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Peripheral Single‐Cell Immune Characteristics Contribute to the Diagnosis of Alzheimer's Disease and Dementia With Lewy Bodies
Conglong Qiu, Danhua Zhang, Majie Wang, Xi Mei, Wei Chen, Haihang Yu, Weiwei Yin, Guoping Peng et al.. CNS Neuroscience & Therapeutics, 2025-01-01
Topic: Amyloid, tau and blood-test diagnosis
These models demonstrated high diagnostic efficacy in distinguishing diseased samples from healthy donors as well as distinguishing AD and DLB cases. The selected features reveal that the primary peripheral immune characteristic of AD is a decrease in total T cells, while DLB is characterized by low expression of I-kappa-B-alpha (IKBα) in the classical monocyte subset. These findings suggest that peripheral immune characteristics could serve as potential biomarkers, facilitating the diagnosis of neurodegenerative diseases.
Key findings
- These models demonstrated high diagnostic efficacy in distinguishing diseased samples from healthy donors as well as distinguishing AD and DLB cases.
- The selected features reveal that the primary peripheral immune characteristic of AD is a decrease in total T cells, while DLB is characterized by low expression of I-kappa-B-alpha (IKBα) in the classical monocyte subset.
- These findings suggest that peripheral immune characteristics could serve as potential biomarkers, facilitating the diagnosis of neurodegenerative diseases.
Why it matters
Models based on peripheral single-cell immune characteristics distinguished diseased samples from healthy donors and distinguished Alzheimer's disease from dementia with Lewy bodies, with Alzheimer's disease showing a decrease in total T cells. These findings are proposed as potential diagnostic biomarkers and do not address treating, curing or preventing Alzheimer's disease.
Study details
- Evidence strengthLow
How this study scored 38/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (CNS Neuroscience & Therapeutics) |
| Journal's citation record | 1 / 4 | CNS Neuroscience & Therapeutics: journal h-index 120 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 2 / 7 | Cited 8 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 2.7 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 2 / 6 | Cited 2.4× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 1 / 4 | Cited 8 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Shaohua Hu: h-index 48 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Zhejiang University: institution h-index 1,040 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 5 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 39754303) |
| Free to read | 2 / 2 | Free to read |
| Total | 38 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1111/cns.70204
- PubMed: 39754303
- Original source →
- Free full text: CNS Neuroscience & Therapeutics →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Qiu, C., Zhang, D., Wang, M., Mei, X., Chen, W., Yu, H., et al. (2025). Peripheral Single‐Cell Immune Characteristics Contribute to the Diagnosis of Alzheimer's Disease and Dementia With Lewy Bodies. CNS Neuroscience & Therapeutics. https://doi.org/10.1111/cns.70204
Vancouver
Qiu C, Zhang D, Wang M, Mei X, Chen W, Yu H, et al. Peripheral Single‐Cell Immune Characteristics Contribute to the Diagnosis of Alzheimer's Disease and Dementia With Lewy Bodies. CNS Neuroscience & Therapeutics. 2025. doi:10.1111/cns.70204. PMID: 39754303.
BibTeX
@article{qiu2025-39754303,
author = {Qiu, Conglong and Zhang, Danhua and Wang, Majie and Mei, Xi and Chen, Wei and Yu, Haihang and Yin, Weiwei and Peng, Guoping and others},
title = {{Peripheral Single‐Cell Immune Characteristics Contribute to the Diagnosis of Alzheimer's Disease and Dementia With Lewy Bodies}},
journal = {CNS Neuroscience \& Therapeutics},
year = {2025},
doi = {10.1111/cns.70204},
pmid = {39754303},
url = {https://doi.org/10.1111/cns.70204}
}
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