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Subclinical cardiac dysfunction increases the risk of stroke and dementia: the Rotterdam Study
de Bruijn RF, Portegies ML, Leening MJ, Bos MJ, Hofman A, van der Lugt A, Niessen WJ, Vernooij MW et al.. Neurology, 2015-01-28
Topic: Risk, prevention and care in population studies
Objective To investigate the association between cardiac function and the risk of stroke and dementia in elderly free of clinical cardiac disease. Additionally, we investigated the relation between cardiac function and MRI markers of subclinical cerebrovascular disease. Methods This study was conducted within the population-based Rotterdam Study.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
de Bruijn, R. F., Portegies, M. L., Leening, M. J., Bos, M. J., Hofman, A., van der Lugt, A., et al. (2015). Subclinical cardiac dysfunction increases the risk of stroke and dementia: the Rotterdam Study. Neurology. https://doi.org/10.1212/wnl.0000000000001289
Vancouver
de Bruijn RF, Portegies ML, Leening MJ, Bos MJ, Hofman A, van der Lugt A, et al. Subclinical cardiac dysfunction increases the risk of stroke and dementia: the Rotterdam Study. Neurology. 2015. doi:10.1212/wnl.0000000000001289. PMID: 25632093.
BibTeX
@article{debruijn2015-25632093,
author = {de Bruijn, R. F. and Portegies, M. L. and Leening, M. J. and Bos, M. J. and Hofman, A. and van der Lugt, A. and Niessen, W. J. and Vernooij, M. W. and others},
title = {{Subclinical cardiac dysfunction increases the risk of stroke and dementia: the Rotterdam Study}},
journal = {Neurology},
year = {2015},
doi = {10.1212/wnl.0000000000001289},
pmid = {25632093},
url = {https://doi.org/10.1212/wnl.0000000000001289}
}
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Key findings
- Additionally, we investigated the relation between cardiac function and MRI markers of subclinical cerebrovascular disease.
- Methods This study was conducted within the population-based Rotterdam Study.
- A total of 3,291 participants (60.8% female, age-range 58-98 years) free of coronary heart disease, heart failure, atrial fibrillation, stroke, and dementia underwent echocardiography in 2002-2005 to measure cardiac function.
- In 2005-2006, a random subset of 577 stroke-free people without dementia underwent brain MRI on which infarcts and white matter lesion volume were assessed.
Why it matters
In older adults without known heart disease, this study found that subclinical cardiac dysfunction was linked to a higher risk of stroke and dementia. It suggests heart function may matter for brain health, but it does not show that treating heart function prevents dementia.
Study details
- Participants3,291
- Effect size60.8%; HR 0.82; HR 0.84
- Evidence strengthLow
How this study scored 52/100
Published in a leading specialty journal. Scored zero for study design and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Neurology) |
| Journal's citation record | 4 / 4 | Neurology: journal h-index 525 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2015 — within 20 year(s) of the newest study here |
| Sample size | 3 / 4 | 3,291 participants |
| Effect reported | 3 / 3 | Effect reported with a statistic (interval, p-value, ratio or similar) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 4 / 7 | Cited 54 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 4.2 citations a year over 13 year(s) since 2015 |
| Impact for its field and year | 3 / 6 | Cited 4.9× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 2 other studies in this library |
| Still being cited | 1 / 4 | Cited 13 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author M. Arfan Ikram: h-index 167 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Delft University of Technology: institution h-index 811 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 25632093) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 52 / 100 | — |
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