P. R., Rattray, M., & Shaw, P. J. (2012). Gene expression profiling in human neurodegenerative disease. Nature reviews. Neurology. https://doi.org/10.1038/nrneurol.2012.156
Vancouver
Cooper-Knock J, Kirby J, Ferraiuolo L, Heath PR, Rattray M, Shaw PJ. Gene expression profiling in human neurodegenerative disease. Nature reviews. Neurology. 2012. doi:10.1038/nrneurol.2012.156. PMID: 22890216.
BibTeX
@article{cooperknock2012-22890216,
author = {Cooper-Knock, J. and Kirby, J. and Ferraiuolo, L. and Heath, P. R. and Rattray, M. and Shaw, P. J.},
title = {{Gene expression profiling in human neurodegenerative disease}},
journal = {Nature reviews. Neurology},
year = {2012},
doi = {10.1038/nrneurol.2012.156},
pmid = {22890216},
url = {https://doi.org/10.1038/nrneurol.2012.156}
}
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