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The Language Profile of Behavioral Variant Frontotemporal Dementia
Hardy CJ, Buckley AH, Downey LE, Lehmann M, Zimmerer VC, Varley RA, Crutch SJ, Rohrer JD et al.. Journal of Alzheimer's disease : JAD, 2016-01-01
Topic: Risk, prevention and care in population studies
Background The language profile of behavioral variant frontotemporal dementia (bvFTD) remains to be fully defined. Objective We aimed to quantify the extent of language deficits in this patient group. Methods We assessed a cohort of patients with bvFTD (n = 24) in relation to patients with semantic variant primary progressive aphasia (svPPA; n = 14), nonfluent variant primary progressive aphasia (nfvPPA; n = 18), and healthy age-matched individuals (n = 24) cross-sectionally and longitudinally using a comprehensive battery of language and general neuropsychological tests. Neuroanatomical associations of language performance were assessed using voxel-based morphometry of patients' brain magnetic resonance images. Results Relative to healthy controls, and after accounting for nonverbal executive performance, patients with bvFTD showed deficits of noun and verb naming and single word comprehension, diminished spontaneous propositional speech, and deterioration in naming performance over time. Within the bvFTD group, patients with MAPT mutations had more severe impairments of noun naming and single word comprehension than patients with C9orf72 mutations. Overall the bvFTD group had less severe language deficits than patients with PPA, but showed a language profile that was qualitatively similar to svPPA. Neuroanatomical correlates of naming and word comprehension performance in bvFTD were identified predominantly in inferior frontal and antero-inferior temporal cortices within the dominant hemispheric language network. Conclusions bvFTD is associated with a language profile including verbal semantic impairment that warrants further evaluation as a novel biomarker.
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APA 7th
Hardy, C. J., Buckley, A. H., Downey, L. E., Lehmann, M., Zimmerer, V. C., Varley, R. A., et al. (2016). The Language Profile of Behavioral Variant Frontotemporal Dementia. Journal of Alzheimer's disease : JAD. https://doi.org/10.3233/jad-150806
Vancouver
Hardy CJ, Buckley AH, Downey LE, Lehmann M, Zimmerer VC, Varley RA, et al. The Language Profile of Behavioral Variant Frontotemporal Dementia. Journal of Alzheimer's disease : JAD. 2016. doi:10.3233/jad-150806. PMID: 26682693.
BibTeX
@article{hardy2016-26682693,
author = {Hardy, C. J. and Buckley, A. H. and Downey, L. E. and Lehmann, M. and Zimmerer, V. C. and Varley, R. A. and Crutch, S. J. and Rohrer, J. D. and others},
title = {{The Language Profile of Behavioral Variant Frontotemporal Dementia}},
journal = {Journal of Alzheimer's disease : JAD},
year = {2016},
doi = {10.3233/jad-150806},
pmid = {26682693},
url = {https://doi.org/10.3233/jad-150806}
}
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Key findings
- Results Relative to healthy controls, and after accounting for nonverbal executive performance, patients with bvFTD showed deficits of noun and verb naming and single word comprehension, diminished spontaneous propositional speech, and deterioration in naming performance over time.
- Overall the bvFTD group had less severe language deficits than patients with PPA, but showed a language profile that was qualitatively similar to svPPA.
- Conclusions bvFTD is associated with a language profile including verbal semantic impairment that warrants further evaluation as a novel biomarker.
Why it matters
This study found that patients with behavioral variant frontotemporal dementia showed language deficits including naming and word comprehension problems, with less severe deficits than primary progressive aphasia. It describes language features of frontotemporal dementia and does not test any treatment, cure, or prevention for Alzheimer's disease.
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Study details
- Participants24
- Evidence strengthModerate
How this study scored 52/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of Alzheimer's disease : JAD) |
| Journal's citation record | 2 / 4 | Journal of Alzheimer s Disease: journal h-index 218 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2016 — within 20 year(s) of the newest study here |
| Sample size | 1 / 4 | 24 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 126 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 10.5 citations a year over 12 year(s) since 2016 |
| Impact for its field and year | 3 / 6 | Cited 6.0× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 5 other studies in this library |
| Still being cited | 2 / 4 | Cited 32 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Jason D. Warren: h-index 95 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University College London: institution h-index 2,029 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 26682693) |
| Free to read | 2 / 2 | Free to read |
| Total | 52 / 100 | — |
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